ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5221–5240 of 6,211 studies

E3 PreliminaryCohortPEM not requiredCross-Sectional

Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy.

Haig-Ferguson, A, Tucker, P, Eaton, N et al.·Archives of disease in childhood·2009

This study looked at 20 children with ME/CFS who had memory and attention problems. Researchers asked the children, their parents, and teachers about these difficulties, and then gave the children a series of tests to measure how well they could focus, remember things, and process information. The children's test scores showed they had real difficulties with attention and memory compared to healthy children their age.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredObservational

Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Journal of psychosomatic research·2009

Researchers compared brain wave patterns during sleep between identical twins where one had ME/CFS and one did not. They found no significant differences in the electrical activity of the brain during sleep between the sick and healthy twins, even though those with ME/CFS reported more sleep problems. This suggests that genetic factors may influence sleep patterns more strongly than the illness itself.

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.

Gupta, Amit, Vij, Garima, Sharma, Sameer et al.·Immunobiology·2009

This study tested whether curcumin, a natural compound found in turmeric, could help reduce fatigue in mice infected with bacteria-like substances. Mice treated with curcumin showed less fatigue behavior and had lower levels of inflammation markers compared to untreated mice. The results suggest curcumin might be worth exploring as a potential treatment for ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pathogenic mechanisms of idiopathic nonallergic rhinitis.

Baraniuk, James N·The World Allergy Organization journal·2009

This study examines why some people develop chronic nasal symptoms like congestion and runny nose that don't have an obvious allergic cause. Researchers found that this condition may actually involve several different problems: structural issues in the nose, nerve sensitivity problems, and autonomic nervous system dysfunction—the same type of nervous system problem found in ME/CFS.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredObservational

Can pacing self-management alter physical behavior and symptom severity in chronic fatigue syndrome? A case series.

Nijs, Jo, van Eupen, Inge, Vandecauter, Jo et al.·Journal of rehabilitation research and development·2009

This small study looked at whether a strategy called "pacing" — learning to balance activity and rest — could help people with ME/CFS feel better and do more. Seven patients received three sessions teaching pacing techniques, and researchers measured their activity levels and symptoms before and after. Patients reported improvements in their ability to do daily tasks and some symptoms like muscle weakness and concentration problems got better, though the changes were modest.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Practice Nurses' views of their role in the management of Chronic Fatigue Syndrome/Myalagic Encephalitis: a qualitative study.

Chew-Graham, Carolyn, Dixon, Rebecca, Shaw, Jonathan W et al.·BMC nursing·2009

This study asked 29 practice nurses (nurses who work in doctor's offices) about their understanding and views of ME/CFS. The researchers found that most nurses knew very little about ME/CFS, had not received formal training, and some held negative attitudes toward the condition. While nurses thought they could help manage ME/CFS patients, they often didn't understand the best evidence-based treatments available.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Web usage data as a means of evaluating public health messaging and outreach.

Tian, Hao, Brimmer, Dana J, Lin, Jin-Mann S et al.·Journal of medical Internet research·2009

This study looked at how many people visited the CDC's ME/CFS website over 18 months and what information they searched for. The website received millions of visits from around the world, showing that many people are looking for reliable information about ME/CFS. The researchers found that a public awareness campaign successfully brought more visitors to the site, and that people were more interested in professional medical information after the campaign ended.

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue?

Meeus, Mira, Mistiaen, Wilhelm, Lambrecht, Luc et al.·Anticancer research·2009

This research review compares immune system abnormalities found in both cancer and ME/CFS, focusing on whether similar immune problems might explain why both conditions cause severe fatigue. The authors identified several immune dysfunctions that appear in both diseases—including problems with natural killer cells, abnormal inflammatory signaling, and increased cellular stress—and suggest these shared immune problems may contribute to the fatigue experienced by patients with either condition.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

An integrated approach to infer causal associations among gene expression, genotype variation, and disease.

Lee, Eunjee, Cho, Seoae, Kim, Kyunga et al.·Genomics·2009

Researchers developed a new method to find which genes might cause ME/CFS by combining three types of medical data: genetic variations people are born with, how active those genes are in the body, and whether someone has the disease. When they tested this method on ME/CFS patients, they found that certain genes—especially one called NR3C1—appear to influence disease risk, and that patients with ME/CFS plus depression may have different genetic causes than those with ME/CFS alone.

E3 PreliminaryCohortPEM not requiredCross-Sectional

[Evaluating fatigue resistance effect of health food by near-infrared tissue oximeter].

Wu, Jian, Ding, Hai-shu, Ye, Da-tian·Guang pu xue yu guang pu fen xi = Guang pu·2009

This study tested whether certain health supplements and coffee could help reduce fatigue in office workers using a special technology that measures oxygen levels in the brain. Researchers found that people who took a fatigue-resistance capsule or drank coffee showed higher oxygen saturation levels compared to those who didn't, suggesting these products might help reduce tiredness.

E3 PreliminaryMechanismPEM requiredMechanistic

Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome.

Sorensen, Bristol, Jones, James F, Vernon, Suzanne D et al.·Molecular medicine (Cambridge, Mass.)·2009

After exercise, people with ME/CFS show higher levels of certain immune molecules (particularly C4a) that may contribute to their post-exercise symptoms. This study looked at which genes were turned on or off in immune cells after exercise and found that people with ME/CFS activated different immune pathways than healthy people—specifically, a pathway called the lectin pathway responded differently. This suggests their immune system may be producing excess inflammatory signals after physical activity.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction.

Ben-Zvi, Amos, Vernon, Suzanne D, Broderick, Gordon·PLoS computational biology·2009

People with ME/CFS often have abnormally low cortisol levels, a hormone that helps the body manage stress and energy. This study used mathematical computer modeling to design a new treatment approach: rather than giving more cortisol (the intuitive approach), the model suggests temporarily suppressing cortisol further until the body's signaling hormone (ACTH) rises enough to trigger the system to reset itself back to normal levels. This counterintuitive strategy could work by exploiting how the body's hormone system naturally behaves.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCase-Control

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome.

Exley, Christopher, Swarbrick, Louise, Gherardi, Rhomain K et al.·Medical hypotheses·2009

This study describes one patient who developed both chronic fatigue syndrome (ME/CFS) and a muscle condition called macrophagic myofasciitis after receiving vaccines containing aluminum adjuvants, and who also had high levels of aluminum in their body. The researchers propose that aluminum accumulation from vaccines might trigger immune system problems that lead to these conditions. This is a single case report rather than a broad study of many patients.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

Lin, Eugene, Hsu, Sen-Yen·Pharmacogenomics·2009

Researchers used advanced statistical methods to look for interactions between genes and between genes and environmental factors (like age, sex, and weight) in ME/CFS patients. They found that a gene called NR3C1 appeared to be involved in patterns that might be related to ME/CFS, and that gender seemed to influence how this gene affected the condition. This suggests that ME/CFS likely develops from a combination of genetic and personal factors rather than from a single cause.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Can sustained arousal explain the Chronic Fatigue Syndrome?

Wyller, Vegard B, Eriksen, Hege R, Malterud, Kirsti·Behavioral and brain functions : BBF·2009

This study proposes that ME/CFS may be caused by the body getting stuck in a constant state of high alert, similar to being continuously stressed. This sustained arousal could develop after infections or emotional stress, especially in people with certain genetic traits or personality types. The researchers suggest this constant activation creates harmful cycles affecting the immune system, hormones, muscles, and thinking—ultimately leading to the overwhelming fatigue that defines ME/CFS.

Autonomic Nervous SystemImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

[Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment].

Rybakina, E G, Shanin, S N, Fomicheva, E E et al.·Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2009

This study used laboratory rats to understand how ME/CFS might develop by triggering an immune response with a synthetic molecule. Researchers found that during this fatigue-like state, immune cells became less active, brain cell communication pathways were dampened, and the body's stress-response system (which normally helps us cope) became less effective. These findings suggest ME/CFS involves problems in how the immune system and brain communicate with each other.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

An extended concept of altered self: chronic fatigue and post-infection syndromes.

Jones, James F·Psychoneuroendocrinology·2008

This paper proposes that ME/CFS and post-infection fatigue may develop when the brain's ability to sense and respond to the body becomes stuck in a protective 'sickness mode' even after the infection has cleared. Rather than being a true ongoing disease, the authors suggest it may be an altered state where the brain continues to trigger immune and stress responses as if the body is still fighting an infection, causing ongoing fatigue and other symptoms.

E3 PreliminaryPEM not required

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

Gilje, Ann Marit, Söderlund, Atle, Malterud, Kirsti·Patient education and counseling·2008

This study asked 12 ME/CFS patients about their experiences with doctors and healthcare. Patients reported that doctors often didn't believe them, didn't listen carefully, or treated them dismissively. Many felt that doctors blamed their symptoms on psychological causes or didn't take them seriously, which was sometimes as painful as the illness itself.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism.

Geisser, Michael E, Strader Donnell, Cathy, Petzke, Frank et al.·Psychosomatics·2008

This study looked at why people with fibromyalgia and ME/CFS experience so many body symptoms. Researchers found that both conditions may share a common problem: the nervous system amplifies sensory signals, making pain and other sensations feel stronger than they might to other people. This heightened sensitivity to stimulation appears to be a key reason why these conditions affect daily functioning, and this mechanism seems separate from depression.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

A precarious balance: using a self-regulation model to conceptualize and treat chronic fatigue syndrome.

Deary, Vincent·British journal of health psychology·2008

This study proposes a new way to understand ME/CFS by looking at how the body and mind try to adapt to living with the illness. The researchers suggest that people with ME/CFS develop a delicate balance with their condition, and when they try to fix things—like pushing through fatigue or avoiding activity—these efforts can sometimes backfire and make symptoms worse. The theory focuses on how physical sensations, emotions, and thoughts become tightly connected and reinforce each other in ME/CFS.

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Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy.

Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.

Pathogenic mechanisms of idiopathic nonallergic rhinitis.

Can pacing self-management alter physical behavior and symptom severity in chronic fatigue syndrome? A case series.

Practice Nurses' views of their role in the management of Chronic Fatigue Syndrome/Myalagic Encephalitis: a qualitative study.

Web usage data as a means of evaluating public health messaging and outreach.

Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue?

An integrated approach to infer causal associations among gene expression, genotype variation, and disease.

[Evaluating fatigue resistance effect of health food by near-infrared tissue oximeter].

Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome.

Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction.

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome.

A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome.

Can sustained arousal explain the Chronic Fatigue Syndrome?

[Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment].

An extended concept of altered self: chronic fatigue and post-infection syndromes.

Obstructions for quality care experienced by patients with chronic fatigue syndrome (CFS)--a case study.

Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism.

A precarious balance: using a self-regulation model to conceptualize and treat chronic fatigue syndrome.

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