ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3501–3520 of 6,209 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Neuropsychological and psychological functioning in chronic fatigue syndrome.

Kane, R L, Gantz, N M, DiPino, R K·Neuropsychiatry, neuropsychology, and behavioral neurology·1997

This study compared 17 people with ME/CFS to 17 healthy controls on thinking and memory tests, as well as psychological well-being. While ME/CFS patients reported feeling cognitively foggy, most formal test scores were similar between groups. However, ME/CFS patients showed significantly higher levels of psychological distress, anxiety, and depression compared to controls.

Cognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

The natural history of concurrent sick building syndrome and chronic fatigue syndrome.

Chester, A C, Levine, P H·Journal of psychiatric research·1997

This study followed 23 people who developed fatigue and other symptoms during an outbreak linked to a problem building environment. Four years later, about two-thirds of the group had improved significantly or felt much better, while about one-third remained quite ill and unable to work. People who improved tended to also see their respiratory symptoms, sore throats, and headaches get better over time.

E2 ModerateBehavioralPEM not requiredObservational

An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome.

White, P D, Cleary, K J·International clinical psychopharmacology·1997

This study tested whether a medication called moclobemide could help people with ME/CFS. Researchers gave 49 patients the drug for 6 weeks and found small improvements in fatigue, depression, and anxiety. The medication worked better for patients who also had depression, with half of them feeling much better, compared to only about one-fifth of those without depression.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Patients with chronic fatigue syndrome and accurate feeling-of-knowing judgments.

Lakein, D A, Fantie, B D, Grafman, J et al.·Journal of clinical psychology·1997

Many people with ME/CFS say they have memory problems, but doctors have had trouble proving this in tests. This study looked at whether the issue might be that ME/CFS patients are bad at judging how confident they should be about their memories. When researchers tested both ME/CFS patients and healthy people on a trivia quiz, they found that both groups were equally good at knowing when they probably got an answer right—even though the ME/CFS patients reported much worse fatigue and cognitive symptoms.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Surveillance for chronic fatigue syndrome--four U.S. cities, September 1989 through August 1993.

Reyes, M, Gary, H E, Dobbins, J G et al.·MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries·1997

Between 1989 and 1993, researchers in four U.S. cities tracked patients with chronic fatigue syndrome (CFS) to understand how common it was and what it looked like. Of 565 patients evaluated, 130 met the CFS criteria. The study found that CFS affected about 4 to 9 people per 100,000 in the general population, but was much more common in white women. Most CFS patients were in their 30s when they got sick and had been ill for about 7 years.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Cuende, J I, Civeira, P, Diez, N et al.·Anales de medicina interna (Madrid, Spain : 1984)·1997

Researchers tested 20 ME/CFS patients for active herpesvirus-6 (HHV-6) infection, a virus that had been suspected as a possible cause of ME/CFS. They found that half the patients had antibodies showing past HHV-6 infection, but sensitive testing detected only small amounts of viral DNA in blood cells and no active viral replication. This suggests that while many ME/CFS patients may have been infected with HHV-6 in the past, the virus is not actively multiplying in their bodies.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome.

Buchwald, D, Wener, M H, Pearlman, T et al.·The Journal of rheumatology·1997

Researchers tested blood samples from 153 patients with severe fatigue to see if certain immune markers were elevated, thinking that an overactive immune system might cause ME/CFS. They found that three markers (C-reactive protein, beta 2-microglobulin, and neopterin) were higher in fatigued patients compared to healthy controls, but these markers couldn't reliably distinguish between ME/CFS and other types of chronic fatigue. The results suggest that some patients have signs of immune activation, but it's unclear whether this is a temporary response to infection or part of the ongoing illness.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome.

Fukuda, K, Dobbins, J G, Wilson, L J et al.·Journal of psychiatric research·1997

Researchers surveyed nearly 1,700 households across four rural Michigan communities to investigate reports of a cluster of chronic fatigue syndrome cases. They found that fatigue was equally common across all communities studied, and the symptoms people with fatigue experienced were similar to generic tiredness rather than distinctly different. The reported cluster of CFS cases could not be confirmed.

E2 ModerateCohortPEM not requiredCross-Sectional

Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.

Kubo, K, Fujiyoshi, T, Yokoyama, M M et al.·Clinical and diagnostic laboratory immunology·1997

Researchers tested whether two viruses—Borna disease virus (BDV) and HTLV-1—might be linked to psychiatric disorders like schizophrenia and depression in Japanese patients. After testing blood samples from 346 patients with psychiatric conditions and 70 healthy people, they found almost no evidence that either virus was associated with these mental health conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

[Prevalence of chronic fatigue syndrome in 4 family practices in Leiden].

Versluis, R G, de Waal, M W, Opmeer, C et al.·Nederlands tijdschrift voor geneeskunde·1997

Researchers in the Netherlands looked at how many people in general medical practices had chronic fatigue syndrome (CFS). They reviewed medical records from about 23,000 patients and found that at least 1-2 out of every 1,000 patients had CFS. Interestingly, they noticed that women were diagnosed with CFS about five times more often than men.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS).

Wearden, A, Appleby, L·Psychological medicine·1997

This study asked people with ME/CFS about memory and concentration problems and then tested them in the lab. While ME/CFS patients reported more trouble concentrating and remembering when reading compared to healthy people, standard lab tests didn't always show measurable differences—except in those with depression. This suggests that cognitive difficulties in ME/CFS may be real but show up more in everyday activities than in controlled lab settings.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

The chronic fatigue syndrome and hyperventilation.

Bazelmans, E, Bleijenberg, G, Vercoulen, J H et al.·Journal of psychosomatic research·1997

This study looked at whether rapid, shallow breathing (hyperventilation) causes ME/CFS or makes it worse. Researchers compared ME/CFS patients with people who hyperventilate but don't have ME/CFS, and healthy people. While ME/CFS patients did show signs of hyperventilation more often than healthy controls, having hyperventilation didn't actually make their fatigue or other symptoms worse.

E2 ModerateCohortPEM not requiredCross-Sectional

The quality of life of persons with chronic fatigue syndrome.

Anderson, J S, Ferrans, C E·The Journal of nervous and mental disease·1997

This study asked 110 people with ME/CFS to rate their quality of life and interviewed 22 of them in depth about their daily experiences. The researchers found that people with ME/CFS reported significantly lower quality of life compared to people with other chronic illnesses, with the biggest problems in health and physical functioning. The detailed interviews helped explain why the numbers were so low and showed that ME/CFS uniquely disrupts many aspects of a person's life.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A population-based incidence study of chronic fatigue.

Lawrie, S M, Manders, D N, Geddes, J R et al.·Psychological medicine·1997

This study looked at how many people develop chronic fatigue in the general population (rather than just in doctor's offices), and what factors might increase the risk. Researchers found that people who were already somewhat fatigued before the study began were more likely to develop chronic fatigue later on. Interestingly, emotional difficulties and psychiatric conditions appeared less common in ME/CFS patients when researchers carefully adjusted for fatigue itself.

E2 ModerateCohortPEM not requiredCross-Sectional

The effects of fatigue on neuropsychological performance in patients with chronic fatigue syndrome, multiple sclerosis, and depression.

Johnson, S K, Lange, G, DeLuca, J et al.·Applied neuropsychology·1997

Researchers tested whether fatigue directly worsens brain performance on a specific attention test (PASAT) in people with ME/CFS, multiple sclerosis, and depression. They found that people with ME/CFS and depression performed worse overall on the test compared to healthy controls, but fatigue itself did not prevent people from improving with practice. This suggests that fatigue may not be the main factor directly causing the thinking difficulties some ME/CFS patients experience.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

Coping and other predictors of outcome in chronic fatigue syndrome: a 1-year follow-up.

Ray, C, Jefferies, S, Weir, W R·Journal of psychosomatic research·1997

This study followed 137 ME/CFS patients for one year to see what factors predicted whether they improved or got worse. About two-thirds of patients reported some improvement over the year. The results showed that people with longer illness duration, cognitive difficulties, and multiple body symptoms tended to have worse outcomes, while mental health symptoms like anxiety and depression did not predict outcomes. Interestingly, patients who believed they could influence their condition through their own actions did better, even if they had to adjust their activities around their illness.

E2 ModerateCohortPEM unclearCross-Sectional

Sleep anomalies in the chronic fatigue syndrome. A comorbidity study.

Fischler, B, Le Bon, O, Hoffmann, G et al.·Neuropsychobiology·1997

This study examined sleep patterns in 49 ME/CFS patients compared to 20 healthy people using overnight sleep monitoring. Patients with ME/CFS had difficulty falling asleep and staying asleep, and spent less time in deep, restorative stage 4 sleep. These sleep problems were distinctive enough that researchers could correctly identify who had ME/CFS based on sleep patterns alone.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

The relationship between fibromyalgia and interstitial cystitis.

Clauw, D J, Schmidt, M, Radulovic, D et al.·Journal of psychiatric research·1997

This study compared symptom patterns in people with fibromyalgia, interstitial cystitis (a bladder pain condition), and healthy people. Researchers found that fibromyalgia and IC patients reported very similar types of symptoms beyond their primary complaints, and both groups showed increased pain sensitivity throughout their bodies—not just in the areas they typically experienced pain.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Pathogenesis and management of delayed orthostatic hypotension in patients with chronic fatigue syndrome.

De Lorenzo, F, Hargreaves, J, Kakkar, V V·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1997

Some ME/CFS patients experience dizziness or fainting when standing up, a condition called orthostatic hypotension. This study tested whether salt supplements could help 22 ME/CFS patients with this symptom. After 8 weeks, salt helped 11 patients feel better, but 10 patients' symptoms returned—and those 10 had lower levels of a hormone called renin that helps regulate blood pressure.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Latent variable models of functional somatic distress.

Robbins, J M, Kirmayer, L J, Hemami, S·The Journal of nervous and mental disease·1997

This study looked at how symptoms of ME/CFS, fibromyalgia, and irritable bowel syndrome relate to each other in nearly 700 patients visiting family medicine clinics. Using statistical methods, researchers found evidence that these conditions may be distinct from one another, rather than being different expressions of the same underlying problem. The findings suggest that depression and anxiety may play a role alongside these syndromes.

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Neuropsychological and psychological functioning in chronic fatigue syndrome.

The natural history of concurrent sick building syndrome and chronic fatigue syndrome.

An open study of the efficacy and adverse effects of moclobemide in patients with the chronic fatigue syndrome.

Patients with chronic fatigue syndrome and accurate feeling-of-knowing judgments.

Surveillance for chronic fatigue syndrome--four U.S. cities, September 1989 through August 1993.

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome.

An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome.

Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.

[Prevalence of chronic fatigue syndrome in 4 family practices in Leiden].

Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS).

The chronic fatigue syndrome and hyperventilation.

The quality of life of persons with chronic fatigue syndrome.

A population-based incidence study of chronic fatigue.

The effects of fatigue on neuropsychological performance in patients with chronic fatigue syndrome, multiple sclerosis, and depression.

Coping and other predictors of outcome in chronic fatigue syndrome: a 1-year follow-up.

Sleep anomalies in the chronic fatigue syndrome. A comorbidity study.

The relationship between fibromyalgia and interstitial cystitis.

Pathogenesis and management of delayed orthostatic hypotension in patients with chronic fatigue syndrome.

Latent variable models of functional somatic distress.

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