ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4601–4620 of 6,209 studies

E3 PreliminaryMechanismPEM unclearCross-Sectional

Brain function characteristics of chronic fatigue syndrome: A task fMRI study.

Shan, Zack Y, Finegan, Kevin, Bhuta, Sandeep et al.·NeuroImage. Clinical·2018

This study compared brain activity in ME/CFS patients and healthy people while they performed a challenging word-color matching task. ME/CFS patients were slower at the task, and their brains showed different patterns of activity—specifically, the brain signals were less complex and adaptive. The findings suggest that ME/CFS patients' brains may need to work harder or recruit more areas to handle cognitive challenges.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

The biopolitics of CFS/ME.

Karfakis, Nikos·Studies in history and philosophy of biological and biomedical sciences·2018

This paper examines how ME/CFS is shaped by different groups—doctors, scientists, government officials, and patients themselves—who all try to define and understand the illness. The author shows that ME/CFS sits uncomfortably between medical and psychiatric explanations, which makes it hard for everyone to agree on what it is and how to treat it. Patients aren't just passive recipients of medical care; they actively educate themselves and push back against explanations they disagree with, which influences how the illness is understood.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Rahmadi, Ridho, Groot, Perry, van Rijn, Marieke Hc et al.·Statistical methods in medical research·2018

This study developed a new statistical method for finding cause-and-effect relationships in long-term health data, even when sample sizes are small. The researchers tested their method on data from people with chronic fatigue syndrome, Alzheimer's disease, and chronic kidney disease, and found it could identify stable patterns of how different health factors influence each other over time.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Beyond total treatment effects in randomised controlled trials: Baseline measurement of intermediate outcomes needed to reduce confounding in mediation investigations.

Landau, Sabine, Emsley, Richard, Dunn, Graham·Clinical trials (London, England)·2018

This study explains the best way to analyze how a treatment works by breaking down its effects into direct and indirect pathways. The researchers tested different statistical methods using a rehabilitation trial in ME/CFS patients and found that one approach (called analysis of covariance) gives the most reliable answers by measuring patients' symptoms before and after treatment.

E3 PreliminaryMechanismPEM unclearMechanistic

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Shao, Changzhuan, Song, Jing, Zhao, Shanguang et al.·Polymers·2018

Researchers tested whether a compound called selenium-polysaccharide (Se-TP) from a Chinese green tea called Ziyang could help rats with fatigue similar to ME/CFS. They found that the treatment improved certain markers in the rats' blood and urine, suggesting it may work by affecting how the body makes and uses steroid hormones and processes amino acids.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

Rusin, Andrej, Seymour, Colin, Mothersill, Carmel·International journal of radiation biology·2018

This study looked at whether ME/CFS and radiation sickness might share similar problems in how cells produce energy. Researchers found evidence that both conditions may involve damage to mitochondria (the "power plants" of cells) and disrupted energy production. They suggest specific biological pathways worth studying to better understand ME/CFS and possibly develop new treatments.

Energy Metabolism

E3 PreliminaryCohortPEM unclearObservational

Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence: a qualitative study.

Brigden, Amberly, Barnett, Julie, Parslow, Roxanne Morin et al.·BMJ paediatrics open·2018

This study looked at how teenagers with ME/CFS use the internet to understand and cope with their condition. Researchers interviewed 9 young people (ages 12-17) about which websites and online spaces they visited. The teenagers found that official health websites were helpful when first diagnosed, but over time they preferred online communities where they could read other patients' stories, get emotional support, and connect with peers who understood what they were going through.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic.

Thomm, Angela M, Schotthoefer, Anna M, Dupuis, Alan P et al.·mSphere·2018

This study developed and tested a new blood test to detect Powassan virus, a tick-borne infection that can cause serious neurological problems. The test uses two steps: first screening with one method, then confirming positive results with a more specific test. The researchers found the test was accurate and could identify Powassan infections in patients living in areas where Lyme disease is common, suggesting this virus may be more prevalent than previously recognized.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature.

Fragkos, Konstantinos C, Barragry, John, Fernando, Charisma Shahi et al.·Zeitschrift fur Gastroenterologie·2018

This case report describes one young woman with ME/CFS and chronic pain who developed severe inflammation in her colon (eosinophilic colitis) after taking two common pain medications—gabapentin and pregabalin. Her symptoms improved when she stopped the medications and received steroid treatment. This is an extremely rare side effect, but doctors should be aware of it if ME/CFS patients taking these drugs develop abdominal pain, diarrhea, and blood cell changes.

E3 PreliminaryMechanismPEM not requiredMechanistic

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis.

Tomljenovic, Dejan, Baudoin, Tomislav, Megla, Zeljka Bukovec et al.·Medical hypotheses·2018

This study looked at how men and women with seasonal allergies respond differently to nasal irritants. Researchers found that women had stronger burning sensations and higher levels of a nerve-signaling chemical called substance P compared to men when exposed to salt water or allergen challenges. This suggests that women's bodies may process nasal irritation through a different biological pathway involving both immune cells and nerve signals.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.

Sedghamiz, Hooman, Morris, Matthew, Craddock, Travis J A et al.·BMC systems biology·2018

This study created a simple computer model to understand how the body's stress-response system (the HPA axis) works and how it can get stuck in unhealthy patterns in conditions like ME/CFS. The researchers found that stress may push this system into a low-cortisol state and keep it there, and that certain treatments might help restore normal daily rhythms. The model worked better and required less data than previous complex models.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Coelogyne cristata Lindley in alleviation of chronic fatigue syndrome in aged Wistar rats.

Mitra, Achintya, Sur, Tapas Kumar, Upadhyay, Sachhidananda et al.·Journal of Ayurveda and integrative medicine·2018

Researchers tested an orchid extract called Coelogyne cristata on aging rats that had been made fatigued through repeated forced swimming. The extract improved the rats' movement, reduced depression-like and anxiety-like behaviors, and restored protective antioxidant levels in their brains, performing similarly to ginseng, a known stress-relief supplement.

E3 PreliminaryGuidelinePEM not requiredGuideline

Therapeutic patient education in adrenal insufficiency.

Guignat, Laurence·Annales d'endocrinologie·2018

This study describes educational programs that help patients with adrenal insufficiency (a condition where the adrenal glands don't make enough hormones) manage their condition safely. The programs teach patients to recognize warning signs of a dangerous crisis, carry emergency medication, adjust their doses for different situations like exercise or travel, and know when to seek medical help. The study notes that similar programs could help people with chronic fatigue syndrome avoid taking too much of their medication.

E3 PreliminaryReviewPEM unclearReview-Narrative

HPV vaccination syndrome: A clinical mirage, or a new tragic fibromyalgia model.

Martínez-Lavín, Manuel·Reumatologia clinica·2018

Some people have reported developing chronic pain and autonomic symptoms (problems with heart rate, blood pressure, and sweating) after receiving the HPV vaccine. This article reviews whether this connection is real and suggests that if it exists, these cases might share similarities with fibromyalgia—a condition involving widespread pain and nervous system dysfunction. The authors propose that understanding fibromyalgia's mechanisms could help diagnose and treat patients who develop symptoms after HPV vaccination.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryPEM not requiredRegistry-Resource

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry.

Watad, Abdulla, Quaresma, Mariana, Bragazzi, Nicola Luigi et al.·Clinical rheumatology·2018

This study examined 300 patients who developed autoimmune diseases after exposure to adjuvants (immune-stimulating substances in vaccines and other products). The most common symptoms were joint pain, muscle pain, and chronic fatigue, and most patients developed another autoimmune condition within about 17 months of exposure. The researchers found that different adjuvants caused slightly different patterns of illness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Petrescu, Anca D, Kain, Jessica, Liere, Victoria et al.·Frontiers in endocrinology·2018

This review examines how the stress hormone system (HPA axis) works and what happens when it breaks down in people with liver disease. The HPA axis is like your body's control center that manages stress responses and many other important functions. The authors explain how inflammation in the liver can disrupt this system, potentially leading to the fatigue and other symptoms seen in both liver disease and chronic fatigue syndrome.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Myalgic Encephalomyelitis (ME) or What? An Operational Definition.

Twisk, Frank·Diagnostics (Basel, Switzerland)·2018

This paper proposes a clear, practical definition of ME (myalgic encephalomyelitis) to help doctors reliably identify and study the condition. The authors argue that ME is a distinct multi-system illness characterized by severe muscle exhaustion after minimal activity, neurological symptoms (like brain fog and autonomic problems), and a pattern of symptom fluctuation and relapse over months or years. Having a precise definition is essential so researchers can study the right patients and develop effective treatments.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Aluminum in vaccines: Does it create a safety problem?

Principi, Nicola, Esposito, Susanna·Vaccine·2018

This review examined whether aluminum in vaccines could cause serious health problems, particularly in children. The researchers looked at existing research on aluminum's effects on the nervous system and found no clear evidence that aluminum in vaccines causes brain damage. However, they noted that a possible link between certain aluminum-containing vaccines and two conditions—macrophagic myofascitis and ME/CFS—needs further investigation before firm conclusions can be made.

Immune System

E3 PreliminaryCohortPEM unclearObservational

Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate: An open-label, proof-of-principle pilot trial.

Comhaire, Frank·Medical hypotheses·2018

Researchers gave 22 ME/CFS patients a supplement containing sodium dichloroacetate to see if it might help their symptoms. About half of the patients (10 out of 22) felt significantly better and their fatigue scores dropped to roughly half of what they were before. The other half of the patients didn't improve, and doctors found that many of them had other underlying health conditions. This small study suggests that for some ME/CFS patients, a problem with how their cells produce energy might be treatable with this supplement.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome.

Oka, Takakazu, Tanahashi, Tokusei, Sudo, Nobuyuki et al.·BioPsychoSocial medicine·2018

This study tested whether a gentle form of yoga practiced while sitting could help reduce fatigue in ME/CFS patients. Fifteen patients who had not improved with standard treatments did sitting isometric yoga twice a week with an instructor plus daily practice at home for eight weeks. After a single session, patients reported feeling less tired and more energetic, with their bodies showing signs of reduced stress and inflammation.

Immune System

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Brain function characteristics of chronic fatigue syndrome: A task fMRI study.

The biopolitics of CFS/ME.

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Beyond total treatment effects in randomised controlled trials: Baseline measurement of intermediate outcomes needed to reduce confounding in mediation investigations.

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence: a qualitative study.

Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic.

Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature.

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis.

High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.

Effect of Coelogyne cristata Lindley in alleviation of chronic fatigue syndrome in aged Wistar rats.

Therapeutic patient education in adrenal insufficiency.

HPV vaccination syndrome: A clinical mirage, or a new tragic fibromyalgia model.

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry.

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Myalgic Encephalomyelitis (ME) or What? An Operational Definition.

Aluminum in vaccines: Does it create a safety problem?

Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate: An open-label, proof-of-principle pilot trial.

Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome.

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