ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4041–4060 of 6,209 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Long Covid.

Zaidi, Asiya Kamber, Dehgani-Mobaraki, Puya·Progress in molecular biology and translational science·2024

Long COVID is a condition where people experience ongoing symptoms weeks or months after having COVID-19. This review examines what might cause Long COVID, including lingering virus in the body, problems with the immune system, and issues with blood vessels and nerves. The authors discuss how doctors can recognize and treat Long COVID, emphasizing that patients often need care from multiple specialists working together.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID's Impact on Patients, Workers, & Society: A review.

Kavanagh, Kevin T, Cormier, Lindsay E, Pontus, Christine et al.·Medicine·2024

About 1 in 10 people who recover from COVID-19 develop long COVID, and roughly 1 in 4 of those people struggle with daily activities like work and self-care. Brain damage has been found in some patients, leading to problems with memory, thinking clearly, and mood changes. The study reviews how long COVID affects patients' jobs, finances, and communities, and emphasizes that gentle recovery approaches work better than pushing too hard, which can cause setbacks lasting days or weeks.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM unclearLongitudinal

Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy.

van der Schaaf, Marieke E, Geerligs, Linda, Toni, Ivan et al.·Psychological medicine·2024

This study looked at how fatigue and pain affect different networks in the brain of ME/CFS patients by taking brain scans at rest. The researchers found that fatigue and pain involve different brain circuits, suggesting they may be caused by different mechanisms. After cognitive behavioral therapy (CBT), patients who improved showed better communication between brain regions associated with movement and the brain's resting network.

Pain and Sensitization

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

BRIEF REPORT: Assessing Adherence and Competence in Delivering Telehealth Group Cognitive Behavioral Stress Management.

May, Marcella, Ream, Molly, Milrad, Sara F et al.·International journal of stress management·2024

This study developed a way to check whether therapists are properly delivering a stress management program called CBSM (Cognitive Behavioral Stress Management) when it's delivered online through video. The researchers watched 146 recorded therapy sessions with ME/CFS patients and their partners to see if therapists were following the program correctly and doing it well. They found that their checklist system worked fairly well, meaning different raters could agree on whether therapists were doing their job properly.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Myalgic encephalomyelitis/chronic fatigue syndrome as a complication of COVID-19 post-acute syndrome in adults. Bibliographic Review].

Carrillo Uguña, Miguel Esteban, Orellana Romero, Paula Michelle·Vertex (Buenos Aires, Argentina)·2024

This review examines how some COVID-19 survivors develop symptoms very similar to ME/CFS weeks or months after their acute infection ends. The authors found that over 87% of COVID-19 patients still experience at least one symptom two months after infection, and some of these symptoms match what ME/CFS patients experience. The study suggests that COVID-19 may trigger ME/CFS-like illness in some adults, similar to how other infections have been linked to ME/CFS in the past.

Long COVID OverlapPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?

Adler, Brittany L, Chung, Tae, Rowe, Peter C et al.·Frontiers in neurology·2024

This review examines how Lyme disease can damage the autonomic nervous system—the part of your nervous system that controls automatic body functions like heart rate, blood pressure, and digestion. The authors argue that this autonomic dysfunction may explain why some people with Lyme disease develop persistent, widespread symptoms similar to those seen in ME/CFS and long COVID. They review existing evidence and propose possible mechanisms for how the Lyme disease bacteria might cause these ongoing problems.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCross-Sectional

"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.

Wojczewski, Silvia, Mayrhofer, Mira, Szabo, Nathalie et al.·BMC public health·2024

This study asked 30 Austrian general practitioners (GPs) about their experiences diagnosing and treating Long-COVID patients during 2022. All GPs had seen Long-COVID patients, but many found treatment frustrating because patients often didn't improve significantly, and costs were high. The study found that GPs working in teams and those in cities with specialist networks managed Long-COVID more easily.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19.

Daynes, Enya, Mills, George, Hull, James H et al.·Chest·2024

This review examines whether pulmonary rehabilitation programs—treatments originally designed to help people with chronic lung diseases—might also help people with long COVID who experience breathlessness and fatigue. The authors suggest that because long COVID and chronic lung diseases cause similar problems with breathing and activity tolerance, rehabilitation programs that combine breathing exercises, strength training, and education could be beneficial for long COVID patients. However, they note that special care is needed for people whose symptoms worsen with exercise (postexertional malaise).

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity.

Bartkowiak-Wieczorek, Joanna, Malesza, Michał, Malesza, Ida et al.·Nutrients·2024

This review examines a compound called 6-MSITC found in wasabi that may have anti-inflammatory and antioxidant properties. Laboratory and animal studies suggest it could help with several conditions including cancer, Alzheimer's disease, and obesity. However, this is primarily a review of existing research rather than a new clinical trial, and more human testing is needed before we know if it truly helps patients.

E3 PreliminaryReviewPEM requiredReview-Narrative

[Interdisciplinary multimodal pain therapy in postviral syndromes and ME/CFS : Features, pitfalls and model concept].

Luchting, Benjamin, Behrends, Uta, Eigner, Bianca et al.·Schmerz (Berlin, Germany)·2024

Standard pain therapy programs often push patients to gradually increase their activity levels, but this approach can be harmful for people with ME/CFS because of postexertional malaise (PEM)—a worsening of symptoms after physical or mental effort. This paper reviews how pain therapy should be redesigned specifically for ME/CFS patients and presents a new model clinic program that carefully adjusts treatment to each person's individual tolerance levels to avoid triggering symptom flares.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not required

Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment.

Ljungström, Maria, Oltra, Elisa, Pardo, Marta·International journal of molecular sciences·2024

This case report describes one patient with ME/CFS who had high levels of stress and an overactive stress-response system in his body. He was treated with a medication called alpha-methyl-p-tyrosine (AMPT), which lowers stress chemicals in the body, and his symptoms improved. The report suggests that some people with ME/CFS may have problems with how their body produces and manages stress chemicals, and this medication might help them.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of electroacupuncture on expression of protein phosphorylation in hippocampus tissues of rats with chronic fatigue syndrome.

Yang, Yan, Sun, Zhong-Ren, Li, Chao-Ran et al.·Zhen ci yan jiu = Acupuncture research·2024

Researchers tested whether acupuncture with electrical stimulation could help rats with an artificially induced fatigue-like condition. After 28 days of treatment, the acupuncture-treated rats showed improvements in their overall condition, anxiety levels, and memory compared to untreated rats. The researchers found changes in brain proteins that might explain how the treatment helped.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cardiac Geometry and Function in Patients with Reflex Syncope.

Coseriu, Giorgia, Schiop-Tentea, Patricia, Apetrei, Csilla-Andrea et al.·Journal of clinical medicine·2024

This review examines how the size and function of the heart relate to fainting episodes in people with reflex syncope. Researchers found that people with smaller hearts and very forceful heartbeats are more prone to fainting, and this pattern is also seen in some people with chronic fatigue syndrome. Understanding these heart differences may help doctors predict who will faint again and choose better treatments.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.

Marshall-Gradisnik, Sonya, Martini Sasso, Etianne, Eaton-Fitch, Natalie et al.·PloS one·2024

This study looked at a specific protein channel (TRPM3) in immune cells called natural killer cells from Gulf War veterans with GWI and compared them to healthy people. The researchers found that TRPM3 doesn't work properly in the Gulf War veterans' cells, whereas it functions normally in healthy people. This finding is important because the same problem with TRPM3 has been seen in ME/CFS patients, suggesting these two illnesses might share a common biological issue.

Immune System

E3 PreliminaryBehavioralPEM unclearCase-Control

The novel application of the Lightning Process to treat Long COVID in primary care - Case report.

Finch, F, Parker, P, Nollett, C et al.·Explore (New York, N.Y.)·2024

This study looked at whether a self-help program called the Lightning Process could help two Long COVID patients manage their fatigue and other symptoms. Both patients reported feeling better in terms of tiredness, physical symptoms, and emotional wellbeing after completing the program and three months later. While these results are encouraging, this is a very small report of just two people, so we need larger studies to know if this approach works for most Long COVID patients.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

Jurek, Joanna Michalina, Castro-Marrero, Jesus·Nutrients·2024

This review examines how changes in gut bacteria may contribute to ME/CFS and long COVID symptoms, and whether taking probiotics or similar microbial preparations might help. The authors looked at existing research to understand the connection between gut health and the brain-immune system, and whether restoring healthy gut bacteria could reduce fatigue, inflammation, and other symptoms in these conditions.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondria Dysfunction and Chronic Fatigue Syndrome.

Ross, Stephanie Maxine·Holistic nursing practice·2024

This review examines how problems with mitochondria—the energy-producing parts of our cells—might contribute to ME/CFS. The study explores the theory that when mitochondria don't work properly, cells can't produce enough energy, which could explain the severe fatigue and exhaustion that ME/CFS patients experience. Understanding this connection may help researchers develop better treatments aimed at restoring cellular energy production.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCross-Sectional

A phenomenological study on the lived experience of men with Chronic Fatigue Syndrome.

Snell, Gracie Elizabeth, Seage, Catherine Heidi, Mercer, Jenny·Journal of health psychology·2024

This study interviewed five men with ME/CFS to understand how they experience the illness differently than women might. The men struggled to accept their diagnosis because they felt their symptoms conflicted with what they thought it meant to be male. They also felt that doctors didn't take their ME/CFS seriously, so they looked for support and validation from other people with the condition instead.

E3 PreliminaryReviewPEM unclearReview-Narrative

Sex differences in vascular endothelial function related to acute and long COVID-19.

Kitselman A, Kayla, Bédard-Matteau, Jérôme, Rousseau, Simon et al.·Vascular pharmacology·2024

This review examines how COVID-19 and long COVID affect blood vessel health differently in men and women. The authors look at how the virus can damage the inner lining of blood vessels, trigger immune problems, and potentially lead to ME/CFS symptoms. They explore whether biological sex differences explain why some people recover while others develop long-term symptoms like fatigue.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

'We have no services for you… so you have to make the best out of it': A qualitative study of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients' dissatisfaction with healthcare services.

Melby, Line, Nair, Roshan das·Health expectations : an international journal of public participation in health care and health policy·2024

This study interviewed 48 people (patients and family members) in Norway about their frustrations with healthcare for ME/CFS. Researchers found that patients struggle with four main problems: services that don't exist for their condition, services that aren't tailored to their individual needs, services that come too late to help, and services that are wrong for ME/CFS altogether. The study suggests that doctors' lack of knowledge about ME/CFS and sometimes disbelief in the condition itself are major reasons why patients feel let down by healthcare.

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Long Covid.

Long COVID's Impact on Patients, Workers, & Society: A review.

Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy.

BRIEF REPORT: Assessing Adherence and Competence in Delivering Telehealth Group Cognitive Behavioral Stress Management.

[Myalgic encephalomyelitis/chronic fatigue syndrome as a complication of COVID-19 post-acute syndrome in adults. Bibliographic Review].

Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?

"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.

Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19.

Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity.

[Interdisciplinary multimodal pain therapy in postviral syndromes and ME/CFS : Features, pitfalls and model concept].

Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment.

Effect of electroacupuncture on expression of protein phosphorylation in hippocampus tissues of rats with chronic fatigue syndrome.

Cardiac Geometry and Function in Patients with Reflex Syncope.

Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.

The novel application of the Lightning Process to treat Long COVID in primary care - Case report.

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

Mitochondria Dysfunction and Chronic Fatigue Syndrome.

A phenomenological study on the lived experience of men with Chronic Fatigue Syndrome.

Sex differences in vascular endothelial function related to acute and long COVID-19.

'We have no services for you… so you have to make the best out of it': A qualitative study of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients' dissatisfaction with healthcare services.

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