ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5381–5400 of 6,211 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Takahashi, Takashi, Yu, Fei, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2006

Researchers gave mice a brewer's yeast extract to see if it could help restore activity levels in a mouse model of ME/CFS. Mice treated with the yeast extract showed significantly better activity levels compared to untreated mice, and the treated mice also had better survival rates. The study suggests that brewer's yeast extract may help by adjusting immune system responses that become imbalanced in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

Lundell, Kathleen, Qazi, Sanjive, Eddy, Linda et al.·Arzneimittel-Forschung·2006

This study looked at 58 ME/CFS patients and found that most had weakened immune systems with low levels of a type of immune cell called B-lymphocytes, and most also had reactivated Epstein-Barr virus (EBV) infection. When researchers gave patients folinic acid (a form of vitamin B), about 81% reported feeling better. The findings suggest that folinic acid might help some ME/CFS patients and that immune problems may play a role in the illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Staines, Donald R·Clinical & developmental immunology·2006

This paper proposes that ME/CFS and similar conditions may develop when the immune system mistakenly attacks certain chemical messengers in the body called vasoactive neuropeptides (VNs). These VNs normally help control heart rate, breathing, temperature, memory, and mood. The authors suggest that after infections or other triggers, people's bodies may lose the ability to recognize these messengers as 'self,' leading to immune attacks that could cause the widespread symptoms seen in ME/CFS.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome.

Goertzel, Benjamin N, Pennachin, Cassio, de Souza Coelho, Lucio et al.·Pharmacogenomics·2006

Researchers looked at genetic variations (called SNPs) in genes related to stress hormones and brain chemistry to see if they could predict who has ME/CFS. Using patterns from 28 specific genetic variants, they correctly identified ME/CFS in about 76% of patients tested. This suggests that genetics play a role in ME/CFS, though genes are not the whole story.

Endocrine Disruption

E3 PreliminaryCommentaryPEM not requiredEditorial

Challenges for molecular profiling of chronic fatigue syndrome.

Vernon, Suzanne D, Whistler, Toni, Aslakson, Eric et al.·Pharmacogenomics·2006

This paper discusses why it's been difficult for scientists to find reliable blood tests (biomarkers) to diagnose ME/CFS and develop treatments. The authors explain that ME/CFS is complex because it affects many body systems at once, and each researcher may focus on different areas based on their expertise. They suggest that blood tests show promise for understanding ME/CFS and that combining genetic information, protein data, and information about patients' environments and behaviors could help researchers better understand why different patients experience the illness differently.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Maoz, Daniel, Shoenfeld, Yehuda·Harefuah·2006

ME/CFS is a serious illness that causes extreme tiredness and other symptoms that interfere with daily life. Doctors often fail to diagnose it correctly, and we still don't fully understand what causes it. This review suggests that ME/CFS likely results from multiple different factors working together, and that two treatments—cognitive behavioral therapy and graded exercise therapy—might help some patients.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Ablin, Jacob N, Shoenfeld, Yehuda, Buskila, Dan·Journal of autoimmunity·2006

This review examines whether infections and vaccinations might trigger fibromyalgia and related conditions like chronic fatigue syndrome. Researchers found that certain infections (like Lyme disease and hepatitis C) have been linked to fibromyalgia, and some people report symptoms starting after vaccinations, but antibiotics and antivirals don't appear to help treat fibromyalgia effectively. The authors suggest that vaccinations might act as one trigger among several factors that together cause these conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome and its diagnosis in internal medicine].

Barbado Hernández, F J, Gómez Cerezo, J, López Rodríguez, M et al.·Anales de medicina interna (Madrid, Spain : 1984)·2006

This article reviews how chronic fatigue syndrome (ME/CFS) is diagnosed and understood within internal medicine practice. The authors discuss the clinical features, diagnostic criteria, and challenges that doctors face when identifying ME/CFS in patients. The paper helps physicians recognize and properly diagnose this condition in their everyday practice.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Immunological dysfunction, vaccination and Gulf War illness.

Peakman, Mark, Skowera, Ania, Hotopf, Matthew·Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2006

This study investigated whether vaccines given to soldiers during the Gulf War might have caused Gulf War illness, a condition similar to ME/CFS. Researchers looked at both epidemiological data (patterns of illness across groups) and immune system studies from veterans. They found a weak link between multiple vaccines and illness, but could not find evidence that vaccines changed the immune system in a way that would explain the illness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The problem of fatigue in neurological disorders].

Kumor, Klaudiusz, Pierzchała, Krystyna·Wiadomosci lekarskie (Warsaw, Poland : 1960)·2006

Fatigue is an extremely common and often severely disabling symptom in many neurological disorders, affecting 40–90% of patients with conditions like multiple sclerosis, Parkinson's disease, and stroke. This review explains that fatigue is a real medical symptom that should be carefully distinguished from depression, weakness, and sleepiness, though these conditions often occur together. Currently, doctors assess fatigue mainly through patient questionnaires, and there is no clear biological test or proven cure—treatments focus on addressing the underlying disease and using behavioral and psychological approaches.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Gene expression profile of empirically delineated classes of unexplained chronic fatigue.

Carmel, Liran, Efroni, Sol, White, Peter D et al.·Pharmacogenomics·2006

Researchers examined genes in blood samples from 111 women with unexplained chronic fatigue to see if different types of fatigue had different gene patterns. They used computer analysis to identify specific genes that were active or inactive in different fatigue groups. They found that certain genes were consistently different between fatigued and healthy people, while other genes only differed in specific fatigue subgroups.

Biomarkers

E3 PreliminaryCohortPEM unclearObservational

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Whitehead, Lisa Claire·Social science & medicine (1982)·2006

This study looked at how 17 people with ME/CFS describe their illness and make sense of it. Researchers found that people often go through different ways of telling their story: first trying to get back to normal (restitution), then feeling overwhelmed by chaos, and eventually finding new meaning in their lives (quest narrative). Understanding these patterns helps explain how people cope with a long-term illness that's hard to diagnose and often misunderstood.

E3 PreliminaryMechanismPEM not requiredMechanistic

Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis.

Ito, N, Nagai, T, Yabe, T et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology·2006

This study tested whether Koso-san, a traditional Japanese herbal medicine, could help reduce depression-like symptoms in mice exposed to stress. Mice given Koso-san showed improved behavior in stress tests, and the herb appeared to normalize stress hormone systems in their brains that were overactive due to the stress exposure.

Endocrine Disruption

E3 PreliminaryPEM unclear

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Teitelbaum, Jacob E, Johnson, Clarence, St Cyr, John·Journal of alternative and complementary medicine (New York, N.Y.)·2006

Researchers gave 41 patients with ME/CFS or fibromyalgia a natural sugar called D-ribose to see if it could help their symptoms. Two-thirds of patients reported feeling noticeably better, with improvements in energy, sleep, mental clarity, pain, and overall well-being. The supplement was well-tolerated with no serious side effects reported.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Highlights from 5th International Conference on HHV-6 and -7.

Komaroff, Anthony L, Jacobson, Steven, Ablashi, Dharam V et al.·Herpes : the journal of the IHMF·2006

Scientists at an international conference discussed new tests to detect two common viruses (HHV-6 and HHV-7) in the body and whether they might trigger nervous system diseases. These viruses can infect brain cells, and researchers think they may play a role in conditions like chronic fatigue syndrome, along with multiple sclerosis and other neurological problems. Better tests are being developed to tell if someone has an active infection or just carries the virus dormant.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--exercise and physical activity].

Greenberg, Shai, Frid, Mordechai·Harefuah·2006

People with ME/CFS often feel extremely tired and struggle with physical activity, experiencing worsening symptoms even after light exercise. This review found that ME/CFS patients typically have lower fitness levels, their hearts work harder during normal activity, and they take longer to recover than healthy people. The good news is that carefully guided exercise programs appear to be the most helpful treatment for improving energy levels, physical function, and daily life activities.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Iasiukiavichene, L, Vasiliauskas, D·Kardiologiia·2006

This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCase-Control

[Multiple chemical sensitivity in sick-building syndrome].

Arnold Llamosas, Pablo A, Arrizabalaga Clemente, Pilar, Bonet Agusti, Montserrat et al.·Medicina clinica·2006

This study describes a dialysis worker who developed severe chronic fatigue and chemical sensitivities after prolonged exposure to poor indoor air quality in a poorly ventilated building. The person experienced eye irritation, breathing problems, and other symptoms that improved when the environmental conditions were examined and their connection to the illness was confirmed. The case highlights that healthcare facilities can expose workers to unhealthy air and chemical environments that may trigger ME/CFS-like illnesses.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredObservational

Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis.

Fostel, Jennifer, Boneva, Roumiana, Lloyd, Andrew·Pharmacogenomics·2006

Researchers used blood tests and symptom questionnaires to look for biological markers that could help identify ME/CFS. They found that ME/CFS involves multiple symptom patterns (fatigue and mood changes being most prominent) and identified 57 genes whose activity differed between people with severe symptoms and those with mild symptoms. However, no single gene or blood test on its own clearly identifies the disease.

Biomarkers

E3 PreliminaryCohortPEM not requiredCross-Sectional

Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study.

Tanaka, Masaaki, Sadato, Norihiro, Okada, Tomohisa et al.·BMC neurology·2006

Researchers used brain imaging to compare how the brains of ME/CFS patients and healthy people responded to sounds while doing a tiring visual task. They found that healthy people's brains stayed responsive to sounds during the task, but ME/CFS patients' brains showed reduced responses to sounds—and this reduction matched how fatigued the patients felt. This suggests that ME/CFS may involve the brain becoming less able to process information that isn't directly related to the main task at hand.

Cognitive Impairment

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis.

Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome.

Challenges for molecular profiling of chronic fatigue syndrome.

[Chronic fatigue syndrome].

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

[The chronic fatigue syndrome and its diagnosis in internal medicine].

Immunological dysfunction, vaccination and Gulf War illness.

[The problem of fatigue in neurological disorders].

Gene expression profile of empirically delineated classes of unexplained chronic fatigue.

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Highlights from 5th International Conference on HHV-6 and -7.

[Chronic fatigue syndrome--exercise and physical activity].

[Chronic fatigue syndrome in cardiology neurohumoral changes].

[Multiple chemical sensitivity in sick-building syndrome].

Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis.

Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research