ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5481–5500 of 6,211 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[Systemic Mycoplasma blood infection in fibromyalgia and chronic fatigue syndrome].

Endresen, Gerhard K M·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2004

This review examined whether bacteria called Mycoplasma found in the blood might be connected to fibromyalgia and chronic fatigue syndrome (ME/CFS). The author looked at existing research to understand if these bacteria could be a cause or contributing factor to these conditions. This was a summary of available evidence rather than a new experiment with patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia syndrome in women.

Shaver, Joan L·The Nursing clinics of North America·2004

This article reviews fibromyalgia syndrome (FMS), a condition causing chronic pain and fatigue that affects far more women than men. The authors describe common symptoms and discuss research into what might cause FMS and related conditions like ME/CFS, IBS, and TMD, as well as current treatment options.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

Midodrine treatment for chronic fatigue syndrome.

Naschitz, J, Dreyfuss, D, Yeshurun, D et al.·Postgraduate medical journal·2004

This study reports on one patient with severe ME/CFS who was treated with midodrine, a medication that helps regulate blood pressure and heart rate control. The patient's symptoms of dysautonomia (problems with the autonomic nervous system that controls automatic body functions) improved with this treatment, and their fatigue also improved. This suggests that treating the autonomic nervous system dysfunction may help some people with ME/CFS feel better.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome (cfs).

Adler, Rolf H·Swiss medical weekly·2004

This review examines whether ME/CFS is a single illness or actually several different conditions. The authors found that ME/CFS involves multiple body systems—including the immune system, nervous system, hormones, and muscles—and that psychological factors also play a role. Rather than one disease, they suggest ME/CFS represents the body's emergency stress responses (fight-or-flight and shutdown) being inappropriately activated, and treatment should address the whole person, not just symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Coordinating the norms and values of medical research, medical practice and patient worlds-the ethics of evidence based medicine in orphaned fields of medicine.

Vos, R, Willems, D, Houtepen, R·Journal of medical ethics·2004

This article discusses a serious problem in medicine: some diseases like ME/CFS are studied much less rigorously than common conditions, leaving patients with weak evidence about what works. The authors argue that doctors and patients deserve better research and communication, especially for these neglected diseases. They suggest a new approach called the 'coordination model' that brings together scientists, doctors, and patients to work out fair and ethical solutions.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fatigue in neuromuscular disease].

Van Engelen, B G M, Kalkman, J S, Schillings, M L et al.·Nederlands tijdschrift voor geneeskunde·2004

Fatigue is a common symptom in many diseases, including neuromuscular disorders like post-polio syndrome and myasthenia gravis. This review found that about 64% of neuromuscular patients experience severe fatigue—a rate similar to multiple sclerosis patients. The authors suggest that using reliable measurement tools and combining different medical specialties could help researchers understand why fatigue happens and develop better treatments.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The HPA axis and the genesis of chronic fatigue syndrome.

Cleare, Anthony J·Trends in endocrinology and metabolism: TEM·2004

This review examines whether ME/CFS involves problems with the body's stress hormone system (the HPA axis). While people with long-standing ME/CFS show some changes in this system, early studies suggest these changes may not be present when the illness first develops. Interestingly, lifestyle factors like inactivity and poor sleep may cause these changes, and they can sometimes improve when these factors are addressed.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Kapfhammer, H P, Rothenhäusler, H B·MMW Fortschritte der Medizin·2004

ME/CFS involves fatigue and exhaustion that can look different from person to person. These symptoms can happen after infections like viruses or alongside mood and anxiety problems. The authors suggest that cognitive-behavioral therapy (a type of talk therapy focused on thoughts and behaviors) combined with antidepressant medication may help some patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Progress in research on chronic fatigue syndrome].

Jiang, Shu-Yun, Yan, Jun-Tao, Fang, Min·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·2004

This review article examines progress in ME/CFS research, bringing together what scientists and doctors have learned about the condition. It looks at how ME/CFS is understood and studied from both Western and traditional Chinese medicine perspectives. The article summarizes the current state of knowledge to help guide future research directions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Subjective health complaints, sensitization, and sustained cognitive activation (stress).

Eriksen, H R, Ursin, H·Journal of psychosomatic research·2004

This review suggests that common symptoms like pain, tiredness, sleep problems, and digestive issues in conditions like ME/CFS may occur when the body's normal sensing system becomes overly sensitive. Rather than being caused by hidden disease, these symptoms may develop when people experience sustained stress and feel helpless, causing the nervous system to amplify normal bodily signals until they become unbearable.

Pain and SensitizationCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: traditional and community-based approaches to rehabilitation.

Taylor, Renee R·Health & social care in the community·2004

This review article examines different ways to help people with ME/CFS improve their functioning and quality of life, since no cure currently exists. The authors look at both traditional rehabilitation methods and newer community-based approaches that use local organizations and real-world settings. They discuss which approaches might work best for different patients and point out both the strengths and weaknesses of the research used to test these treatments.

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Wang, Xin Q, Takahashi, Takashi, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2004

Researchers tested a Japanese herbal medicine called Hochu-ekki-to (TJ-41) in mice with an experimentally induced condition similar to ME/CFS. Mice treated with the herb showed better activity levels and survived longer than untreated mice, suggesting the herb may help reduce activity loss associated with chronic fatigue-like conditions.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Myasthenia gravis: diagnostic mimics.

Engstrom, John W·Seminars in neurology·2004

This paper helps doctors tell the difference between myasthenia gravis (MG) and other conditions that look similar. MG causes muscle weakness that comes and goes, especially in the eyes and face. The authors review many other diseases—including neurological problems, infections, and other conditions—that can be mistaken for MG but are actually something else.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Kuibitang on lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Shin, Hye-Young, An, Nyeon-Hyoung, Cha, Yun-Jin et al.·Journal of ethnopharmacology·2004

This study tested whether Kuibitang (KBT), a traditional herbal treatment used in South Korea, could affect immune system chemicals in people with ME/CFS. Researchers added KBT to blood cells from CFS patients and healthy people, then stimulated those cells to see how they responded. They found that KBT reduced some inflammatory chemicals but increased others, suggesting it might help balance the abnormal immune responses seen in CFS.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Polyneuritis cranialis HHV-6 infection associated].

Brustia, Diego, Uglietti, Alessia, Garavelli, Pietro Luigi·Recenti progressi in medicina·2004

This case study describes one patient with a rare condition called polyneuritis cranialis (weakness affecting multiple nerves in the head and face) that was linked to a human herpesvirus-6 (HHV-6) infection. The patient was treated with an antiviral medication called ganciclovir, and her symptoms improved only after the virus was completely cleared from her body.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: a review].

Carlo-Stella, Nicoletta, Lorusso, Lorenzo, Candura, Stefano M et al.·Recenti progressi in medicina·2004

ME/CFS is a serious illness that causes extreme tiredness and disability, but many doctors don't recognize or diagnose it properly. This review explains what we know about ME/CFS, including possible causes like infections and immune system problems, and describes a research effort to collect biological samples from patients to better understand the disease.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome.

Steinau, Martin, Unger, Elizabeth R, Vernon, Suzanne D et al.·Journal of molecular medicine (Berlin, Germany)·2004

Researchers looked at immune cells from one ME/CFS patient and one healthy person to find differences in which genes were turned on or off. They found about 10 genes that behaved differently between the two people, with most differences present even before exercise. Many of these genes are involved in immune function, suggesting that ME/CFS may involve problems with how the immune system works.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders.

Cox, I J, Puri, B K·Prostaglandins, leukotrienes, and essential fatty acids·2004

This study reviewed how a specialized brain imaging technique called magnetic resonance spectroscopy can be used to detect chemical changes in the brains of people with chronic fatigue syndrome and other neuropsychiatric conditions. The technique is non-invasive and allows doctors to measure things like energy production, brain cell function, and neurotransmitter activity without surgery. The authors summarized findings from previous research showing what these brain chemistry changes look like in ME/CFS patients.

E3 PreliminaryPEM not required

[Appraisal of Lyme borreliosis].

Hausotter, W·Versicherungsmedizin·2004

Lyme disease is an infection spread by tick bites that can cause many different symptoms affecting multiple body systems. This article discusses how doctors can better identify and diagnose Lyme disease, especially since its symptoms overlap with conditions like fibromyalgia and chronic fatigue syndrome. People who work outdoors in areas where Lyme disease is common face higher infection risks and may qualify for financial compensation if diagnosed.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Carnitines and its congeners: a metabolic pathway to the regulation of immune response and inflammation.

Famularo, Giuseppe, De Simone, Claudio, Trinchieri, Vito et al.·Annals of the New York Academy of Sciences·2004

This review discusses carnitine, a natural substance in the body that helps cells produce energy from fats. Carnitine levels are low in several conditions involving immune problems, including ME/CFS. The authors suggest that low carnitine may contribute to immune dysfunction and excessive inflammation, and that carnitine treatment might help restore normal immune function.

Energy MetabolismImmune System

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Evidence browser

[Systemic Mycoplasma blood infection in fibromyalgia and chronic fatigue syndrome].

Fibromyalgia syndrome in women.

Midodrine treatment for chronic fatigue syndrome.

Chronic fatigue syndrome (cfs).

Coordinating the norms and values of medical research, medical practice and patient worlds-the ethics of evidence based medicine in orphaned fields of medicine.

[Fatigue in neuromuscular disease].

The HPA axis and the genesis of chronic fatigue syndrome.

[Chronic fatigue syndrome].

[Progress in research on chronic fatigue syndrome].

Subjective health complaints, sensitization, and sustained cognitive activation (stress).

Chronic fatigue syndrome: traditional and community-based approaches to rehabilitation.

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Myasthenia gravis: diagnostic mimics.

Effect of Kuibitang on lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

[Polyneuritis cranialis HHV-6 infection associated].

[Chronic fatigue syndrome: a review].

Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome.

In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders.

[Appraisal of Lyme borreliosis].

Carnitines and its congeners: a metabolic pathway to the regulation of immune response and inflammation.

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