ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

501–520 of 729 studies

E3 PreliminaryGuidelinePEM unclearGuideline

A practical framework for Long COVID treatment in primary care.

Brode, W Michael, Melamed, Esther·Life sciences·2024

This paper provides a practical guide for primary care doctors treating Long COVID patients. It outlines a four-step approach: first, managing energy levels to avoid crashes after activity; second, carefully graduated rehabilitation for physical, mental, and emotional recovery; third, treating specific symptoms like fatigue and pain; and fourth, considering experimental treatments when appropriate.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID's Impact on Patients, Workers, & Society: A review.

Kavanagh, Kevin T, Cormier, Lindsay E, Pontus, Christine et al.·Medicine·2024

About 1 in 10 people who recover from COVID-19 develop long COVID, and roughly 1 in 4 of those people struggle with daily activities like work and self-care. Brain damage has been found in some patients, leading to problems with memory, thinking clearly, and mood changes. The study reviews how long COVID affects patients' jobs, finances, and communities, and emphasizes that gentle recovery approaches work better than pushing too hard, which can cause setbacks lasting days or weeks.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredCase-Control

Pediatric and adult patients with ME/CFS following COVID-19: A structured approach to diagnosis using the Munich Berlin Symptom Questionnaire (MBSQ).

Peo, Laura-Carlotta, Wiehler, Katharina, Paulick, Johannes et al.·European journal of pediatrics·2024

This study looked at young people (ages 11-25) who developed ME/CFS after having COVID-19, even when their initial infection was mild or asymptomatic. Researchers created new questionnaires called the Munich Berlin Symptom Questionnaires (MBSQs) to help doctors diagnose ME/CFS more easily and consistently. The study found that ten young patients had severe problems with daily activities and quality of life after developing ME/CFS following COVID-19.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

Seylanova, Nina, Chernyavskaya, Anastasia, Degtyareva, Natalia et al.·The European respiratory journal·2024

This study developed a standardized list of health outcomes and measurement tools that doctors and researchers should use when evaluating children and young people with long COVID. International experts from 37 countries agreed on seven key areas to measure: fatigue, post-exertion symptoms, changes in work or school, and cardiovascular, neurological, gastrointestinal, and physical problems. They also identified specific questionnaires that work best for measuring fatigue, digestive symptoms, thinking problems, and overall functioning.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.

Wojczewski, Silvia, Mayrhofer, Mira, Szabo, Nathalie et al.·BMC public health·2024

This study asked 30 Austrian general practitioners (GPs) about their experiences diagnosing and treating Long-COVID patients during 2022. All GPs had seen Long-COVID patients, but many found treatment frustrating because patients often didn't improve significantly, and costs were high. The study found that GPs working in teams and those in cities with specialist networks managed Long-COVID more easily.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

Post-Acute Sequelae of SARS-CoV-2 Infections: Exercise Limitation and Rehabilitation.

Mathew, Joscilin, Nugent, Kenneth·The Yale journal of biology and medicine·2024

Some people who had COVID-19 develop long-lasting symptoms and struggle with exercise—a condition called long COVID. This article explains that exercise problems can happen for different reasons: heart issues, lung problems, weak muscles, being out of shape, or symptoms that seem worse than what physical tests show. While many patients improve with standard rehabilitation programs, those with post-exertional malaise (getting worse after activity) need special, carefully monitored exercise plans.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project.

Gamer, Jackson, Van Booven, Derek J, Zarnowski, Oskar et al.·International journal of molecular sciences·2023

This study looked at how genes behave differently in men and women with ME/CFS when their bodies are stressed by exercise. Researchers tested blood samples from 33 ME/CFS patients and 34 healthy people before, during, and after exercise. They found that men and women with ME/CFS showed different patterns of gene activity in response to exercise—men's immune systems showed more dramatic changes, while women's genes related to stress response and virus handling showed bigger changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Development and measurement properties of the PEM/PESE activity questionnaire (PAQ).

Davenport, Todd E, Stevens, Staci R, Stevens, Jared et al.·Work (Reading, Mass.)·2023

This study created and tested a new questionnaire called the PAQ that helps measure how post-exertional malaise (PEM) affects a person's ability to do everyday activities. Patients chose three activities that were important to them and rated how much their performance had changed compared to their good days and before they got sick. The questionnaire was given to 675 people twice to make sure it reliably measured the same thing each time, and the results showed it works well.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grande, Tilman, Grande, Bettina, Gerner, Patrick et al.·Medicina (Kaunas, Lithuania)·2023

This article discusses how talking therapy (psychotherapy) might help people with ME/CFS cope better, even though it cannot cure the disease itself. The authors emphasize that ME/CFS is a physical illness requiring physical treatments, and they highlight that post-exertional malaise (getting worse after activity) is a key symptom that therapists should understand. They propose a practical approach to therapy that respects these facts while still helping patients manage their emotional wellbeing.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID.

Tate, Warren P, Walker, Max O M, Peppercorn, Katie et al.·International journal of molecular sciences·2023

ME/CFS is a complex illness that typically starts after a viral infection, though other stressful events can also trigger it. This review explains that different patients experience different combinations of symptoms and respond differently to treatments—what helps one person may not help another. The authors discuss how the immune system may shift from a temporary response to a lasting problem, and how the brain's immune system may cause the neurological symptoms people experience.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Long COVID: major findings, mechanisms and recommendations.

Davis, Hannah E, McCorkell, Lisa, Vogel, Julia Moore et al.·Nature reviews. Microbiology·2023

Long COVID is a serious illness affecting at least 10% of people who had COVID-19, with an estimated 65 million people worldwide experiencing it. The condition causes over 200 different symptoms affecting many body systems, similar to ME/CFS and other post-viral illnesses. This review examines what scientists have learned about Long COVID's causes and effects, though better diagnostic tests and treatments are still urgently needed.

Long COVID OverlapPost-Exertional Malaise

E3 PreliminaryCohortPEM requiredObservational

Atopy and Elevation of IgE, IgG3, and IgG4 May Be Risk Factors for Post COVID-19 Condition in Children and Adolescents.

Körner, Robert Walter, Bansemir, Ole Yannick, Franke, Rosa et al.·Children (Basel, Switzerland)·2023

This study examined 28 children and teens who developed long-lasting symptoms after COVID-19 infection. The researchers found that most patients had allergies and unusually high levels of immune proteins called IgE, IgG3, and IgG4. About three in ten patients also met criteria for ME/CFS, experiencing severe fatigue, breathing problems, and post-exertional malaise (feeling worse after activity). Most patients gradually improved over about a year, though some took longer to recover.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Suppressed immune and metabolic responses to intestinal damage-associated microbial translocation in myalgic encephalomyelitis/chronic fatigue syndrome.

Uhde, Melanie, Indart, Alyssa C, Green, Peter H R et al.·Brain, behavior, & immunity - health·2023

This study found that people with ME/CFS have a weakened immune response to bacteria that leak through a damaged gut lining, along with unusual changes in how their bodies process glucose and other nutrients. The immune system appears to be suppressed in some ways while overactive in others, and these patterns were linked to metabolic changes. These findings suggest that gut health and metabolic dysfunction may play important roles in ME/CFS symptoms.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Myalgic Encephalomyelitis-Chronic Fatigue Syndrome Common Data Element item content analysis.

Slavin, Mary D, Bailey, Hannah M, Hickey, Emily J et al.·PloS one·2023

This study examined how well existing questionnaires measure the main symptoms of ME/CFS. Researchers looked at 38 different symptom-assessment tools and found they do a good job measuring physical symptoms like fatigue, sleep problems, and pain. However, most tools don't adequately measure how ME/CFS limits daily activities and participation in work, social life, and other important areas of life.

Post-Exertional Malaise

E3 PreliminaryCohortPEM requiredCase-Control

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

Jinushi, Ryuhei, Nishiguchi, Sho, Masuda, Sakue et al.·Clinical case reports·2023

This study describes a patient who developed ME/CFS after recovering from COVID-19. The researchers found that this patient had lower-than-normal levels of acylcarnitine, a substance the body uses to produce energy. The study reviews existing research on how COVID-19 can lead to ME/CFS, a condition that causes severe fatigue and symptoms that worsen after physical activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM requiredMechanistic

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Maya, Jessica, Leddy, Sabrina M, Gottschalk, C Gunnar et al.·International journal of molecular sciences·2023

Researchers studied immune cells called lymphocytes from ME/CFS patients and found that these cells use fatty acids (a type of fuel) differently than healthy people's immune cells do. When immune cells are activated or working hard, ME/CFS patients' cells rely more heavily on burning fat for energy compared to cells from healthy controls. This suggests that ME/CFS patients' immune systems may have a fundamental problem with how they fuel their cells.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

A review of cytokine-based pathophysiology of Long COVID symptoms.

Low, Russell N, Low, Ryan J, Akrami, Athena·Frontiers in medicine·2023

This review examines how Long COVID may develop through a chain reaction of immune system problems. When the virus infects the body, it can trigger ongoing inflammation that affects both the immune system and the brain, potentially causing blood clots in small vessels. This combination may explain symptoms like fatigue, brain fog, and pain that Long COVID and ME/CFS patients experience.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryCommentaryPEM requiredEditorial

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Vøllestad, Nina K, Mengshoel, Anne Marit·Frontiers in physiology·2023

This paper reviews how post-exertional malaise (PEM)—the worsening of symptoms after physical or mental activity—is experienced and studied in ME/CFS patients. Patients describe PEM in many different ways and report that it can start immediately or be delayed by days, lasting anywhere from a few days to months. When researchers use standardized exercise tests in laboratories, they see more immediate symptom worsening, but the duration still varies widely between patients.

Autonomic Nervous SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients.

Glass, Katherine A, Germain, Arnaud, Huang, Yuhsin V et al.·International journal of molecular sciences·2023

Researchers tested urine samples from ME/CFS patients and healthy people before and after intense exercise. They found that healthy people's urine chemistry changed noticeably after exercise (showing normal recovery), but ME/CFS patients' urine chemistry barely changed. This suggests that ME/CFS patients' bodies may not be adapting properly to physical stress the way healthy bodies do.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Post-COVID and ME/CFS - DoWe Need New Disease Theories?

Schauenburg, Henning·Zeitschrift fur Psychosomatische Medizin und Psychotherapie·2023

This review examines how post-COVID illness and ME/CFS develop and persist, looking beyond just physical symptoms to understand how the brain perceives and responds to the body. The authors suggest that standard medical tests only partially explain chronic fatigue, and that a newer theory called 'Predictive Coding' may help us understand how the mind and body interact in these complex conditions. The goal is to develop better treatments while avoiding the harmful stigma of labeling these as 'just psychological' problems.

Post-Exertional Malaise

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A practical framework for Long COVID treatment in primary care.

Long COVID's Impact on Patients, Workers, & Society: A review.

Pediatric and adult patients with ME/CFS following COVID-19: A structured approach to diagnosis using the Munich Berlin Symptom Questionnaire (MBSQ).

Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children".

"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.

Post-Acute Sequelae of SARS-CoV-2 Infections: Exercise Limitation and Rehabilitation.

Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project.

Development and measurement properties of the PEM/PESE activity questionnaire (PAQ).

The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID.

Long COVID: major findings, mechanisms and recommendations.

Atopy and Elevation of IgE, IgG3, and IgG4 May Be Risk Factors for Post COVID-19 Condition in Children and Adolescents.

Suppressed immune and metabolic responses to intestinal damage-associated microbial translocation in myalgic encephalomyelitis/chronic fatigue syndrome.

Myalgic Encephalomyelitis-Chronic Fatigue Syndrome Common Data Element item content analysis.

A case of post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post-exertional malaise and low serum acylcarnitine level.

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

A review of cytokine-based pathophysiology of Long COVID symptoms.

Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients.

Post-COVID and ME/CFS - DoWe Need New Disease Theories?

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