ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5361–5380 of 6,165 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Ablin, Jacob N, Shoenfeld, Yehuda, Buskila, Dan·Journal of autoimmunity·2006

This review examines whether infections and vaccinations might trigger fibromyalgia and related conditions like chronic fatigue syndrome. Researchers found that certain infections (like Lyme disease and hepatitis C) have been linked to fibromyalgia, and some people report symptoms starting after vaccinations, but antibiotics and antivirals don't appear to help treat fibromyalgia effectively. The authors suggest that vaccinations might act as one trigger among several factors that together cause these conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

Lundell, Kathleen, Qazi, Sanjive, Eddy, Linda et al.·Arzneimittel-Forschung·2006

This study looked at 58 ME/CFS patients and found that most had weakened immune systems with low levels of a type of immune cell called B-lymphocytes, and most also had reactivated Epstein-Barr virus (EBV) infection. When researchers gave patients folinic acid (a form of vitamin B), about 81% reported feeling better. The findings suggest that folinic acid might help some ME/CFS patients and that immune problems may play a role in the illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

Kasatkin, D S, Spirin, N N·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2006

This review describes how fatigue in multiple sclerosis (MS) can happen in different ways: tiredness even at rest, exhaustion during activity, and fatigue linked to MS flare-ups. The authors explain that fatigue likely involves both brain-based and body-based mechanisms, and often occurs alongside depression and sleep problems, suggesting these conditions may share common biological causes related to brain chemicals like serotonin.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Q fever.

Parker, Neil R, Barralet, Jennifer H, Bell, Alan Morton·Lancet (London, England)·2006

Q fever is an infection spread from animals to humans that usually causes flu-like symptoms, pneumonia, and liver inflammation. While most people recover on their own, some develop serious heart infections or long-term complications including chronic fatigue syndrome. This review describes Q fever's various presentations and available vaccines, with notes that awareness and symptoms vary by region.

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

Glass, Jennifer M·Current rheumatology reports·2006

Many people with fibromyalgia and chronic fatigue syndrome report problems with memory and thinking clearly. When researchers tested these patients' cognitive abilities, they found real difficulties with memory and how quickly patients process information. Brain imaging studies showed that patients' brains work differently during thinking tasks, requiring more activation than expected.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Devanur, L D, Kerr, J R·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

ME/CFS affects about 1 in 100 to 1 in 250 people worldwide and is diagnosed based on clinical symptoms after ruling out other diseases. Research shows that ME/CFS likely involves multiple factors: immune system problems, stress, infections (such as Epstein-Barr virus), and exposure to certain chemicals or toxins. Currently there is no proven cure, but treating underlying infections may help some patients.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Causes of death among patients with chronic fatigue syndrome.

Jason, Leonard A, Corradi, Karina, Gress, Sara et al.·Health care for women international·2006

This study looked at 166 people with ME/CFS who had passed away to understand what caused their deaths. The researchers found that heart failure, suicide, and cancer were the three leading causes, together accounting for nearly 60% of deaths. Notably, people with ME/CFS who died from cancer or suicide were much younger—in their late 30s to mid-40s—compared to people in the general population who died from these same causes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The problem of fatigue in neurological disorders].

Kumor, Klaudiusz, Pierzchała, Krystyna·Wiadomosci lekarskie (Warsaw, Poland : 1960)·2006

Fatigue is an extremely common and often severely disabling symptom in many neurological disorders, affecting 40–90% of patients with conditions like multiple sclerosis, Parkinson's disease, and stroke. This review explains that fatigue is a real medical symptom that should be carefully distinguished from depression, weakness, and sleepiness, though these conditions often occur together. Currently, doctors assess fatigue mainly through patient questionnaires, and there is no clear biological test or proven cure—treatments focus on addressing the underlying disease and using behavioral and psychological approaches.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Takahashi, Takashi, Yu, Fei, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2006

Researchers gave mice a brewer's yeast extract to see if it could help restore activity levels in a mouse model of ME/CFS. Mice treated with the yeast extract showed significantly better activity levels compared to untreated mice, and the treated mice also had better survival rates. The study suggests that brewer's yeast extract may help by adjusting immune system responses that become imbalanced in ME/CFS.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Challenges for molecular profiling of chronic fatigue syndrome.

Vernon, Suzanne D, Whistler, Toni, Aslakson, Eric et al.·Pharmacogenomics·2006

This paper discusses why it's been difficult for scientists to find reliable blood tests (biomarkers) to diagnose ME/CFS and develop treatments. The authors explain that ME/CFS is complex because it affects many body systems at once, and each researcher may focus on different areas based on their expertise. They suggest that blood tests show promise for understanding ME/CFS and that combining genetic information, protein data, and information about patients' environments and behaviors could help researchers better understand why different patients experience the illness differently.

Diagnostics

E3 PreliminaryMechanismPEM unclearCross-Sectional

Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

Smith, Alicia K, White, Peter D, Aslakson, Eric et al.·Pharmacogenomics·2006

This study looked at whether different genetic variations in the stress-response system (HPA axis) and mood-related brain chemistry might explain why ME/CFS affects people differently. Researchers identified five distinct subgroups of people with chronic fatigue and found that three of these groups had different versions of specific genes compared to healthy people, suggesting that ME/CFS may not be one disease but rather several different conditions with different underlying genetic causes.

Endocrine Disruption

E3 PreliminaryCohortPEM unclearCase-Control

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Toda, Katsuhiro, Kimura, Hiroaki·Hiroshima journal of medical sciences·2006

This case report describes one 28-year-old man with ME/CFS who was treated with a medication called Neurotropin (four tablets daily). His fatigue and widespread pain began improving within a week, and his sleep, focus, and memory improved within two weeks. He stopped taking the medication after 11 weeks and remained symptom-free for at least 5 months afterward.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Staines, Donald R·Medical hypotheses·2005

This article explores a theory that ME/CFS and related conditions like fibromyalgia might be caused by problems with special chemical messengers in the body called vasoactive neuropeptides. These chemicals normally help control blood vessels, inflammation, and immune function. The authors suggest that if this theory is correct, several treatments might help—including replacing these chemicals, using certain medications, or modifying genes—though they emphasize this is still speculative and unproven.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

Glozier, N·Occupational medicine (Oxford, England)·2005

This is a detailed review article about ME/CFS written for occupational health professionals. The article examines what is known about ME/CFS, including how it affects people's ability to work, and highlights the significant gaps in our understanding of the condition. The main message is that ME/CFS remains poorly understood, which makes it difficult for doctors, employers, and patients to manage effectively.

E3 PreliminaryReviewPEM unclearReview-Narrative

A new view on hypocortisolism.

Fries, Eva, Hesse, Judith, Hellhammer, Juliane et al.·Psychoneuroendocrinology·2005

Some people with ME/CFS, fibromyalgia, and PTSD have abnormally low levels of cortisol, a stress hormone their body normally produces. This review suggests that this low cortisol may develop after the body's stress system works overtime for a long time. Interestingly, while low cortisol contributes to symptoms like fatigue, pain, and stress sensitivity, it may also provide some protective benefits to the body.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

A patient's journey with myalgic encephalomyelitis.

Ong, Bie Nio, Evans, Daphne, Bartlam, Andrew·BMJ (Clinical research ed.)·2005

This study tells the personal story of one patient's experience living with ME/CFS, documenting how the illness affected their daily life, symptoms, and journey seeking medical care. Through this individual's account, the researchers highlight the real challenges people with ME/CFS face in their everyday activities and interactions with healthcare providers. The patient's narrative shows how ME/CFS impacts not just physical health, but also emotional wellbeing and social relationships.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

Nijs, Jo, De Meirleir, Kenny·In vivo (Athens, Greece)·2005

This study looks at a specific immune system pathway called the 2-5A synthetase/RNase L pathway that may be broken in ME/CFS patients. Researchers found that in ME/CFS, this pathway is overactive but also working improperly—it's being broken down into unusual pieces instead of functioning normally. This abnormal pathway appears connected to reduced natural killer cell function and problems with how cells die when they should.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Exercise prescription for individuals with chronic fatigue syndrome.

Wallman, Karen E, Morton, Alan R, Goodman, Carmel et al.·The Medical journal of Australia·2005

This review article examines how exercise should be prescribed for people with ME/CFS, looking at what is known from medical literature. The authors discuss different approaches to exercise and what safety considerations are important for this patient group. The review helps clarify when and how exercise might be appropriate for ME/CFS patients.

E3 PreliminaryCohortPEM not requiredCase-Control

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Mears, Tim·Acupuncture in medicine : journal of the British Medical Acupuncture Society·2005

This case report describes one patient with ME/CFS (chronic fatigue syndrome) who received electroacupuncture treatment. While the acupuncture did not cure the condition, the patient reported significant symptom improvement and was eventually able to return to work. This is one of the first published studies looking at how acupuncture might help ME/CFS patients.

Interventions

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Improving the diagnostic criteria and procedures for chronic fatigue syndrome.

King, Caroline, Jason, Leonard A·Biological psychology·2005

Doctors have used different definitions to diagnose ME/CFS since 1988, but these definitions were never tested scientifically to see if they actually work well. This study compared 15 people with ME/CFS, 15 with depression, and 15 healthy people to find better ways to diagnose ME/CFS. The researchers found that adding new symptoms, measuring how severe symptoms are, and using specific tests could help doctors diagnose ME/CFS more accurately.

Diagnostics

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Evidence Atlas

Evidence browser

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

Q fever.

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: new trends and future directions.

Chronic fatigue syndrome.

Causes of death among patients with chronic fatigue syndrome.

[The problem of fatigue in neurological disorders].

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Challenges for molecular profiling of chronic fatigue syndrome.

Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders.

Chronic fatigue syndrome: it's tiring not knowing much--an in-depth review for occupational health professionals.

A new view on hypocortisolism.

A patient's journey with myalgic encephalomyelitis.

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

Exercise prescription for individuals with chronic fatigue syndrome.

Acupuncture in the treatment of post viral fatigue syndrome--a case report.

Improving the diagnostic criteria and procedures for chronic fatigue syndrome.

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Metabolism & Mitochondria

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