ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

381–400 of 6,209 studies

E0 ConsensusReviewPEM unclearReview-Narrative

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.

Slyepchenko, Anastasiya, Maes, Michael, Jacka, Felice N et al.·Psychotherapy and psychosomatics·2017

This review examines how changes in gut bacteria and a 'leaky gut' (where bacteria can cross the intestinal barrier) may contribute to depression and related conditions like ME/CFS. The authors found evidence that diet, gut bacteria composition, and immune system activation are interconnected, and that these connections may explain why depression often occurs alongside conditions like irritable bowel syndrome, ME/CFS, obesity, and diabetes.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Exercise therapy for chronic fatigue syndrome.

Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan et al.·The Cochrane database of systematic reviews·2017

This review looked at eight research studies testing whether exercise therapy helps people with ME/CFS feel less fatigued and improve their daily functioning. Overall, patients who did exercise therapy felt less tired and reported better sleep and physical function compared to those who received standard care or relaxation therapy. Exercise therapy appeared to work about as well as cognitive-behavioral therapy (talking therapy), though more research is needed to figure out the best type, intensity, and duration of exercise for each patient.

Sleep

E0 ConsensusReviewPEM not requiredReview-Narrative

Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

Mahjoub, Fatemeh, Salari, Roshanak, Noras, Mohammad Reza et al.·Journal of evidence-based complementary & alternative medicine·2017

This study looked at how traditional Persian medicine approaches fibromyalgia and ME/CFS, which are conditions that cause widespread pain and extreme tiredness. The researchers compared ancient Persian medical texts, particularly writings by the physician Avicenna, with modern understanding of these diseases. They found that traditional medicine recognized fatigue as a complex condition with different types, each with distinct symptoms.

Pain and Sensitization

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and the immune system: Where are we now?

Mensah, Fane Kojo Fosu, Bansal, Amolak Singh, Ford, Brian et al.·Neurophysiologie clinique = Clinical neurophysiology·2017

ME/CFS is a complex illness that causes exhaustion, headaches, and thinking problems, and gets worse with activity. Researchers have suspected for years that the immune system plays a role in ME/CFS, but studies have produced confusing and sometimes contradictory results. This review examines what we currently know about immune system changes in ME/CFS and discusses promising new research directions, including the possibility that certain immune-targeting treatments might help patients improve.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Pediatric chronic fatigue syndrome: current perspectives.

Crawley, Esther·Pediatric health, medicine and therapeutics·2017

This review examines ME/CFS in children, showing it is a common condition that significantly affects children and their families. The good news is that most children improve when they receive specialized treatment from doctors who understand this illness. The review summarizes what we know about how many children get ME/CFS, what factors may be involved, and what treatments have evidence supporting them.

Interventions

E0 ConsensusReviewPEM unclearReview-Narrative

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome.

Castro-Marrero, Jesus, Sáez-Francàs, Naia, Santillo, Dafna et al.·British journal of pharmacology·2017

This review looked at all available research on treatments for ME/CFS to see what actually helps patients. The researchers found that while some treatments like behavioral therapy, pacing strategies, and nutritional supplements show promise, the evidence is still limited because most studies were small and used different methods. The authors conclude that personalized pacing and treating nutritional deficiencies are reasonable approaches, but much larger and better-designed studies are urgently needed to know what really works.

E0 ConsensusReviewPEM not requiredSystematic-Review

Acupuncture and moxibustion for chronic fatigue syndrome in traditional Chinese medicine: a systematic review and meta-analysis.

Wang, Taiwu, Xu, Cong, Pan, Keli et al.·BMC complementary and alternative medicine·2017

This study reviewed 31 previous research trials examining whether acupuncture and moxibustion (traditional Chinese treatments involving needles and heat) help treat ME/CFS. The researchers found that combining multiple acupuncture and moxibustion techniques appeared more effective than using just one technique, and both were more effective than sham acupuncture (fake treatment). However, the overall quality of the research studies reviewed was weak, so stronger evidence is needed before drawing firm conclusions.

Interventions

E0 ConsensusReviewPEM unclearReview-Narrative

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways.

Morris, Gerwyn, Anderson, George, Maes, Michael·Molecular neurobiology·2017

This review examines why people with ME/CFS often have low cortisol levels (a stress hormone). The researchers found that the problem likely starts with an overactive immune system producing excessive inflammatory markers, which then damages the body's stress-hormone system. This is important because it suggests the low cortisol is a consequence of the disease, not its cause.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Practical management of chronic fatigue syndrome or myalgic encephalomyelitis in childhood.

Brigden, Amberly, Loades, Maria, Abbott, Anna et al.·Archives of disease in childhood·2017

This article provides practical guidance on how doctors should diagnose and treat ME/CFS in children and teenagers. ME/CFS is a serious condition that affects at least 1 in 100 secondary school students in the UK, causing severe fatigue and limiting daily activities. Although effective treatments exist, many young people with ME/CFS don't get diagnosed or receive help they need.

Diagnostics

E0 ConsensusReviewPEM unclearSystematic-Review

Children's experiences of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review and meta-ethnography of qualitative studies.

Parslow, Roxanne M, Harris, Sarah, Broughton, Jessica et al.·BMJ open·2017

This study reviewed 10 research papers about how children with ME/CFS experience their illness. The researchers found that ME/CFS causes major disruption to children's lives, affecting their ability to go to school, see friends, and plan their futures. Children struggle when doctors don't recognize or understand their condition, but they cope better when they have support from family, friends, and healthcare providers who believe their illness is real.

E0 ConsensusReviewPEM unclearReview-Narrative

Exercise and the Athlete With Infectious Mononucleosis.

Shephard, Roy J·Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·2017

This review examines how infectious mononucleosis (a viral illness caused by Epstein-Barr virus) affects young athletes and whether it can lead to chronic fatigue syndrome. The main finding is that with proper diagnosis and a few weeks of rest followed by gradual return to activity, most athletes recover fully within 2-3 months, and serious complications like splenic rupture are rare.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

Psychological Interventions for Children with Functional Somatic Symptoms: A Systematic Review and Meta-Analysis.

Bonvanie, Irma J, Kallesøe, Karen H, Janssens, Karin A M et al.·The Journal of pediatrics·2017

This review looked at 27 studies testing whether talking therapies and psychological treatments help children with long-lasting physical symptoms like pain, fatigue, and nausea. The researchers found that psychological treatments did help reduce symptoms, disability, and school absences, and these improvements lasted even after treatment ended.

E0 ConsensusReviewPEM unclearEvidence-Map

The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE.

Scheibenbogen, Carmen, Freitag, Helma, Blanco, Julià et al.·Journal of translational medicine·2017

Researchers across Europe are working together to find biological markers (signs in blood or body tests) that could help diagnose ME/CFS and track how treatments work. This study reviewed all the biomarker research happening in Europe and created a database of what scientists are studying. The goal is to develop reliable tests that doctors could use in the future to diagnose ME/CFS and improve clinical trials.

Biomarkers

E0 ConsensusReviewPEM not requiredSystematic-Review

Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A systematic review and meta-analysis.

Joustra, Monica L, Minovic, Isidor, Janssens, Karin A M et al.·PloS one·2017

This review looked at whether people with ME/CFS and fibromyalgia have low levels of vitamins and minerals, and whether taking supplements helps. Researchers found very little evidence that vitamin or mineral deficiencies cause these illnesses or that supplements improve symptoms. While some studies showed lower vitamin E levels in patients, this finding disappeared when looking only at higher-quality research.

E0 ConsensusReviewPEM not requiredMeta-Analysis

[Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses].

Pinquart, Martin·Praxis der Kinderpsychologie und Kinderpsychiatrie·2017

This study reviewed research on how children with long-term illnesses and their parents cope emotionally. The researchers found that children with ME/CFS and chronic headaches showed the highest levels of depression and anxiety. Interestingly, parents were often more distressed than their sick children, particularly parents of children with HIV/AIDS or cerebral palsy.

E0 ConsensusReviewPEM not requiredSystematic-Review

Do evidence based interventions for chronic fatigue syndrome improve sleep? A systematic review and narrative synthesis.

Russell, Charlotte, Kyle, Simon D, Wearden, Alison J·Sleep medicine reviews·2017

This review looked at whether two common treatments for ME/CFS—cognitive behavioural therapy (CBT) and graded exercise therapy (GET)—actually help people sleep better. The researchers found only 8 studies that measured sleep as an outcome. GET showed some promise for improving sleep, but results were inconsistent across different studies. CBT had very limited evidence, with only one study out of two showing sleep improvements. Overall, we know very little about whether adding specific sleep management techniques to these treatments makes a difference.

Sleep

E0 ConsensusReviewPEM unclearSystematic-Review

The treatment of fatigue by non-invasive brain stimulation.

Lefaucheur, Jean-Pascal, Chalah, Moussa A, Mhalla, Alaa et al.·Neurophysiologie clinique = Clinical neurophysiology·2017

Researchers reviewed 15 studies examining whether non-invasive brain stimulation techniques—specifically transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS)—can reduce fatigue in various conditions including ME/CFS. While most studies showed promising results, especially in multiple sclerosis and fibromyalgia, the evidence remains limited and inconsistent because different studies used different methods and measured fatigue in different ways.

E0 ConsensusReviewPEM unclearSystematic-Review

Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and D-lactic acidosis: a systematic review.

Wallis, Amy, Ball, Michelle, McKechnie, Sandra et al.·Journal of translational medicine·2017

This study compared symptoms reported in cases of D-lactic acidosis (a rare condition where a specific type of acid builds up in the body) with symptoms of ME/CFS. Researchers found that many neurological symptoms—like brain fog, movement problems, and nerve-related issues—appeared in both conditions. Both groups also had gut bacteria imbalances and stomach problems. The authors suggest that ME/CFS might involve similar gut-related processes as D-lactic acidosis, but stress that we need more research to understand if this connection is real.

Energy Metabolism

E0 ConsensusReviewPEM not requiredSystematic-Review

Role of dietary modification in alleviating chronic fatigue syndrome symptoms: a systematic review.

Jones, Kathryn, Probst, Yasmine·Australian and New Zealand journal of public health·2017

Researchers reviewed 22 studies looking at whether changing what you eat could help ME/CFS symptoms. They found some promise with certain supplements like omega-3 fatty acids and D-ribose, as well as foods high in polyphenols (like berries and green tea). However, the evidence overall was limited and inconsistent—meaning we don't yet have clear dietary recommendations that work reliably for most ME/CFS patients.

Interventions

E0 ConsensusReviewPEM not requiredEditorial

Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA).

Ameratunga, Rohan, Gillis, David, Gold, Michael et al.·The journal of allergy and clinical immunology. In practice·2017

This study examined whether a theory called ASIA (a proposed condition blamed on vaccine adjuvants like aluminum) is supported by scientific evidence. Researchers looked at data from people who received allergen immunotherapy, which contains much more aluminum than vaccines, and found they actually had fewer autoimmune diseases, not more. The study concludes that current evidence does not support the idea that aluminum in vaccines causes autoimmune problems.

Immune System

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Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.

Exercise therapy for chronic fatigue syndrome.

Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

Chronic fatigue syndrome and the immune system: Where are we now?

Pediatric chronic fatigue syndrome: current perspectives.

Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome.

Acupuncture and moxibustion for chronic fatigue syndrome in traditional Chinese medicine: a systematic review and meta-analysis.

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways.

Practical management of chronic fatigue syndrome or myalgic encephalomyelitis in childhood.

Children's experiences of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review and meta-ethnography of qualitative studies.

Exercise and the Athlete With Infectious Mononucleosis.

Psychological Interventions for Children with Functional Somatic Symptoms: A Systematic Review and Meta-Analysis.

The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE.

Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A systematic review and meta-analysis.

[Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses].

Do evidence based interventions for chronic fatigue syndrome improve sleep? A systematic review and narrative synthesis.

The treatment of fatigue by non-invasive brain stimulation.

Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and D-lactic acidosis: a systematic review.

Role of dietary modification in alleviating chronic fatigue syndrome symptoms: a systematic review.

Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA).

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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