ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5021–5040 of 6,211 studies

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

Fagermoen, Even, Sulheim, Dag, Winger, Anette et al.·BMC research notes·2012

This small study tested whether a blood pressure medication called clonidine could be safe and helpful for teenagers with ME/CFS. Five teenagers took a low dose of clonidine for two weeks, and researchers measured drug levels in their blood, how their hearts and blood pressure responded to position changes, and any side effects. The medication appeared safe with no serious problems, and it seemed to help improve their body's blood pressure responses.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Validation of the three-factor model of the PSQI in a large sample of chronic fatigue syndrome (CFS) patients.

Mariman, An, Vogelaers, Dirk, Hanoulle, Ignace et al.·Journal of psychosomatic research·2012

This study tested whether a sleep questionnaire commonly used in research works properly for people with ME/CFS. Researchers asked 413 patients with ME/CFS to fill out the Pittsburgh Sleep Quality Index (PSQI), which measures sleep problems. They found that the questionnaire best divides sleep issues into three separate categories: sleep efficiency (how much time you actually sleep), perceived sleep quality (how good your sleep feels), and daily disturbances (how tiredness affects daytime functioning).

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

Ma, Xiaochu, Zhou, Shiying, Wei, Meili et al.·Virus genes·2012

This study investigated whether XMRV, a virus previously thought to be associated with chronic fatigue syndrome, could actually infect human cells. Researchers found that XMRV is a laboratory-made virus created accidentally during experiments with mouse tissues, not a naturally occurring pathogen. Testing showed that XMRV cannot infect human immune cells, suggesting it is unlikely to cause disease in people.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pain in patients with chronic fatigue syndrome: time for specific pain treatment?

Nijs, Jo, Crombez, Geert, Meeus, Mira et al.·Pain physician·2012

This review found that pain in ME/CFS is not caused by damaged muscles or joints, but rather comes from how the nervous system processes pain signals—a condition called central sensitization. The study suggests that education about how pain works in ME/CFS, along with cognitive behavioral therapy focused on fatigue, may help patients manage their pain better.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study.

Aschbacher, Kirstin, Adam, Emma K, Crofford, Leslie J et al.·Brain, behavior, and immunity·2012

This study examined how the body's stress-response system (the HPA axis) works differently in people with ME/CFS and fibromyalgia compared to healthy people. Researchers measured stress hormones (cortisol and ACTH) every 10 minutes for 24 hours and used computer modeling to understand each person's unique hormone patterns. They found that nighttime hormone patterns were different in patients versus healthy controls, and these patterns were linked to symptoms like pain, fatigue, and poor sleep.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Tracy, Mooney·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2012

This article provides an overview of chronic fatigue syndrome (ME/CFS), describing what the condition is and how it affects patients. The authors discuss the symptoms people experience, including severe tiredness that doesn't improve with rest, and other health problems that often occur alongside it. The article aims to help healthcare providers, particularly nurses, understand ME/CFS better so they can provide appropriate care and support.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis.

Burns, Dianne·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2012

ME/CFS is a serious illness that affects many body systems, especially the nervous and immune systems, and can impact anyone regardless of age, race, or background. This guideline article helps nurses and healthcare workers recognize and support ME/CFS patients by providing practical knowledge and management strategies. The recommendations can be used by healthcare professionals in different settings to better care for people living with this condition.

Diagnostics

E3 PreliminaryGuidelinePEM not requiredGuideline

[Persistent fatigue following Q fever].

Keijmel, Stephan P, Morroy, Gabriëlla, Delsing, Corine E et al.·Nederlands tijdschrift voor geneeskunde·2012

After a bacterial infection called Q fever, about 1 in 5 patients develop long-lasting fatigue and other symptoms called Q fever fatigue syndrome (QFS). This guideline from the Netherlands helps doctors diagnose and treat QFS consistently. Many patients recover on their own within six months, but those who don't may benefit from cognitive behavioral therapy, a type of talk therapy that helps people manage chronic fatigue.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Carnitine derivatives: clinical usefulness.

Malaguarnera, Mariano·Current opinion in gastroenterology·2012

This review article discusses carnitine and its chemical cousins (acetyl-L-carnitine and propionyl-L-carnitine), which are natural substances your body uses to convert food into energy. The authors explain that these compounds may help with various conditions including chronic fatigue syndrome, depression, memory problems, and heart disease, and appear to be safe with few side effects.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.

Yamamoto, Shigeyuki, Ouchi, Yasuomi, Nakatsuka, Daisaku et al.·PloS one·2012

Some people with ME/CFS have antibodies in their blood that target a chemical receptor in the brain called the muscarinic cholinergic receptor. This study used brain imaging (PET scans) to compare the brains of ME/CFS patients with and without these antibodies. Patients with these antibodies showed lower levels of these receptors in their brains, but this difference did not affect their thinking or memory performance.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearCross-Sectional

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Light, A R, Bateman, L, Jo, D et al.·Journal of internal medicine·2012

This study looked at how genes are turned on and off in people with ME/CFS before and after moderate exercise. Researchers found that about 71% of ME/CFS patients showed increased activity in genes related to nerve signaling and stress response after exercise, which correlated with their fatigue and pain levels. A smaller subgroup (29%) showed a different pattern, with decreased activity in one specific gene, and these patients were more likely to have orthostatic intolerance (dizziness when standing).

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue.

Felger, J C, Cole, S W, Pace, T W W et al.·Psychological medicine·2012

When patients received interferon-alpha treatment (used for hepatitis C and cancer), researchers looked at immune cell genes to understand why the treatment causes depression and fatigue. They found that one gene called OAS2, previously linked to chronic fatigue syndrome, was especially active in patients who developed depression and fatigue during treatment. This suggests that immune system changes may directly contribute to these symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The relationship between muscle pain and fatigue.

Mastaglia, Frank L·Neuromuscular disorders : NMD·2012

When muscles work hard, pain and fatigue often happen together and can make it harder to exercise. This review examines how pain and tiredness are connected in people with muscle disorders, and explores whether brain stimulation techniques might help reduce both symptoms. Researchers used special magnetic brain stimulation tools to study how the brain controls muscles during exhausting activity.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Suma, S, Veerendra Kumar, B·Indian journal of dental research : official publication of Indian Society for Dental Research·2012

This paper discusses jaw and joint problems (temporomandibular disorders) that commonly occur alongside conditions like ME/CFS and fibromyalgia. It explains that these jaw problems are often overlooked because they stem from increased pain sensitivity related to stress and psychological factors, rather than just physical damage. The authors argue that dentists need to recognize these connections and adjust their treatment approach for patients with these overlapping conditions.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Lack of evidence for a role of xenotropic murine leukemia virus-related virus in the pathogenesis of prostate cancer and/or chronic fatigue syndrome.

Hong, Ping, Li, Jinming·Virus research·2012

A virus called XMRV was once thought to possibly cause ME/CFS and prostate cancer, but this review found no solid evidence supporting that connection. The authors looked at multiple studies and concluded that most positive findings were likely due to contamination in lab samples, not actual infection. This virus does not appear to play a role in causing ME/CFS.

E3 PreliminaryReviewPEM unclearReview-Narrative

Peripheral and central mechanisms of fatigue in inflammatory and noninflammatory rheumatic diseases.

Staud, Roland·Current rheumatology reports·2012

Fatigue in rheumatic diseases like ME/CFS, fibromyalgia, and lupus comes from both physical body problems and mental/central nervous system factors, not just one or the other. Doctors can measure physical fatigue through muscle tests and mental fatigue through questionnaires. Importantly, pain and mood problems are often stronger predictors of fatigue than the disease activity itself, and treatments for both medication and lifestyle changes can help.

Pain and Sensitization

E3 PreliminaryPEM unclearRegistry-Resource

Worst Cases Reported to the NAFKAM International Registry of Exceptional Courses of Disease.

Fønnebø, Vinjar, Drageset, Brit J, Salamonsen, Anita·Global advances in health and medicine·2012

This study reviewed detailed case reports from a registry that documented the most severe cases of ME/CFS—patients whose illness followed unusual or particularly debilitating courses. The researchers examined these exceptional cases to better understand the range and severity of disease progression in ME/CFS. By studying the worst-case scenarios, the team aimed to identify patterns that might help doctors recognize and support the most severely affected patients.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Metacognitive factors in chronic fatigue syndrome.

Maher-Edwards, Lorraine, Fernie, Bruce A, Murphy, Gabrielle et al.·Clinical psychology & psychotherapy·2012

This study explored how ME/CFS patients think about their thinking—specifically, their beliefs about analyzing and solving problems related to their symptoms. Researchers found that patients have both helpful and unhelpful thoughts about trying to understand their illness, and they often focus on either distracting themselves or monitoring their symptoms closely. The study suggests that these thought patterns may play a role in how ME/CFS symptoms develop or persist.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.

Lalremruta, Vanphawng, Prasanna, Gurunath S·Indian journal of pharmacology·2012

Researchers tested whether an extract from the leaves of a plant called Aegle marmelos (also known as bael fruit) could help reduce fatigue-like symptoms in rats. Rats that were forced to swim daily developed fatigue-like behaviors, and when treated with the plant extract, they showed improvement in activity levels, reduced anxiety, and better stress markers in their blood compared to untreated rats.

E3 PreliminaryMechanismPEM not requiredMechanistic

Characterization, mapping, and distribution of the two XMRV parental proviruses.

Cingöz, Oya, Paprotka, Tobias, Delviks-Frankenberry, Krista A et al.·Journal of virology·2012

This study investigated XMRV, a virus that was once thought to be linked to ME/CFS. Researchers discovered that XMRV was not created naturally in mice but instead was accidentally made in a laboratory when two different mouse viruses combined during a cancer experiment. The study shows that XMRV could not have originated in nature because its two parent viruses are found in different geographic mouse populations and have never naturally occurred together in the wild.

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Evidence browser

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

Validation of the three-factor model of the PSQI in a large sample of chronic fatigue syndrome (CFS) patients.

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

Pain in patients with chronic fatigue syndrome: time for specific pain treatment?

Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study.

Chronic fatigue syndrome.

Chronic fatigue syndrome or myalgic encephalomyelitis.

[Persistent fatigue following Q fever].

Carnitine derivatives: clinical usefulness.

Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.

Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome.

Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue.

The relationship between muscle pain and fatigue.

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Lack of evidence for a role of xenotropic murine leukemia virus-related virus in the pathogenesis of prostate cancer and/or chronic fatigue syndrome.

Peripheral and central mechanisms of fatigue in inflammatory and noninflammatory rheumatic diseases.

Worst Cases Reported to the NAFKAM International Registry of Exceptional Courses of Disease.

Metacognitive factors in chronic fatigue syndrome.

Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.

Characterization, mapping, and distribution of the two XMRV parental proviruses.

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