ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5461–5480 of 6,211 studies

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Moss, Jill·Journal of child health care : for professionals working with children in the hospital and community·2005

Children and young people with ME/CFS often have difficulty explaining what activities they can or cannot do on any given day, making it hard for parents and doctors to understand their abilities. Researchers worked with 251 young people from a ME support organization to create a simple 0-100% scale that young people themselves helped design and test. The result was a practical tool that 99% of young people felt accurately measured their functional abilities.

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

Nijs, Jo, Vaes, Peter, De Meirleir, Kenny·Occupational therapy international·2005

Researchers created a simple questionnaire called the CFS-APQ to measure how much ME/CFS affects a patient's ability to do daily activities. They tested this questionnaire on hundreds of patients and found it works reliably—meaning patients give consistent answers when asked the same questions again—and it accurately reflects how sick someone is.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of determinants of the extent of disagreement within clinical guideline development groups.

Hutchings, A, Raine, R, Sanderson, C et al.·Quality & safety in health care·2005

This study looked at how doctors and mental health professionals reach agreement on which treatments are appropriate for different conditions, including chronic fatigue syndrome (ME/CFS). Researchers tested whether different ways of running these decision-making meetings affected how much the professionals disagreed with each other. They found that the way meetings were structured didn't really change how much disagreement there was—doctors were more likely to agree on some treatments (like cognitive behavioral therapy) than others.

E3 PreliminaryCohortPEM unclearCross-Sectional

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization.

Casado, Begoña, Zanone, Chiara, Annovazzi, Laura et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2005

Researchers collected urine samples from people with ME/CFS, people with ME/CFS plus fibromyalgia, and healthy controls to look for chemical differences. Using a specialized lab technique called electrophoresis, they found that the urine samples from people with these conditions showed distinct patterns of chemicals compared to healthy people. These patterns might potentially be used as biological markers to help identify and understand these illnesses.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2005

This study found that people with ME/CFS have lower levels of omega-3 fatty acids (healthy fats found in fish) and higher levels of other types of fats compared to healthy people. These imbalances were linked to lower zinc levels and problems with immune cells called T cells, which help fight infection. The researchers suggest that omega-3 supplements might help ME/CFS patients.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Characterization of virus isolates by particle-associated nucleic acid PCR.

Stang, Alexander, Korn, Klaus, Wildner, Oliver et al.·Journal of clinical microbiology·2005

Researchers developed a new laboratory method called PAN-PCR that can identify viruses in patient samples even when standard tests fail to detect them. This technique works by finding viral genetic material protected inside virus particles and then copying and analyzing it. As a test case, they used this method on a mouth sample from a ME/CFS patient and successfully identified herpes simplex virus type 1, which had been missed by conventional testing.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Lange, G, Steffener, J, Cook, D B et al.·NeuroImage·2005

This study used brain imaging to see what happens when people with ME/CFS listen to complex spoken information. Researchers found that people with ME/CFS could understand the information just as well as healthy people, but their brains had to work much harder to do it—using more brain regions and requiring greater effort. This provides scientific proof that the thinking and concentration difficulties ME/CFS patients report are real and visible on brain scans.

Cognitive Impairment

E3 PreliminaryBehavioralPEM unclear

Ayurvedic treatment of chronic fatigue syndrome--a case report.

Vinjamury, Sivarama Prasad, Singh, Betsy B·Alternative therapies in health and medicine·2005

This case report describes one patient with chronic fatigue syndrome (ME/CFS) who received treatment using Ayurveda, a traditional medicine system from India. The authors documented whether Ayurvedic treatments helped reduce the patient's fatigue and other symptoms. While the patient showed some improvement, this is just one person's experience and cannot tell us whether this approach works for most people with ME/CFS.

Interventions

E3 PreliminaryCohortPEM not required

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Kodama, Mitsuo, Kodama, Toshiko·International journal of molecular medicine·2005

This study describes a treatment approach combining high-dose vitamin C infusions with hormonal supplements (DHEA and cortisol) in patients with interstitial pneumonia, which the authors propose may be related to ME/CFS. Over 9 years, the researchers tracked whether this treatment reduced flare-ups and prevented complications like cancer and depression. The treatment appeared to help reduce active pneumonia symptoms, though it did not prevent long-term scarring of the lungs.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Nijs, Jo, Van de Velde, Bart, De Meirleir, Kenny·Medical hypotheses·2005

This study proposes a theory about why ME/CFS patients experience widespread pain. The researchers suggest that a molecule called nitric oxide may cause the central nervous system (the brain and spinal cord) to become overly sensitive, amplifying pain signals throughout the body. They propose that viral infections or other pathogens associated with ME/CFS may trigger this chain reaction, and that behaviors like catastrophizing or avoiding activity may either contribute to or result from this heightened sensitivity.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

The HPA axis and the genesis of chronic fatigue syndrome.

Cleare, Anthony J·Trends in endocrinology and metabolism: TEM·2004

This review examines whether ME/CFS involves problems with the body's stress hormone system (the HPA axis). While people with long-standing ME/CFS show some changes in this system, early studies suggest these changes may not be present when the illness first develops. Interestingly, lifestyle factors like inactivity and poor sleep may cause these changes, and they can sometimes improve when these factors are addressed.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in a cognitive perspective. A therapeutic model].

d'Elia, Giacomo·Lakartidningen·2004

This paper describes how cognitive therapy—a type of talk therapy focused on thoughts and beliefs—can help people with ME/CFS. The approach recognizes that unhelpful thoughts about the illness (like believing symptoms mean serious physical harm) can interact with real physical problems and low mood, creating a cycle that keeps people tired and inactive. A therapist works with the patient to gently challenge these beliefs and plan small increases in activity to show that feared outcomes don't happen.

E3 PreliminaryMechanismPEM requiredMechanistic

Exercise lowers pain threshold in chronic fatigue syndrome.

Whiteside, Alan, Hansen, Stig, Chaudhuri, Abhijit·Pain·2004

This study looked at how exercise affects pain sensitivity in people with ME/CFS compared to healthy people. When healthy volunteers exercised, their pain threshold (the point at which they felt pain) went up, making them less sensitive to pain. However, in ME/CFS patients, the pain threshold actually decreased after exercise, meaning they became more sensitive to pain. This suggests that the body's natural pain-blocking system may not work properly in ME/CFS.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Physiology and pathophysiology of the 5-HT3 receptor.

Färber, L, Haus, U, Späth, M et al.·Scandinavian journal of rheumatology. Supplement·2004

This review examines how a specific brain chemical receptor called 5-HT3 works in the body and what happens when it malfunctions. The researchers found that blocking this receptor with certain medications may help treat several conditions, including ME/CFS, by reducing symptoms like nausea, pain, and anxiety. However, scientists still don't fully understand exactly how this receptor causes problems in these different illnesses.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Manual-based cognitive behaviour therapy for chronic fatigue syndrome: therapists' adherence and perceptions.

Bazelmans, Ellen, Prins, Judith B, Hoogveld, Sigrid et al.·Cognitive behaviour therapy·2004

This study looked at how well therapists followed a standardized treatment manual when using cognitive behavior therapy (CBT) to treat ME/CFS patients. Researchers recorded therapy sessions and asked therapists about their experiences. They found that therapists generally stuck to the treatment plan, but many found ME/CFS patients harder to treat than patients with other conditions, mostly because of difficulty building patient confidence and motivation.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome.

Okada, Tomohisa, Tanaka, Masaaki, Kuratsune, Hirohiko et al.·BMC neurology·2004

This study used brain imaging to compare the brains of people with ME/CFS to healthy individuals. Researchers found that people with ME/CFS had smaller gray matter (the thinking part of the brain) in specific areas of the prefrontal cortex, which is the region responsible for decision-making and regulating sensations. Importantly, the amount of shrinkage in one area of the prefrontal cortex matched how severe each person's fatigue was, suggesting this brain region may play a key role in how our bodies experience and manage fatigue.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue in neurological disorders.

Chaudhuri, Abhijit, Behan, Peter O·Lancet (London, England)·2004

This review examines fatigue in various neurological diseases, including ME/CFS. The authors explain that fatigue can result from problems in muscle function (where muscles can't sustain effort) or problems in the brain and nervous system (where the brain perceives activities as requiring excessive effort). They suggest that imbalances in stress hormones and disrupted communication between key brain regions may underlie persistent fatigue.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: a review].

Carlo-Stella, Nicoletta, Lorusso, Lorenzo, Candura, Stefano M et al.·Recenti progressi in medicina·2004

ME/CFS is a serious illness that causes extreme tiredness and disability, but many doctors don't recognize or diagnose it properly. This review explains what we know about ME/CFS, including possible causes like infections and immune system problems, and describes a research effort to collect biological samples from patients to better understand the disease.

Immune System

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Evidence browser

Development of a functional ability scale for children and young people with myalgic encephalopathy (ME)/chronic fatigue syndrome (CFS).

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

The Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ): an overview.

An experimental study of determinants of the extent of disagreement within clinical guideline development groups.

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization.

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Characterization of virus isolates by particle-associated nucleic acid PCR.

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Ayurvedic treatment of chronic fatigue syndrome--a case report.

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

The HPA axis and the genesis of chronic fatigue syndrome.

[Chronic fatigue syndrome in a cognitive perspective. A therapeutic model].

Exercise lowers pain threshold in chronic fatigue syndrome.

Physiology and pathophysiology of the 5-HT3 receptor.

Manual-based cognitive behaviour therapy for chronic fatigue syndrome: therapists' adherence and perceptions.

Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome.

Fatigue in neurological disorders.

[Chronic fatigue syndrome: a review].

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