ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3721–3740 of 6,209 studies

E2 ModerateCohortPEM not requiredCross-Sectional

[Overview of our patients with chronic fatigue syndrome (CFS) from the pathoetiological aspects].

Matsuda, J, Gohchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

Researchers studied 285 people who reported severe fatigue, and confirmed that 55 of them actually had chronic fatigue syndrome (CFS) using official diagnostic criteria. They tested patients' blood for signs of viral infections and measured certain immune cell markers to understand what might be causing CFS. This study looked at various biological factors that could explain why people develop this condition.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The economic impact of chronic fatigue syndrome.

Lloyd, A R, Pender, H·The Medical journal of Australia·1992

This study looked at how much money ME/CFS costs—not just for patients themselves, but for the healthcare system and society overall. Researchers surveyed 42 patients in one Australian region about their medical expenses and lost income, then used those numbers to estimate what ME/CFS might cost across all of Australia. They found the disease creates a huge financial burden that had been largely overlooked by policymakers.

E2 ModerateCohortPEM not requiredObservational

Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome.

Levine, P H, Jacobson, S, Pocinki, A G et al.·Archives of internal medicine·1992

Researchers studied four different outbreaks of ME/CFS in the Nevada-California region over 3 years, following patients through interviews and blood tests to look for viral causes. They found that almost all patients recovered and returned to their normal activities within the 3-year period. The viruses they tested for—including Epstein-Barr virus and others—were not responsible for the illness, though one outbreak may have been triggered by a parasite called giardia.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Hudson, J I, Goldenberg, D L, Pope, H G et al.·The American journal of medicine·1992

This study looked at women diagnosed with fibromyalgia to see what other health conditions they commonly experience. The researchers found that fibromyalgia often occurs together with migraines, irritable bowel syndrome, chronic fatigue syndrome, depression, and panic disorder. This pattern suggests these conditions might share a common underlying biological cause.

E2 ModerateCohortPEM not requiredCross-Sectional

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Ichise, M, Salit, I E, Abbey, S E et al.·Nuclear medicine communications·1992

This study used a special brain imaging technique called SPECT to measure blood flow in different regions of the brain in ME/CFS patients and healthy controls. Researchers found that most ME/CFS patients (80%) had reduced blood flow in several brain areas compared to healthy people, particularly in the front, side, and back regions of the brain. This provides the first objective evidence that ME/CFS may involve changes in how blood flows to the brain.

E2 ModerateCohortPEM unclearObservational

Does chronic fatigue syndrome predispose to non-Hodgkin's lymphoma?

Levine, P H, Peterson, D, McNamee, F L et al.·Cancer research·1992

Some people with ME/CFS have reported concerns about developing lymphoma (a type of blood cancer). This study looked at cancer rates in Nevada before and after documented ME/CFS outbreaks in the mid-1980s to see if there was an increase in non-Hodgkin's lymphoma cases. The researchers found that cancer rates followed the same patterns as the rest of the country, with no unusual spike linked to ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Human spumavirus antibodies in sera from African patients.

Mahnke, C, Kashaiya, P, Rössler, J et al.·Archives of virology·1992

Researchers tested blood samples from over 3,000 people in Africa and Europe to look for antibodies to a virus called human spumavirus. They found that about 3% of people worldwide had signs of this virus in their blood, but in African patients the rate was much higher at 6.3%. Notably, patients with ME/CFS, multiple sclerosis, and Graves' disease showed very low or no evidence of this virus.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Attention and short-term memory in chronic fatigue syndrome patients: an event-related potential analysis.

Scheffers, M K, Johnson, R, Grafman, J et al.·Neurology·1992

This study compared brain activity and reaction times between 13 people with ME/CFS and 13 healthy volunteers using brain scans while they performed attention and memory tasks. The ME/CFS patients showed much slower and more variable reaction times, but their memory and thinking abilities appeared normal. The researchers found that the brain's basic attention and memory processes were working similarly in both groups, suggesting the slowness came from problems with how the brain signals muscles to respond.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Sleep, Epstein-Barr virus infection, musculoskeletal pain, and depressive symptoms in chronic fatigue syndrome.

Whelton, C L, Salit, I, Moldofsky, H·The Journal of rheumatology·1992

This study compared sleep patterns, virus exposure, and symptoms in 14 ME/CFS patients versus 12 healthy people. Patients reported sleep that didn't feel refreshing and had unusual brain wave patterns during sleep, but didn't show excessive daytime sleepiness. The study found no evidence that a chronic Epstein-Barr virus infection was causing the illness, but patients did have more widespread pain, tender points, and depression symptoms.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome criteria. A critique of the requirement for multiple physical complaints.

Katon, W, Russo, J·Archives of internal medicine·1992

This study looked at 285 people with chronic fatigue to understand whether having many physical symptoms was linked to psychiatric conditions like depression and anxiety. Researchers found that patients reporting more unexplained physical symptoms were significantly more likely to have current or past psychiatric diagnoses. The authors suggest that ME/CFS diagnostic criteria should be changed to include people with fatigue and few physical symptoms, and potentially exclude those with many physical complaints.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community.

Price, R K, North, C S, Wessely, S et al.·Public health reports (Washington, D.C. : 1974)·1992

This study looked at how common chronic fatigue syndrome (CFS) is in the general population by surveying over 13,500 people between 1981 and 1984. Researchers found that while about 23% of people reported experiencing persistent fatigue at some point in their lives, actual CFS meeting strict diagnostic criteria was extremely rare—only 1 person in the entire study group had the condition. When researchers excluded people with other medical or psychiatric illnesses, CFS became even rarer.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Ureaplasma urealyticum and Mycoplasma hominis in women with systemic lupus erythematosus.

Ginsburg, K S, Kundsin, R B, Walter, C W et al.·Arthritis and rheumatism·1992

This study looked for a type of bacteria called mycoplasma in urine samples from women with two different conditions: systemic lupus erythematosus (SLE, an autoimmune disease) and ME/CFS (chronic fatigue syndrome). They found that mycoplasma was much more common in the SLE group (63%) than in the ME/CFS group (4.5%), suggesting these conditions may have different underlying causes.

E2 ModerateCohortPEM not requiredCase-Control

Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression.

Lloyd, A, Hickie, I, Hickie, C et al.·Clinical and experimental immunology·1992

This study compared immune system function in patients with ME/CFS, people with depression, and healthy individuals. Researchers found that ME/CFS patients had weaker immune responses than both groups, suggesting their immune problems are distinct from depression-related immune changes. This indicates that ME/CFS involves direct immune system dysfunction rather than these problems simply being caused by depression.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Epstein-Barr virus serology in the chronic fatigue syndrome.

Woodward, C G, Cox, R A·The Journal of infection·1992

Researchers tested blood samples from 136 ME/CFS patients to look for signs of past or ongoing Epstein-Barr virus (EBV) infection, comparing them to healthy blood donors. They found that CFS patients had higher levels of certain EBV antibodies than the control group, but these differences weren't consistent enough to be useful for diagnosing individual patients. The study also found that some patients had signs of other viral infections alongside the EBV markers.

Immune System

E2 ModerateCohortPEM not requiredObservational

[Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital].

Ogawa, R, Toyama, S, Matsumoto, H·Nihon rinsho. Japanese journal of clinical medicine·1992

This study looked at 134 ME/CFS patients seen at one hospital in Japan and found that many had immune system abnormalities, including weakened natural killer cells and reactions to common substances like dust and pollen. Researchers also discovered some patients had low levels of certain fatty acids in their blood. When treated with a traditional Chinese herbal medicine called Ren-Shen-Yang-Rong-Tang, about 73% of patients were able to return to work or school.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

Kawai, K, Kawai, A·Internal medicine (Tokyo, Japan)·1992

This study examined whether Epstein-Barr virus (EBV), a common virus that causes infectious mononucleosis, might be connected to chronic fatigue syndrome (CFS). Researchers tested 22 patients with long-lasting fatigue and found that those with definite CFS had higher levels of certain EBV antibodies compared to patients with milder symptoms and healthy controls. The study suggests a possible link between EBV activation and the severity of fatigue experienced.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome: I. Epstein-Barr virus immune response and molecular epidemiology.

Jones, J F, Streib, J, Baker, S et al.·Journal of medical virology·1991

This study looked at how the immune system responds to Epstein-Barr virus (EBV) in ME/CFS patients compared to healthy people who have been infected with EBV. Researchers found that immune cells from ME/CFS patients were much more likely to grow uncontrollably in the lab (30% vs 8%), and patients showed more signs of active viral infection in their blood. These findings suggest that some ME/CFS patients may have difficulty controlling EBV reactivation.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis.

Bertram, G, Dreiner, N, Krueger, G R et al.·In vivo (Athens, Greece)·1991

This study looked at 215 patients with infectious mononucleosis to see which viruses were causing their illness. Researchers found that most patients had Epstein-Barr virus (EBV), but many also had human herpesvirus-6 (HHV-6) at the same time. About 40% of patients had active infection with both viruses, and some had a third virus (CMV) as well. Patients were followed for two years to track changes in their virus levels.

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome in Minnesota.

Peterson, P K, Schenck, C H, Sherman, R·Minnesota medicine·1991

This study looked at 135 people in Minnesota with ME/CFS to understand who gets the disease and how it develops. Most patients reported that their illness started suddenly with what looked like an infection, and fatigue was their worst symptom. When researchers checked in with some patients a year later, none had fully recovered, though about 40% felt somewhat better.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Depression and somatization in the chronic fatigue syndrome.

Lane, T J, Manu, P, Matthews, D A·The American journal of medicine·1991

This study looked at 60 patients diagnosed with chronic fatigue syndrome (CFS) to see how often they had depression or other psychiatric conditions. Researchers found that most CFS patients (78%) had some kind of mental health disorder, similar to a control group of fatigued people without CFS. However, CFS patients were more likely to have somatization disorder (believing physical symptoms have a physical cause) and were more likely to attribute their illness to a physical problem rather than psychological stress.

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[Overview of our patients with chronic fatigue syndrome (CFS) from the pathoetiological aspects].

The economic impact of chronic fatigue syndrome.

Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome.

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Does chronic fatigue syndrome predispose to non-Hodgkin's lymphoma?

Human spumavirus antibodies in sera from African patients.

Attention and short-term memory in chronic fatigue syndrome patients: an event-related potential analysis.

Sleep, Epstein-Barr virus infection, musculoskeletal pain, and depressive symptoms in chronic fatigue syndrome.

Chronic fatigue syndrome criteria. A critique of the requirement for multiple physical complaints.

Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community.

Ureaplasma urealyticum and Mycoplasma hominis in women with systemic lupus erythematosus.

Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression.

Epstein-Barr virus serology in the chronic fatigue syndrome.

[Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital].

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

Chronic fatigue syndrome: I. Epstein-Barr virus immune response and molecular epidemiology.

Frequent double infection with Epstein-Barr virus and human herpesvirus-6 in patients with acute infectious mononucleosis.

Chronic fatigue syndrome in Minnesota.

Depression and somatization in the chronic fatigue syndrome.

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