ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4021–4040 of 6,162 studies

E3 PreliminaryMechanismPEM unclearMechanistic

The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome.

Huitsing, Kaylin, Tritsch, Tara, Arias, Francisco Javier Carrera et al.·Molecular medicine (Cambridge, Mass.)·2024

This study explores why people with ME/CFS often experience dry eyes, sore throats, and stuffy noses. Researchers investigated whether problems with mucin proteins—substances that create protective layers in your mouth, nose, and eyes—might contribute to ME/CFS symptoms. Using computer analysis and genetic data, they hypothesized that weakened mucus membranes could lead to chronic inflammation in these areas, potentially worsening the condition.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of electroacupuncture on expression of protein phosphorylation in hippocampus tissues of rats with chronic fatigue syndrome.

Yang, Yan, Sun, Zhong-Ren, Li, Chao-Ran et al.·Zhen ci yan jiu = Acupuncture research·2024

Researchers tested whether acupuncture with electrical stimulation could help rats with an artificially induced fatigue-like condition. After 28 days of treatment, the acupuncture-treated rats showed improvements in their overall condition, anxiety levels, and memory compared to untreated rats. The researchers found changes in brain proteins that might explain how the treatment helped.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cardiac Geometry and Function in Patients with Reflex Syncope.

Coseriu, Giorgia, Schiop-Tentea, Patricia, Apetrei, Csilla-Andrea et al.·Journal of clinical medicine·2024

This review examines how the size and function of the heart relate to fainting episodes in people with reflex syncope. Researchers found that people with smaller hearts and very forceful heartbeats are more prone to fainting, and this pattern is also seen in some people with chronic fatigue syndrome. Understanding these heart differences may help doctors predict who will faint again and choose better treatments.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

SEMIPARAMETRIC BIVARIATE HIERARCHICAL STATE SPACE MODEL WITH APPLICATION TO HORMONE CIRCADIAN RELATIONSHIP.

You, Mengying, Guo, Wensheng·The annals of applied statistics·2024

This study looked at two stress hormones—ACTH and cortisol—in people with ME/CFS and fibromyalgia compared to healthy controls. Using a new mathematical method to track these hormones over time, researchers found that healthy people show a normal daily rhythm in how these hormones work together, while patients with ME/CFS and fibromyalgia show an irregular, unpredictable pattern instead.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Mitochondria Dysfunction and Chronic Fatigue Syndrome.

Ross, Stephanie Maxine·Holistic nursing practice·2024

This review examines how problems with mitochondria—the energy-producing parts of our cells—might contribute to ME/CFS. The study explores the theory that when mitochondria don't work properly, cells can't produce enough energy, which could explain the severe fatigue and exhaustion that ME/CFS patients experience. Understanding this connection may help researchers develop better treatments aimed at restoring cellular energy production.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

[Therapeutic effect and mechanism of Jingfang Granules on chronic fatigue syndrome based on intestinal flora and metabolomics].

Wang, Kun, Wei, Fang-Jiao, Cui, De-Yu et al.·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2024

Researchers tested a traditional Chinese herbal treatment called Jingfang Granules on mice with fatigue symptoms similar to ME/CFS. The treatment improved the mice's physical endurance, reduced markers of exhaustion and inflammation in the blood and tissues, and appeared to work by restoring healthy gut bacteria and adjusting how the body processes certain amino acids.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

Jurek, Joanna Michalina, Castro-Marrero, Jesus·Nutrients·2024

This review examines how changes in gut bacteria may contribute to ME/CFS and long COVID symptoms, and whether taking probiotics or similar microbial preparations might help. The authors looked at existing research to understand the connection between gut health and the brain-immune system, and whether restoring healthy gut bacteria could reduce fatigue, inflammation, and other symptoms in these conditions.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypocortisolemic ASIA: a vaccine- and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis.

Ruiz-Pablos, Manuel, Paiva, Bruno, Zabaleta, Aintzane·Frontiers in immunology·2024

This review proposes that ME/CFS, long COVID, and post-vaccine syndrome may share a common cause: an immune system problem that damages the pituitary gland (a small gland that controls many hormones). The researchers suggest that in genetically susceptible people, a weak initial response to viruses can lead to an overactive immune response that mistakenly attacks the body's own pituitary gland, lowering levels of crucial hormones like cortisol. They propose that treatments like antivirals, steroids, and antioxidants might help by reducing inflammation and restoring hormone balance.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations-A Narrative Review.

Gutiérrez-Hellín, Jorge, Del Coso, Juan, Franco-Andrés, Arturo et al.·Nutrients·2024

This review article examines how creatine, a natural substance that helps muscles produce energy, might help people beyond just athletes. The authors suggest creatine supplementation could reduce fatigue in women during certain phases of their menstrual cycle, help vegans and vegetarians compensate for lower creatine from their diet, and potentially support people with chronic fatigue syndrome, muscle loss, and other health conditions by improving how their cells produce energy.

Energy Metabolism

E3 PreliminaryGuidelinePEM unclearGuideline

Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative.

Darbyshire, Julie, Greenhalgh, Trisha, Bakerly, Nawar D et al.·Clinical medicine (London, England)·2024

This study looked at how ten long COVID clinics across the UK could improve their care for patients by sharing what they were learning with each other. From 2021 to 2023, clinic staff and patients met regularly to discuss the best ways to help people with long COVID, focusing on problems like breathing difficulties, heart rate issues, tiredness, and brain fog. The team created practical guides to help doctors provide better, more consistent care.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryCommentaryPEM not requiredEditorial

What Makes It Tick: Exploring the Mechanisms of Post-treatment Lyme Disease Syndrome.

Wester, Kate E, Nwokeabia, Bianca C, Hassan, Rehana et al.·Cureus·2024

This article discusses Post-treatment Lyme disease Syndrome (PTLDS), a condition where some people experience lasting fatigue, pain, and thinking problems for more than six months after being treated with antibiotics for Lyme disease. The authors suggest these symptoms may result from the body's immune system continuing to react to damage caused by the Lyme bacteria, even after the infection is gone. Currently, there is no blood test or scan to diagnose PTLDS, so doctors rely on patient symptoms and medical history.

Immune System

E3 PreliminaryGuidelinePEM unclearGuideline

A practical framework for Long COVID treatment in primary care.

Brode, W Michael, Melamed, Esther·Life sciences·2024

This paper provides a practical guide for primary care doctors treating Long COVID patients. It outlines a four-step approach: first, managing energy levels to avoid crashes after activity; second, carefully graduated rehabilitation for physical, mental, and emotional recovery; third, treating specific symptoms like fatigue and pain; and fourth, considering experimental treatments when appropriate.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

Long COVID: a new disease?

Mirofsky, Matias, Catalano, Hugo·Medicina·2024

This article discusses whether Long COVID should be considered a new disease and examines how medical systems can avoid overtreatment. The authors note that Long COVID shares similarities with other post-infection illnesses like ME/CFS and fibromyalgia, and they argue that careful, thoughtful medical care is important to prevent unnecessary treatments from making patients worse.

Long COVID Overlap

E3 PreliminaryReviewPEM not requiredReview-Narrative

Infectious Mononucleosis: An Updated Review.

Leung, Alexander K C, Lam, Joseph M, Barankin, Benjamin·Current pediatric reviews·2024

Infectious mononucleosis is a common viral infection caused by the Epstein-Barr virus (EBV) that mainly affects teenagers and young adults. Most people recover on their own within a few months, though severe fatigue can occur. This review explains the symptoms, how doctors diagnose it, and how to treat it—mainly through rest and avoiding strenuous activity.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The interplay between Sars-Cov-2 infection related cardiovascular diseases and depression. Common mechanisms, shared symptoms.

Gonjilashvili, Ana, Tatishvili, Sophio·American heart journal plus : cardiology research and practice·2024

This review examines how COVID-19 can affect both the heart and mental health, and why these problems often occur together. The authors explain that inflammation, unhealthy lifestyle changes, and communication between organs may all play a role. They note that long COVID shares many symptoms with heart and brain problems—like fatigue, brain fog, dizziness, chest pain, and depression—which is why patients need care from multiple medical specialists.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Exploring the arcuate fasciculus from a clinical perspective.

Shao, Zhi Ding, Gong, Yu Juan, Ren, Jing et al.·Frontiers in neuroscience·2023

This review examines a bundle of nerve fibers in the brain called the arcuate fasciculus, which helps connect language centers. Researchers found that several conditions—including ME/CFS, stroke, brain tumors, and others—can damage these nerve fibers in measurable ways. New brain imaging techniques can now visualize and measure this damage, which may help doctors understand what goes wrong and develop better treatments.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredSystematic-Review

Understanding mental fatigue and its detection: a comparative analysis of assessments and tools.

Kunasegaran, Kaveena, Ismail, Ahamed Miflah Hussain, Ramasamy, Shamala et al.·PeerJ·2023

Mental fatigue is a common problem that makes it harder to concentrate, process information, and make decisions. Currently, doctors mainly ask patients to describe their fatigue using questionnaires, which can be unreliable because people's answers are subjective. This review compared different methods of detecting mental fatigue—including questionnaires, heart rate measurements, stress hormones, brain scans, and eye movement tests—to find the most objective and accurate tool.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice.

Zhu, Yang, Wang, Jingya, Yao, Lin et al.·Anatomical record (Hoboken, N.J. : 2007)·2023

This study tested whether electroacupuncture (a treatment involving tiny needles and electrical stimulation) could help mice with a condition similar to ME/CFS. Researchers found that electroacupuncture improved the mice's ability to move and strengthened their heart function by reducing levels of a particular chemical messenger (nitric oxide) in the body.

E3 PreliminaryCommentaryPEM requiredEditorial

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Vøllestad, Nina K, Mengshoel, Anne Marit·Frontiers in physiology·2023

This paper reviews how post-exertional malaise (PEM)—the worsening of symptoms after physical or mental activity—is experienced and studied in ME/CFS patients. Patients describe PEM in many different ways and report that it can start immediately or be delayed by days, lasting anywhere from a few days to months. When researchers use standardized exercise tests in laboratories, they see more immediate symptom worsening, but the duration still varies widely between patients.

Autonomic Nervous SystemPost-Exertional Malaise

E3 PreliminaryCommentaryPEM unclear

Long-COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Potential neurophysiological biomarkers for these enigmatic entities.

Versace, Viviana, Tankisi, Hatice·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2023

This editorial discusses potential nerve-based tests that might help identify and distinguish Long-COVID and ME/CFS—two conditions that share similar exhaustion and brain symptoms but are still poorly understood. The authors review existing neurophysiological tools (tests that measure nerve and muscle function) that could potentially serve as objective biomarkers to help doctors diagnose these conditions more reliably. They highlight the need for further research to validate these tests and better understand what's happening in patients' nervous systems.

Biomarkers

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The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome.

Effect of electroacupuncture on expression of protein phosphorylation in hippocampus tissues of rats with chronic fatigue syndrome.

Cardiac Geometry and Function in Patients with Reflex Syncope.

SEMIPARAMETRIC BIVARIATE HIERARCHICAL STATE SPACE MODEL WITH APPLICATION TO HORMONE CIRCADIAN RELATIONSHIP.

Mitochondria Dysfunction and Chronic Fatigue Syndrome.

[Therapeutic effect and mechanism of Jingfang Granules on chronic fatigue syndrome based on intestinal flora and metabolomics].

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

Hypocortisolemic ASIA: a vaccine- and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis.

Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations-A Narrative Review.

Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative.

What Makes It Tick: Exploring the Mechanisms of Post-treatment Lyme Disease Syndrome.

A practical framework for Long COVID treatment in primary care.

Long COVID: a new disease?

Infectious Mononucleosis: An Updated Review.

The interplay between Sars-Cov-2 infection related cardiovascular diseases and depression. Common mechanisms, shared symptoms.

Exploring the arcuate fasciculus from a clinical perspective.

Understanding mental fatigue and its detection: a comparative analysis of assessments and tools.

Electroacupuncture at BL15 attenuates chronic fatigue syndrome by downregulating iNOS/NO signaling in C57BL/6 mice.

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Long-COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Potential neurophysiological biomarkers for these enigmatic entities.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research