ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5421–5440 of 6,211 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Coxiella burnetii infection.

Kazar, Jan·Annals of the New York Academy of Sciences·2005

Coxiella burnetii is a bacterium that causes Q fever, a disease spread mainly through contact with infected animals like cattle, sheep, and goats. Most people infected have no symptoms or mild flu-like illness, but some develop chronic complications including chronic fatigue syndrome. This review examines how the bacterium survives in the body and causes different forms of disease depending on a person's immune system and overall health.

E3 PreliminaryCohortPEM not requiredCase-Control

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Masuda, Akinori, Kihara, Takashi, Fukudome, Tsuyoshi et al.·Journal of psychosomatic research·2005

This study followed two ME/CFS patients who tried a type of heat therapy called far-infrared sauna (heated to 60°C) combined with warming afterward. After about 15-25 sessions, both patients reported major improvements in fatigue, pain, sleep problems, and fever. They continued the therapy once or twice a week for a year and did not get worse, even after stopping their previous medication.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredObservational

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Fernández-Solà, Joaquim, Lluís Padierna, Meritxell, Nogué Xarau, Santiago et al.·Medicina clinica·2005

This study followed 26 people who developed ME/CFS after being exposed to insecticide sprays at their workplace. Most patients were women who first experienced airway inflammation and digestive problems, followed by brain fog, muscle pain, and fatigue. About one-third also developed chemical sensitivity. The researchers emphasize that proper ventilation and safety precautions during and after insecticide use are crucial to prevent these illnesses.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia?

Bellanti, Joseph A, Sabra, Aderbal, Castro, Henry J et al.·Allergy and asthma proceedings·2005

This review article explores whether allergies and immune system problems might play a role in three conditions: ADHD, chronic fatigue syndrome (CFS), and fibromyalgia. The authors suggest that while the exact causes of these disorders remain unknown, allergic reactions—including reactions to foods—may trigger or worsen symptoms in all three conditions. They propose that problems in the body's neuroendocrine-immune system (the network connecting the brain, hormones, and immune function) are central to understanding these illnesses.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Maher, K J, Klimas, N G, Fletcher, M A·Clinical and experimental immunology·2005

This study found that people with ME/CFS have lower levels of a protein called perforin in their immune cells, particularly in natural killer cells. Perforin is a weapon that immune cells use to fight off infections and abnormal cells. The researchers suggest this deficiency might help explain why people with ME/CFS often have weakened immune function.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Shin, Yong-Il, Lee, Myeong Soo·The American journal of Chinese medicine·2005

This study looked at whether Qi therapy (a hands-on energy-based technique from traditional Chinese medicine) might help people with ME/CFS feel better. Two patients who received Qi therapy reported feeling more mentally relaxed and found it easier to cope with their pain and tiredness. While these are only two cases and more research is needed, the results suggest Qi therapy might be worth studying further as a complementary approach.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Staines, Donald R·Medical hypotheses·2005

This paper proposes that ME/CFS and similar fatigue disorders may be caused by the immune system attacking special messenger molecules in the body called vasoactive neuropeptides. These molecules normally help control energy metabolism, nerve function, and immune responses. The authors suggest that when antibodies damage these molecules, it could explain the severe fatigue and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryPEM not required

Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder?

Doljansky, J T, Kannety, H, Dagan, Y·Chronobiology international·2005

A 47-year-old man with chronic fatigue syndrome developed a severely disrupted sleep-wake cycle after 20 years of working under very bright lights (used for diamond grading) often late into the night. When he switched to treatment combining melatonin at bedtime, bright light therapy in the morning, and avoiding bright light at night, his sleep pattern stabilized and his daytime tiredness improved significantly within one week.

Sleep

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome.

Wagner, Dieter, Nisenbaum, Rosane, Heim, Christine et al.·Population health metrics·2005

Researchers created and tested a new questionnaire called the CDC CFS Symptom Inventory to help measure the many different symptoms that people with ME/CFS experience—not just fatigue, but also other important symptoms like problems with memory, sleep, and pain. They gave this questionnaire to 164 people (some with ME/CFS, some with other illnesses, and some without fatigue) and found that the questionnaire reliably distinguished people with ME/CFS from others and worked well when compared to existing fatigue measurement tools.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Symptom overlap and comorbidity of irritable bowel syndrome with other conditions.

Frissora, Christine L, Koch, Kenneth L·Current gastroenterology reports·2005

This review examined how irritable bowel syndrome (IBS) frequently occurs alongside other conditions, both in the digestive system and elsewhere in the body, including chronic fatigue syndrome and fibromyalgia. The authors explored why these conditions often happen together and what they might have in common. Understanding these connections could help doctors better recognize and treat patients who experience multiple overlapping symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

A patient's journey with myalgic encephalomyelitis.

Ong, Bie Nio, Evans, Daphne, Bartlam, Andrew·BMJ (Clinical research ed.)·2005

This study tells the personal story of one patient's experience living with ME/CFS, documenting how the illness affected their daily life, symptoms, and journey seeking medical care. Through this individual's account, the researchers highlight the real challenges people with ME/CFS face in their everyday activities and interactions with healthcare providers. The patient's narrative shows how ME/CFS impacts not just physical health, but also emotional wellbeing and social relationships.

E3 PreliminaryCommentaryPEM unclearEditorial

Supporting people with severe myalgic encephalomyelitis.

Crowhurst, Greg·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2005

This article helps nurses better understand ME/CFS, a serious condition that is often misunderstood by healthcare providers. The author describes the main symptoms people experience and discusses how healthcare services can support patients. The article emphasizes that ME/CFS is a real physical illness that needs more research to help doctors and nurses care for people with it properly.

Interventions

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Contesting stigma and contested emotions: personal experience and public perception of specific phobias.

Davidson, Joyce·Social science & medicine (1982)·2005

This study interviewed people with specific phobias (intense, irrational fears of particular objects or situations) in the UK to understand how stigma and disbelief affect their daily lives. Like ME/CFS patients, people with phobias face judgment and skepticism from doctors and the public, even though their symptoms are real and distressing. The research shows that people with phobias develop ways to cope with and manage others' dismissive attitudes toward their condition.

E3 PreliminaryCommentaryPEM unclearEditorial

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2005

This paper proposes that low magnesium levels combined with disrupted biological clocks (your body's natural 24-hour rhythm) may contribute to asthma that gets worse at night. The authors suggest that magnesium depletion is different from simple magnesium deficiency—it involves a deeper dysregulation that cannot be fixed by supplements alone. They propose two subtypes based on whether the biological clock is overactive (linked to nighttime asthma) or underactive (linked to daytime symptoms).

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: its importance in occupational medicine].

Wiszniewska, Marta, Walusiak, Jolanta, Wittczak, Tomasz et al.·Medycyna pracy·2005

This paper reviews what we know about ME/CFS, including what causes it, how it presents in patients, and how doctors can diagnose it. Since extreme tiredness appears in many different health conditions—both physical and mental—the authors explain how doctors can tell ME/CFS apart from other illnesses. The paper also covers treatment approaches and emphasizes why occupational health doctors need to understand ME/CFS to protect workers' health.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Persistent nonallergic rhinosinusitis.

Staevska, Maria, Baraniuk, James N·Current allergy and asthma reports·2005

This review describes different types of nasal and sinus inflammation that are not caused by allergies. The authors propose a new way to organize these conditions based on whether they involve certain immune cells (eosinophils or neutrophils) or other mechanisms like hormonal changes. Interestingly, they mention that nonallergic rhinitis can occur in chronic fatigue syndrome (ME/CFS) and may involve nerve-related sensitivity.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Lange, G, Steffener, J, Cook, D B et al.·NeuroImage·2005

This study used brain imaging to see what happens when people with ME/CFS listen to complex spoken information. Researchers found that people with ME/CFS could understand the information just as well as healthy people, but their brains had to work much harder to do it—using more brain regions and requiring greater effort. This provides scientific proof that the thinking and concentration difficulties ME/CFS patients report are real and visible on brain scans.

Cognitive Impairment

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

Naschitz, Jochanan E, Rozenbaum, Michael, Fields, Madeline et al.·Clinical science (London, England : 1979)·2005

Researchers developed new methods to detect specific patterns in how the body's heart rate and blood pressure respond to physical stress (tilting upright) in people with familial Mediterranean fever (FMF). They found that people with FMF show distinctive cardiovascular responses that can be measured and used to help identify the condition. The study shows this approach might also work for other diseases, including ME/CFS.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

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Coxiella burnetii infection.

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

[Chronic fatigue syndrome and multiple chemical hypersensitivity after insecticide exposure].

Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia?

Chronic fatigue syndrome is associated with diminished intracellular perforin.

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?

Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep disorder?

Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome.

Symptom overlap and comorbidity of irritable bowel syndrome with other conditions.

A patient's journey with myalgic encephalomyelitis.

Supporting people with severe myalgic encephalomyelitis.

Contesting stigma and contested emotions: personal experience and public perception of specific phobias.

Magnesium depletion with hypo- or hyper- function of the biological clock may be involved in chronopathological forms of asthma.

[Chronic fatigue syndrome: its importance in occupational medicine].

Persistent nonallergic rhinosinusitis.

Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: a BOLD fMRI study of verbal working memory.

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

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