ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4621–4640 of 6,188 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric Properties and Factor Structure of a Long and Shortened Version of the Cognitive and Behavioural Responses Questionnaire.

Ryan, Elizabeth G, Vitoratou, Silia, Goldsmith, Kimberley A et al.·Psychosomatic medicine·2018

This study tested a questionnaire designed to measure how people with ME/CFS think and behave in response to their illness—such as pushing through fatigue or avoiding activity. Researchers created a shorter, easier-to-use version of the original questionnaire by removing unnecessary questions while keeping the important ones. Both versions were found to be reliable and accurate tools for understanding these psychological responses.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Wang, Xue, Qu, Yidi, Zhang, Yongfeng et al.·Oxidative medicine and cellular longevity·2018

This study tested whether a medicinal mushroom called Sarcodon imbricatus could reduce fatigue in mice with chronic fatigue syndrome. The mushroom extract improved the mice's exercise ability, reduced tiredness, and boosted the body's natural antioxidant defenses—systems that protect cells from damage.

Energy Metabolism

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Measurement error, time lag, unmeasured confounding: Considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials.

Goldsmith, K A, Chalder, T, White, P D et al.·Statistical methods in medical research·2018

This study examined how treatments work in the PACE trial by using advanced statistical methods to track changes in patients' symptoms and functioning over time. The researchers tested different ways of analyzing data to understand whether improvements in one area (like activity levels) might explain improvements in another area (like fatigue). They found that accounting for measurement errors and considering the timing of measurements was important for getting accurate results.

E3 PreliminaryGuidelinePEM not requiredGuideline

Therapeutic patient education in adrenal insufficiency.

Guignat, Laurence·Annales d'endocrinologie·2018

This study describes educational programs that help patients with adrenal insufficiency (a condition where the adrenal glands don't make enough hormones) manage their condition safely. The programs teach patients to recognize warning signs of a dangerous crisis, carry emergency medication, adjust their doses for different situations like exercise or travel, and know when to seek medical help. The study notes that similar programs could help people with chronic fatigue syndrome avoid taking too much of their medication.

E3 PreliminaryCohortPEM unclearCross-Sectional

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study.

Castro-Marrero, Jesús, Serrano-Pertierra, Esther, Oliveira-Rodríguez, Myriam et al.·Journal of extracellular vesicles·2018

This small pilot study looked at tiny particles called extracellular vesicles (EVs) in the blood of ME/CFS patients compared to healthy people. The researchers found that ME/CFS patients had higher amounts of these particles, and the particles were smaller than in healthy controls. This suggests that blood tests measuring these particles might one day help doctors identify ME/CFS.

Biomarkers

E3 PreliminaryPEM not requiredRegistry-Resource

Supplementation with Robuvit® in post-traumatic stress disorders associated to high oxidative stress.

Belcaro, Gianni, Luzzi, Roberta, Hosoi, Morio et al.·Minerva medica·2018

This study looked at whether a plant-based supplement called Robuvit® could help people with PTSD (post-traumatic stress disorder) recover faster alongside standard therapy. Over 4 weeks, people who took Robuvit® along with therapy showed greater improvements in symptoms like intrusive memories, nightmares, flashbacks, sleep problems, and fatigue compared to those who received therapy alone.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach.

Strassheim, Victoria, Welford, Jenny, Ballantine, Rob et al.·Autonomic neuroscience : basic & clinical·2018

This review examines fatigue in people with PoTS (postural tachycardia syndrome), a condition where heart rate increases abnormally when standing. The authors explain why fatigue happens in PoTS, how it overlaps with ME/CFS, and describe practical approaches doctors can use to help manage it by treating the individual causes of fatigue in each patient.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclear

Tenuous link between chronic fatigue syndrome and pyruvate dehydrogenase deficiency.

Bliksrud, Yngve Thomas·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2017

This study examined whether a specific metabolic enzyme problem called pyruvate dehydrogenase deficiency might be connected to ME/CFS. The researchers found only a weak or unclear link between this enzyme deficiency and ME/CFS symptoms, suggesting it is not a major cause of the illness for most patients.

Energy Metabolism

E3 PreliminaryCohortPEM unclear

A woman in her 50s with chronic fatigue syndrome, sepsis and hyponatraemia.

Tazmini, Kiarash, Meling, Torstein R, Skattør, Thor Håkon et al.·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2017

This case report describes a woman in her 50s with ME/CFS who developed a serious blood infection (sepsis) and low sodium levels in her blood. The doctors documented her medical history and response to treatment. This single case highlights how ME/CFS patients can develop additional serious medical complications that require careful monitoring and treatment.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

Li, Kefeng, Naviaux, Jane C, Bright, A Taylor et al.·Metabolomics : Official journal of the Metabolomic Society·2017

Researchers developed a new, efficient blood test that can measure over 600 different molecules (metabolites) in a single sample to help diagnose ME/CFS. The test was validated by showing it could correctly identify ME/CFS patients with 95% accuracy compared to healthy controls, even when tested again more than a year later by different researchers.

Biomarkers

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

He, Min, Chen, Wenwen, Wang, Mengmeng et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2017

Researchers developed a precise laboratory test to measure seven active ingredients from Bu-zhong-yi-qi-tang, a traditional herbal medicine used in East Asia for digestive problems, cancer, and chronic fatigue. They gave this herb to rats and tracked where these ingredients ended up in the body, finding they concentrated mainly in the digestive system.

E3 PreliminaryMechanismPEM not requiredMechanistic

The variation of the 5-hydroxytryptamine system between chronic unpredictable mild stress rats and chronic fatigue syndrome rats induced by forced treadmill running.

Cao, Yin, Li, Qinglin·Neuroreport·2017

This study compared how serotonin (a brain chemical linked to mood and energy) works differently in two types of animal models—one mimicking stress-related depression and another mimicking ME/CFS. Surprisingly, the two conditions showed opposite patterns: the stress model had low serotonin levels, while the fatigue model had high serotonin levels, suggesting these conditions may involve different biological mechanisms even though both cause low activity and mood problems.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The interface between chronic fatigue syndrome and depression: A psychobiological and neurophysiological conundrum.

Larkin, Derek, Martin, Colin R·Neurophysiologie clinique = Clinical neurophysiology·2017

Many people with ME/CFS experience depression alongside their physical symptoms, but it's unclear whether depression causes the fatigue, results from it, or whether they share common underlying biological causes. This paper reviews what we know about the connection between ME/CFS and depression, examining possible explanations from brain function, immune system activity, and psychological factors. Understanding this relationship better could help doctors develop more effective treatments that address both the fatigue and mood symptoms.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Wang, Xiang-Yi, Liu, Chang-Zheng, Lei, Bo·Zhen ci yan jiu = Acupuncture research·2017

Researchers tested whether acupuncture could help rats with chronic fatigue syndrome by measuring changes in immune system markers. Acupuncture was applied to three specific points for two weeks, and the treated rats showed improved tiredness and swimming performance compared to untreated rats. The study suggests acupuncture may work by rebalancing immune system signals that become disrupted in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.

Petrides, George, Zalewski, Pawel, McCulloch, David et al.·Fatigue : biomedicine, health & behavior·2017

This study looked at how the nervous system controls the heart in people with ME/CFS, focusing on a specific part called the sympathetic nervous system. Researchers used specialized imaging to examine nerve connections in the heart and compared them to problems with autonomic function (the automatic nervous system that controls heart rate and blood pressure). The findings suggest that differences in heart nerve connections may be related to why some ME/CFS patients experience autonomic symptoms like dizziness and heart rate changes.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Frontline Temporomandibular Joint/Orofacial Pain Therapy for Every Dental Practice.

Germain, Lisa, Malcmacher, Louis·Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2017

This article explains how dentists can help patients with temporomandibular joint (jaw joint) and orofacial pain using straightforward, conservative treatment approaches. The authors note that jaw pain often occurs alongside other pain conditions, including chronic fatigue syndrome (ME/CFS), and suggest that dentists with proper training can be a first line of care for these patients.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Characterization of a protein-bound polysaccharide from Herba Epimedii and its metabolic mechanism in chronic fatigue syndrome.

Chi, Aiping, Shen, Zhimei, Zhu, Wenfei et al.·Journal of ethnopharmacology·2017

This study tested a natural compound extracted from Herba Epimedii (a traditional Chinese herb) to see if it could help treat chronic fatigue. Researchers gave the compound to rats with CFS-like symptoms and measured changes in their urine chemistry. They found that the treatment reversed several chemical imbalances associated with fatigue, suggesting the herb may work by restoring normal metabolism.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

Loades, M E, Chalder, T·Behavioural and cognitive psychotherapy·2017

Many young people with ME/CFS also experience depression, and both conditions can be treated with a talking therapy called cognitive behavioural therapy (CBT). This paper compares how CBT is used for these two conditions in children and teenagers, explaining that while the approaches share some similarities, they focus on different problems and use different strategies to help each condition.

Interventions

E3 PreliminaryMechanismPEM requiredMechanistic

Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Cook, Dane B, Light, Alan R, Light, Kathleen C et al.·Brain, behavior, and immunity·2017

This study examined what happens in the brains of ME/CFS patients after exercise. Researchers asked 15 patients and 15 healthy people to exercise for 30 minutes, then used brain imaging to see how their brains worked before and 24 hours after exercise. ME/CFS patients' symptoms got much worse after exercise, their thinking and memory got worse, and their brain activity changed in specific ways—showing that exercise triggered real, measurable changes in how their brains functioned.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

CNS findings in chronic fatigue syndrome and a neuropathological case report.

Ferrero, Kimberly, Silver, Mitchell, Cocchetto, Alan et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2017

This study examines brain tissue from one person who had ME/CFS and died, looking for physical changes that might explain the illness. Researchers found several abnormalities in the brain including areas of damaged nerve fibers, tangles similar to those seen in Alzheimer's disease, and deposits of a protein called amyloid. These findings suggest that ME/CFS may involve damage to the brain's structure and deserve further investigation.

Neuroinflammation

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Psychometric Properties and Factor Structure of a Long and Shortened Version of the Cognitive and Behavioural Responses Questionnaire.

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Measurement error, time lag, unmeasured confounding: Considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials.

Therapeutic patient education in adrenal insufficiency.

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study.

Supplementation with Robuvit® in post-traumatic stress disorders associated to high oxidative stress.

Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach.

Tenuous link between chronic fatigue syndrome and pyruvate dehydrogenase deficiency.

A woman in her 50s with chronic fatigue syndrome, sepsis and hyponatraemia.

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

The variation of the 5-hydroxytryptamine system between chronic unpredictable mild stress rats and chronic fatigue syndrome rats induced by forced treadmill running.

The interface between chronic fatigue syndrome and depression: A psychobiological and neurophysiological conundrum.

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.

Frontline Temporomandibular Joint/Orofacial Pain Therapy for Every Dental Practice.

Characterization of a protein-bound polysaccharide from Herba Epimedii and its metabolic mechanism in chronic fatigue syndrome.

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

CNS findings in chronic fatigue syndrome and a neuropathological case report.

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