ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5461–5480 of 6,188 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Muscle metabolism with blood flow restriction in chronic fatigue syndrome.

McCully, Kevin K, Smith, Sinclair, Rajaei, Sheeva et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2004

This study looked at whether ME/CFS patients have problems with blood flow and how their muscles use oxygen during recovery from exercise. Researchers compared 19 ME/CFS patients to 11 healthy people and found that ME/CFS patients had reduced blood flow to muscles during recovery, but this did not actually impair how well their muscles worked or used oxygen.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome.

Skowera, A, Cleare, A, Blair, D et al.·Clinical and experimental immunology·2004

This study looked at immune cells in the blood of ME/CFS patients to see if they respond differently than in healthy people. Researchers found that ME/CFS patients had higher levels of immune cells that produce type 2 cytokines—signaling molecules associated with a particular type of immune response. This suggests the immune system in ME/CFS may be stuck in an unusual activation pattern.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Developing and evaluating community-based services through participatory action research: two case examples.

Taylor, Renée R, Braveman, Brent, Hammel, Joy·The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2004

This study shows how occupational therapists can work together with ME/CFS patients and their communities to design better support services. Instead of experts telling people what they need, this approach lets patients and community members have a real voice in deciding what services should be created and how they should work. The researchers used two real-world examples—one with ME/CFS patients and one with AIDS patients—to show how this partnership approach can lead to more helpful and empowering services.

E3 PreliminaryReviewPEM not requiredReview-Narrative

In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.

Chaudhuri, A, Behan, P O·Prostaglandins, leukotrienes, and essential fatty acids·2004

This study used a special type of MRI scan called magnetic resonance spectroscopy (MRS) to look at how cells work in ME/CFS patients. The scans showed that muscle cells may become too acidic during exercise, and brain cells may have signs of stress. These findings suggest that ME/CFS involves problems with how cells produce and use energy.

E3 PreliminaryReviewPEM not requiredReview-Narrative

In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders.

Cox, I J, Puri, B K·Prostaglandins, leukotrienes, and essential fatty acids·2004

This study reviewed how a specialized brain imaging technique called magnetic resonance spectroscopy can be used to detect chemical changes in the brains of people with chronic fatigue syndrome and other neuropsychiatric conditions. The technique is non-invasive and allows doctors to measure things like energy production, brain cell function, and neurotransmitter activity without surgery. The authors summarized findings from previous research showing what these brain chemistry changes look like in ME/CFS patients.

E3 PreliminaryMechanismPEM not requiredObservational

Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan.

Miike, Teruhisa, Tomoda, Akemi, Jhodoi, Takako et al.·Brain & development·2004

This study followed children with chronic fatigue syndrome (CFS) in Japan over 15 years to understand why they experience severe tiredness and difficulty learning and remembering information. The researchers found that these children had problems with their autonomic nervous system (the automatic system controlling heart rate, temperature, and digestion), disrupted sleep-wake cycles similar to jet lag, and reduced blood flow to certain brain areas. Understanding these patterns may help explain why learning becomes so difficult for children with CFS.

SleepCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Carnitines and its congeners: a metabolic pathway to the regulation of immune response and inflammation.

Famularo, Giuseppe, De Simone, Claudio, Trinchieri, Vito et al.·Annals of the New York Academy of Sciences·2004

This review discusses carnitine, a natural substance in the body that helps cells produce energy from fats. Carnitine levels are low in several conditions involving immune problems, including ME/CFS. The authors suggest that low carnitine may contribute to immune dysfunction and excessive inflammation, and that carnitine treatment might help restore normal immune function.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Wang, Xin Q, Takahashi, Takashi, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2004

Researchers tested a Japanese herbal medicine called Hochu-ekki-to (TJ-41) in mice with an experimentally induced condition similar to ME/CFS. Mice treated with the herb showed better activity levels and survived longer than untreated mice, suggesting the herb may help reduce activity loss associated with chronic fatigue-like conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Q fever (coxiellosis): epidemiology and pathogenesis.

Woldehiwet, Zerai·Research in veterinary science·2004

Q fever is an infection caused by bacteria that spread from animals to humans, usually through contact with infected livestock. In some people, Q fever causes a long-lasting illness with fatigue, similar to ME/CFS symptoms. This review summarizes what we know about how Q fever spreads and why it makes people sick.

E3 PreliminaryCohortPEM not requiredCase-Control

[Polyneuritis cranialis HHV-6 infection associated].

Brustia, Diego, Uglietti, Alessia, Garavelli, Pietro Luigi·Recenti progressi in medicina·2004

This case study describes one patient with a rare condition called polyneuritis cranialis (weakness affecting multiple nerves in the head and face) that was linked to a human herpesvirus-6 (HHV-6) infection. The patient was treated with an antiviral medication called ganciclovir, and her symptoms improved only after the virus was completely cleared from her body.

E3 PreliminaryMechanismPEM not requiredMechanistic

Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome.

Steinau, Martin, Unger, Elizabeth R, Vernon, Suzanne D et al.·Journal of molecular medicine (Berlin, Germany)·2004

Researchers looked at immune cells from one ME/CFS patient and one healthy person to find differences in which genes were turned on or off. They found about 10 genes that behaved differently between the two people, with most differences present even before exercise. Many of these genes are involved in immune function, suggesting that ME/CFS may involve problems with how the immune system works.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of determinants of group judgments in clinical guideline development.

Raine, Rosalind, Sanderson, Colin, Hutchings, Andrew et al.·Lancet (London, England)·2004

This study examined how doctors develop medical guidelines by testing whether expert opinions match what research evidence actually shows. Researchers asked different groups of doctors to rate whether certain treatments (like therapy or antidepressants) were appropriate for conditions including chronic fatigue syndrome. They found that doctors' judgments agreed with published research only about half the time, and that having a literature review and certain group compositions helped improve accuracy.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome (cfs).

Adler, Rolf H·Swiss medical weekly·2004

This review examines whether ME/CFS is a single illness or actually several different conditions. The authors found that ME/CFS involves multiple body systems—including the immune system, nervous system, hormones, and muscles—and that psychological factors also play a role. Rather than one disease, they suggest ME/CFS represents the body's emergency stress responses (fight-or-flight and shutdown) being inappropriately activated, and treatment should address the whole person, not just symptoms.

Immune System

E3 PreliminaryPEM not required

[Appraisal of Lyme borreliosis].

Hausotter, W·Versicherungsmedizin·2004

Lyme disease is an infection spread by tick bites that can cause many different symptoms affecting multiple body systems. This article discusses how doctors can better identify and diagnose Lyme disease, especially since its symptoms overlap with conditions like fibromyalgia and chronic fatigue syndrome. People who work outdoors in areas where Lyme disease is common face higher infection risks and may qualify for financial compensation if diagnosed.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Subjective health complaints, sensitization, and sustained cognitive activation (stress).

Eriksen, H R, Ursin, H·Journal of psychosomatic research·2004

This review suggests that common symptoms like pain, tiredness, sleep problems, and digestive issues in conditions like ME/CFS may occur when the body's normal sensing system becomes overly sensitive. Rather than being caused by hidden disease, these symptoms may develop when people experience sustained stress and feel helpless, causing the nervous system to amplify normal bodily signals until they become unbearable.

Pain and SensitizationCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent.

DiVasta, Amy Desrochers, Alexander, Mark E·Current opinion in pediatrics·2004

This review article explains that fainting is common in teenagers, but most cases are not caused by serious heart problems. Doctors can identify the few teenagers with real heart disease using a detailed patient history, physical examination, and an electrocardiogram (ECG). The article emphasizes that teenagers with certain conditions—including chronic fatigue syndrome, eating disorders, and exercise-related fainting—need extra careful evaluation because their heart problems may be more serious or harder to manage.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Myasthenia gravis: diagnostic mimics.

Engstrom, John W·Seminars in neurology·2004

This paper helps doctors tell the difference between myasthenia gravis (MG) and other conditions that look similar. MG causes muscle weakness that comes and goes, especially in the eyes and face. The authors review many other diseases—including neurological problems, infections, and other conditions—that can be mistaken for MG but are actually something else.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Progress in research on chronic fatigue syndrome].

Jiang, Shu-Yun, Yan, Jun-Tao, Fang, Min·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·2004

This review article examines progress in ME/CFS research, bringing together what scientists and doctors have learned about the condition. It looks at how ME/CFS is understood and studied from both Western and traditional Chinese medicine perspectives. The article summarizes the current state of knowledge to help guide future research directions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Coordinating the norms and values of medical research, medical practice and patient worlds-the ethics of evidence based medicine in orphaned fields of medicine.

Vos, R, Willems, D, Houtepen, R·Journal of medical ethics·2004

This article discusses a serious problem in medicine: some diseases like ME/CFS are studied much less rigorously than common conditions, leaving patients with weak evidence about what works. The authors argue that doctors and patients deserve better research and communication, especially for these neglected diseases. They suggest a new approach called the 'coordination model' that brings together scientists, doctors, and patients to work out fair and ethical solutions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: traditional and community-based approaches to rehabilitation.

Taylor, Renee R·Health & social care in the community·2004

This review article examines different ways to help people with ME/CFS improve their functioning and quality of life, since no cure currently exists. The authors look at both traditional rehabilitation methods and newer community-based approaches that use local organizations and real-world settings. They discuss which approaches might work best for different patients and point out both the strengths and weaknesses of the research used to test these treatments.

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Evidence Atlas

Evidence browser

Muscle metabolism with blood flow restriction in chronic fatigue syndrome.

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome.

Developing and evaluating community-based services through participatory action research: two case examples.

In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.

In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders.

Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan.

Carnitines and its congeners: a metabolic pathway to the regulation of immune response and inflammation.

Effect of Hochu-ekki-to (TJ-41), a Japanese Herbal Medicine, on Daily Activity in a Murine Model of Chronic Fatigue Syndrome.

Q fever (coxiellosis): epidemiology and pathogenesis.

[Polyneuritis cranialis HHV-6 infection associated].

Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome.

An experimental study of determinants of group judgments in clinical guideline development.

Chronic fatigue syndrome (cfs).

[Appraisal of Lyme borreliosis].

Subjective health complaints, sensitization, and sustained cognitive activation (stress).

Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent.

Myasthenia gravis: diagnostic mimics.

[Progress in research on chronic fatigue syndrome].

Coordinating the norms and values of medical research, medical practice and patient worlds-the ethics of evidence based medicine in orphaned fields of medicine.

Chronic fatigue syndrome: traditional and community-based approaches to rehabilitation.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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