ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

501–520 of 737 studies

E3 PreliminaryCohortPEM unclearCase-Control

Circulating microaggregates as biomarkers for the Post-COVID syndrome.

Hermann, M, Lisch, C, Gerth, R et al.·IDCases·2024

This study describes one patient with long COVID who experienced severe fatigue, worsening after exertion, pain, and neurological symptoms. Researchers used a special microscopy technique to examine the patient's blood and found tiny clumps of blood cells and proteins (microaggregates) that shouldn't normally be there. After the patient received blood-thinning medications and antiviral treatment, these clumps dissolved and their symptoms significantly improved.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Assessing Functional Capacity in Myalgic Encephalopathy/Chronic Fatigue Syndrome: A Patient-Informed Questionnaire.

Sommerfelt, Kristian, Schei, Trude, Seton, Katharine A et al.·Journal of clinical medicine·2024

Researchers created a new questionnaire called FUNCAP to measure how much people with ME/CFS can actually do in their daily lives. The tool has two versions: a longer one with 55 questions (for doctors and disability assessments) and a shorter one with 27 questions (for regular check-ups). After testing it with thousands of patients from Norway and around the world, they found it works reliably and accurately captures the impact of ME/CFS on real-life activities.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19.

Daynes, Enya, Mills, George, Hull, James H et al.·Chest·2024

This review examines whether pulmonary rehabilitation programs—treatments originally designed to help people with chronic lung diseases—might also help people with long COVID who experience breathlessness and fatigue. The authors suggest that because long COVID and chronic lung diseases cause similar problems with breathing and activity tolerance, rehabilitation programs that combine breathing exercises, strength training, and education could be beneficial for long COVID patients. However, they note that special care is needed for people whose symptoms worsen with exercise (postexertional malaise).

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life, and Immunologic Variables in Long COVID.

Abbasi, Asghar, Gattoni, Chiara, Iacovino, Michelina et al.·Journal of clinical medicine·2024

This study tested whether supervised aerobic exercise training could help people with long COVID. Fourteen participants completed 20 sessions of exercise training over 10 weeks. After training, people reported feeling less fatigued, less anxious and depressed, and had better heart and lung fitness—without experiencing harmful immune system changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Current update on the neurological manifestations of long COVID: more questions than answers.

Stefanou, Maria-Ioanna, Panagiotopoulos, Evangelos, Palaiodimou, Lina et al.·EXCLI journal·2024

This review examines the nerve and brain-related symptoms that can persist after COVID-19 infection, which doctors call long COVID. About one-third of COVID-19 survivors experience lasting neurological problems such as fatigue, brain fog, sleep issues, and problems with smell or taste that can last at least 12 months. The authors discuss what we currently know about why these symptoms happen and what treatments might help.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

A Practical Approach to Tailor the Term Long COVID for Diagnostics, Therapy and Epidemiological Research for Improved Long COVID Patient Care.

Hoffmann, Kathryn, Stingl, Michael, O'Mahony, Liam et al.·Infectious diseases and therapy·2024

This paper proposes a clearer way to define and categorize long COVID by splitting it into three distinct groups: ongoing COVID-19 symptoms, diseases triggered or worsened by COVID-19, and post-acute COVID condition (which includes symptoms like post-exertional malaise and brain fog). Using clearer definitions and standardized medical codes would help doctors diagnose patients more accurately and allow researchers to study long COVID more effectively.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

Jurek, Joanna Michalina, Castro-Marrero, Jesus·Nutrients·2024

This review examines how changes in gut bacteria may contribute to ME/CFS and long COVID symptoms, and whether taking probiotics or similar microbial preparations might help. The authors looked at existing research to understand the connection between gut health and the brain-immune system, and whether restoring healthy gut bacteria could reduce fatigue, inflammation, and other symptoms in these conditions.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryGuidelinePEM unclearGuideline

A practical framework for Long COVID treatment in primary care.

Brode, W Michael, Melamed, Esther·Life sciences·2024

This paper provides a practical guide for primary care doctors treating Long COVID patients. It outlines a four-step approach: first, managing energy levels to avoid crashes after activity; second, carefully graduated rehabilitation for physical, mental, and emotional recovery; third, treating specific symptoms like fatigue and pain; and fourth, considering experimental treatments when appropriate.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID's Impact on Patients, Workers, & Society: A review.

Kavanagh, Kevin T, Cormier, Lindsay E, Pontus, Christine et al.·Medicine·2024

About 1 in 10 people who recover from COVID-19 develop long COVID, and roughly 1 in 4 of those people struggle with daily activities like work and self-care. Brain damage has been found in some patients, leading to problems with memory, thinking clearly, and mood changes. The study reviews how long COVID affects patients' jobs, finances, and communities, and emphasizes that gentle recovery approaches work better than pushing too hard, which can cause setbacks lasting days or weeks.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredCase-Control

Pediatric and adult patients with ME/CFS following COVID-19: A structured approach to diagnosis using the Munich Berlin Symptom Questionnaire (MBSQ).

Peo, Laura-Carlotta, Wiehler, Katharina, Paulick, Johannes et al.·European journal of pediatrics·2024

This study looked at young people (ages 11-25) who developed ME/CFS after having COVID-19, even when their initial infection was mild or asymptomatic. Researchers created new questionnaires called the Munich Berlin Symptom Questionnaires (MBSQs) to help doctors diagnose ME/CFS more easily and consistently. The study found that ten young patients had severe problems with daily activities and quality of life after developing ME/CFS following COVID-19.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

Seylanova, Nina, Chernyavskaya, Anastasia, Degtyareva, Natalia et al.·The European respiratory journal·2024

This study developed a standardized list of health outcomes and measurement tools that doctors and researchers should use when evaluating children and young people with long COVID. International experts from 37 countries agreed on seven key areas to measure: fatigue, post-exertion symptoms, changes in work or school, and cardiovascular, neurological, gastrointestinal, and physical problems. They also identified specific questionnaires that work best for measuring fatigue, digestive symptoms, thinking problems, and overall functioning.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.

Wojczewski, Silvia, Mayrhofer, Mira, Szabo, Nathalie et al.·BMC public health·2024

This study asked 30 Austrian general practitioners (GPs) about their experiences diagnosing and treating Long-COVID patients during 2022. All GPs had seen Long-COVID patients, but many found treatment frustrating because patients often didn't improve significantly, and costs were high. The study found that GPs working in teams and those in cities with specialist networks managed Long-COVID more easily.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

Post-Acute Sequelae of SARS-CoV-2 Infections: Exercise Limitation and Rehabilitation.

Mathew, Joscilin, Nugent, Kenneth·The Yale journal of biology and medicine·2024

Some people who had COVID-19 develop long-lasting symptoms and struggle with exercise—a condition called long COVID. This article explains that exercise problems can happen for different reasons: heart issues, lung problems, weak muscles, being out of shape, or symptoms that seem worse than what physical tests show. While many patients improve with standard rehabilitation programs, those with post-exertional malaise (getting worse after activity) need special, carefully monitored exercise plans.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredMechanistic

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.

Vu, Luyen Tien, Ahmed, Faraz, Zhu, Hongya et al.·Cell reports. Medicine·2024

Researchers used advanced technology to examine immune cells from ME/CFS patients and healthy controls, both at rest and after exercise. They found that ME/CFS patients have problems with a type of immune cell called monocytes that appear abnormal and may be moving into tissues inappropriately. After exercise, patients showed additional problems with platelets (cells involved in blood clotting), suggesting the disease involves multiple layers of immune system dysfunction.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID: mechanisms, risk factors and recovery.

Astin, Rónan, Banerjee, Amitava, Baker, Mark R et al.·Experimental physiology·2023

This review examines Long COVID—a prolonged illness affecting some people after COVID-19 infection—and compares it to similar post-viral conditions like ME/CFS. Researchers found that Long COVID involves problems with the heart and lungs, muscle function, and how the body regulates its nervous system. The review discusses various treatment approaches being tested, including exercise programs, breathing exercises, and techniques to help calm an overactive nervous system.

Post-Exertional Malaise

E3 PreliminaryPEM required

My experience with ME/CFS and implications: A personal narrative.

Sirotiak, Zoe·Work (Reading, Mass.)·2023

This article shares the personal story of a young woman who is also a physical therapist and developed ME/CFS after a COVID-19 infection. She describes how the condition dramatically changed her life and how healthcare providers, including rehabilitation specialists, often lack the knowledge needed to properly help ME/CFS patients. The author highlights that ME/CFS remains poorly understood and undertreated, with few proven treatments available.

Post-Exertional Malaise

E3 PreliminaryPEM required

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes.

Hebebrand, Johannes, Antel, Jochen, von Piechowski, Linda et al.·Frontiers in psychiatry·2023

This case report describes a 17-year-old boy who had both anorexia nervosa (an eating disorder) and probable ME/CFS (a condition causing extreme fatigue and pain after exertion). He was treated with a medication called metreleptin for short periods. Notably, the treatment appeared to improve not only his eating disorder symptoms but also his ME/CFS symptoms like fatigue and post-exertional muscle pain. This raises the possibility that metreleptin might help people with ME/CFS, especially those who have also lost significant weight.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grande, Tilman, Grande, Bettina, Gerner, Patrick et al.·Medicina (Kaunas, Lithuania)·2023

This article discusses how talking therapy (psychotherapy) might help people with ME/CFS cope better, even though it cannot cure the disease itself. The authors emphasize that ME/CFS is a physical illness requiring physical treatments, and they highlight that post-exertional malaise (getting worse after activity) is a key symptom that therapists should understand. They propose a practical approach to therapy that respects these facts while still helping patients manage their emotional wellbeing.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Vøllestad, Nina K, Mengshoel, Anne Marit·Frontiers in physiology·2023

This paper reviews how post-exertional malaise (PEM)—the worsening of symptoms after physical or mental activity—is experienced and studied in ME/CFS patients. Patients describe PEM in many different ways and report that it can start immediately or be delayed by days, lasting anywhere from a few days to months. When researchers use standardized exercise tests in laboratories, they see more immediate symptom worsening, but the duration still varies widely between patients.

Autonomic Nervous SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID: major findings, mechanisms and recommendations.

Davis, Hannah E, McCorkell, Lisa, Vogel, Julia Moore et al.·Nature reviews. Microbiology·2023

Long COVID is a serious illness affecting at least 10% of people who had COVID-19, with an estimated 65 million people worldwide experiencing it. The condition causes over 200 different symptoms affecting many body systems, similar to ME/CFS and other post-viral illnesses. This review examines what scientists have learned about Long COVID's causes and effects, though better diagnostic tests and treatments are still urgently needed.

Long COVID OverlapPost-Exertional Malaise

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Circulating microaggregates as biomarkers for the Post-COVID syndrome.

Assessing Functional Capacity in Myalgic Encephalopathy/Chronic Fatigue Syndrome: A Patient-Informed Questionnaire.

Pulmonary Rehabilitation for People With Persistent Symptoms After COVID-19.

A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life, and Immunologic Variables in Long COVID.

Current update on the neurological manifestations of long COVID: more questions than answers.

A Practical Approach to Tailor the Term Long COVID for Diagnostics, Therapy and Epidemiological Research for Improved Long COVID Patient Care.

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID.

A practical framework for Long COVID treatment in primary care.

Long COVID's Impact on Patients, Workers, & Society: A review.

Pediatric and adult patients with ME/CFS following COVID-19: A structured approach to diagnosis using the Munich Berlin Symptom Questionnaire (MBSQ).

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.

Post-Acute Sequelae of SARS-CoV-2 Infections: Exercise Limitation and Rehabilitation.

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.

Long COVID: mechanisms, risk factors and recovery.

My experience with ME/CFS and implications: A personal narrative.

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes.

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Long COVID: major findings, mechanisms and recommendations.

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