ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5801–5820 of 6,211 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: an update.

Komaroff, A L, Buchwald, D S·Annual review of medicine·1998

This review examines chronic fatigue syndrome (ME/CFS), a serious condition where people experience extreme tiredness and other symptoms that last at least six months. The authors explain that ME/CFS is not simply depression or a mental health problem, but rather involves real physical changes in the body including immune system activation and issues with hormone-regulating glands. Understanding these biological features helps validate that ME/CFS is a genuine medical illness deserving proper research and treatment.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.

Demitrack, M A, Crofford, L J·Annals of the New York Academy of Sciences·1998

This study found that people with ME/CFS have reduced activity in their stress-response system—a network in the brain called the HPA axis that normally helps the body cope with physical and emotional challenges. The researchers discovered that this underactive response pattern is different from what happens in depression, and it may explain why stress and exertion worsen ME/CFS symptoms. The findings suggest that problems with specific brain chemicals involved in stress regulation may contribute to the condition.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Bennett, R·Current opinion in rheumatology·1998

This review examines how fibromyalgia, chronic fatigue syndrome, and widespread pain are related conditions that share similar features. Researchers found that these conditions run in families, involve abnormal pain processing in the nervous system, and may share some underlying biological problems like growth hormone imbalances and low blood pressure. Several medications and treatments showed promise in reducing symptoms.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and chronic fatigue: the holistic perspective.

Kenner, C·Holistic nursing practice·1998

This article discusses fibromyalgia syndrome and chronic fatigue syndrome (CFS), two conditions that affect mostly women and can significantly impact physical and emotional health. The authors argue that treating these conditions effectively requires a comprehensive, team-based approach that includes both conventional medical care and complementary therapies. They emphasize that patients and families need support strategies tailored to their individual situations to manage these long-term illnesses.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with chronic fatigue syndrome.

Conti, F, Pittoni, V, Sacerdote, P et al.·Clinical and experimental rheumatology·1998

Researchers measured levels of beta-endorphin, a natural chemical in the body that helps reduce pain and promotes well-being, in immune cells from ME/CFS patients and healthy people. They found that ME/CFS patients had significantly lower levels of this chemical compared to healthy controls. The authors suggest this difference might help explain why ME/CFS causes fatigue and weakness.

Immune System

E3 PreliminaryBehavioralPEM unclear

A 56-year-old woman with chronic fatigue syndrome, 1 year later.

Delbanco, T L, Daley, J, Hartman, E E·JAMA·1998

This study describes the medical journey of one woman with ME/CFS over the course of a year, documenting how her symptoms changed and how different treatments affected her condition. The researchers tracked her experiences to provide insight into what living with ME/CFS is like over time and what approaches doctors tried to help her.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone.

Visser, J, Blauw, B, Hinloopen, B et al.·The Journal of infectious diseases·1998

This study looked at immune cells called CD4 T cells from ME/CFS patients and found they produced less of a protective immune protein called interferon-gamma compared to healthy people. Interestingly, these cells were also much more sensitive to dexamethasone, a steroid medication—it took 10-20 times less of the drug to suppress certain immune functions in ME/CFS patients than in controls. This suggests that the stress hormone system and immune system may be working abnormally together in ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclear

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

Corrado, G, Riezzo, G, Rea, P et al.·Italian journal of gastroenterology and hepatology·1998

This study looked at stomach function in a teenager with ME/CFS by measuring how quickly food moves through the stomach and checking the electrical signals that control stomach contractions. The researchers found that this patient's stomach was working normally in both measures, suggesting that stomach problems may not be the cause of ME/CFS symptoms in this case.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The social course of schizophrenia: local and societal factors.

Hicks, M H, Kleinman, A, Yang, L·The Kaohsiung journal of medical sciences·1998

This study looks at how chronic illnesses like ME/CFS are shaped not just by the disease itself, but by social and family factors around us. The researchers studied schizophrenia across different cultures to understand how our families, jobs, community, healthcare system, and laws affect how we experience and manage our illness. They suggest this same idea applies to many chronic conditions including ME/CFS.

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome].

Litzman, J, Lokaj, J, Fucíková, T·Casopis lekaru ceskych·1998

This article discusses chronic fatigue syndrome as a growing health concern in the Czech Republic. The authors explain that doctors cannot yet identify what causes the disease or how it develops in the body, and no single blood test can diagnose it. While some doctors suggest counseling or antidepressants to help with symptoms, treatments targeting the immune system or viruses have not proven effective in rigorous studies.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a review for clinicians.

Goshorn, R K·Seminars in neurology·1998

This review explains that ME/CFS is a real condition characterized by long-lasting fatigue, muscle and joint pain, sleep problems, and thinking difficulties. While doctors don't yet fully understand what causes ME/CFS, research suggests it involves subtle problems with the nervous system, hormones, and immune function. Treatment focuses on managing symptoms to help patients feel better, though the approach is personalized since every patient is different.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome.

Glaser, R, Kiecolt-Glaser, J K·The American journal of medicine·1998

This review examines whether ME/CFS might be triggered by viruses interacting with stress and the immune system. While doctors had noticed that people with ME/CFS often have signs of viral infection, previous research hadn't found a clear virus-to-ME/CFS connection. The authors explore how stress, dormant viruses like Epstein-Barr, and the body's immune response could work together to cause ME/CFS symptoms.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Cellular sequences in stealth viruses.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1998

Researchers found that a virus called a stealth virus, isolated from ME/CFS patients, contains genetic material that closely matches sequences found in human cells. When they tested samples from four different ME/CFS patients, they found variations in the virus's genetic code, suggesting these viruses may be genetically unstable. This discovery raises questions about whether these viruses might be involved in ME/CFS and how they exchange genetic information with human cells.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and fibromyalgia. Dilemmas in diagnosis and clinical management.

Demitrack, M A·The Psychiatric clinics of North America·1998

This article reviews what we know about ME/CFS and fibromyalgia, two conditions that cause severe tiredness and pain and are often misunderstood. The authors explain that these illnesses involve both physical and mental health factors working together, rather than being purely 'in your head' or purely physical. They provide doctors with practical guidelines for better diagnosis and treatment of these challenging conditions.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Newman, Michael E., Shapira, Baruch, Lerer, Bernard·The international journal of neuropsychopharmacology·1998

This review examines a test called the fenfluramine challenge test, which measures how well the brain's serotonin system is working by looking at prolactin levels after taking fenfluramine. The researchers found that people with depression typically had a blunted (reduced) prolactin response, and that some people with chronic fatigue syndrome might have had an enhanced response, though not many studies existed in this group.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroimaging in chronic fatigue syndrome.

Lange, G, Wang, S, DeLuca, J et al.·The American journal of medicine·1998

This review examines how brain imaging scans can help understand ME/CFS. Researchers looked at two main types of scans: MRI scans that show the structure of the brain, and SPECT scans that show blood flow in the brain. The article discusses what these imaging techniques have revealed so far and what challenges doctors face in using them to diagnose ME/CFS.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurobehavioral properties of chemical sensitivity syndromes.

Weiss, B·Neurotoxicology·1998

This review examines four conditions that involve chemical sensitivity and fatigue-like symptoms: Multiple Chemical Sensitivity Syndrome, Sick Building Syndrome, Chronic Fatigue Syndrome, and Gulf War Syndrome. The authors explore different theories about why people develop these conditions, including psychiatric factors, learned behavioral responses, changes in how the nervous system works, and problems with the immune system's stress response. The review suggests that laboratory studies and controlled clinical trials could help determine which explanations are correct.

Endocrine DisruptionPain and Sensitization

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Reviewing the reviews: the example of chronic fatigue syndrome.

Joyce, J, Rabe-Hesketh, S, Wessely, S·JAMA·1998

This study examined how researchers write review articles about ME/CFS and found that what gets included depends heavily on the author's background and where they're from. Scientists with laboratory training tend to focus on lab-based research, while psychiatrists tend to focus on psychiatric research. Authors also tend to cite papers from their own country much more often than papers from other countries.

E3 PreliminaryCohortPEM not requiredCase-Control

Dysfunction of natural killer activity in a family with chronic fatigue syndrome.

Levine, P H, Whiteside, T L, Friberg, D et al.·Clinical immunology and immunopathology·1998

Researchers studied a family where 8 members had ME/CFS and found that their natural killer (NK) cells—immune cells that help fight infections and cancer—were not working as well as they should. Some unaffected family members also had lower NK activity, suggesting this might be an inherited trait. The findings raise the possibility that a genetic weakness in immune function could increase risk for both ME/CFS and cancer in this family.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Silicone breast implants and autoimmune disease.

Brown, S L, Langone, J J, Brinton, L A·Journal of the American Medical Women's Association (1972)·1998

In 1992, the FDA paused approval of silicone breast implants due to safety concerns, particularly worries about autoimmune diseases like scleroderma. This editorial reviews studies conducted since then and finds that while large increases in connective tissue disease overall were ruled out, studies were too small to detect rare diseases. The authors note that new methodologies for studying conditions like fibromyalgia and chronic fatigue syndrome might help answer whether implants cause a specific syndrome.

Immune System

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Evidence browser

Chronic fatigue syndrome: an update.

Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Fibromyalgia and chronic fatigue: the holistic perspective.

Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with chronic fatigue syndrome.

A 56-year-old woman with chronic fatigue syndrome, 1 year later.

CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone.

Normal gastric emptying time and myoelectrical activity in an adolescent with chronic fatigue syndrome.

The social course of schizophrenia: local and societal factors.

[Chronic fatigue syndrome].

Chronic fatigue syndrome: a review for clinicians.

Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome.

Cellular sequences in stealth viruses.

Chronic fatigue syndrome and fibromyalgia. Dilemmas in diagnosis and clinical management.

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Neuroimaging in chronic fatigue syndrome.

Neurobehavioral properties of chemical sensitivity syndromes.

Reviewing the reviews: the example of chronic fatigue syndrome.

Dysfunction of natural killer activity in a family with chronic fatigue syndrome.

Silicone breast implants and autoimmune disease.

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