ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5761–5780 of 6,211 studies

E3 PreliminaryMechanismPEM not requiredCase-Control

Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome.

Vojdani, A, Lapp, C W·Immunopharmacology and immunotoxicology·1999

This study found that certain immune proteins called 2-5A and PKR are elevated in the blood of ME/CFS patients, whether their illness was triggered by a viral infection or chemical exposure. The researchers discovered that these two triggers activate these proteins through different biological pathways—viruses primarily use an immune signaling molecule called interferon-beta, while chemicals activate them mainly through heat shock proteins.

BiomarkersImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: current concepts of pathogenesis and treatment.

Lloyd, A R, Hickie, I, Peterson, P K·Current clinical topics in infectious diseases·1999

This review article examines what scientists understood in 1999 about how ME/CFS develops and what treatments might help. The authors synthesize existing knowledge about the condition's causes, which involve the immune system, infections, and other body system changes. They discuss various approaches to managing symptoms and improving function for people living with ME/CFS.

Interventions

E3 PreliminaryCohortPEM not requiredCase-Control

Recognition of chronic carbon monoxide poisoning.

Knobeloch, L, Jackson, R·WMJ : official publication of the State Medical Society of Wisconsin·1999

This study describes three families in Wisconsin whose members were diagnosed with chronic fatigue syndrome, depression, and other illnesses that turned out to be caused by carbon monoxide leaks from faulty home heating systems. The families' symptoms—including fatigue, headaches, dizziness, and confusion—went undiagnosed until heating contractors found the problem. The authors remind doctors to consider carbon monoxide poisoning when patients have vague, ongoing symptoms, especially during winter.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The neuroendocrinology of chronic fatigue syndrome: focus on the hypothalamic-pituitary-adrenal axis.

Scott, L V, Dinan, T G·Functional neurology·1999

This study examined how the stress-response system in the brain works differently in people with ME/CFS. The researchers focused on the hypothalamic-pituitary-adrenal (HPA) axis, which is the body's main system for managing stress and producing cortisol. The study reviewed evidence suggesting this system may not function normally in ME/CFS patients, potentially contributing to their symptoms.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCase-Control

Monitoring and assessing symptoms of chronic fatigue syndrome: use of time series regression.

Jason, L A, Tryon, W W, Taylor, R R et al.·Psychological reports·1999

This study asked one person with ME/CFS to track their symptoms hourly and daily to understand what makes fatigue better or worse. Researchers found that energy levels, physical activity, and mental effort were closely connected to how tired the person felt. This detailed tracking method could help doctors and researchers better understand ME/CFS patterns.

E3 PreliminaryGuidelinePEM not requiredGuideline

[Symptomatic and concurrent depressions].

Terra, J L·La Revue du praticien·1999

This paper explains that when people have depression, they often also have other mental health or physical health problems at the same time. Examples include anxiety disorders, alcohol use problems, eating disorders, and medical conditions like heart disease, cancer, and chronic fatigue syndrome. The authors provide guidance to help doctors decide which condition to treat first when someone has multiple problems occurring together.

E3 PreliminaryReviewPEM unclearReview-Narrative

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Wessely, S, Hotopf, M·Bailliere's best practice & research. Clinical rheumatology·1999

This research article examines whether fibromyalgia is truly a separate disease or whether it's actually similar to other conditions like ME/CFS, irritable bowel syndrome, and chronic chest pain. The authors reviewed historical records, clinical observations, and population-level data and concluded that fibromyalgia shares many features with other unexplained illnesses rather than being completely distinct.

E3 PreliminaryPEM unclear

Case of chronic fatigue syndrome after Crimean war and Indian mutiny.

Jones, E, Wessely, S·BMJ (Clinical research ed.)·1999

This historical research paper examines cases of chronic fatigue syndrome (then called different names) that occurred in soldiers during the Crimean War and Indian Mutiny in the 1800s. The authors looked back at medical records from these time periods to document how fatigue illnesses affected military personnel. This work shows that ME/CFS-like conditions are not new to modern times but have been documented for well over a century.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome.

De Becker, P, De Meirleir, K, Joos, E et al.·Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1999

This study tested how the adrenal glands respond to a hormone signal in ME/CFS patients compared to healthy people. Researchers gave a hormone called ACTH to 22 ME/CFS patients and 14 healthy controls, then measured DHEA levels over an hour. While starting DHEA levels were normal, ME/CFS patients showed a weaker increase in DHEA after the hormone injection compared to healthy controls.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

[Autoimmune fatigue syndrome and fibromyalgia syndrome].

Itoh, Y, Igarashi, T, Tatsuma, N et al.·Nihon Ika Daigaku zasshi·1999

This study looked at two patients who were initially thought to have autoimmune fatigue syndrome (a condition where the immune system may attack the body and cause tiredness) but were later found to have fibromyalgia (widespread muscle pain and tender points). The researchers wondered if these two conditions might be related, so they checked how many tender points fibromyalgia patients had and looked at their immune markers. They found that patients with certain immune patterns had more tender points, suggesting autoimmunity might play a role in both conditions.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Acute effects of thirty minutes of light-intensity, intermittent exercise on patients with chronic fatigue syndrome.

Clapp, L L, Richardson, M T, Smith, J F et al.·Physical therapy·1999

This study looked at whether 30 minutes of light, on-and-off walking on a treadmill would make symptoms worse in people with ME/CFS. Ten participants did 10 short 3-minute walks with 3-minute rest breaks in between. The researchers found that this type of gentle, intermittent exercise did not worsen symptoms immediately or up to a week afterward.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM not requiredGuideline

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians.

Godwin, M, Delva, D, Miller, K et al.·Canadian family physician Medecin de famille canadien·1999

This guideline helps family doctors systematically evaluate adults who come to them complaining of fatigue lasting less than 6 months. Rather than ordering many expensive tests, the guidelines recommend doctors first talk with patients about their symptoms and do a physical exam, paying special attention to psychological and social factors that might cause tiredness. The guideline then tells doctors which tests to consider based on what they find.

E3 PreliminaryMechanismPEM not requiredObservational

Patterns of waking EEG spectral power in chemically intolerant individuals during repeated chemical exposures.

Bell, I R, Szarek, M J, Dicenso, D R et al.·The International journal of neuroscience·1999

Some people experience discomfort or symptoms from exposure to low levels of chemicals and odors. This study measured brain electrical activity (EEG) in people with chemical intolerance before and after exposure to mild chemical odors across two sessions. Researchers found that people with chemical intolerance who had made major lifestyle changes showed different brain patterns than those who hadn't, suggesting the brain may become increasingly sensitive to these exposures over time.

Pain and Sensitization

E3 PreliminaryCohortPEM unclearCase-Control

Managing chronic fatigue syndrome: overview and case study.

Jason, L A, Melrose, H, Lerman, A et al.·AAOHN journal : official journal of the American Association of Occupational Health Nurses·1999

This study explains 'envelope theory,' a practical approach where people with ME/CFS stay within their energy limits to avoid crashes and gradually build tolerance. By tracking energy levels over time, patients and doctors can better understand each person's unique patterns and what activities trigger setbacks.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM not requiredGuideline

Social Security Ruling, SSR 99-2p.; titles II and XVI; evaluating cases involving chronic fatigue syndrome (CFS). Social Security Administration. Notice of Social Security ruling.

Federal register·1999

The Social Security Administration issued an official ruling in 1999 to help people with ME/CFS get disability benefits. The ruling states that ME/CFS is a real medical condition that can prevent someone from working, but only when doctors find specific signs or lab results that support the diagnosis. This ruling was meant to make sure all disability examiners across the country evaluate ME/CFS cases using the same fair standards.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome--a clinical entity or a complex of symptoms of various pathologic conditions].

Magdić, B, Ilić, T, Jovankić, O et al.·Vojnosanitetski pregled·1999

This paper examines whether ME/CFS is a single distinct disease or whether it might actually be a collection of different medical conditions that share similar symptoms. The authors review the clinical characteristics and evidence to help determine what ME/CFS really is from a medical standpoint.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunological aspects of pathophysiology of chronic fatigue syndrome].

Matsumoto, Y·Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·1999

This study examined how the immune system functions differently in people with ME/CFS compared to healthy individuals. The researchers looked at various immune markers to understand what might be going wrong in the body during this illness. This type of research helps scientists figure out whether ME/CFS is caused by immune system problems.

Immune System

E3 PreliminaryPEM not requiredRegistry-Resource

The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment.

Buchwald, D, Herrell, R, Ashton, S et al.·Twin research : the official journal of the International Society for Twin Studies·1999

Researchers created a registry of twin pairs where at least one person had chronic fatigue to better understand the condition. They recruited 204 twin pairs through support groups, doctors, and other sources, and had 177 complete their detailed questionnaires and phone interviews. This registry was designed to help scientists study what causes chronic fatigue and whether genetics or life circumstances play a bigger role.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Cognitive behavior therapy for chronic fatigue syndrome: a case study.

Prins, J B, Bleijenberg, G·Journal of behavior therapy and experimental psychiatry·1999

This study followed one 26-year-old woman with ME/CFS who received cognitive behavior therapy (CBT)—a type of talk therapy focused on changing unhelpful thinking patterns and behaviors. Over 33 months, she worked with therapists on topics like building a sense of control, managing physical activity carefully, and reducing worry about her body. By the end, her fatigue and ability to function improved significantly, moving from very severe to levels similar to healthy people.

E3 PreliminaryCohortPEM not requiredCase-Control

Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome.

Rowe, P C, Barron, D F, Calkins, H et al.·The Journal of pediatrics·1999

This study looked at 12 teenagers who had both ME/CFS and a connective tissue condition called Ehlers-Danlos syndrome (EDS). All of them also experienced problems with blood pressure and heart rate when standing up (orthostatic intolerance). The researchers found that abnormal connective tissue in blood vessels may cause blood to pool in the legs when standing, which could explain why these conditions often occur together.

Autonomic Nervous System

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Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome.

Chronic fatigue syndrome: current concepts of pathogenesis and treatment.

Recognition of chronic carbon monoxide poisoning.

The neuroendocrinology of chronic fatigue syndrome: focus on the hypothalamic-pituitary-adrenal axis.

Monitoring and assessing symptoms of chronic fatigue syndrome: use of time series regression.

[Symptomatic and concurrent depressions].

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Case of chronic fatigue syndrome after Crimean war and Indian mutiny.

Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome.

[Autoimmune fatigue syndrome and fibromyalgia syndrome].

Acute effects of thirty minutes of light-intensity, intermittent exercise on patients with chronic fatigue syndrome.

Investigating fatigue of less than 6 months' duration. Guidelines for family physicians.

Patterns of waking EEG spectral power in chemically intolerant individuals during repeated chemical exposures.

Managing chronic fatigue syndrome: overview and case study.

Social Security Ruling, SSR 99-2p.; titles II and XVI; evaluating cases involving chronic fatigue syndrome (CFS). Social Security Administration. Notice of Social Security ruling.

[The chronic fatigue syndrome--a clinical entity or a complex of symptoms of various pathologic conditions].

[Immunological aspects of pathophysiology of chronic fatigue syndrome].

The Chronic Fatigue Twin Registry: method of construction, composition, and zygosity assignment.

Cognitive behavior therapy for chronic fatigue syndrome: a case study.

Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome.

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