ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5401–5420 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Practitioner review: chronic fatigue syndrome in childhood.

Elena Garralda, M, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2005

This review examines how ME/CFS appears in children and teenagers and discusses the best ways to help them recover. The authors found that ME/CFS in young people is often triggered by infections and can be diagnosed using the same criteria as in adults. They recommend a family-based approach using cognitive behavior therapy and gradually increasing activity, which has shown promise in helping children regain function.

E3 PreliminaryReviewPEM unclearReview-Narrative

A new view on hypocortisolism.

Fries, Eva, Hesse, Judith, Hellhammer, Juliane et al.·Psychoneuroendocrinology·2005

Some people with ME/CFS, fibromyalgia, and PTSD have abnormally low levels of cortisol, a stress hormone their body normally produces. This review suggests that this low cortisol may develop after the body's stress system works overtime for a long time. Interestingly, while low cortisol contributes to symptoms like fatigue, pain, and stress sensitivity, it may also provide some protective benefits to the body.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice.

Singal, Anjali, Kaur, Surinder, Tirkey, Naveen et al.·Journal of medicinal food·2005

This study tested whether green tea extract and a compound found in green tea called catechin could help reduce fatigue in mice that were forced to swim repeatedly. The researchers found that these treatments reduced signs of fatigue and lowered harmful chemical damage (oxidative stress) in the brains of fatigued mice, suggesting they might be helpful for people with ME/CFS.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.

Kaushik, N, Fear, D, Richards, S C M et al.·Journal of clinical pathology·2005

Researchers compared blood cells from 25 ME/CFS patients with 25 healthy people to see if genes were turned on or off differently. They found 16 genes with different activity levels in ME/CFS patients—most were overactive. These changes suggest problems with immune cell activation, nerve function, and how cells produce energy, which could help explain why ME/CFS causes fatigue and other symptoms.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Nijs, Jo, Van de Velde, Bart, De Meirleir, Kenny·Medical hypotheses·2005

This study proposes a theory about why ME/CFS patients experience widespread pain. The researchers suggest that a molecule called nitric oxide may cause the central nervous system (the brain and spinal cord) to become overly sensitive, amplifying pain signals throughout the body. They propose that viral infections or other pathogens associated with ME/CFS may trigger this chain reaction, and that behaviors like catastrophizing or avoiding activity may either contribute to or result from this heightened sensitivity.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Exercise prescription for individuals with chronic fatigue syndrome.

Wallman, Karen E, Morton, Alan R, Goodman, Carmel et al.·The Medical journal of Australia·2005

This review article examines how exercise should be prescribed for people with ME/CFS, looking at what is known from medical literature. The authors discuss different approaches to exercise and what safety considerations are important for this patient group. The review helps clarify when and how exercise might be appropriate for ME/CFS patients.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

Gutenbrunner, C, Linden, M, Gerdes, N et al.·Die Rehabilitation·2005

This paper discusses how chronic fatigue and exhaustion affect people undergoing rehabilitation for various medical conditions. The authors reviewed how fatigue is defined, how often it occurs in different patient groups (from 50-90% depending on the condition), and whether rehabilitation can help improve it. They suggest that fatigue symptoms do improve somewhat with rehabilitation, though some symptoms can remain.

E3 PreliminaryGuidelinePEM not requiredGuideline

[Report from the Health Council of the Netherlands on the chronic fatigue syndrome: moving away from the body-mind dichotomy with a view to effective prevention and treatment].

Bolk, J H·Nederlands tijdschrift voor geneeskunde·2005

This Dutch Health Council report recognizes ME/CFS as a real, serious illness that genuinely affects people's lives, even though doctors cannot find obvious physical signs or blood tests to confirm it. The report suggests that stress and the gap between what the body can handle and what people try to do play important roles in the condition. It recommends moving away from the idea that ME/CFS is purely 'in your head' or purely physical, and instead seeing it as involving both body and mind together.

E3 PreliminaryReviewPEM unclearReview-Narrative

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Staines, Donald R·Medical hypotheses·2005

This article explores a theory that ME/CFS and related conditions like fibromyalgia might be caused by problems with special chemical messengers in the body called vasoactive neuropeptides. These chemicals normally help control blood vessels, inflammation, and immune function. The authors suggest that if this theory is correct, several treatments might help—including replacing these chemicals, using certain medications, or modifying genes—though they emphasize this is still speculative and unproven.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.

Kerr, J R·Journal of veterinary medicine. B, Infectious diseases and veterinary public health·2005

This study examined how parvovirus B19 might trigger chronic fatigue syndrome (CFS) in some people. Researchers found that patients with prolonged symptoms after B19 infection had high levels of inflammatory chemicals in their blood, and identified certain genetic variations that may make some people more susceptible to developing CFS after B19 infection. They also discovered that the virus may persist in the body by hiding in human genes, and found that people carrying B19 virus DNA had altered expression of several genes involved in cell structure and immune function.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Glozier, N·Occupational medicine (Oxford, England)·2005

This is a detailed review article about ME/CFS written for occupational health professionals. The article examines what is known about ME/CFS, including how it affects people's ability to work, and highlights the significant gaps in our understanding of the condition. The main message is that ME/CFS remains poorly understood, which makes it difficult for doctors, employers, and patients to manage effectively.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

Tomoda, Akemi, Joudoi, Takako, Rabab, El-Mezayen et al.·Psychiatry research·2005

This study examined immune system chemicals called cytokines in people with ME/CFS compared to healthy volunteers. Researchers took blood cells from both groups and stimulated them in the laboratory to see how they would respond. They found that ME/CFS patients produced lower levels of certain immune chemicals, particularly one called TGF-beta1, which might play a role in the inflammation seen in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.

Frémont, Marc, El Bakkouri, Karim, Vaeyens, Freya et al.·Experimental and molecular pathology·2005

In ME/CFS, immune cells produce abnormal levels of proteins involved in fighting viral infections. This study found that a protective molecule called 2-5A can shield a key antiviral protein (RNase L) from being broken down by inflammatory enzymes. However, in ME/CFS patients, cells tend to produce smaller versions of 2-5A, which cannot provide this protection, leading to the accumulation of damaged RNase L protein.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Characterization of virus isolates by particle-associated nucleic acid PCR.

Stang, Alexander, Korn, Klaus, Wildner, Oliver et al.·Journal of clinical microbiology·2005

Researchers developed a new laboratory method called PAN-PCR that can identify viruses in patient samples even when standard tests fail to detect them. This technique works by finding viral genetic material protected inside virus particles and then copying and analyzing it. As a test case, they used this method on a mouth sample from a ME/CFS patient and successfully identified herpes simplex virus type 1, which had been missed by conventional testing.

E3 PreliminaryReviewPEM unclearReview-Narrative

A patient's journey with myalgic encephalomyelitis.

Ong, Bie Nio, Evans, Daphne, Bartlam, Andrew·BMJ (Clinical research ed.)·2005

This study tells the personal story of one patient's experience living with ME/CFS, documenting how the illness affected their daily life, symptoms, and journey seeking medical care. Through this individual's account, the researchers highlight the real challenges people with ME/CFS face in their everyday activities and interactions with healthcare providers. The patient's narrative shows how ME/CFS impacts not just physical health, but also emotional wellbeing and social relationships.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Drug targets in stress-related disorders.

Covelli, Vito, Passeri, Maria Elena, Leogrande, Domenica et al.·Current medicinal chemistry·2005

This review examines how stress affects both the nervous and immune systems, and explores potential drug treatments for stress-related disorders. The authors discuss how the body's stress response systems can trigger or worsen conditions like chronic fatigue syndrome (CFS), and suggest that medicines targeting immune cell activity and inflammatory chemicals may help. They found that CFS patients have different immune patterns compared to depressed patients, which could guide future treatment approaches.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Coxiella burnetii infection.

Kazar, Jan·Annals of the New York Academy of Sciences·2005

Coxiella burnetii is a bacterium that causes Q fever, a disease spread mainly through contact with infected animals like cattle, sheep, and goats. Most people infected have no symptoms or mild flu-like illness, but some develop chronic complications including chronic fatigue syndrome. This review examines how the bacterium survives in the body and causes different forms of disease depending on a person's immune system and overall health.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Aetiology and pathogenesis of chronic fatigue syndrome: a review.

Mihrshahi, Robin, Beirman, Robyn·The New Zealand medical journal·2005

This review article examines what scientists currently understand about what causes ME/CFS and how the illness develops. The authors looked at research across four main areas: infections, immune system problems, hormonal and nervous system imbalances, and mental health factors. They suggest that ME/CFS likely results from a combination of these factors rather than a single cause.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Masuda, Akinori, Kihara, Takashi, Fukudome, Tsuyoshi et al.·Journal of psychosomatic research·2005

This study followed two ME/CFS patients who tried a type of heat therapy called far-infrared sauna (heated to 60°C) combined with warming afterward. After about 15-25 sessions, both patients reported major improvements in fatigue, pain, sleep problems, and fever. They continued the therapy once or twice a week for a year and did not get worse, even after stopping their previous medication.

Pain and SensitizationSleep

E3 PreliminaryBehavioralPEM not requiredCase-Control

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

Shin, Yong-Il, Lee, Myeong Soo·The American journal of Chinese medicine·2005

This study looked at whether Qi therapy (a hands-on energy-based technique from traditional Chinese medicine) might help people with ME/CFS feel better. Two patients who received Qi therapy reported feeling more mentally relaxed and found it easier to cope with their pain and tiredness. While these are only two cases and more research is needed, the results suggest Qi therapy might be worth studying further as a complementary approach.

Pain and Sensitization

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Practitioner review: chronic fatigue syndrome in childhood.

A new view on hypocortisolism.

Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice.

Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.

Pain in patients with chronic fatigue syndrome: does nitric oxide trigger central sensitisation?

Exercise prescription for individuals with chronic fatigue syndrome.

[Significance of the chronic fatigue syndrome in rehabilitation medicine--status and perspectives].

[Report from the Health Council of the Netherlands on the chronic fatigue syndrome: moving away from the body-mind dichotomy with a view to effective prevention and treatment].

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.

Characterization of virus isolates by particle-associated nucleic acid PCR.

A patient's journey with myalgic encephalomyelitis.

Drug targets in stress-related disorders.

Coxiella burnetii infection.

Aetiology and pathogenesis of chronic fatigue syndrome: a review.

The effects of repeated thermal therapy for two patients with chronic fatigue syndrome.

Qi therapy (external qigong) for chronic fatigue syndrome: case studies.

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