ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3521–3540 of 6,161 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

MMPI profiles of patients with chronic fatigue syndrome.

Schmaling, K B, Jones, J F·Journal of psychosomatic research·1996

This study examined personality and psychological profiles in 53 ME/CFS patients compared to 43 healthy people using a standard psychological test called the MMPI. Researchers also measured levels of Epstein-Barr virus (a virus often linked to ME/CFS) in all participants. They found that ME/CFS patients showed higher virus levels and distinctive patterns on the psychological test, particularly in areas related to physical symptoms, mood, and anxiety.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive functioning in patients with chronic fatigue syndrome.

Michiels, V, Cluydts, R, Fischler, B et al.·Journal of clinical and experimental neuropsychology·1996

This study found that people with ME/CFS performed worse than healthy controls on thinking and memory tests. Patients showed slower processing speed, difficulty concentrating, and trouble learning and remembering new information. However, the researchers noted that cognitive problems varied widely between patients, so not everyone with ME/CFS experiences the same level of difficulty.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

A national assessment of the service, support, and housing preferences by persons with chronic fatigue syndrome. Toward a comprehensive rehabilitation program.

Jason, L A, Ferrari, J R, Taylor, R R et al.·Evaluation & the health professions·1996

Nearly 1,000 people with ME/CFS across North America were surveyed about what services and support would help them most. The survey found that patients wanted better education about ME/CFS for doctors and the public, and preferred support groups and self-help resources over other types of treatment assistance. These results can help guide the development of programs specifically designed to support people with ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.

Sisto, S A, LaManca, J, Cordero, D L et al.·The American journal of medicine·1996

Researchers tested how well women with ME/CFS could exercise compared to healthy controls by having them walk on a treadmill until exhaustion. Women with ME/CFS had lower aerobic fitness levels than healthy controls, but their hearts and lungs appeared to work normally. Importantly, the maximal exercise test did not cause a major flare-up of fatigue or other ME/CFS symptoms.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.

Grant, J E, Veldee, M S, Buchwald, D·Journal of the American Dietetic Association·1996

This study looked at what people with ME/CFS were eating and measured specific nutrients in their blood and body. Researchers compared the diets and nutrient levels of ME/CFS patients to see if there were any patterns or deficiencies that might be related to their illness. This was one of the first studies to systematically examine nutrition in ME/CFS patients.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Assessing somatization disorder in the chronic fatigue syndrome.

Johnson, S K, DeLuca, J, Natelson, B H·Psychosomatic medicine·1996

This study compared how often doctors diagnosed somatization disorder (a condition where emotional distress causes physical symptoms) in ME/CFS patients versus people with multiple sclerosis, depression, or no illness. The researchers found that whether symptoms were labeled as 'psychiatric' or 'physical' dramatically changed the diagnosis rate, suggesting that labeling is somewhat arbitrary in ME/CFS. Very few patients in any group actually met strict diagnostic criteria for somatization disorder.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Descriptive epidemiology of chronic fatigue syndrome based on a nationwide survey in Japan.

Minowa, M, Jiamo, M·Journal of epidemiology·1996

Researchers surveyed hospitals across Japan in 1992 to understand how many people have ME/CFS and how it spreads. They found that about 0.85 cases per 100,000 people were diagnosed that year, with slightly more women affected than men. The number of cases appeared to be growing from 1992 to 1993, and a small percentage of cases started after an infection.

E2 ModerateCohortPEM not requiredCase-Control

A case-control study to assess possible triggers and cofactors in chronic fatigue syndrome.

MacDonald, K L, Osterholm, M T, LeDell, K H et al.·The American journal of medicine·1996

This study compared 47 people with ME/CFS to 47 matched healthy controls to identify what might trigger or contribute to the illness. Researchers found that people with ME/CFS were more likely to have exercised regularly before getting sick, and women with ME/CFS were more likely to have never had children. Depression was more common after ME/CFS developed, though it wasn't more common before illness onset.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

The localization of pain in chronic fatigue syndrome on a pain drawing according to grid areas.

Líndal, E, Bergmann, S, Thorlacius, S et al.·Perceptual and motor skills·1996

This study looked at where people with ME/CFS experience pain by having them mark painful areas on a body diagram divided into sections. The researchers wanted to understand the pattern of pain locations across different body regions in ME/CFS patients. This type of mapping can help doctors better understand how pain is distributed in the condition.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Lymphocyte subsets, apoptosis, and cytokines in patients with chronic fatigue syndrome.

Swanink, C M, Vercoulen, J H, Galama, J M et al.·The Journal of infectious diseases·1996

This study compared immune system markers in blood samples from 76 ME/CFS patients and 69 healthy controls to see if immune abnormalities could explain fatigue severity. Researchers found one immune marker (CD11b on CD8 cells) was lower in ME/CFS patients, but most other immune measures were similar between groups, and none of these markers correlated with how severe a patient's fatigue or depression was.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

An examination of the working case definition of chronic fatigue syndrome.

Komaroff, A L, Fagioli, L R, Geiger, A M et al.·The American journal of medicine·1996

Researchers studied 281 patients with severe, long-lasting fatigue to see how well the official definition of ME/CFS worked. They compared these patients to healthy people and people with similar conditions like multiple sclerosis and depression. The study found that certain symptoms—like muscle pain, post-exertion exhaustion, headaches, and flu-like symptoms—were very common in ME/CFS patients but rare in the other groups.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Preliminary determination of a molecular basis of chronic fatigue syndrome.

McGregor, N R, Dunstan, R H, Zerbes, M et al.·Biochemical and molecular medicine·1996

Researchers tested the urine of 20 ME/CFS patients and 45 healthy controls to look for chemical differences. They found that ME/CFS patients had different levels of several substances in their urine, particularly one called CFSUM1 and beta-alanine, which were higher in patients with more severe symptoms. These findings suggest ME/CFS may have measurable biological markers that could help identify the condition.

BiomarkersEnergy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

'Seronegative' Sjögren's syndrome manifested as a subset of chronic fatigue syndrome.

Nishikai, M, Akiya, K, Tojo, T et al.·British journal of rheumatology·1996

This study looked at whether some people diagnosed with ME/CFS who also experience dry eyes and mouth might actually have a related condition called Sjögren's syndrome. Researchers tested one-third of ME/CFS patients with these dry symptoms against several official diagnostic criteria for Sjögren's syndrome and found they met the criteria. However, these patients tested negative for the antibodies typically found in Sjögren's syndrome, making them an unusual variant of the disease.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Serum carnitine and disabling fatigue in multiple sclerosis.

Fukazawa, T, Sasaki, H, Kikuchi, S et al.·Psychiatry and clinical neurosciences·1996

This study tested whether a substance called carnitine, which helps muscles use fat for energy, might be low in people with multiple sclerosis (MS) and could explain their severe fatigue. Researchers compared carnitine levels in 25 MS patients and healthy people of similar age and sex, but found no differences between groups or between MS patients with and without severe fatigue.

Energy Metabolism

E2 ModerateCohortPEM not requiredObservational

Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome.

Kitani, T, Kuratsune, H, Fuke, I et al.·Microbiology and immunology·1996

This 1996 study investigated whether a virus called Borna disease virus (BDV) might be connected to chronic fatigue syndrome (ME/CFS). Borna disease virus naturally infects animals like horses and sheep, and researchers found evidence of this virus or antibodies to it in some ME/CFS patients. The study suggests there may be a link between BDV infection and ME/CFS symptoms, though more research is needed to understand if and how this virus contributes to the condition.

Immune System

E2 ModerateCohortPEM not requiredObservational

No findings of enteroviruses in Swedish patients with chronic fatigue syndrome.

Lindh, G, Samuelson, A, Hedlund, K O et al.·Scandinavian journal of infectious diseases·1996

Researchers tested 34 Swedish patients with ME/CFS to see if a virus called enterovirus might be causing their illness. They looked for the virus in stool samples, blood, spinal fluid, and muscle tissue using several different detection methods. The study found no evidence of enterovirus infection in any of the patients tested.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Clinical and neurocognitive features of the post Lyme syndrome.

Bujak, D I, Weinstein, A, Dornbush, R L·The Journal of rheumatology·1996

This study looked at people who had Lyme disease and continued to have fatigue, joint pain, and memory problems even after antibiotic treatment. Researchers compared 23 of these patients to 23 people who recovered fully from Lyme disease. The group with ongoing symptoms performed worse on memory and concentration tests, reported more sleep and mood problems, and showed signs of greater emotional distress.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Selective impairment of auditory processing in chronic fatigue syndrome: a comparison with multiple sclerosis and healthy controls.

Johnson, S K, DeLuca, J, Diamond, B J et al.·Perceptual and motor skills·1996

This study tested whether people with ME/CFS have trouble processing sounds specifically, or if they struggle with processing information in general. Researchers compared people with ME/CFS, people with multiple sclerosis, and healthy people on two similar tasks—one using sounds and one using visuals. People with ME/CFS performed worse on the sound-based task but did better on the visual task, suggesting their brains may have particular difficulty processing auditory information.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

Conti, F, Magrini, L, Priori, R et al.·Allergy·1996

This study measured a protein called eosinophil cationic protein (ECP) in the blood of ME/CFS patients to see if their immune cells called eosinophils were overly active. Researchers found that ME/CFS patients had significantly higher ECP levels than healthy controls, and most ME/CFS patients also tested positive for allergies. However, ME/CFS patients with allergies did not have higher ECP levels than those without allergies, suggesting the connection may be more complex than initially expected.

Immune System

E2 ModerateCohortPEM not requiredObservational

The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections.

Hana, I, Vrubel, J, Pekarek, J et al.·Biotherapy (Dordrecht, Netherlands)·1996

This study looked at 222 patients with weak immune systems, many of whom also had ME/CFS and/or chronic viral infections (EBV or CMV). They were treated with transfer factor, a type of immune-boosting therapy, given as injections over 8 weeks. The researchers found that younger patients improved more often than older patients, with failure rates rising significantly in those over 54 years old.

Immune System

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MMPI profiles of patients with chronic fatigue syndrome.

Cognitive functioning in patients with chronic fatigue syndrome.

A national assessment of the service, support, and housing preferences by persons with chronic fatigue syndrome. Toward a comprehensive rehabilitation program.

Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.

Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.

Assessing somatization disorder in the chronic fatigue syndrome.

Descriptive epidemiology of chronic fatigue syndrome based on a nationwide survey in Japan.

A case-control study to assess possible triggers and cofactors in chronic fatigue syndrome.

The localization of pain in chronic fatigue syndrome on a pain drawing according to grid areas.

Lymphocyte subsets, apoptosis, and cytokines in patients with chronic fatigue syndrome.

An examination of the working case definition of chronic fatigue syndrome.

Preliminary determination of a molecular basis of chronic fatigue syndrome.

'Seronegative' Sjögren's syndrome manifested as a subset of chronic fatigue syndrome.

Serum carnitine and disabling fatigue in multiple sclerosis.

Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome.

No findings of enteroviruses in Swedish patients with chronic fatigue syndrome.

Clinical and neurocognitive features of the post Lyme syndrome.

Selective impairment of auditory processing in chronic fatigue syndrome: a comparison with multiple sclerosis and healthy controls.

Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections.

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