ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4841–4860 of 6,209 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[Research progress of fecal microbiota transplantation].

Dai, Ting, Tang, Tongyu·Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2015

This review discusses fecal microbiota transplantation (FMT), a procedure where healthy bacteria from donor stool are transferred to patients to restore a damaged gut microbiome. The gut bacteria can be damaged by antibiotics or disease, leading to infections and other health problems. Researchers are exploring whether FMT might help treat several conditions, including chronic fatigue syndrome (ME/CFS), but it is not yet standard medical treatment because many doctors and patients are hesitant about the approach.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

THE CAUSES AND SYMPTOMS OF SOMATOFORM DISORDERS IN CHILDREN (REVIEW).

Khundadze, M, Mkheidze, R, Geladze, N et al.·Georgian medical news·2015

This review article examines somatoform disorders—conditions where physical symptoms occur without a clear physical cause—in children and teenagers. It covers several conditions including chronic fatigue syndrome, and discusses why these disorders happen, how they present differently, and how doctors can diagnose and treat them. The authors note that these conditions have become more common over the past 20 years.

E3 PreliminaryReviewPEM unclearReview-Narrative

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Tarakji, B, Ashok, N, Alakeel, R et al.·Annals of medical and health sciences research·2014

This review looked at reported side effects from the Hepatitis B vaccine given to children and adults. While the vaccine is generally considered safe, researchers found reports of various health complications that occurred after vaccination, including some that affect the mouth and jaw. The authors note that most side effects go away on their own, but a few can be serious and need hospital care.

E3 PreliminaryMechanismPEM not requiredMechanistic

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Medow, Marvin S, Sood, Shilpa, Messer, Zachary et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2014

Many ME/CFS patients experience dizziness and cognitive problems when standing up because blood flow to the brain decreases. This study tested whether a medication called phenylephrine, which raises blood pressure, could help restore brain blood flow and improve thinking tasks during standing. The researchers found that phenylephrine reduced the brain blood flow drop and helped ME/CFS patients perform better on memory tests while upright.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.

Kern, Janet K, Geier, David A, Bjørklund, Geir et al.·Neuro endocrinology letters·2014

This review article examines whether mercury vapor released from dental fillings (amalgams) might cause or worsen ME/CFS, fibromyalgia, depression, and anxiety. The authors found that studies linking mercury exposure to fatigue, anxiety, and depression symptoms are similar to what people experience with ME/CFS, and that some patients improved after having their amalgam fillings removed. The authors conclude that mercury from dental fillings deserves serious consideration when investigating chronic fatigue and related conditions.

E3 PreliminaryMechanismPEM not requiredMechanistic

Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis.

Kang, Saeromi, Lee, Kyoung-Pil, Park, Soo-Jin et al.·Journal of ethnopharmacology·2014

Researchers tested a natural compound called α-cubebenoate, found in a traditional plant called Schisandra chinensis, to see if it could reduce inflammation. In laboratory tests with immune cells and in mice, the compound successfully reduced the production of inflammatory molecules that are believed to contribute to fatigue and illness. This suggests the plant compound may have potential as a treatment for conditions involving excessive inflammation.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Nakatomi, Yasuhito, Mizuno, Kei, Ishii, Akira et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2014

This study used a special brain imaging technique called PET scans to look for signs of inflammation in the brains of ME/CFS patients. Researchers found that people with ME/CFS had higher levels of brain inflammation markers in several key brain regions compared to healthy controls. The amount of inflammation was linked to how severe patients' cognitive problems, pain, and depression were.

Neuroinflammation

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Rimes, Katharine A, Wingrove, Janet, Moss-Morris, Rona et al.·Behavioural and cognitive psychotherapy·2014

This study developed clear guidelines describing what skills therapists need to deliver cognitive behavioural therapy (CBT) for ME/CFS and related conditions. Researchers gathered input from experienced therapists to create competence frameworks for both brief interventions and longer, more intensive treatments. These guidelines can help train new therapists and identify what skills they need to learn.

E3 PreliminaryCohortPEM unclearObservational

A qualitative natural history study of ME/CFS in the community.

Anderson, Valerie R, Jason, Leonard A, Hlavaty, Laura E·Health care for women international·2014

This study interviewed 19 people with ME/CFS who were living in their communities (rather than patients seen at specialty clinics) to understand their experiences with the illness over time. The researchers found that ME/CFS affects people in multiple ways—physically, emotionally, and socially—and that how communities and healthcare providers respond to patients can significantly impact their illness progression and quality of life.

E3 PreliminaryMechanismPEM requiredObservational

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment.

Keller, Betsy A, Pryor, John Luke, Giloteaux, Ludovic·Journal of translational medicine·2014

This study tested whether people with ME/CFS can perform the same on an exercise test when it's repeated the next day, similar to how healthy people typically do. The researchers found that ME/CFS patients performed significantly worse on the second test—using about 14% less oxygen and doing about 12% less work—even though they were trying their hardest both times. This suggests that doing one exercise test may give doctors an unrealistic picture of what ME/CFS patients can actually do.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Loebel, Madlen, Strohschein, Kristin, Giannini, Carolin et al.·PloS one·2014

This study looked at how the immune system responds to Epstein-Barr virus (EBV), a common virus that causes mono, in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients have a weaker immune response to EBV, particularly in their B cells and T cells—the immune cells that normally fight off this virus. The findings suggest that ME/CFS patients may have difficulty controlling EBV reactivation in their bodies.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome.

Winger, Anette, Ekstedt, Mirjam, Wyller, Vegard B et al.·Journal of clinical nursing·2014

This study listened to 18 teenagers with ME/CFS about what life is really like living with this illness. The teenagers described feeling left behind by the world, isolated from friends and school, struggling to be seen and understood by others, and dealing with a body that doesn't work the way they expect. Despite these challenges, most young people expressed hope for improvement in the future.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Adolescents and mothers value referral to a specialist service for chronic fatigue syndrome or myalgic encephalopathy (CFS/ME).

Beasant, Lucy, Mills, Nicola, Crawley, Esther·Primary health care research & development·2014

This study asked 13 mothers and 12 teenagers with ME/CFS about their experiences getting help from a specialist ME/CFS service. Most families found it difficult and took a long time to access the specialist clinic, but once they got there, both teenagers and mothers felt it was valuable. The specialist service helped confirm the diagnosis, improved symptom management, and helped communication between doctors and schools.

InterventionsDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).

Morris, Gerwyn, Berk, Michael, Galecki, Piotr et al.·Molecular neurobiology·2014

This study explores how ME/CFS may involve the immune system attacking the body's own tissues (autoimmunity). Researchers found that up to 60% of ME/CFS patients show signs of autoimmune responses, likely triggered by a combination of stress on cells, viral infections, and problems with how the body produces energy. The study identifies several pathways that could lead to these harmful immune reactions and discusses potential treatments.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

What is called symptom?

Eriksen, Thor Eirik, Risør, Mette Bech·Medicine, health care, and philosophy·2014

This paper explores what we actually mean by the word 'symptom' in medicine. The authors argue that when doctors can't find a clear medical cause for illness—like ME/CFS—our usual way of thinking about symptoms breaks down. They suggest we need to understand symptoms in broader ways, including how patients' social lives, personal experiences, and individual circumstances shape how they experience illness.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Morris, Gerwyn, Maes, Michael·Current neuropharmacology·2014

This study proposes that ME/CFS involves a harmful cycle where the body's immune system becomes overactive and produces damaging molecules called oxidative stress. These problems can be triggered by infections, gut bacteria leaking into the bloodstream, or problems with the energy-producing parts of cells called mitochondria. Once started, this cycle feeds on itself, causing brain inflammation, reduced blood flow to the brain, and damage to cells throughout the body.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

Fischer, David Benjamin, William, Arsani Hany, Strauss, Adam Campbell et al.·Fatigue : biomedicine, health & behavior·2014

This review examines potential blood tests and biological markers that could help doctors better understand and diagnose ME/CFS. Currently, ME/CFS is diagnosed mainly based on symptoms because we lack clear objective tests. The authors suggest that identifying specific biomarkers—measurable biological signs—could help identify different subtypes of ME/CFS, which might respond better to different treatments.

BiomarkersImmune System

E3 PreliminaryMechanismPEM unclearObservational

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, Batovska, Jana et al.·PloS one·2014

This study looked for tiny molecular messages called microRNAs in the blood of ME/CFS patients to see if they might work as a diagnostic tool. Researchers compared blood samples from ME/CFS patients and healthy people, and found three microRNAs that were higher in ME/CFS patients. This is an early-stage discovery that could eventually help doctors identify ME/CFS more easily through a simple blood test.

Biomarkers

E3 PreliminaryCohortPEM not requiredObservational

Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.

Gaber, Tarek A-Z K, Oo, Wah Wah, Ringrose, Hollie·NeuroRehabilitation·2014

This study looked at whether people with Multiple Sclerosis (MS) might also have ME/CFS at the same time. Researchers examined 64 MS patients and found that 14% of them—all women—also met the diagnostic criteria for ME/CFS. Their fatigue and other symptoms like pain and headaches couldn't be fully explained by their MS alone, suggesting the two conditions can occur together in the same person.

E3 PreliminaryMechanismPEM not requiredMechanistic

A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation.

Yasui, Masaya, Yoshimura, Takashi, Takeuchi, So et al.·Glia·2014

This study used rats exposed to continuous stress to model ME/CFS and fibromyalgia, finding that stress caused pain sensitivity without any actual tissue damage or infection. The researchers discovered that immune cells in the spinal cord called microglia became activated in stressed animals, and blocking this activation with a drug called minocycline reduced their pain. This suggests that abnormal pain in ME/CFS may stem from brain and spinal cord inflammation rather than damage to muscles or skin.

Neuroinflammation

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Evidence browser

[Research progress of fecal microbiota transplantation].

THE CAUSES AND SYMPTOMS OF SOMATOFORM DISORDERS IN CHILDREN (REVIEW).

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.

Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.

Identification of a novel anti-inflammatory compound, α-cubebenoate from Schisandra chinensis.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

A qualitative natural history study of ME/CFS in the community.

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment.

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

'Sometimes it feels as if the world goes on without me': adolescents' experiences of living with chronic fatigue syndrome.

Adolescents and mothers value referral to a specialist service for chronic fatigue syndrome or myalgic encephalopathy (CFS/ME).

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).

What is called symptom?

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.

A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research