ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4861–4880 of 6,188 studies

E3 PreliminaryMechanismPEM unclearCross-Sectional

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Nakatomi, Yasuhito, Mizuno, Kei, Ishii, Akira et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2014

This study used a special brain imaging technique called PET scans to look for signs of inflammation in the brains of ME/CFS patients. Researchers found that people with ME/CFS had higher levels of brain inflammation markers in several key brain regions compared to healthy controls. The amount of inflammation was linked to how severe patients' cognitive problems, pain, and depression were.

Neuroinflammation

E3 PreliminaryCohortPEM unclearObservational

A qualitative natural history study of ME/CFS in the community.

Anderson, Valerie R, Jason, Leonard A, Hlavaty, Laura E·Health care for women international·2014

This study interviewed 19 people with ME/CFS who were living in their communities (rather than patients seen at specialty clinics) to understand their experiences with the illness over time. The researchers found that ME/CFS affects people in multiple ways—physically, emotionally, and socially—and that how communities and healthcare providers respond to patients can significantly impact their illness progression and quality of life.

E3 PreliminaryMechanismPEM unclearObservational

Clinical features in patients with long-lasting macrophagic myofasciitis.

Rigolet, Muriel, Aouizerate, Jessie, Couette, Maryline et al.·Frontiers in neurology·2014

This study describes macrophagic myofasciitis (MMF), a condition where aluminum from vaccines persists in muscle tissue and causes long-lasting symptoms similar to ME/CFS, including widespread pain, severe fatigue, and significant problems with thinking and memory. Patients show patterns of brain abnormalities on imaging scans, and their cognitive problems appear to be caused by brain dysfunction rather than just pain or depression. The researchers found that standard treatments don't work well for these patients, making their condition particularly disabling.

Neuroinflammation

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.

Brown, Abigail A, Jason, Leonard A·Fatigue : biomedicine, health & behavior·2014

This study tested whether a questionnaire called the DePaul Symptom Questionnaire (DSQ) accurately measures the symptoms people with ME/CFS experience. Researchers found that ME/CFS symptoms naturally group into three main categories: problems with the nervous system and immune system, problems with thinking and memory, and a worsening of symptoms after physical activity. The questionnaire was shown to be a reliable tool for identifying and measuring these symptom patterns in ME/CFS patients.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Tarakji, B, Ashok, N, Alakeel, R et al.·Annals of medical and health sciences research·2014

This review looked at reported side effects from the Hepatitis B vaccine given to children and adults. While the vaccine is generally considered safe, researchers found reports of various health complications that occurred after vaccination, including some that affect the mouth and jaw. The authors note that most side effects go away on their own, but a few can be serious and need hospital care.

E3 PreliminaryReviewPEM unclearReview-Narrative

Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.

Maughan, David, Toth, Michael·Biology·2014

This review examines why fatigue happens in chronic diseases like ME/CFS, multiple sclerosis, and heart failure. The authors point out that fatigue comes from a mix of problems in how the body uses energy, how the nervous system works, and how muscles function. They emphasize that inactivity and loss of fitness may contribute significantly to fatigue, and this is often overlooked when researchers only focus on the disease itself.

E3 PreliminaryReviewPEM unclearReview-Narrative

What is called symptom?

Eriksen, Thor Eirik, Risør, Mette Bech·Medicine, health care, and philosophy·2014

This paper explores what we actually mean by the word 'symptom' in medicine. The authors argue that when doctors can't find a clear medical cause for illness—like ME/CFS—our usual way of thinking about symptoms breaks down. They suggest we need to understand symptoms in broader ways, including how patients' social lives, personal experiences, and individual circumstances shape how they experience illness.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Miller, Andrew H, Jones, James F, Drake, Daniel F et al.·PloS one·2014

This study used brain imaging to look at a specific part of the brain called the basal ganglia, which helps control movement and reward responses. Researchers found that people with ME/CFS had less activity in certain regions of this brain area compared to healthy people, and the amount of reduced activity was related to how severe their fatigue symptoms were.

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Chung, Ka-Fai, Yu, Branda Yee-Man, Yung, Kam-Ping et al.·Comprehensive psychiatry·2014

This study tested whether a fatigue measurement tool called the MFI-20 works well for people with depression. Researchers gave the test to 137 people with depression and found it reliably measured different types of tiredness—physical and mental exhaustion, reduced energy, and loss of motivation. The tool successfully tracked changes in fatigue over time and correlated with other health measures.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Stress triggers coronary mast cells leading to cardiac events.

Alevizos, Michail, Karagkouni, Anna, Panagiotidou, Smaro et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2014

When we experience stress, our body releases chemicals that can activate immune cells in the heart called mast cells. These activated mast cells release inflammatory substances that can trigger heart problems or make existing heart disease worse. This review found that stress-related activation of heart mast cells may be a key pathway connecting emotional stress to heart attacks and coronary artery disease.

Immune System

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Comparing and Contrasting Consensus versus Empirical Domains.

Jason, Leonard A, Kot, Bobby, Sunnquist, Madison et al.·Fatigue : biomedicine, health & behavior·2014

Researchers compared different sets of diagnostic criteria used to identify ME/CFS patients. They looked at criteria developed by expert groups (like the Canadian Consensus Criteria) and compared them to criteria identified through statistical analysis of actual patient data. The study found that the fatigue and post-exertional malaise domain (worsening symptoms after activity) was the best feature for distinguishing ME/CFS patients from healthy people, and that older diagnostic criteria were less accurate.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Gherardi, Romain K, Cadusseau, Josette, Authier, François-jérôme·Bulletin de l'Academie nationale de medecine·2014

This review examines how aluminum-based vaccine adjuvants (immune-boosting ingredients) may rarely cause long-term health problems in susceptible people, including muscle pain, exhaustion, and brain fog that can last years. The researchers found that aluminum particles can travel from the injection site through the body to distant organs and the brain, and that a specific immune protein called MCP-1 may control how much this happens. For most people, aluminum adjuvants are safe, but genetic and environmental differences may make some individuals more vulnerable to prolonged effects.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of compound bushen recipe on chronic fatigue syndrome in C. elegans: an experimental study].

Nie, Li-jin, Cai, Wai-jiao, Zhang, Xin-min et al.·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2014

Researchers tested a traditional Chinese herbal recipe called compound bushen recipe (CBR) in a simple organism (C. elegans) to see if it could help with stress tolerance and lifespan—similar to what happens in chronic fatigue syndrome. The treatment showed promising results: it helped organisms survive better under heat stress, protein damage, and oxidative stress, and improved movement and feeding behaviors without harming reproduction.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Metabolism in chronic fatigue syndrome.

Armstrong, Christopher W, McGregor, Neil R, Butt, Henry L et al.·Advances in clinical chemistry·2014

This review examines how the body produces and uses energy in people with ME/CFS. Research suggests that people with ME/CFS have problems with how their bodies break down food and nutrients for energy, and their cells may not be using their energy factories (mitochondria) efficiently. The review highlights that metabolomics—a technique that measures thousands of molecules in the body at once—could be a powerful tool for understanding what goes wrong in ME/CFS.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis.

Kang, Saeromi, Lee, Kyoung-Pil, Park, Soo-Jin et al.·Journal of ethnopharmacology·2014

Researchers tested a natural compound called α-cubebenoate, found in a traditional plant called Schisandra chinensis, to see if it could reduce inflammation. In laboratory tests with immune cells and in mice, the compound successfully reduced the production of inflammatory molecules that are believed to contribute to fatigue and illness. This suggests the plant compound may have potential as a treatment for conditions involving excessive inflammation.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The gut microbiome and the brain.

Galland, Leo·Journal of medicinal food·2014

Your gut bacteria can communicate with your brain in several ways: they produce substances that trigger your immune system, create chemicals that affect your mood and sleep, and send signals directly to your brain through a major nerve called the vagus nerve. When the balance of gut bacteria is disrupted, this communication can go wrong and may contribute to problems like chronic fatigue, brain fog, and mood changes.

NeuroinflammationGut MicrobiomeImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.

Dhingra, Mamta Sachdeva, Dhingra, Sameer, Kumria, Rachna et al.·Pharmacological reports : PR·2014

This study tested whether a new compound derived from gallic acid (a plant antioxidant) could help reverse the harmful effects of chronic stress in mice. Researchers stressed mice by making them swim daily for 15 days, then treated them with the compound and measured changes in anxiety, memory, and harmful molecules in the brain. The treated mice showed improvements in movement, reduced anxiety, better memory, and lower levels of inflammation compared to untreated stressed mice.

E3 PreliminaryReviewPEM unclearReview-Narrative

Prolonged school non-attendance in adolescence: a practical approach.

Hawkrigg, S, Payne, D N·Archives of disease in childhood·2014

This article discusses why some teenagers stop attending school and how doctors can help them return. The authors explain that missing school can lead to serious problems like depression and difficulties with relationships and jobs later in life. They suggest a practical framework for understanding why a student is absent and developing a plan to help them go back to school.

E3 PreliminaryReviewPEM unclearReview-Narrative

Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

Höck, Anna Dorothea·In vivo (Athens, Greece)·2014

This review explains how vitamin D3 deficiency may contribute to severe fatigue and depression in conditions like ME/CFS. Vitamin D3 helps regulate the immune system, and without enough of it, the body's natural defenses become unbalanced, allowing infections and inflammation to persist. The authors suggest that vitamin D3 supplements might help prevent or improve these chronic conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Spectrum of mast cell activation disorders.

Petra, Anastasia I, Panagiotidou, Smaro, Stewart, Julia M et al.·Expert review of clinical immunology·2014

Mast cells are immune cells that can become overactive and release chemicals causing symptoms like flushing, itching, dizziness, stomach problems, headaches, and brain fog. This review describes different types of mast cell activation disorders and explains how they can overlap with conditions like ME/CFS and fibromyalgia. The authors suggest these conditions exist on a spectrum and outline how doctors can test for and treat them.

Immune System

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Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

A qualitative natural history study of ME/CFS in the community.

Clinical features in patients with long-lasting macrophagic myofasciitis.

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.

What is called symptom?

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Stress triggers coronary mast cells leading to cardiac events.

Comparing and Contrasting Consensus versus Empirical Domains.

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

[Effect of compound bushen recipe on chronic fatigue syndrome in C. elegans: an experimental study].

Metabolism in chronic fatigue syndrome.

Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis.

The gut microbiome and the brain.

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.

Prolonged school non-attendance in adolescence: a practical approach.

Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

Spectrum of mast cell activation disorders.

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