ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5501–5520 of 6,188 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: a review].

Carlo-Stella, Nicoletta, Lorusso, Lorenzo, Candura, Stefano M et al.·Recenti progressi in medicina·2004

ME/CFS is a serious illness that causes extreme tiredness and disability, but many doctors don't recognize or diagnose it properly. This review explains what we know about ME/CFS, including possible causes like infections and immune system problems, and describes a research effort to collect biological samples from patients to better understand the disease.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Muscle metabolism with blood flow restriction in chronic fatigue syndrome.

McCully, Kevin K, Smith, Sinclair, Rajaei, Sheeva et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2004

This study looked at whether ME/CFS patients have problems with blood flow and how their muscles use oxygen during recovery from exercise. Researchers compared 19 ME/CFS patients to 11 healthy people and found that ME/CFS patients had reduced blood flow to muscles during recovery, but this did not actually impair how well their muscles worked or used oxygen.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Progress in research on chronic fatigue syndrome].

Jiang, Shu-Yun, Yan, Jun-Tao, Fang, Min·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·2004

This review article examines progress in ME/CFS research, bringing together what scientists and doctors have learned about the condition. It looks at how ME/CFS is understood and studied from both Western and traditional Chinese medicine perspectives. The article summarizes the current state of knowledge to help guide future research directions.

E3 PreliminaryMechanismPEM unclearMechanistic

Altered central nervous system signal during motor performance in chronic fatigue syndrome.

Siemionow, Vlodek, Fang, Yin, Calabrese, Leonard et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2004

This study measured brain electrical activity in ME/CFS patients and healthy people while they performed repeated hand-squeezing exercises. The researchers found that ME/CFS patients showed different brain activity patterns—particularly increased slower brain waves and larger electrical signals related to movement control—especially when the exercises became tiring. These brain activity differences might help doctors develop better ways to diagnose ME/CFS.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Coordinating the norms and values of medical research, medical practice and patient worlds-the ethics of evidence based medicine in orphaned fields of medicine.

Vos, R, Willems, D, Houtepen, R·Journal of medical ethics·2004

This article discusses a serious problem in medicine: some diseases like ME/CFS are studied much less rigorously than common conditions, leaving patients with weak evidence about what works. The authors argue that doctors and patients deserve better research and communication, especially for these neglected diseases. They suggest a new approach called the 'coordination model' that brings together scientists, doctors, and patients to work out fair and ethical solutions.

E3 PreliminaryMechanismPEM not requiredMechanistic

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

Fulle, Stefania, Belia, Silvia, Vecchiet, Jacopo et al.·Neuromuscular disorders : NMD·2003

This study examined muscle cell structures called sarcoplasmic reticulum, which are responsible for controlling muscle contractions. Researchers found that in ME/CFS patients, these structures show signs of damage from oxidative stress, which may interfere with how muscles contract and relax. The damage appears to affect how calcium moves in and out of muscle cells, potentially explaining why patients experience fatigue.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Applying exercise to the management of fibromyalgia.

Ambrose, Kirsten, Lyden, Angela K, Clauw, Daniel J·Current pain and headache reports·2003

This article reviews research on how exercise affects fibromyalgia and chronic fatigue syndrome. While medications are commonly used to treat these conditions, studies show that exercise can significantly reduce pain and tiredness. The authors suggest that exercise should be combined with other treatments as part of a comprehensive care plan.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

An overview of chronic fatigue syndrome.

Jackson, Elizabeth·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article reviews what we know about ME/CFS, including the symptoms people commonly experience and how they can be treated. The author describes a new model of patient care that was tested in the community, which combines several different therapeutic approaches to help manage the condition.

Interventions

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.

Smirnova, Iva V, Pall, Martin L·Molecular and cellular biochemistry·2003

This study measured a specific type of damage to proteins in the blood of ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients had significantly higher levels of this protein damage, suggesting their cells may be experiencing more oxidative stress—a type of cellular damage similar to rust forming on metal. This finding supports the idea that oxidative stress may be involved in ME/CFS.

E3 PreliminaryMechanismPEM not requiredObservational

The effect of granisetron, a 5-HT3 receptor antagonist, in the treatment of chronic fatigue syndrome patients--a pilot study.

The, G K H, Prins, J, Bleijenberg, G et al.·The Netherlands journal of medicine·2003

Researchers tested whether a medication called granisetron, which affects a brain chemical involved in nausea and other functions, might help ME/CFS patients feel less fatigued. Five women with ME/CFS took the medication for one month and reported significant improvements in how tired they felt and how much they could do. However, this was a very small study without a comparison group, so much more research is needed to confirm these results.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

The radicalized self: the impact on the self of the contested nature of the diagnosis of chronic fatigue syndrome.

Clarke, Juanne N, James, Susan·Social science & medicine (1982)·2003

This study explores how people with ME/CFS cope with the challenge that their illness is not universally accepted by doctors and society. Patients experience both the physical burden of the disease and the emotional strain of having their condition disputed or questioned. The research found that people with ME/CFS often develop new ways of understanding themselves and their identity as a way to cope with this lack of recognition.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome.

Razumovsky, Alexander Y, DeBusk, Karen, Calkins, Hugh et al.·Journal of neuroimaging : official journal of the American Society of Neuroimaging·2003

When people with ME/CFS stand up quickly, they often experience dizziness and fainting. This study used ultrasound to measure blood flow in the brain during a tilt test and compared it between ME/CFS patients and healthy people. The researchers found that blood flow patterns in the brain were actually similar between the two groups, even though ME/CFS patients felt symptoms faster.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome.

Whistler, Toni, Unger, Elizabeth R, Nisenbaum, Rosane et al.·Journal of translational medicine·2003

This study looked at blood samples from people with ME/CFS to see if the disease might actually be several different conditions rather than one. Researchers found that when they grouped patients by how their illness started, certain genes were turned on or off differently. These genes are involved in how the body produces energy, particularly through breaking down sugars and other molecules. This suggests that ME/CFS patients may have different underlying problems with their body's energy production systems.

Energy Metabolism

E3 PreliminaryCommentaryPEM not requiredEditorial

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Englebienne, P, Verhas, M, Herst, C V et al.·Medical hypotheses·2003

This study proposes a potential explanation for why some ME/CFS patients experience severe fatigue despite having normal thyroid blood tests. The researchers suggest that certain immune proteins called interferons may trigger the production of other proteins that interfere with thyroid hormone function at the cellular level, making the body behave as if it has low thyroid activity even though standard thyroid tests appear normal.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Chatterjee, Tapabrata·Journal of the Indian Medical Association·2003

This article reviews how ME/CFS affects children and teens, a group that is often overlooked in medical research. The authors explain the current diagnostic criteria used to identify the condition and discuss available treatments, though they note that how well these treatments work and what happens to patients over time remains unclear.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes.

Endresen, Gerhard K M·Rheumatology international·2003

This review looked at whether a type of bacteria called mycoplasma might be found in the blood of people with ME/CFS and fibromyalgia. Researchers found mycoplasma in about half of patients with these conditions, compared to only 10% of healthy people. Some patients who received long-term antibiotic treatment appeared to recover completely, suggesting mycoplasma infection might be treatable in certain cases.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The neurological significance of abnormal natural killer cell activity in chronic toxigenic mold exposures.

Anyanwu, Ebere, Campbell, Andrew W, Jones, Joseph et al.·TheScientificWorldJournal·2003

This review examines how toxic molds found in homes and buildings can damage the immune system, specifically affecting natural killer cells—white blood cells that help fight infections. When people are exposed to these molds over time, their natural killer cells may stop working normally, which could contribute to symptoms like fatigue, memory problems, sleep trouble, depression, headaches, and fevers that resemble ME/CFS.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Kurup, Ravi Kumar, Kurup, Parameswara Achutha·The International journal of neuroscience·2003

This study examined chemical pathways in the brains of 15 ME/CFS patients, focusing on how the body produces energy and manages stress. Researchers found that people with ME/CFS had lower levels of important protective molecules and higher levels of harmful byproducts, along with imbalances in brain chemicals that affect mood, energy, and pain. The study suggests these biochemical problems may be linked to how the brain is organized in people with ME/CFS.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

Taylor, Renee R, Kielhofner, Gary W·Occupational therapy in health care·2003

This study explains how occupational therapists can better help people with ME/CFS by using a structured approach called the Model of Human Occupation. This framework helps therapists understand how the condition affects a person's motivation, daily habits, roles, and ability to do activities they care about. The paper provides practical guidance and a real-world example of how to assess and treat ME/CFS patients using this approach.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Aaron, Leslie A, Buchwald, Dedra·Best practice & research. Clinical rheumatology·2003

Many people with fibromyalgia also experience other chronic conditions like ME/CFS, irritable bowel syndrome, and jaw pain. This review examines how often these conditions occur together and suggests that doctors should check for multiple conditions when treating fibromyalgia patients. Treatment works better when it addresses all of a patient's overlapping symptoms, not just one condition.

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Evidence browser

[Chronic fatigue syndrome: a review].

Muscle metabolism with blood flow restriction in chronic fatigue syndrome.

[Progress in research on chronic fatigue syndrome].

Altered central nervous system signal during motor performance in chronic fatigue syndrome.

Coordinating the norms and values of medical research, medical practice and patient worlds-the ethics of evidence based medicine in orphaned fields of medicine.

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

Applying exercise to the management of fibromyalgia.

An overview of chronic fatigue syndrome.

Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.

The effect of granisetron, a 5-HT3 receptor antagonist, in the treatment of chronic fatigue syndrome patients--a pilot study.

The radicalized self: the impact on the self of the contested nature of the diagnosis of chronic fatigue syndrome.

Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome.

Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome.

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes.

The neurological significance of abnormal natural killer cell activity in chronic toxigenic mold exposures.

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

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