ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5201–5220 of 6,188 studies

E3 PreliminaryMechanismPEM unclearCross-Sectional

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome).

Puri, B K, Agour, M, Gunatilake, K D R et al.·Prostaglandins, leukotrienes, and essential fatty acids·2009

This study used brain imaging to measure levels of a protective molecule called glutathione in the brains of people with ME/CFS. Researchers had expected glutathione levels to be lower in ME/CFS patients because it was reduced in their blood, but surprisingly, the brain levels were similar between patients and healthy controls. The study found no evidence that taking glutathione supplements would help with ME/CFS brain-related symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Q Fever in Tunisia].

Kaabia, N, Letaief, A·Pathologie-biologie·2009

Q fever is an infection caused by bacteria from animals that spreads to humans, usually through breathing contaminated air. While most people infected have no symptoms or mild flu-like illness, some can develop a chronic form that includes long-term fatigue. This review examines how common Q fever is in Tunisia and why doctors there often miss or misdiagnose it.

E3 PreliminaryCohortPEM not requiredCross-Sectional

[Evaluating fatigue resistance effect of health food by near-infrared tissue oximeter].

Wu, Jian, Ding, Hai-shu, Ye, Da-tian·Guang pu xue yu guang pu fen xi = Guang pu·2009

This study tested whether certain health supplements and coffee could help reduce fatigue in office workers using a special technology that measures oxygen levels in the brain. Researchers found that people who took a fatigue-resistance capsule or drank coffee showed higher oxygen saturation levels compared to those who didn't, suggesting these products might help reduce tiredness.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

A gene signature for post-infectious chronic fatigue syndrome.

Gow, John W, Hagan, Suzanne, Herzyk, Pawel et al.·BMC medical genomics·2009

This study looked at whether certain genes are turned on or off differently in people with ME/CFS compared to healthy people. Researchers examined blood cells from 8 men with post-infectious ME/CFS and 7 healthy men, testing the activity of nearly 39,000 genes. They found that 366 genes were expressed differently between the two groups, particularly in areas related to immune function, oxidative stress, and cell death.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Practice Nurses' views of their role in the management of Chronic Fatigue Syndrome/Myalagic Encephalitis: a qualitative study.

Chew-Graham, Carolyn, Dixon, Rebecca, Shaw, Jonathan W et al.·BMC nursing·2009

This study asked 29 practice nurses (nurses who work in doctor's offices) about their understanding and views of ME/CFS. The researchers found that most nurses knew very little about ME/CFS, had not received formal training, and some held negative attitudes toward the condition. While nurses thought they could help manage ME/CFS patients, they often didn't understand the best evidence-based treatments available.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Functional somatic syndromes from the view of cultural anthropology].

Nakagami, Ayako, Tsujiuchi, Takuya·Nihon rinsho. Japanese journal of clinical medicine·2009

This study explains how culture and society shape the way people experience and describe illnesses like ME/CFS. The authors point out that doctors and patients often understand illness differently—doctors focus on what they can measure (disease), while patients focus on how the illness affects their daily life (illness). Understanding these different viewpoints can help doctors and patients communicate better and work together.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Kumar, Anil, Garg, Ruchika·Fundamental & clinical pharmacology·2009

Researchers tested whether three common antidepressant medications could help reduce fatigue-like symptoms and improve mood and activity levels in mice subjected to repeated stress. All three medications tested—imipramine, desipramine, and citalopram—reduced immobility (fatigue-like behavior), improved movement and activity, decreased anxiety, and reduced markers of cellular damage caused by oxidative stress in the stressed mice.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?

Van Houdenhove, Boudewijn, Van Den Eede, Filip, Luyten, Patrick·Medical hypotheses·2009

This study explores why many ME/CFS patients have problems with their stress hormone system, particularly a gland in the brain called the hypothalamus. The researchers suggest that ME/CFS might involve a breakdown in how the body normally responds to stress, leading to an imbalance that triggers excessive inflammation and sickness symptoms like exhaustion and pain sensitivity.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming.

Kuo, Yao-Haur, Tsai, Wei-Jern, Loke, Soy-Hwee et al.·Journal of ethnopharmacology·2009

This study tested whether a natural plant supplement called Astragalus membranaceus flavonoids (AMF) could help rats with chronic fatigue caused by stress and food restriction. The rats that received AMF showed improvements in immune function, better energy for swimming, and restored normal immune system balance compared to untreated fatigued rats.

Immune System

E3 PreliminaryBehavioralPEM not requiredObservational

Can pacing self-management alter physical behavior and symptom severity in chronic fatigue syndrome? A case series.

Nijs, Jo, van Eupen, Inge, Vandecauter, Jo et al.·Journal of rehabilitation research and development·2009

This small study looked at whether a strategy called "pacing" — learning to balance activity and rest — could help people with ME/CFS feel better and do more. Seven patients received three sessions teaching pacing techniques, and researchers measured their activity levels and symptoms before and after. Patients reported improvements in their ability to do daily tasks and some symptoms like muscle weakness and concentration problems got better, though the changes were modest.

E3 PreliminaryReviewPEM unclearReview-Narrative

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

Maes, Michael, Twisk, Frank Nm·Neuro endocrinology letters·2009

This review examines why people with ME/CFS may develop heart problems earlier than others. The researchers found that ME/CFS involves abnormal inflammation and oxidative stress (damage from harmful molecules in the body), along with low levels of protective antioxidants. These biological changes can damage the heart and blood vessels, potentially explaining why some ME/CFS patients experience heart failure at much younger ages than the general population.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Vij, Garima, Gupta, Amit, Chopra, Kanwaljit·Fundamental & clinical pharmacology·2009

Researchers tested whether naringin, a natural compound found in citrus fruits, could help reduce fatigue-like symptoms in mice exposed to immune challenges and stress. Mice treated with naringin showed improvements in their activity levels, pain sensitivity, and markers of cellular damage compared to untreated mice, suggesting that reducing oxidative stress might help manage fatigue symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Can sustained arousal explain the Chronic Fatigue Syndrome?

Wyller, Vegard B, Eriksen, Hege R, Malterud, Kirsti·Behavioral and brain functions : BBF·2009

This study proposes that ME/CFS may be caused by the body getting stuck in a constant state of high alert, similar to being continuously stressed. This sustained arousal could develop after infections or emotional stress, especially in people with certain genetic traits or personality types. The researchers suggest this constant activation creates harmful cycles affecting the immune system, hormones, muscles, and thinking—ultimately leading to the overwhelming fatigue that defines ME/CFS.

Autonomic Nervous SystemImmune System

E3 PreliminaryBehavioralPEM not requiredObservational

Clinical observation on the effects of Bo's abdominal acupuncture in 40 cases of chronic fatigue syndrome.

Huang, Yong, Liao, Xiao-ming, Li, Xiao-xi et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2008

This study looked at whether a traditional Chinese acupuncture technique called Bo's abdominal acupuncture could help 40 people with chronic fatigue syndrome. Patients received acupuncture treatments once daily for 2 weeks, and researchers measured their symptoms and fatigue levels before and after treatment. The results showed that patients reported improvements in fatigue, loss of appetite, sleep problems, memory issues, diarrhea, and general pain.

Interventions

E3 PreliminaryPEM not required

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

Gilje, Ann Marit, Söderlund, Atle, Malterud, Kirsti·Patient education and counseling·2008

This study asked 12 ME/CFS patients about their experiences with doctors and healthcare. Patients reported that doctors often didn't believe them, didn't listen carefully, or treated them dismissively. Many felt that doctors blamed their symptoms on psychological causes or didn't take them seriously, which was sometimes as painful as the illness itself.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications.

Nijs, Jo, Frémont, Marc·Expert opinion on therapeutic targets·2008

This review examines how the immune system's internal functions may be broken in ME/CFS patients. Researchers found that a specific immune protein called RNase L appears to be damaged in people with this illness, and this damage may be connected to why patients have low natural killer cell function and poor exercise tolerance. The authors suggest that targeting this damaged protein pathway could be a promising new treatment approach.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Kerr, Jonathan R·Current rheumatology reports·2008

Researchers used gene testing to look at which genes are turned on or off differently in people with ME/CFS compared to healthy people. They found 88 genes with different activity levels, mostly related to immune function and infection fighting. Importantly, they discovered that ME/CFS patients appear to fall into at least seven different subtypes based on their gene patterns, suggesting that ME/CFS may not be one single disease but rather several related conditions that might need different treatments.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Anaesthesia for patients with idiopathic environmental intolerance and chronic fatigue syndrome.

Fisher, M McD, Rose, M·British journal of anaesthesia·2008

This study looked at how anesthesia should be safely given to ME/CFS patients undergoing surgery. Researchers found that while some patients experienced side effects after anesthesia, these were not severe allergic reactions and were usually temporary. The study suggests that doctors can use standard anesthesia techniques for ME/CFS patients, simply avoiding any drugs the patient has previously reacted badly to.

Pain and Sensitization

E3 PreliminaryPEM unclear

Can exercise limits prevent post-exertional malaise in chronic fatigue syndrome? An uncontrolled clinical trial.

Nijs, Jo, Almond, Freya, De Becker, Pascale et al.·Clinical rehabilitation·2008

This study tested whether limiting both how hard and how long people with ME/CFS exercise could prevent post-exertional malaise (feeling much worse after activity). Twenty-four patients did a controlled walking test designed to stay within their personal limits. While tiredness improved within 24 hours, pain increased and didn't fully go away, and some patients reported their overall health got worse. The exercise limits helped prevent major health changes but didn't completely stop symptom flare-ups.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Medication-induced mitochondrial damage and disease.

Neustadt, John, Pieczenik, Steve R·Molecular nutrition & food research·2008

Mitochondria are the energy-producing structures in our cells, and when they are damaged, they don't work properly. This review article explains that many common medications—including psychiatric drugs, cholesterol medications, and pain relievers like acetaminophen—can damage mitochondria, which may explain some of their harmful side effects. Since ME/CFS involves problems with energy production, understanding how medications damage mitochondria and how certain nutrients might help repair them could be important for patients.

Energy Metabolism

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Evidence browser

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome).

[Q Fever in Tunisia].

[Evaluating fatigue resistance effect of health food by near-infrared tissue oximeter].

A gene signature for post-infectious chronic fatigue syndrome.

Practice Nurses' views of their role in the management of Chronic Fatigue Syndrome/Myalagic Encephalitis: a qualitative study.

[Functional somatic syndromes from the view of cultural anthropology].

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?

Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming.

Can pacing self-management alter physical behavior and symptom severity in chronic fatigue syndrome? A case series.

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.

Can sustained arousal explain the Chronic Fatigue Syndrome?

Clinical observation on the effects of Bo's abdominal acupuncture in 40 cases of chronic fatigue syndrome.

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications.

Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Anaesthesia for patients with idiopathic environmental intolerance and chronic fatigue syndrome.

Can exercise limits prevent post-exertional malaise in chronic fatigue syndrome? An uncontrolled clinical trial.

Medication-induced mitochondrial damage and disease.

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