ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5781–5800 of 6,188 studies

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Hormonal influences on stress-induced neutrophil mobilization in health and chronic fatigue syndrome.

Cannon, J G, Angel, J B, Abad, L W et al.·Journal of clinical immunology·1998

Researchers compared how the bodies of women with ME/CFS and healthy women respond to exercise, focusing on immune cells called neutrophils and stress hormones. Both groups showed similar increases in neutrophils after 15 minutes of stepping exercise. However, in healthy women, the neutrophil response was linked to hormone levels (like cortisol and progesterone), while these connections were absent in women with ME/CFS—suggesting their hormonal regulation of immune cells may work differently.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.

Demitrack, M A, Crofford, L J·Annals of the New York Academy of Sciences·1998

This study found that people with ME/CFS have reduced activity in their stress-response system—a network in the brain called the HPA axis that normally helps the body cope with physical and emotional challenges. The researchers discovered that this underactive response pattern is different from what happens in depression, and it may explain why stress and exertion worsen ME/CFS symptoms. The findings suggest that problems with specific brain chemicals involved in stress regulation may contribute to the condition.

Endocrine Disruption

E3 PreliminaryCommentaryPEM unclearEditorial

Silicone breast implants and autoimmune disease.

Brown, S L, Langone, J J, Brinton, L A·Journal of the American Medical Women's Association (1972)·1998

In 1992, the FDA paused approval of silicone breast implants due to safety concerns, particularly worries about autoimmune diseases like scleroderma. This editorial reviews studies conducted since then and finds that while large increases in connective tissue disease overall were ruled out, studies were too small to detect rare diseases. The authors note that new methodologies for studying conditions like fibromyalgia and chronic fatigue syndrome might help answer whether implants cause a specific syndrome.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Newman, Michael E., Shapira, Baruch, Lerer, Bernard·The international journal of neuropsychopharmacology·1998

This review examines a test called the fenfluramine challenge test, which measures how well the brain's serotonin system is working by looking at prolactin levels after taking fenfluramine. The researchers found that people with depression typically had a blunted (reduced) prolactin response, and that some people with chronic fatigue syndrome might have had an enhanced response, though not many studies existed in this group.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a review for clinicians.

Goshorn, R K·Seminars in neurology·1998

This review explains that ME/CFS is a real condition characterized by long-lasting fatigue, muscle and joint pain, sleep problems, and thinking difficulties. While doctors don't yet fully understand what causes ME/CFS, research suggests it involves subtle problems with the nervous system, hormones, and immune function. Treatment focuses on managing symptoms to help patients feel better, though the approach is personalized since every patient is different.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Natural killer cells and natural killer cell activity in chronic fatigue syndrome.

Whiteside, T L, Friberg, D·The American journal of medicine·1998

This study examines natural killer (NK) cells—white blood cells that help fight infections and abnormal cells—in people with ME/CFS. The researchers found that many ME/CFS patients have lower-than-normal NK cell activity. The study explores why this happens and how it might be related to the disease, while also noting that findings have been difficult to confirm across different studies.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Sawada, M et al.·International journal of molecular medicine·1998

This study found that most ME/CFS patients in Japan had lower-than-normal levels of a hormone called DHEA-S, which is made by the adrenal glands. DHEA-S helps regulate mood, memory, stress response, sleep, and anxiety. The researchers suggest that low DHEA-S levels might explain some of the brain-related symptoms ME/CFS patients experience, like depression and cognitive problems.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome.

Crofford, L J·Zeitschrift fur Rheumatologie·1998

This review examines the stress response system (HPA axis) in fibromyalgia and chronic fatigue syndrome. The authors suggest that problems with this stress system may be connected to common symptoms like pain, exhaustion, sleep problems, and mood changes. Several treatments that help patients—including exercise and certain antidepressants—appear to work partly by affecting this stress response system.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

See, D M, Cimoch, P, Chou, S et al.·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1998

This study tested whether a supplement containing eight specific sugars (called glyconutrients) could help fix immune system problems in ME/CFS patients. Researchers added the supplement to immune cells from ME/CFS patients and healthy controls in a laboratory dish and measured whether it improved immune function. The supplement appeared to increase the activity of several types of immune cells and reduce cell death in ME/CFS patients' immune cells.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Fibromyalgia. A critical review].

Cathébras, P, Lauwers, A, Rousset, H·Annales de medecine interne·1998

Fibromyalgia is a chronic pain condition that affects about 2% of the general population, with symptoms including widespread pain, fatigue, and sleep problems. This review examines how fibromyalgia overlaps with other conditions like ME/CFS and depression, and discusses why current treatments like antidepressants and therapy have limited effectiveness. The authors suggest that fibromyalgia may develop through interconnected factors rather than a single cause.

SleepDiagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Future directions in exercise and immunology: regulation and integration.

Mackinnon, L T·International journal of sports medicine·1998

This editorial discusses how exercise affects the immune system and raises important questions for future research. It explores whether athletes' bodies are actually fighting infections less effectively, whether reducing certain immune responses might sometimes be helpful, and how exercise training might help people with conditions like chronic fatigue syndrome improve their immune function.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Pathogenesis of chronic fatigue syndrome and fibromyalgia.

Klimas, N·Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·1998

This 1998 review article explores how ME/CFS and fibromyalgia may develop, focusing on potential biological mechanisms in the body. The researchers, led by Dr. Nancy Klimas, examined connections between growth hormone, immune system dysfunction, and the symptoms patients experience. Understanding these underlying causes is an important step toward better treatments.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The connection between chronic fatigue syndrome and neurally mediated hypotension.

Wilke, W S, Fouad-Tarazi, F M, Cash, J M et al.·Cleveland Clinic journal of medicine·1998

Some ME/CFS patients experience a problem where their blood pressure drops abnormally when they stand up, a condition called neurally mediated hypotension. This review examines research showing that this blood pressure response may be linked to ME/CFS symptoms. Understanding this connection could help explain why some patients feel worse with certain activities and may guide treatment options.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

[The non-specific environmental syndromes MCS (Multiple Chemical Sensitivity), IEI (Idiopathic Environmental Intolerance) and SBS (Sick Building Syndrome)].

Csef, H·Fortschritte der Medizin·1998

This review examines three similar conditions—Multiple Chemical Sensitivity (MCS), Idiopathic Environmental Intolerance (IEI), and Sick Building Syndrome (SBS)—that cause people to feel sick when exposed to ordinary environmental triggers like chemicals or buildings. The authors note these conditions share important similarities with ME/CFS and fibromyalgia, and discuss different treatment approaches. The review highlights how controversial these conditions are, with some doctors accepting them while others remain skeptical.

E3 PreliminaryCohortPEM unclear

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

Corrado, G, Riezzo, G, Rea, P et al.·Italian journal of gastroenterology and hepatology·1998

This study looked at stomach function in a teenager with ME/CFS by measuring how quickly food moves through the stomach and checking the electrical signals that control stomach contractions. The researchers found that this patient's stomach was working normally in both measures, suggesting that stomach problems may not be the cause of ME/CFS symptoms in this case.

E3 PreliminaryMechanismPEM unclearObservational

Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome.

Evengard, B, Nilsson, C G, Lindh, G et al.·Pain·1998

Researchers measured a pain-signaling chemical called substance P in the spinal fluid of 15 people with ME/CFS. They found that all the ME/CFS patients had normal levels of this chemical. This is important because fibromyalgia—a condition with similar symptoms—typically shows elevated substance P levels. This finding suggests that ME/CFS and fibromyalgia may be caused by different biological problems, even though patients experience some overlapping symptoms.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

The psychotherapeutic effects of estrogens.

Panay, N, Studd, J W·Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·1998

This review examines how estrogen, a hormone in women's bodies, may affect mood, thinking ability, and symptoms of depression. The authors found that estrogen therapy can help treat depression and improve memory in some women, and that early research suggests it might also help with fatigue and mood in women with chronic fatigue syndrome (ME/CFS).

E3 PreliminaryCohortPEM not requiredCase-Control

Dysfunction of natural killer activity in a family with chronic fatigue syndrome.

Levine, P H, Whiteside, T L, Friberg, D et al.·Clinical immunology and immunopathology·1998

Researchers studied a family where 8 members had ME/CFS and found that their natural killer (NK) cells—immune cells that help fight infections and cancer—were not working as well as they should. Some unaffected family members also had lower NK activity, suggesting this might be an inherited trait. The findings raise the possibility that a genetic weakness in immune function could increase risk for both ME/CFS and cancer in this family.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic orofacial muscle pain: a new approach to diagnosis and management.

Klineberg, I, McGregor, N, Butt, H et al.·The Alpha omegan·1998

This study looked at different types of muscle pain conditions, including fibromyalgia and jaw pain, and found they affect men and women differently. The researchers suggest that some people may be genetically vulnerable to chronic pain, and that infections at the start of illness might play a role. They found links between abnormal fat levels, muscle metabolism problems, and fibromyalgia, which may also be connected to chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

Ogawa, M, Nishiura, T, Yoshimura, M et al.·European journal of clinical investigation·1998

This study looked at how a common amino acid called L-arginine affects immune cells called natural killer cells in ME/CFS patients compared to healthy people. The researchers found that L-arginine boosted natural killer cell activity in healthy volunteers, but this boost didn't happen in ME/CFS patients. The difference appears to be related to how the body produces nitric oxide, a chemical messenger involved in immune function.

Immune System

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Hormonal influences on stress-induced neutrophil mobilization in health and chronic fatigue syndrome.

Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.

Silicone breast implants and autoimmune disease.

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Chronic fatigue syndrome: a review for clinicians.

Natural killer cells and natural killer cell activity in chronic fatigue syndrome.

Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome.

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

[Fibromyalgia. A critical review].

Future directions in exercise and immunology: regulation and integration.

Pathogenesis of chronic fatigue syndrome and fibromyalgia.

The connection between chronic fatigue syndrome and neurally mediated hypotension.

[The non-specific environmental syndromes MCS (Multiple Chemical Sensitivity), IEI (Idiopathic Environmental Intolerance) and SBS (Sick Building Syndrome)].

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome.

The psychotherapeutic effects of estrogens.

Dysfunction of natural killer activity in a family with chronic fatigue syndrome.

Chronic orofacial muscle pain: a new approach to diagnosis and management.

Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

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