ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4621–4640 of 6,163 studies

E3 PreliminaryCommentaryPEM not requiredEditorial

Causes, assessment and management of fatigue in critically ill patients.

Cajanding, Ruff Jm·British journal of nursing (Mark Allen Publishing)·2017

Fatigue is one of the most distressing symptoms experienced by patients in intensive care units (ICUs), and it often continues long after patients leave the hospital. This article discusses what causes fatigue in critically ill patients, how doctors and nurses can better recognize and assess it, and what treatments might help. The authors emphasize that nurses play an important role in identifying patients at risk and managing their fatigue.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Inducing Somatic Symptoms in Functional Syndrome Patients: Effects of Manipulating State Negative Affect.

Van Den Houte, Maaike, Bogaerts, Katleen, Van Diest, Ilse et al.·Psychosomatic medicine·2017

This study looked at whether negative emotions can trigger or worsen physical symptoms in people with ME/CFS and fibromyalgia. Researchers showed patients and healthy people emotionally negative, neutral, and positive pictures, then asked them to report what physical symptoms they felt. Patients with ME/CFS and fibromyalgia reported more symptoms after viewing negative pictures, while healthy people did not. The effect was stronger in patients who had difficulty recognizing their own feelings or who became deeply absorbed in things.

E3 PreliminaryCohortPEM unclearCase-Control

A thermal dysregulation problem after breast cancer surgery; what could be?

Rüstemova, Diana, Genc, Aysun, Bora, Gül et al.·Medicine·2017

A 41-year-old woman developed a persistent feeling of being cold after breast cancer surgery and was diagnosed with ME/CFS after other conditions were ruled out. She improved significantly with aerobic exercise done for at least 30 minutes, three or more days per week. This case suggests that abnormal temperature regulation—feeling unusually cold or hot—may be a symptom of ME/CFS that doctors should watch for.

E3 PreliminaryBehavioralPEM unclearObservational

A qualitative investigation of eating difficulties in adolescents with chronic fatigue syndrome/myalgic encephalomyelitis.

Harris, Sarah, Gilbert, Matthew, Beasant, Lucy et al.·Clinical child psychology and psychiatry·2017

This study looked at why some teenagers with ME/CFS have trouble eating. Researchers interviewed 11 teenagers and found that eating difficulties were caused by stomach symptoms, fatigue making it hard to eat, and changes in how food tasted or smelled. These eating problems affected their weight, energy levels, mood, and family life. The teenagers found that changing what they ate, family support, and medical help (like medications) were helpful.

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic encephalomyelitis: International Consensus Criteria.

Journal of internal medicine·2017

This guideline establishes internationally agreed-upon criteria for diagnosing ME/CFS, helping doctors around the world recognize the condition consistently. It brings together expert knowledge to create clear standards for who has ME/CFS based on symptoms like post-exertional malaise (worsening after activity), sleep problems, cognitive difficulties, and pain. Having a shared definition makes it easier for patients to get accurate diagnoses and for researchers to study the same condition across different countries.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

Rowe, Peter C, Underhill, Rosemary A, Friedman, Kenneth J et al.·Frontiers in pediatrics·2017

This guide helps doctors understand and diagnose ME/CFS in children and teenagers. ME/CFS causes extreme tiredness and makes it hard for young people to do physical or mental activities—with symptoms often getting worse after even small efforts and lasting for days or longer. The guide explains that there is no single test for ME/CFS, so doctors must diagnose it based on symptoms and by ruling out other conditions, and recommends that treatment focus on finding the right balance between rest and activity.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Cellular bioenergetics is impaired in patients with chronic fatigue syndrome.

Tomas, Cara, Brown, Audrey, Strassheim, Victoria et al.·PloS one·2017

This study examined how cells in ME/CFS patients produce energy differently than in healthy people. Researchers tested immune cells from patients and found that when these cells are under stress, they cannot ramp up their energy production as much as healthy cells can. This suggests that ME/CFS patients' cells may struggle to meet energy demands, especially during periods of physical or mental exertion.

Energy Metabolism

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

American journal of epidemiology·2017

This study describes how researchers set up a large project to better understand and diagnose ME/CFS across multiple medical centers. The researchers created a system to carefully collect information about ME/CFS patients over time, combining both new patient data and information from medical records. This kind of organized approach helps scientists learn more about the condition and how to recognize it accurately.

E3 PreliminaryCohortPEM not requiredCase-Control

Sympathetic neural hyperalgesia edema syndrome as a cause of autoimmune hearing loss.

Check, J H·Clinical and experimental obstetrics & gynecology·2017

This case study describes one woman with ME/CFS, pelvic pain, and diarrhea who was given the stimulant medication dextroamphetamine to help with fertility. Unexpectedly, not only did her ME/CFS symptoms improve, but her hearing loss—which had not responded to months of steroid treatment—also significantly improved, as confirmed by hearing tests.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

Picariello, Federica, Ali, Sheila, Foubister, Caroline et al.·British journal of health psychology·2017

This study looked at what 13 ME/CFS patients thought about cognitive behavioural therapy (CBT), a talking therapy that helps people change unhelpful thinking patterns and behaviors. Most patients were satisfied with CBT and felt better, though not completely recovered. The study found that the personal support from a therapist and accepting that ME/CFS involves both physical and mental factors were important for success.

Interventions

E3 PreliminaryBehavioralPEM unclearCross-Sectional

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Taylor, Anna K, Loades, Maria, Brigden, Amberly Lc et al.·Clinical child psychology and psychiatry·2017

This study talked with nine young people (aged 13-17) who have ME/CFS and depression to understand how these two conditions connect. Most young people felt that ME/CFS caused their depression because the illness stopped them doing activities they loved and changed their daily lives. Many also noticed that feeling sad made their ME/CFS symptoms worse, creating a difficult cycle. The researchers found that different combinations of treatments—like talking therapy, medicine, and careful activity planning—worked best for different people.

E3 PreliminaryReviewPEM not requiredReview-Narrative

A sociological stance on fatigue and tiredness: Social inequalities, norms and representations.

Loriol, Marc·Neurophysiologie clinique = Clinical neurophysiology·2017

This study examines fatigue from a social perspective, looking at how people's work and living conditions, social environment, and cultural beliefs affect their experience of exhaustion. Rather than treating fatigue only as a medical problem, the authors explore how different groups in society experience and understand tiredness differently, and how societal expectations about work and productivity shape whether someone feels appropriately tired or dangerously exhausted.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

He, Min, Chen, Wenwen, Wang, Mengmeng et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2017

Researchers developed a precise laboratory test to measure seven active ingredients from Bu-zhong-yi-qi-tang, a traditional herbal medicine used in East Asia for digestive problems, cancer, and chronic fatigue. They gave this herb to rats and tracked where these ingredients ended up in the body, finding they concentrated mainly in the digestive system.

E3 PreliminaryMechanismPEM not requiredMechanistic

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

Crépeaux, Guillemette, Eidi, Housam, David, Marie-Odile et al.·Toxicology·2017

This study gave mice different amounts of aluminum hydroxide (a substance used in vaccines) injected into muscle and then checked their brains 6 months later. Surprisingly, the mice that received the lowest dose showed cognitive and movement changes, increased immune cell activity in the brain, and accumulated more aluminum in their brains—while the mice given higher doses did not. This unusual pattern suggests that aluminum's harmful effects may not simply follow the traditional "more dose = more harm" rule.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings.

Gerwyn, Morris, Maes, Michael·Current rheumatology reports·2017

This review examines why ME/CFS patients experience muscle fatigue and pain. Researchers found that several biological problems may contribute to these symptoms: damaged cellular energy factories (mitochondria), harmful stress molecules building up in the body, and reduced production of protective proteins. These problems together may explain why ME/CFS patients get tired quickly and struggle with exercise.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

Important factors to consider when treating children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): perspectives of health professionals from specialist services.

Parslow, Roxanne M, Shaw, Alison, Haywood, Kirstie L et al.·BMC pediatrics·2017

This study asked specialist doctors and nurses who treat children with ME/CFS what they believe are the most important things to measure when checking how well a child is doing. The experts identified four key areas: symptoms (like fatigue and pain), physical ability to do things, participation in school and social activities, and emotional wellbeing. The goal is to create a better way to measure treatment success that matches what children and families actually care about.

E3 PreliminaryCohortPEM not requiredCase-Control

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.

Colaris, Maartje J L, de Boer, Mintsje, van der Hulst, Rene R et al.·Immunologic research·2017

This study compared 200 patients with silicone breast implants who developed autoimmune and inflammatory symptoms (a condition called ASIA) across two time periods—100 patients in 2014 and 100 historical patients from the 1980s–1990s. The researchers found that the symptoms remained similar over 30 years, including fatigue, joint pain, brain fog, and fever. About half of the patients who had their implants removed experienced symptom improvement.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Glassford, Julian A G·Frontiers in physiology·2017

This article reviews research suggesting that ME/CFS may result from problems in how the nervous system and immune system interact. The author discusses how physical strain on the spine and nerves, combined with prolonged infections and immune activation, may trigger a chain reaction of inflammation in the brain and throughout the body. This inflammation can affect energy production, hormone balance, and how the body processes pain.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCase-Control

A tiny tick can cause a big health problem.

John, Manuel, Raman, M, Ryan, Keith·Indian journal of ophthalmology·2017

This study describes rare cases of ticks biting people on the eyelid area in India. Ticks are tiny bugs that can carry serious diseases. The doctors had to carefully remove the ticks to avoid leaving parts behind, which could cause infection. The study highlights that tick-borne diseases, including ones that can cause chronic fatigue and other long-term health problems, are becoming more common in India and need prompt treatment.

E3 PreliminaryCommentaryPEM unclearEditorial

[Environmental medical syndromes].

Wiesmüller, Gerhard A, Hornberg, Claudia·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2017

This editorial discusses several conditions that seem related to environmental exposures and stress, including ME/CFS, fibromyalgia, and multiple chemical sensitivities. The authors explain that we don't yet fully understand what causes these conditions or how to diagnose and treat them properly. They emphasize that doctors should take patients seriously and help them even while research continues to find answers.

Diagnostics

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Causes, assessment and management of fatigue in critically ill patients.

Inducing Somatic Symptoms in Functional Syndrome Patients: Effects of Manipulating State Negative Affect.

A thermal dysregulation problem after breast cancer surgery; what could be?

A qualitative investigation of eating difficulties in adolescents with chronic fatigue syndrome/myalgic encephalomyelitis.

Myalgic encephalomyelitis: International Consensus Criteria.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer.

Cellular bioenergetics is impaired in patients with chronic fatigue syndrome.

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

Sympathetic neural hyperalgesia edema syndrome as a cause of autoimmune hearing loss.

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

A sociological stance on fatigue and tiredness: Social inequalities, norms and representations.

Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings.

Important factors to consider when treating children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): perspectives of health professionals from specialist services.

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

A tiny tick can cause a big health problem.

[Environmental medical syndromes].

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