ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5441–5460 of 6,211 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Staines, Donald R·Medical hypotheses·2005

This article explores a theory that ME/CFS and related conditions like fibromyalgia might be caused by problems with special chemical messengers in the body called vasoactive neuropeptides. These chemicals normally help control blood vessels, inflammation, and immune function. The authors suggest that if this theory is correct, several treatments might help—including replacing these chemicals, using certain medications, or modifying genes—though they emphasize this is still speculative and unproven.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Diagnosing asthenia and chronic fatigue syndrome].

Aslangul, Elisabeth, Le Jeunne, Claire·La Revue du praticien·2005

This article discusses how doctors can distinguish between general tiredness (asthenia) and ME/CFS, which is a serious long-term illness characterized by severe fatigue that doesn't improve with rest. The authors review the clinical features and diagnostic approaches that help healthcare providers identify ME/CFS in their patients. Understanding these differences is important so patients receive appropriate diagnosis and care.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.

Frémont, Marc, El Bakkouri, Karim, Vaeyens, Freya et al.·Experimental and molecular pathology·2005

In ME/CFS, immune cells produce abnormal levels of proteins involved in fighting viral infections. This study found that a protective molecule called 2-5A can shield a key antiviral protein (RNase L) from being broken down by inflammatory enzymes. However, in ME/CFS patients, cells tend to produce smaller versions of 2-5A, which cannot provide this protection, leading to the accumulation of damaged RNase L protein.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Persistent nonallergic rhinosinusitis.

Staevska, Maria, Baraniuk, James N·Current allergy and asthma reports·2005

This review describes different types of nasal and sinus inflammation that are not caused by allergies. The authors propose a new way to organize these conditions based on whether they involve certain immune cells (eosinophils or neutrophils) or other mechanisms like hormonal changes. Interestingly, they mention that nonallergic rhinitis can occur in chronic fatigue syndrome (ME/CFS) and may involve nerve-related sensitivity.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neuropathology in rhinosinusitis.

Baraniuk, James N, Petrie, Kristina Naranch, Le, Uyenphuong et al.·American journal of respiratory and critical care medicine·2005

Researchers tested how the nasal passages of people with ME/CFS, sinusitis, allergies, and healthy controls responded to salt water spray. They found that people with ME/CFS experienced unusual nerve sensitivity (feeling more pain) but their mucus-producing glands didn't respond normally to the stimulus. This suggests that ME/CFS involves a different pattern of how nerves and mucus glands work in the nose compared to other nasal conditions.

Neuroinflammation

E3 PreliminaryCohortPEM unclearCross-Sectional

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization.

Casado, Begoña, Zanone, Chiara, Annovazzi, Laura et al.·Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2005

Researchers collected urine samples from people with ME/CFS, people with ME/CFS plus fibromyalgia, and healthy controls to look for chemical differences. Using a specialized lab technique called electrophoresis, they found that the urine samples from people with these conditions showed distinct patterns of chemicals compared to healthy people. These patterns might potentially be used as biological markers to help identify and understand these illnesses.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

Naschitz, Jochanan E, Rozenbaum, Michael, Fields, Madeline et al.·Clinical science (London, England : 1979)·2005

Researchers developed new methods to detect specific patterns in how the body's heart rate and blood pressure respond to physical stress (tilting upright) in people with familial Mediterranean fever (FMF). They found that people with FMF show distinctive cardiovascular responses that can be measured and used to help identify the condition. The study shows this approach might also work for other diseases, including ME/CFS.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Glozier, N·Occupational medicine (Oxford, England)·2005

This is a detailed review article about ME/CFS written for occupational health professionals. The article examines what is known about ME/CFS, including how it affects people's ability to work, and highlights the significant gaps in our understanding of the condition. The main message is that ME/CFS remains poorly understood, which makes it difficult for doctors, employers, and patients to manage effectively.

E3 PreliminaryGuidelinePEM not requiredGuideline

[Report from the Health Council of the Netherlands on the chronic fatigue syndrome: moving away from the body-mind dichotomy with a view to effective prevention and treatment].

Bolk, J H·Nederlands tijdschrift voor geneeskunde·2005

This Dutch Health Council report recognizes ME/CFS as a real, serious illness that genuinely affects people's lives, even though doctors cannot find obvious physical signs or blood tests to confirm it. The report suggests that stress and the gap between what the body can handle and what people try to do play important roles in the condition. It recommends moving away from the idea that ME/CFS is purely 'in your head' or purely physical, and instead seeing it as involving both body and mind together.

E3 PreliminaryReviewPEM unclearReview-Narrative

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Staines, Donald R·Medical hypotheses·2005

This paper proposes that ME/CFS and similar fatigue disorders may be caused by the immune system attacking special messenger molecules in the body called vasoactive neuropeptides. These molecules normally help control energy metabolism, nerve function, and immune responses. The authors suggest that when antibodies damage these molecules, it could explain the severe fatigue and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryCohortPEM not required

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Kodama, Mitsuo, Kodama, Toshiko·International journal of molecular medicine·2005

This study describes a treatment approach combining high-dose vitamin C infusions with hormonal supplements (DHEA and cortisol) in patients with interstitial pneumonia, which the authors propose may be related to ME/CFS. Over 9 years, the researchers tracked whether this treatment reduced flare-ups and prevented complications like cancer and depression. The treatment appeared to help reduce active pneumonia symptoms, though it did not prevent long-term scarring of the lungs.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The role of enterovirus in chronic fatigue syndrome.

Chia, J K S·Journal of clinical pathology·2005

This review examines whether enteroviruses—common viruses that cause respiratory and stomach infections—might play a role in ME/CFS. Researchers found that these viruses can sometimes persist in the body long-term and produce symptoms similar to ME/CFS. Laboratory and animal studies showed that viral RNA (genetic material) can remain in muscles and cause ongoing inflammation, which matches what has been seen in tissue samples from ME/CFS patients.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Practitioner review: chronic fatigue syndrome in childhood.

Elena Garralda, M, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2005

This review examines how ME/CFS appears in children and teenagers and discusses the best ways to help them recover. The authors found that ME/CFS in young people is often triggered by infections and can be diagnosed using the same criteria as in adults. They recommend a family-based approach using cognitive behavior therapy and gradually increasing activity, which has shown promise in helping children regain function.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Neuro endocrinology letters·2005

This study found that people with ME/CFS have lower levels of omega-3 fatty acids (healthy fats found in fish) and higher levels of other types of fats compared to healthy people. These imbalances were linked to lower zinc levels and problems with immune cells called T cells, which help fight infection. The researchers suggest that omega-3 supplements might help ME/CFS patients.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Supporting people with severe myalgic encephalomyelitis.

Crowhurst, Greg·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2005

This article helps nurses better understand ME/CFS, a serious condition that is often misunderstood by healthcare providers. The author describes the main symptoms people experience and discusses how healthcare services can support patients. The article emphasizes that ME/CFS is a real physical illness that needs more research to help doctors and nurses care for people with it properly.

Interventions

E3 PreliminaryBehavioralPEM unclearCase-Control

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Driver, Christine·The Journal of analytical psychology·2005

This study examines how the mind and body become deeply connected in people with ME/CFS, making it hard to regulate both emotions and physical symptoms. Through detailed analysis of one patient's therapy, the researcher explores how early experiences with parents may affect how the body and mind communicate and function together in ME/CFS.

E3 PreliminaryMechanismPEM not requiredMechanistic

Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.

Kerr, J R·Journal of veterinary medicine. B, Infectious diseases and veterinary public health·2005

This study examined how parvovirus B19 might trigger chronic fatigue syndrome (CFS) in some people. Researchers found that patients with prolonged symptoms after B19 infection had high levels of inflammatory chemicals in their blood, and identified certain genetic variations that may make some people more susceptible to developing CFS after B19 infection. They also discovered that the virus may persist in the body by hiding in human genes, and found that people carrying B19 virus DNA had altered expression of several genes involved in cell structure and immune function.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

Tomoda, Akemi, Joudoi, Takako, Rabab, El-Mezayen et al.·Psychiatry research·2005

This study examined immune system chemicals called cytokines in people with ME/CFS compared to healthy volunteers. Researchers took blood cells from both groups and stimulated them in the laboratory to see how they would respond. They found that ME/CFS patients produced lower levels of certain immune chemicals, particularly one called TGF-beta1, which might play a role in the inflammation seen in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.

Kaushik, N, Fear, D, Richards, S C M et al.·Journal of clinical pathology·2005

Researchers compared blood cells from 25 ME/CFS patients with 25 healthy people to see if genes were turned on or off differently. They found 16 genes with different activity levels in ME/CFS patients—most were overactive. These changes suggest problems with immune cell activation, nerve function, and how cells produce energy, which could help explain why ME/CFS causes fatigue and other symptoms.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome.

Wagner, Dieter, Nisenbaum, Rosane, Heim, Christine et al.·Population health metrics·2005

Researchers created and tested a new questionnaire called the CDC CFS Symptom Inventory to help measure the many different symptoms that people with ME/CFS experience—not just fatigue, but also other important symptoms like problems with memory, sleep, and pain. They gave this questionnaire to 164 people (some with ME/CFS, some with other illnesses, and some without fatigue) and found that the questionnaire reliably distinguished people with ME/CFS from others and worked well when compared to existing fatigue measurement tools.

Diagnostics

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Evidence browser

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

[Diagnosing asthenia and chronic fatigue syndrome].

2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.

Persistent nonallergic rhinosinusitis.

Neuropathology in rhinosinusitis.

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization.

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

[Report from the Health Council of the Netherlands on the chronic fatigue syndrome: moving away from the body-mind dichotomy with a view to effective prevention and treatment].

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

The role of enterovirus in chronic fatigue syndrome.

Practitioner review: chronic fatigue syndrome in childhood.

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.

Supporting people with severe myalgic encephalomyelitis.

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.

Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome.

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