ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4041–4060 of 6,162 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Impact of SARS-CoV-2/COVID-19 on Provision of Medical Care to Patients With Systemic Autoimmune Rheumatic Disease and the Practice of Rheumatology.

Bankole, Adegbenga A, Nwaonu, Jane, Saeed, Jahanzeb·Cureus·2023

This article reviews how the COVID-19 pandemic changed how doctors care for patients with autoimmune rheumatic diseases and how rheumatologists practice medicine. The pandemic caused clinic closures, introduced telemedicine, and raised new questions about whether immunosuppressive medications are safe during viral infections. Rheumatologists now help distinguish between long COVID symptoms and autoimmune disease symptoms, and help manage COVID-19 patients in hospitals.

E3 PreliminaryCohortPEM unclearCase-Control

Modulation of Beta-Adrenergic Autoantibodies Over Time in Post-Viral ME/CFS is Related to Fatigue and Pain Symptoms.

Busch, Lena, Schriek, Carsten, Paul, Matthias et al.·The Israel Medical Association journal : IMAJ·2023

This study followed one patient with ME/CFS that developed after a viral infection and measured special proteins in their blood called autoantibodies that mistakenly attack the body's own receptors. When these autoantibodies increased over time, the patient's fatigue and pain symptoms got worse. The researchers also found changes in nerve fibers in the skin that matched these increases, suggesting these autoantibodies may play a role in ME/CFS symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Research progress on central mechanism of acupuncture treatment for chronic fatigue syndrome.

Li, Bin-Bin, Feng, Chu-Wen, Qu, Yuan-Yuan et al.·World journal of acupuncture-moxibustion·2023

This review examined how ME/CFS affects the brain and nervous system by looking at laboratory tests and brain imaging studies. Researchers found that people with ME/CFS have changes in brain structure, abnormal inflammation, and problems with chemical messengers in the brain. The study also explored how acupuncture might help correct some of these brain abnormalities in animal models of the condition.

Neuroinflammation

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue.

Banovic, Ingrid, Scrima, Fabrizio, Fornasieri, Isabelle et al.·BMC psychology·2023

Researchers tested a new questionnaire called the MCAS to measure chronic fatigue and exhaustion in French-speaking patients. The questionnaire asks about physical tiredness, how much fatigue limits daily life, and how it affects relationships. The study found that the MCAS works well and can detect differences in fatigue severity between people with different conditions, including ME/CFS.

E3 PreliminaryReviewPEM unclearReview-Narrative

Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?

Kell, Douglas B, Pretorius, Etheresia·The Biochemical journal·2023

This study proposes that in Long COVID and other post-infection diseases, a blood protein called fibrinogen can fold into an abnormal shape that forms sticky clots called fibrinaloids. These unusual clots may trigger the immune system to attack the body's own tissues (autoimmunity) because the abnormal folding creates new structures the immune system doesn't recognize. The authors suggest this process is similar to what happens in prion diseases and other protein-misfolding conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of transcutaneous electrical acupoint stimulation on learning and memory ability of chronic fatigue syndrome rats and its mechanisms].

Zhong, Xiao-Ling, Tong, Bo-Ying, Yang, Yi-Han et al.·Zhen ci yan jiu = Acupuncture research·2023

This study tested whether a non-invasive electrical stimulation treatment applied to specific acupuncture points could help rats with chronic fatigue improve their memory and learning. Researchers found that the treatment reduced fatigue symptoms and improved memory performance in fatigued rats, possibly by protecting brain cells in the memory center of the brain.

Neuroinflammation

E3 PreliminaryCohortPEM unclearObservational

Bodies in lockdown: Young women's narratives of falling severely ill with ME/CFS during childhood and adolescence.

Krabbe, Silje Helen, Mengshoel, Anne Marit, Schrøder Bjorbækmo, Wenche et al.·Health care for women international·2023

This study listened to the stories of 13 young women who became severely ill with ME/CFS during their childhood or teenage years. The researchers found that these women experienced a gradual loss of their normal, active lives, felt increasingly isolated and abandoned by others, and struggled with uncertainty about their future. The study highlights how challenging and life-altering this illness can be during crucial developmental years.

E3 PreliminaryCohortPEM unclearCase-Control

Systemic exertion intolerance disease associated to neuroendocrine dysfunction and cortical atrophy: a case report.

López-Amador, Noé·Family practice·2023

This case report describes one patient with ME/CFS who had abnormal hormone levels (low thyroid and adrenal hormones, but high cortisol) and brain imaging showing shrinkage of the brain's outer layer. When treated with a low dose of a medication called modafinil along with lifestyle changes, the patient's symptoms improved. The study highlights that ME/CFS can have measurable physical changes and that doctors need better tools to diagnose and treat this condition.

Endocrine Disruption

E3 PreliminaryCohortPEM requiredCase-Control

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

Jinushi, Ryuhei, Nishiguchi, Sho, Masuda, Sakue et al.·Clinical case reports·2023

This study describes a patient who developed ME/CFS after recovering from COVID-19. The researchers found that this patient had lower-than-normal levels of acylcarnitine, a substance the body uses to produce energy. The study reviews existing research on how COVID-19 can lead to ME/CFS, a condition that causes severe fatigue and symptoms that worsen after physical activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grande, Tilman, Grande, Bettina, Gerner, Patrick et al.·Medicina (Kaunas, Lithuania)·2023

This article discusses how talking therapy (psychotherapy) might help people with ME/CFS cope better, even though it cannot cure the disease itself. The authors emphasize that ME/CFS is a physical illness requiring physical treatments, and they highlight that post-exertional malaise (getting worse after activity) is a key symptom that therapists should understand. They propose a practical approach to therapy that respects these facts while still helping patients manage their emotional wellbeing.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Du Preez, Stanley, Eaton-Fitch, Natalie, Smith, Peter K et al.·Biomolecules·2023

This study looked at how calcium moves into immune cells called NK cells in ME/CFS patients compared to healthy people. Researchers found that calcium enters these cells differently in ME/CFS patients—it flows in more slowly when activated but responds more strongly when blocked. This suggests a problem with a specific calcium channel called TRPM7 that may be involved in why NK cells don't work properly in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Plasma miR-195-5p predicts the severity of Covid-19 in hospitalized patients.

Moatar, Alexandra Ioana, Chis, Aimee Rodica, Romanescu, Mirabela et al.·Scientific reports·2023

Researchers studied a tiny molecule in the blood called miR-195 in COVID-19 patients to see if it could predict who would get sicker. They found that miR-195 levels measured in the first two days after hospital admission were very good at telling the difference between patients with mild and severe COVID-19. Interestingly, their analysis suggests this molecule may affect how heart cells produce energy, which could be relevant to long COVID and chronic fatigue syndrome.

Biomarkers

E3 PreliminaryCohortPEM not requiredCase-Control

Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream.

Saha, Arunava, Balakrishnan, Suryanarayanan, Trivedi, Nitin et al.·AACE clinical case reports·2023

This case report describes a woman with chronic fatigue syndrome who accidentally poisoned herself by swallowing topical hydrocortisone cream as a replacement for prescription prednisone. She developed dangerously high blood pressure and a severe drop in potassium levels, which can cause life-threatening heart problems. The key lesson is that over-the-counter medications can cause serious harm if used incorrectly, even when applied to skin.

E3 PreliminaryMechanismPEM not requiredMechanistic

Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.

Chaoran, L I, Yan, Yang, Chuwen, Feng et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2023

This study tested whether moxibustion (a traditional Chinese medicine technique using heat) could help treat chronic fatigue syndrome in rats. Researchers found that moxibustion improved fatigue-like symptoms and restored balance to the gut bacteria and chemical levels that were abnormal in fatigued rats. The results suggest that moxibustion may work by fixing problems in the gut microbiome (bacteria) and the metabolites (chemical byproducts) they produce.

Gut Microbiome

E3 PreliminaryCohortPEM unclearObservational

Using Communities of Practice Theory to Understand the Crisis of Identity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Murray, Rebecca, Turner, Lynda·Chronic illness·2023

This study looked at how ME/CFS affects how people see themselves and their identity. Researchers created a private Facebook group with 22 people who have ME/CFS and asked them to share their experiences. They found that supportive communities—whether online or with understanding people—help patients develop a stronger sense of self that isn't defined solely by illness or shame.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Coaching to strengthen critical success factors in integrative care for chronic fatigue patients: the Patient Needs-Resources Model.

Araja, Diana, Krumina, Angelika, Nora-Krukle, Zaiga et al.·Frontiers in neuroscience·2023

This article discusses how to improve care for people with ME/CFS by using a comprehensive, team-based approach that includes coaching. The authors argue that coaching—similar to working with a personal guide—can help patients better manage their symptoms, understand their own strengths and abilities, and feel more motivated and hopeful about their treatment. The article suggests this integrated approach combining multiple specialists and patient coaching could help optimize care for chronic fatigue, especially important as ME/CFS-like conditions became more common during and after COVID-19.

E3 PreliminaryMechanismPEM unclearMechanistic

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.

Cocchetto, Alan, Seymour, Colin, Mothersill, Carmel·International journal of molecular sciences·2023

This study proposes a theory about how radiation exposure might trigger ME/CFS in some patients. The authors suggest that low-level radiation causes a chain reaction in the body involving free radicals (damaging molecules) and immune dysfunction, possibly linked to skin and blood cell problems. They reviewed evidence from people exposed to radiation (like after Chernobyl) who developed ME/CFS symptoms, to build a biological model explaining how this might happen.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

Hanson, Maureen R·PLoS pathogens·2023

This review examines the evidence that viral infections may trigger or contribute to ME/CFS. Researchers looked at how viruses could potentially cause the long-lasting fatigue, pain, and other symptoms that define this condition. The study explores possible mechanisms by which a viral infection might set off a chain of events leading to ME/CFS.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue: What investigations? And what for?].

Gramont, B, Goutte, J, Féasson, L et al.·La Revue de medecine interne·2023

When people feel tired all the time, doctors need to figure out why. This article explains how doctors should approach chronic fatigue: by asking careful questions, doing a physical exam, and using only necessary blood tests. It emphasizes that chronic fatigue often has multiple causes—physical, emotional, and life circumstances—working together, and that exercise testing and personalized activity programs are the most helpful treatments.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC).

Paniskaki, Krystallenia, Goretzki, Sarah, Anft, Moritz et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2023

This study looked at children who had COVID-19 and developed long-lasting symptoms like breathing problems, fatigue, and brain fog—a condition called pediatric long COVID. Researchers found that these children had more immune cells fighting the virus that were less effective than usual, and these cells released inflammatory chemicals that may have been causing their symptoms. The findings suggest that ongoing immune system activation after COVID-19 might explain why some children develop persistent health problems similar to ME/CFS.

Immune System

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Evidence browser

Impact of SARS-CoV-2/COVID-19 on Provision of Medical Care to Patients With Systemic Autoimmune Rheumatic Disease and the Practice of Rheumatology.

Modulation of Beta-Adrenergic Autoantibodies Over Time in Post-Viral ME/CFS is Related to Fatigue and Pain Symptoms.

Research progress on central mechanism of acupuncture treatment for chronic fatigue syndrome.

Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue.

Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?

[Effect of transcutaneous electrical acupoint stimulation on learning and memory ability of chronic fatigue syndrome rats and its mechanisms].

Bodies in lockdown: Young women's narratives of falling severely ill with ME/CFS during childhood and adolescence.

Systemic exertion intolerance disease associated to neuroendocrine dysfunction and cortical atrophy: a case report.

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.

Plasma miR-195-5p predicts the severity of Covid-19 in hospitalized patients.

Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream.

Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.

Using Communities of Practice Theory to Understand the Crisis of Identity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Coaching to strengthen critical success factors in integrative care for chronic fatigue patients: the Patient Needs-Resources Model.

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome.

[Chronic fatigue: What investigations? And what for?].

Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC).

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