ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3701–3720 of 6,188 studies

E2 ModerateCohortPEM unclearObservational

Alleged link between hepatitis B vaccine and chronic fatigue syndrome.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1992

This 1992 study examined whether the hepatitis B vaccine might be linked to ME/CFS. Researchers looked at cases where people reported developing chronic fatigue symptoms after receiving the vaccine. This early observation-based study raised questions about a possible connection that researchers wanted to investigate further.

E2 ModerateCohortPEM not requiredCross-Sectional

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

Kawai, K, Kawai, A·Internal medicine (Tokyo, Japan)·1992

This study examined whether Epstein-Barr virus (EBV), a common virus that causes infectious mononucleosis, might be connected to chronic fatigue syndrome (CFS). Researchers tested 22 patients with long-lasting fatigue and found that those with definite CFS had higher levels of certain EBV antibodies compared to patients with milder symptoms and healthy controls. The study suggests a possible link between EBV activation and the severity of fatigue experienced.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The economic impact of chronic fatigue syndrome.

Lloyd, A R, Pender, H·The Medical journal of Australia·1992

This study looked at how much money ME/CFS costs—not just for patients themselves, but for the healthcare system and society overall. Researchers surveyed 42 patients in one Australian region about their medical expenses and lost income, then used those numbers to estimate what ME/CFS might cost across all of Australia. They found the disease creates a huge financial burden that had been largely overlooked by policymakers.

E2 ModerateCohortPEM not requiredCase-Control

Monospot and VP1 tests in chronic fatigue syndrome and major depression.

Lynch, S P, Seth, R V, Main, J·Journal of the Royal Society of Medicine·1992

This study tested whether two blood tests (Monospot and VP1) could help identify ME/CFS by comparing 34 ME/CFS patients with 34 people who had depression. While some patients tested positive for VP1 virus markers, the tests could not reliably tell the two groups apart, and results were inconsistent when patients were retested six months later.

E2 ModerateCohortPEM not requiredCross-Sectional

[Overview of our patients with chronic fatigue syndrome (CFS) from the pathoetiological aspects].

Matsuda, J, Gohchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

Researchers studied 285 people who reported severe fatigue, and confirmed that 55 of them actually had chronic fatigue syndrome (CFS) using official diagnostic criteria. They tested patients' blood for signs of viral infections and measured certain immune cell markers to understand what might be causing CFS. This study looked at various biological factors that could explain why people develop this condition.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

[Chronic fatigue syndrome--study of 51 cases treated at the Second Tokyo National Hospital].

Nishikai, M·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 51 patients with ME/CFS to look for physical and immune system clues about the illness. Researchers found that most patients had tender points similar to those seen in fibromyalgia, elevated antibodies to Epstein-Barr virus (a common virus), and lower numbers of certain immune cells called NK cells. These findings suggest that viral infections and immune system problems may play a role in ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Positive and negative social support in a chronic illness.

Ray, C·Psychological reports·1992

This study looked at how social support affects the emotional well-being of people with ME/CFS. Researchers surveyed 207 patients and found that positive support from others (like encouragement and practical help) was connected to lower anxiety, while negative support (like criticism or dismissal) was linked to both increased anxiety and depression. This suggests that the quality of relationships and social interactions may play a role in how ME/CFS patients experience mental health symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Ichise, M, Salit, I E, Abbey, S E et al.·Nuclear medicine communications·1992

This study used a special brain imaging technique called SPECT to measure blood flow in different regions of the brain in ME/CFS patients and healthy controls. Researchers found that most ME/CFS patients (80%) had reduced blood flow in several brain areas compared to healthy people, particularly in the front, side, and back regions of the brain. This provides the first objective evidence that ME/CFS may involve changes in how blood flows to the brain.

E2 ModerateCohortPEM not requiredCross-Sectional

Fluctuations in perceived energy and mood among patients with chronic fatigue syndrome.

Wood, C, Magnello, M E, Sharpe, M C·Journal of the Royal Society of Medicine·1992

This study looked at how energy and mood change throughout the day in people with ME/CFS compared to healthy people. Patients with active ME/CFS had lower energy levels overall, though their energy peaked mid-morning (10 AM-12 PM) similar to healthy controls. People who had recovered from ME/CFS showed energy levels between the sick and healthy groups, and depression scores were higher in those still ill.

E2 ModerateCohortPEM not requiredCross-Sectional

Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community.

Price, R K, North, C S, Wessely, S et al.·Public health reports (Washington, D.C. : 1974)·1992

This study looked at how common chronic fatigue syndrome (CFS) is in the general population by surveying over 13,500 people between 1981 and 1984. Researchers found that while about 23% of people reported experiencing persistent fatigue at some point in their lives, actual CFS meeting strict diagnostic criteria was extremely rare—only 1 person in the entire study group had the condition. When researchers excluded people with other medical or psychiatric illnesses, CFS became even rarer.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Sleep, Epstein-Barr virus infection, musculoskeletal pain, and depressive symptoms in chronic fatigue syndrome.

Whelton, C L, Salit, I, Moldofsky, H·The Journal of rheumatology·1992

This study compared sleep patterns, virus exposure, and symptoms in 14 ME/CFS patients versus 12 healthy people. Patients reported sleep that didn't feel refreshing and had unusual brain wave patterns during sleep, but didn't show excessive daytime sleepiness. The study found no evidence that a chronic Epstein-Barr virus infection was causing the illness, but patients did have more widespread pain, tender points, and depression symptoms.

Pain and SensitizationSleep

E2 ModerateCohortPEM not requiredObservational

Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome.

Linde, A, Andersson, B, Svenson, S B et al.·The Journal of infectious diseases·1992

This study compared immune system markers in the blood of people with acute EBV infection (infectious mononucleosis), people recovering from EBV, and people with ME/CFS who had evidence of EBV reactivation. The researchers found that while acute EBV infection caused strong immune activation markers, people with ME/CFS did not show these same activation patterns, suggesting that active EBV reactivation may not be the primary cause of ME/CFS symptoms.

Immune System

E2 ModerateCohortPEM not requiredObservational

[Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital].

Ogawa, R, Toyama, S, Matsumoto, H·Nihon rinsho. Japanese journal of clinical medicine·1992

This study looked at 134 ME/CFS patients seen at one hospital in Japan and found that many had immune system abnormalities, including weakened natural killer cells and reactions to common substances like dust and pollen. Researchers also discovered some patients had low levels of certain fatty acids in their blood. When treated with a traditional Chinese herbal medicine called Ren-Shen-Yang-Rong-Tang, about 73% of patients were able to return to work or school.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Hudson, J I, Goldenberg, D L, Pope, H G et al.·The American journal of medicine·1992

This study looked at women diagnosed with fibromyalgia to see what other health conditions they commonly experience. The researchers found that fibromyalgia often occurs together with migraines, irritable bowel syndrome, chronic fatigue syndrome, depression, and panic disorder. This pattern suggests these conditions might share a common underlying biological cause.

E2 ModerateCohortPEM not requiredObservational

Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome.

Levine, P H, Jacobson, S, Pocinki, A G et al.·Archives of internal medicine·1992

Researchers studied four different outbreaks of ME/CFS in the Nevada-California region over 3 years, following patients through interviews and blood tests to look for viral causes. They found that almost all patients recovered and returned to their normal activities within the 3-year period. The viruses they tested for—including Epstein-Barr virus and others—were not responsible for the illness, though one outbreak may have been triggered by a parasite called giardia.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

General practitioners' experience of the chronic fatigue syndrome.

Ho-Yen, D O, McNamara, I·The British journal of general practice : the journal of the Royal College of General Practitioners·1991

Researchers surveyed doctors in Scotland to understand how common ME/CFS is and how they view the condition. Most doctors (71%) believed ME/CFS is real, though some were uncertain. The study found about 1-2 people per 1,000 patients have ME/CFS, with more women affected than men, and it particularly affects people in their 30s and 40s.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A comparative psychiatric assessment of patients with chronic fatigue syndrome and muscle disease.

Wood, G C, Bentall, R P, Göpfert, M et al.·Psychological medicine·1991

This study compared the mental health of 34 patients with ME/CFS to 24 patients with muscle disease. Researchers found that people with ME/CFS were more likely to have psychiatric conditions like depression or anxiety—about 41% had clear psychiatric diagnoses and another 27% had partial ones. In contrast, only about 17% of muscle disease patients had psychiatric conditions. This suggests ME/CFS patients face a higher risk of developing psychiatric issues, though the study doesn't explain why.

E2 ModerateCohortPEM not requiredCase-Control

Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases.

Bell, K M, Cookfair, D, Bell, D S et al.·Reviews of infectious diseases·1991

After seven children in a farming community developed ME/CFS, researchers asked all students in the school district about their symptoms and possible causes. They found 21 students with CFS symptoms and compared them to matched healthy students. Three factors stood out as being strongly linked to CFS: having family members with CFS symptoms, recently drinking raw milk, and having a history of allergies or asthma.

E2 ModerateCohortPEM unclearCross-Sectional

Immune responsiveness in chronic fatigue syndrome.

Milton, J D, Clements, G B, Edwards, R H·Postgraduate medical journal·1991

This 1991 study tested whether ME/CFS was caused by a persistent viral infection or a weakened immune response to viruses. Researchers compared immune markers and virus-fighting abilities in ME/CFS patients, healthy controls, and people with muscular dystrophy. They found no significant differences between groups, suggesting that standard viral infection or immune dysfunction wasn't the primary cause of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis.

Bertram, G, Dreiner, N, Krueger, G R et al.·In vivo (Athens, Greece)·1991

This study looked at 215 patients with infectious mononucleosis to see which viruses were causing their illness. Researchers found that most patients had Epstein-Barr virus (EBV), but many also had human herpesvirus-6 (HHV-6) at the same time. About 40% of patients had active infection with both viruses, and some had a third virus (CMV) as well. Patients were followed for two years to track changes in their virus levels.

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Alleged link between hepatitis B vaccine and chronic fatigue syndrome.

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

The economic impact of chronic fatigue syndrome.

Monospot and VP1 tests in chronic fatigue syndrome and major depression.

[Overview of our patients with chronic fatigue syndrome (CFS) from the pathoetiological aspects].

[Chronic fatigue syndrome--study of 51 cases treated at the Second Tokyo National Hospital].

Positive and negative social support in a chronic illness.

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Fluctuations in perceived energy and mood among patients with chronic fatigue syndrome.

Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community.

Sleep, Epstein-Barr virus infection, musculoskeletal pain, and depressive symptoms in chronic fatigue syndrome.

Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome.

[Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital].

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome.

General practitioners' experience of the chronic fatigue syndrome.

A comparative psychiatric assessment of patients with chronic fatigue syndrome and muscle disease.

Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases.

Immune responsiveness in chronic fatigue syndrome.

Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis.

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