ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4841–4860 of 6,188 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-barr virus infection masquerading as acute leukemia: a report of two cases and review of literature.

Chhabra, Puneet, Law, Arjun Dutt, Sharma, Upender et al.·Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2014

This study describes two cases where patients were initially thought to have acute leukemia based on blood tests, but they actually had Epstein-Barr virus (EBV) infections instead. One patient had infectious mononucleosis, and the other had a rare EBV-related immune condition. The study shows that EBV can sometimes look like leukemia under a microscope, which can lead to misdiagnosis.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.

Kern, Janet K, Geier, David A, Bjørklund, Geir et al.·Neuro endocrinology letters·2014

This review article examines whether mercury vapor released from dental fillings (amalgams) might cause or worsen ME/CFS, fibromyalgia, depression, and anxiety. The authors found that studies linking mercury exposure to fatigue, anxiety, and depression symptoms are similar to what people experience with ME/CFS, and that some patients improved after having their amalgam fillings removed. The authors conclude that mercury from dental fillings deserves serious consideration when investigating chronic fatigue and related conditions.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Rimes, Katharine A, Wingrove, Janet, Moss-Morris, Rona et al.·Behavioural and cognitive psychotherapy·2014

This study developed clear guidelines describing what skills therapists need to deliver cognitive behavioural therapy (CBT) for ME/CFS and related conditions. Researchers gathered input from experienced therapists to create competence frameworks for both brief interventions and longer, more intensive treatments. These guidelines can help train new therapists and identify what skills they need to learn.

E3 PreliminaryMechanismPEM not requiredMechanistic

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Medow, Marvin S, Sood, Shilpa, Messer, Zachary et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2014

Many ME/CFS patients experience dizziness and cognitive problems when standing up because blood flow to the brain decreases. This study tested whether a medication called phenylephrine, which raises blood pressure, could help restore brain blood flow and improve thinking tasks during standing. The researchers found that phenylephrine reduced the brain blood flow drop and helped ME/CFS patients perform better on memory tests while upright.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryMechanismPEM unclearCross-Sectional

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Nakatomi, Yasuhito, Mizuno, Kei, Ishii, Akira et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2014

This study used a special brain imaging technique called PET scans to look for signs of inflammation in the brains of ME/CFS patients. Researchers found that people with ME/CFS had higher levels of brain inflammation markers in several key brain regions compared to healthy controls. The amount of inflammation was linked to how severe patients' cognitive problems, pain, and depression were.

Neuroinflammation

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Comparing and Contrasting Consensus versus Empirical Domains.

Jason, Leonard A, Kot, Bobby, Sunnquist, Madison et al.·Fatigue : biomedicine, health & behavior·2014

Researchers compared different sets of diagnostic criteria used to identify ME/CFS patients. They looked at criteria developed by expert groups (like the Canadian Consensus Criteria) and compared them to criteria identified through statistical analysis of actual patient data. The study found that the fatigue and post-exertional malaise domain (worsening symptoms after activity) was the best feature for distinguishing ME/CFS patients from healthy people, and that older diagnostic criteria were less accurate.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.

Maughan, David, Toth, Michael·Biology·2014

This review examines why fatigue happens in chronic diseases like ME/CFS, multiple sclerosis, and heart failure. The authors point out that fatigue comes from a mix of problems in how the body uses energy, how the nervous system works, and how muscles function. They emphasize that inactivity and loss of fitness may contribute significantly to fatigue, and this is often overlooked when researchers only focus on the disease itself.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.

Brown, Abigail A, Jason, Leonard A·Fatigue : biomedicine, health & behavior·2014

This study tested whether a questionnaire called the DePaul Symptom Questionnaire (DSQ) accurately measures the symptoms people with ME/CFS experience. Researchers found that ME/CFS symptoms naturally group into three main categories: problems with the nervous system and immune system, problems with thinking and memory, and a worsening of symptoms after physical activity. The questionnaire was shown to be a reliable tool for identifying and measuring these symptom patterns in ME/CFS patients.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

Clinical features in patients with long-lasting macrophagic myofasciitis.

Rigolet, Muriel, Aouizerate, Jessie, Couette, Maryline et al.·Frontiers in neurology·2014

This study describes macrophagic myofasciitis (MMF), a condition where aluminum from vaccines persists in muscle tissue and causes long-lasting symptoms similar to ME/CFS, including widespread pain, severe fatigue, and significant problems with thinking and memory. Patients show patterns of brain abnormalities on imaging scans, and their cognitive problems appear to be caused by brain dysfunction rather than just pain or depression. The researchers found that standard treatments don't work well for these patients, making their condition particularly disabling.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Gherardi, Romain K, Cadusseau, Josette, Authier, François-jérôme·Bulletin de l'Academie nationale de medecine·2014

This review examines how aluminum-based vaccine adjuvants (immune-boosting ingredients) may rarely cause long-term health problems in susceptible people, including muscle pain, exhaustion, and brain fog that can last years. The researchers found that aluminum particles can travel from the injection site through the body to distant organs and the brain, and that a specific immune protein called MCP-1 may control how much this happens. For most people, aluminum adjuvants are safe, but genetic and environmental differences may make some individuals more vulnerable to prolonged effects.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Miller, Andrew H, Jones, James F, Drake, Daniel F et al.·PloS one·2014

This study used brain imaging to look at a specific part of the brain called the basal ganglia, which helps control movement and reward responses. Researchers found that people with ME/CFS had less activity in certain regions of this brain area compared to healthy people, and the amount of reduced activity was related to how severe their fatigue symptoms were.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: Case Definitions and Diagnostic Assessment.

Williams, Yolonda J, Jantke, Rachel L, Jason, Leonard A·New York State psychologist·2014

This article explains why doctors have difficulty diagnosing ME/CFS and why patients often struggle to get proper care. The researchers found that there are disagreements about how to define and diagnose the illness, which makes it harder for healthcare providers to recognize it and treat it correctly. They call for better education of doctors and clearer diagnostic guidelines.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Stress triggers coronary mast cells leading to cardiac events.

Alevizos, Michail, Karagkouni, Anna, Panagiotidou, Smaro et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2014

When we experience stress, our body releases chemicals that can activate immune cells in the heart called mast cells. These activated mast cells release inflammatory substances that can trigger heart problems or make existing heart disease worse. This review found that stress-related activation of heart mast cells may be a key pathway connecting emotional stress to heart attacks and coronary artery disease.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The saga of XMRV: a virus that infects human cells but is not a human virus.

Arias, Maribel, Fan, Hung·Emerging microbes & infections·2014

In 2006, scientists discovered a virus called XMRV and thought it might cause both prostate cancer and chronic fatigue syndrome (ME/CFS). After years of research and controversy, it became clear that XMRV was not actually infecting humans naturally. Instead, the virus had accidentally been created in a laboratory when human cancer cells were grown inside immunocompromised mice, where two mouse viruses combined to form XMRV. This discovery was important because it showed why initial findings linking XMRV to these diseases were false.

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA).

Agmon-Levin, Nancy, Zafrir, Yaron, Kivity, Shaye et al.·Immunologic research·2014

This study looked at 19 people who developed chronic fatigue syndrome (CFS) or fibromyalgia (FM) after receiving the hepatitis B vaccine. Researchers found that most patients experienced multiple symptoms including fatigue, muscle/joint pain, and neurological problems within weeks to months of vaccination. The study suggests that in some cases, these conditions may be triggered by the vaccine's components, particularly in people with genetic predisposition to autoimmune diseases.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

Höck, Anna Dorothea·In vivo (Athens, Greece)·2014

This review explains how vitamin D3 deficiency may contribute to severe fatigue and depression in conditions like ME/CFS. Vitamin D3 helps regulate the immune system, and without enough of it, the body's natural defenses become unbalanced, allowing infections and inflammation to persist. The authors suggest that vitamin D3 supplements might help prevent or improve these chronic conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The gut microbiome and the brain.

Galland, Leo·Journal of medicinal food·2014

Your gut bacteria can communicate with your brain in several ways: they produce substances that trigger your immune system, create chemicals that affect your mood and sleep, and send signals directly to your brain through a major nerve called the vagus nerve. When the balance of gut bacteria is disrupted, this communication can go wrong and may contribute to problems like chronic fatigue, brain fog, and mood changes.

NeuroinflammationGut MicrobiomeImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Spectrum of mast cell activation disorders.

Petra, Anastasia I, Panagiotidou, Smaro, Stewart, Julia M et al.·Expert review of clinical immunology·2014

Mast cells are immune cells that can become overactive and release chemicals causing symptoms like flushing, itching, dizziness, stomach problems, headaches, and brain fog. This review describes different types of mast cell activation disorders and explains how they can overlap with conditions like ME/CFS and fibromyalgia. The authors suggest these conditions exist on a spectrum and outline how doctors can test for and treat them.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Metabolism in chronic fatigue syndrome.

Armstrong, Christopher W, McGregor, Neil R, Butt, Henry L et al.·Advances in clinical chemistry·2014

This review examines how the body produces and uses energy in people with ME/CFS. Research suggests that people with ME/CFS have problems with how their bodies break down food and nutrients for energy, and their cells may not be using their energy factories (mitochondria) efficiently. The review highlights that metabolomics—a technique that measures thousands of molecules in the body at once—could be a powerful tool for understanding what goes wrong in ME/CFS.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome.

Wang, Jia, Sun, Chengxin, Zheng, Yan et al.·Archives of pharmacal research·2014

Researchers tested a compound extracted from ginseng called WGPA-A in mice to see if it could help reduce fatigue. They found that mice given WGPA-A could swim longer before becoming tired, and the treatment reduced signs of cellular damage (oxidative stress) and improved the health of mitochondria—the energy-producing structures inside muscle cells. This suggests ginseng compounds might help fight fatigue by protecting cells from damage.

Energy Metabolism

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Epstein-barr virus infection masquerading as acute leukemia: a report of two cases and review of literature.

Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Comparing and Contrasting Consensus versus Empirical Domains.

Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.

Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.

Clinical features in patients with long-lasting macrophagic myofasciitis.

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Chronic Fatigue Syndrome: Case Definitions and Diagnostic Assessment.

Stress triggers coronary mast cells leading to cardiac events.

The saga of XMRV: a virus that infects human cells but is not a human virus.

Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA).

Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

The gut microbiome and the brain.

Spectrum of mast cell activation disorders.

Metabolism in chronic fatigue syndrome.

The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome.

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Metabolism & Mitochondria

Biomarkers

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