ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4581–4600 of 6,188 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Insights & Advances in Care.

Bested, Alison·Alternative therapies in health and medicine·2018

This article reviews current knowledge and treatment options for ME/CFS, a condition that causes severe fatigue and other symptoms that get worse with activity. The author, Dr. Alison Bested, discusses what we know about how the condition affects the body and explores various approaches to managing symptoms and improving quality of life.

E3 PreliminaryMechanismPEM unclearMechanistic

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Mensah, Fane F K, Armstrong, Christopher W, Reddy, Venkat et al.·Frontiers in immunology·2018

This study looked at a specific type of immune cell marker called CD24 found on B cells (infection-fighting cells) in ME/CFS patients. Researchers found that ME/CFS patients have more CD24+ B cells than healthy people, and these cells behave differently when it comes to energy use and cell survival. The findings suggest that ME/CFS may involve problems with how B cells handle energy metabolism.

Immune System

E3 PreliminaryGuidelinePEM unclearGuideline

Dutch Health Council Advisory Report on Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: Taking the Wrong Turn.

Twisk, Frank·Diagnostics (Basel, Switzerland)·2018

The Dutch Health Council released an official report recognizing ME/CFS as a serious, multi-system disease rather than primarily a psychological condition. The report recommends establishing specialized medical centers, training doctors better about ME/CFS, and improving how disability benefits are assessed for patients. However, the report's new definition of ME/CFS may create unintended problems for future research and patient care.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Autonomic dysfunction and HPV immunization: an overview.

Blitshteyn, Svetlana, Brinth, Louise, Hendrickson, Jeanne E et al.·Immunologic research·2018

This review looked at case reports from multiple countries describing people who developed serious symptoms after HPV vaccination, including extreme fatigue, pain, dizziness, and cognitive problems. These symptoms are similar to those seen in ME/CFS, POTS, and other conditions. The authors suggest that in some genetically vulnerable people, the vaccine might trigger an immune system response that affects the nervous system, but they emphasize that timing alone doesn't prove the vaccine caused the illness.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic.

Thomm, Angela M, Schotthoefer, Anna M, Dupuis, Alan P et al.·mSphere·2018

This study developed and tested a new blood test to detect Powassan virus, a tick-borne infection that can cause serious neurological problems. The test uses two steps: first screening with one method, then confirming positive results with a more specific test. The researchers found the test was accurate and could identify Powassan infections in patients living in areas where Lyme disease is common, suggesting this virus may be more prevalent than previously recognized.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Stress, inflammation and natural treatments.

Theoharides, T C, Kavalioti, M·Journal of biological regulators and homeostatic agents·2018

This study explores how stress and inflammation work together to cause several conditions including ME/CFS, fibromyalgia, and others. The researchers found that immune cells called mast cells and brain cells called microglia may communicate in ways that trigger inflammation during stress. They suggest that a natural supplement combining luteolin and Ashwagandha might help reduce this inflammation and benefit patients with these conditions.

NeuroinflammationImmune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.

Jason, Leonard A, Sunnquist, Madison·Frontiers in pediatrics·2018

Researchers created a questionnaire called the DePaul Symptom Questionnaire (DSQ) to help doctors and scientists consistently measure ME/CFS symptoms in patients. The questionnaire was refined over time and adapted for different groups, including children. This tool helps ensure that when people are diagnosed with ME/CFS, they're being assessed in the same way across different clinics and studies.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.

Wallis, Amy, Ball, Michelle, Butt, Henry et al.·Journal of translational medicine·2018

This study tested whether treating an overgrowth of Streptococcus bacteria in the gut could help ME/CFS patients, particularly those with brain fog and sleep problems. Forty-four patients received alternating weeks of an antibiotic and a probiotic for 4 weeks. The treatment reduced the problematic bacteria and improved several symptoms including sleep quality, attention, and memory, though it did not significantly affect fatigue or mood.

SleepCognitive Impairment

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Stevens, Staci, Snell, Chris, Stevens, Jared et al.·Frontiers in pediatrics·2018

This study explains how doctors can properly test ME/CFS patients using a special exercise test called CPET (cardiopulmonary exercise test) done on two consecutive days. The first test measures how much exercise a patient can do, while the second test 24 hours later shows how much the patient's performance has dropped due to post-exertional malaise (PEM)—the symptom flare that happens after exertion. This two-day approach objectively demonstrates one of the key features of ME/CFS: the inability to recover normal function after exercise.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Petrescu, Anca D, Kain, Jessica, Liere, Victoria et al.·Frontiers in endocrinology·2018

This review examines how the stress hormone system (HPA axis) works and what happens when it breaks down in people with liver disease. The HPA axis is like your body's control center that manages stress responses and many other important functions. The authors explain how inflammation in the liver can disrupt this system, potentially leading to the fatigue and other symptoms seen in both liver disease and chronic fatigue syndrome.

Immune System

E3 PreliminaryMechanismPEM requiredCross-Sectional

Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis using the novel application of autoMACS magnetic separation and flow cytometry.

Balinas, Cassandra, Nguyen, Thao, Johnston, Samantha et al.·Asian Pacific journal of allergy and immunology·2018

This study looked at immune cells called mast cells in people with ME/CFS, comparing them to people with a known mast cell disorder and healthy volunteers. Mast cells help the body fight viruses and allergies. The researchers found differences in how these cells behave when exposed to viral-like substances, suggesting mast cells may play a role in ME/CFS symptoms.

Immune System

E3 PreliminaryReviewPEM requiredReview-Narrative

Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.

Blomberg, Jonas, Gottfries, Carl-Gerhard, Elfaitouri, Amal et al.·Frontiers in immunology·2018

This study proposes that ME/CFS may develop when a person's immune system mistakenly attacks their own body after an infection, particularly affecting energy production in muscles and the brain. The researchers suggest that some people may have a genetic tendency to develop these harmful immune responses, especially when their gut bacteria are out of balance. When exposed to a triggering infection, the immune system can begin attacking proteins involved in energy metabolism and nerve function, leading to the exhaustion and post-exertion symptoms that characterize ME/CFS.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Yamamura, Takashi, Ono, Hirohiko, Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study found that people with ME/CFS have unusual patterns of immune system chemicals (cytokines) in their blood and spinal fluid, and some patients have antibodies that attack their own bodies. When researchers treated some ME/CFS patients with a medication that removes certain immune cells called B cells, patients improved. This suggests that ME/CFS may be caused by the immune system mistakenly attacking the body.

NeuroinflammationImmune System

E3 PreliminaryGuidelinePEM not requiredGuideline

Therapeutic patient education in adrenal insufficiency.

Guignat, Laurence·Annales d'endocrinologie·2018

This study describes educational programs that help patients with adrenal insufficiency (a condition where the adrenal glands don't make enough hormones) manage their condition safely. The programs teach patients to recognize warning signs of a dangerous crisis, carry emergency medication, adjust their doses for different situations like exercise or travel, and know when to seek medical help. The study notes that similar programs could help people with chronic fatigue syndrome avoid taking too much of their medication.

E3 PreliminaryMechanismPEM unclearMechanistic

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Shao, Changzhuan, Song, Jing, Zhao, Shanguang et al.·Polymers·2018

Researchers tested whether a compound called selenium-polysaccharide (Se-TP) from a Chinese green tea called Ziyang could help rats with fatigue similar to ME/CFS. They found that the treatment improved certain markers in the rats' blood and urine, suggesting it may work by affecting how the body makes and uses steroid hormones and processes amino acids.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dong, Jia-Zi, Wei, Yun-Tao, Xu, Huan-Yu et al.·Zhen ci yan jiu = Acupuncture research·2018

This study tested whether acupuncture at a specific point (ST 36) could improve muscle weakness in rats with a chronic fatigue condition. Researchers found that the treatment increased muscle strength and improved how the rats' muscles produce energy by activating protective cellular pathways. The results suggest acupuncture may help muscle cells work more efficiently and reduce damage from fatigue.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome.

van der Schaaf, Marieke E, Roelofs, Karin, de Lange, Floris P et al.·Biological psychiatry. Cognitive neuroscience and neuroimaging·2018

This study used brain imaging to understand why people with ME/CFS feel so fatigued and struggle with physical effort. Researchers asked patients and healthy people to squeeze a hand device at different force levels and give them feedback on their performance. People with ME/CFS were more likely to use less effort after feedback, especially at higher effort levels, and this related to lower activity in a brain region involved in decision-making and planning.

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Coelogyne cristata Lindley in alleviation of chronic fatigue syndrome in aged Wistar rats.

Mitra, Achintya, Sur, Tapas Kumar, Upadhyay, Sachhidananda et al.·Journal of Ayurveda and integrative medicine·2018

Researchers tested an orchid extract called Coelogyne cristata on aging rats that had been made fatigued through repeated forced swimming. The extract improved the rats' movement, reduced depression-like and anxiety-like behaviors, and restored protective antioxidant levels in their brains, performing similarly to ginseng, a known stress-relief supplement.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Rahmadi, Ridho, Groot, Perry, van Rijn, Marieke Hc et al.·Statistical methods in medical research·2018

This study developed a new statistical method for finding cause-and-effect relationships in long-term health data, even when sample sizes are small. The researchers tested their method on data from people with chronic fatigue syndrome, Alzheimer's disease, and chronic kidney disease, and found it could identify stable patterns of how different health factors influence each other over time.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.

Boissoneault, Jeff, Sevel, Landrew, Robinson, Michael E et al.·Journal of clinical and experimental neuropsychology·2018

Researchers used brain scans to study what happens in the brain when healthy people remember feeling tired versus happy. They found that fatigue activated different brain regions than happiness did, particularly areas involved in vision and a structure called the globus pallidum. This helps scientists understand the brain basis of fatigue without the complications of studying people who have chronic fatigue syndrome with other medical conditions.

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Evidence Atlas

Evidence browser

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Insights & Advances in Care.

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Dutch Health Council Advisory Report on Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: Taking the Wrong Turn.

Autonomic dysfunction and HPV immunization: an overview.

Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic.

Stress, inflammation and natural treatments.

The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions.

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons.

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis using the novel application of autoMACS magnetic separation and flow cytometry.

Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Therapeutic patient education in adrenal insufficiency.

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome.

Effect of Coelogyne cristata Lindley in alleviation of chronic fatigue syndrome in aged Wistar rats.

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.

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