ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3481–3500 of 6,209 studies

E2 ModerateCohortPEM unclearCross-Sectional

Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

Baraniuk, J N, Clauw, D, Yuta, A et al.·American journal of rhinology·1998

Many people with ME/CFS experience nasal congestion and rhinitis symptoms, but don't test positive for allergies. This study analyzed nasal fluid from ME/CFS patients and compared it to people with allergies, cystic fibrosis, and healthy controls to understand what might be causing these symptoms. The researchers found that ME/CFS patients' nasal fluid looked similar to healthy controls, suggesting that the constant baseline secretion processes in the nose are not abnormal in ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and verbal learning in patients with chronic fatigue syndrome.

Michiels, V, Cluydts, R, Fischler, B·Journal of the International Neuropsychological Society : JINS·1998

This study tested thinking and memory skills in 20 people with ME/CFS and compared them to 22 healthy people. The researchers found that people with ME/CFS had difficulty with attention tasks that required handling multiple pieces of information at once, and they performed worse on remembering spoken information. However, their ability to focus on a single thing while ignoring distractions appeared to work normally.

Cognitive Impairment

E2 ModerateCohortPEM unclearObservational

Effect of noise stress on chronic fatigue syndrome patients.

Beh, H C·The Journal of nervous and mental disease·1997

This study looked at how noise affects people with ME/CFS, examining whether environmental sounds make their symptoms worse. The research observed how patients responded to noise stress as part of understanding the condition better. This type of research helps identify triggers that may worsen fatigue and other ME/CFS symptoms.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

[Prevalence of chronic fatigue syndrome and primary fibromyalgia syndrome in The Netherlands].

Bazelmans, E, Vercoulen, J H, Galama, J M et al.·Nederlands tijdschrift voor geneeskunde·1997

This study asked general doctors across the Netherlands how many ME/CFS and fibromyalgia patients they saw in their practices. Based on their responses, researchers estimated that about 112 out of every 100,000 people in the Netherlands have ME/CFS, and 157 out of every 100,000 have fibromyalgia. The study found that both conditions affect mostly women and tend to develop in early-to-middle adulthood.

E2 ModerateCohortPEM unclearCase-Control

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome.

Bennett, A L, Chao, C C, Hu, S et al.·Journal of clinical immunology·1997

Researchers measured a protein called TGF-beta in the blood of ME/CFS patients and compared it to healthy people and patients with other diseases like lupus and multiple sclerosis. They found that ME/CFS patients had significantly higher levels of this protein than all the other groups studied. This suggests that TGF-beta might play a role in ME/CFS, though more research is needed to understand exactly how.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Cuende, J I, Civeira, P, Diez, N et al.·Anales de medicina interna (Madrid, Spain : 1984)·1997

Researchers tested 20 ME/CFS patients for active herpesvirus-6 (HHV-6) infection, a virus that had been suspected as a possible cause of ME/CFS. They found that half the patients had antibodies showing past HHV-6 infection, but sensitive testing detected only small amounts of viral DNA in blood cells and no active viral replication. This suggests that while many ME/CFS patients may have been infected with HHV-6 in the past, the virus is not actively multiplying in their bodies.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

A population-based incidence study of chronic fatigue.

Lawrie, S M, Manders, D N, Geddes, J R et al.·Psychological medicine·1997

This study looked at how many people develop chronic fatigue in the general population (rather than just in doctor's offices), and what factors might increase the risk. Researchers found that people who were already somewhat fatigued before the study began were more likely to develop chronic fatigue later on. Interestingly, emotional difficulties and psychiatric conditions appeared less common in ME/CFS patients when researchers carefully adjusted for fatigue itself.

E2 ModerateCohortPEM not requiredCross-Sectional

Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome.

Buchwald, D, Wener, M H, Pearlman, T et al.·The Journal of rheumatology·1997

Researchers tested blood samples from 153 patients with severe fatigue to see if certain immune markers were elevated, thinking that an overactive immune system might cause ME/CFS. They found that three markers (C-reactive protein, beta 2-microglobulin, and neopterin) were higher in fatigued patients compared to healthy controls, but these markers couldn't reliably distinguish between ME/CFS and other types of chronic fatigue. The results suggest that some patients have signs of immune activation, but it's unclear whether this is a temporary response to infection or part of the ongoing illness.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

The natural history of concurrent sick building syndrome and chronic fatigue syndrome.

Chester, A C, Levine, P H·Journal of psychiatric research·1997

This study followed 23 people who developed fatigue and other symptoms during an outbreak linked to a problem building environment. Four years later, about two-thirds of the group had improved significantly or felt much better, while about one-third remained quite ill and unable to work. People who improved tended to also see their respiratory symptoms, sore throats, and headaches get better over time.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Screening for psychiatric disorders in chronic fatigue and chronic fatigue syndrome.

Buchwald, D, Pearlman, T, Kith, P et al.·Journal of psychosomatic research·1997

This study looked at how common mental health conditions are in people with chronic fatigue and ME/CFS, and tested whether a simple questionnaire could help identify these conditions. Researchers interviewed 281 patients and found that about one-third had a current mental health disorder, while over 80% had experienced one at some point in their lives. A screening tool called the General Health Questionnaire performed reasonably well at spotting current psychiatric conditions, though it wasn't perfect.

E2 ModerateBehavioralPEM not requiredLongitudinal

Coping and other predictors of outcome in chronic fatigue syndrome: a 1-year follow-up.

Ray, C, Jefferies, S, Weir, W R·Journal of psychosomatic research·1997

This study followed 137 ME/CFS patients for one year to see what factors predicted whether they improved or got worse. About two-thirds of patients reported some improvement over the year. The results showed that people with longer illness duration, cognitive difficulties, and multiple body symptoms tended to have worse outcomes, while mental health symptoms like anxiety and depression did not predict outcomes. Interestingly, patients who believed they could influence their condition through their own actions did better, even if they had to adjust their activities around their illness.

E2 ModerateBehavioralPEM not requiredObservational

An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome.

White, P D, Cleary, K J·International clinical psychopharmacology·1997

This study tested whether a medication called moclobemide could help people with ME/CFS. Researchers gave 49 patients the drug for 6 weeks and found small improvements in fatigue, depression, and anxiety. The medication worked better for patients who also had depression, with half of them feeling much better, compared to only about one-fifth of those without depression.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Immune responses associated with chronic fatigue syndrome: a case-control study.

Mawle, A C, Nisenbaum, R, Dobbins, J G et al.·The Journal of infectious diseases·1997

Researchers compared immune system measurements between ME/CFS patients and healthy controls to see if immune differences could reliably detect the illness. While previous studies reported many immune differences, this careful study found most standard immune tests showed no difference between patients and controls. However, when they looked at specific subgroups—such as patients whose illness started suddenly versus gradually—they did find some immune differences, suggesting that ME/CFS may not be a single uniform immune condition.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Patterns of utilization of medical care and perceptions of the relationship between doctor and patient with chronic illness including chronic fatigue syndrome.

Twemlow, S W, Bradshaw, S L, Coyne, L et al.·Psychological reports·1997

This study surveyed 609 people with ME/CFS to understand how their relationships with doctors differ from those of other patients with medical conditions. People with ME/CFS reported missing about 65 days of work per year due to illness, experienced more side effects from medical treatments, spent more money on healthcare, and visited more specialists than patients with typical medical conditions. The researchers found that doctors may need to pay more attention to how ME/CFS patients perceive their illness and their doctor-patient relationship, as these beliefs can affect how well treatments work.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The chronic fatigue syndrome and hyperventilation.

Bazelmans, E, Bleijenberg, G, Vercoulen, J H et al.·Journal of psychosomatic research·1997

This study looked at whether rapid, shallow breathing (hyperventilation) causes ME/CFS or makes it worse. Researchers compared ME/CFS patients with people who hyperventilate but don't have ME/CFS, and healthy people. While ME/CFS patients did show signs of hyperventilation more often than healthy controls, having hyperventilation didn't actually make their fatigue or other symptoms worse.

E2 ModerateCohortPEM unclearCase-Control

A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome.

Harmon, D L, McMaster, D, McCluskey, D R et al.·Annals of clinical biochemistry·1997

This study looked at whether a specific genetic variant related to how the body processes folate (a B vitamin) is more common in people with ME/CFS compared to healthy controls. The researchers found that this particular genetic variation was not significantly more frequent in ME/CFS patients, suggesting this specific genetic factor is unlikely to be a major cause of the condition.

Energy Metabolism

E2 ModerateCohortPEM not requiredCase-Control

Brain MR in chronic fatigue syndrome.

Greco, A, Tannock, C, Brostoff, J et al.·AJNR. American journal of neuroradiology·1997

Researchers used brain MRI scans to look for white matter abnormalities (areas of damage in the brain's connecting tissue) in 43 ME/CFS patients and compared them to 43 healthy control subjects. While some abnormalities were found in both groups, there was no pattern of brain changes that was unique to ME/CFS, suggesting that MRI scans alone cannot diagnose the condition.

E2 ModerateCohortPEM not requiredCase-Control

Fatiguing illness among employees in three large state office buildings, California, 1993: was there an outbreak?

Shefer, A, Dobbins, J G, Fukuda, K et al.·Journal of psychiatric research·1997

Researchers surveyed over 3,300 state office workers in California to see if there was an unusual outbreak of long-lasting fatigue or ME/CFS-like illness. They found that about 18% of workers reported fatigue lasting at least a month, but this rate was similar in buildings thought to have clusters and in a comparison building, suggesting there was no outbreak. The study identified that certain groups—including women, Hispanic workers, Native American workers, and those with lower income or education—were more likely to report fatigue.

Diagnostics

E2 ModerateBehavioralPEM unclearCross-Sectional

Physical activity in chronic fatigue syndrome: assessment and its role in fatigue.

Vercoulen, J H, Bazelmans, E, Swanink, C M et al.·Journal of psychiatric research·1997

This study looked at how active people with ME/CFS actually are compared to healthy people and patients with multiple sclerosis (MS). Researchers used three different methods to measure activity: questionnaires, daily logs, and a wearable device. They found that ME/CFS patients were less active than healthy people, similar to MS patients, but ME/CFS patients were more likely to avoid activities they feared would make their fatigue worse.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic debilitating fatigue in Irish general practice: a survey of general practitioners' experience.

Fitzgibbon, E J, Murphy, D, O'Shea, K et al.·The British journal of general practice : the journal of the Royal College of General Practitioners·1997

Irish doctors were surveyed about their experience treating patients with chronic, debilitating fatigue. The study found that fatigue is common in general practice—affecting about 1 in 1,000 people—with twice as many women as men affected. However, doctors used very different approaches to treating these patients and many were unhappy with the care they could provide.

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Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.

Attention and verbal learning in patients with chronic fatigue syndrome.

Effect of noise stress on chronic fatigue syndrome patients.

[Prevalence of chronic fatigue syndrome and primary fibromyalgia syndrome in The Netherlands].

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome.

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

A population-based incidence study of chronic fatigue.

Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome.

The natural history of concurrent sick building syndrome and chronic fatigue syndrome.

Screening for psychiatric disorders in chronic fatigue and chronic fatigue syndrome.

Coping and other predictors of outcome in chronic fatigue syndrome: a 1-year follow-up.

An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome.

Immune responses associated with chronic fatigue syndrome: a case-control study.

Patterns of utilization of medical care and perceptions of the relationship between doctor and patient with chronic illness including chronic fatigue syndrome.

The chronic fatigue syndrome and hyperventilation.

A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome.

Brain MR in chronic fatigue syndrome.

Fatiguing illness among employees in three large state office buildings, California, 1993: was there an outbreak?

Physical activity in chronic fatigue syndrome: assessment and its role in fatigue.

Chronic debilitating fatigue in Irish general practice: a survey of general practitioners' experience.

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