ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5801–5820 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

The psychotherapeutic effects of estrogens.

Panay, N, Studd, J W·Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·1998

This review examines how estrogen, a hormone in women's bodies, may affect mood, thinking ability, and symptoms of depression. The authors found that estrogen therapy can help treat depression and improve memory in some women, and that early research suggests it might also help with fatigue and mood in women with chronic fatigue syndrome (ME/CFS).

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in young persons].

de Jong, L W, Prins, J B, Fiselier, T J et al.·Nederlands tijdschrift voor geneeskunde·1997

This study looked at ME/CFS in teenagers in the Netherlands, finding that about 10-20 out of every 100,000 teenagers have the condition. The researchers found that teenagers with ME/CFS often have long-term fatigue that significantly affects school attendance and daily life. They identified that how parents respond, a teenager's beliefs about their illness, and reduced physical activity can all make the condition last longer.

E3 PreliminaryCohortPEM unclearCross-Sectional

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Strom, S S, Baldwin, B J, Sigurdson, A J et al.·Plastic and reconstructive surgery·1997

This study surveyed 292 women who had received saline breast implants to learn about their satisfaction and health outcomes. Most women were happy with their implants and reported getting regular mammograms. A small number of women reported health conditions including chronic fatigue syndrome, but the study was not designed to investigate whether implants caused these conditions.

E3 PreliminaryMechanismPEM not requiredObservational

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Abad, L W et al.·Journal of clinical immunology·1997

This study examined whether people with ME/CFS have abnormal levels of immune signaling molecules (called interleukins) in their blood compared to healthy people. Researchers collected blood samples from women with ME/CFS and matched healthy controls at different points in their menstrual cycles, and tested how their immune cells responded to physical activity. The findings suggest that ME/CFS may involve differences in how the immune system communicates, possibly related to hormonal changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Evengård, B, Lipkin, W I·Lakartidningen·1997

This review examines Borna disease virus (BDV), a virus found in animals worldwide that can affect the nervous system. Researchers have wondered whether BDV might also infect humans and contribute to conditions like ME/CFS, depression, and schizophrenia. This article summarizes what scientists know about BDV and discusses how it might cause illness in people.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Clements, A, Sharpe, M, Simkin, S et al.·Journal of psychosomatic research·1997

This study interviewed 66 people with ME/CFS to understand what they believe causes their illness and how they think they can manage it. Most patients believed their illness was primarily physical, though over half also thought stress played a role. Patients felt they could control symptoms by reducing activity, but believed they could not influence the underlying disease itself.

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for enteroviral persistence in humans.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1997

Researchers tested blood samples from 8 people with ME/CFS and found traces of enterovirus (a type of virus) in samples taken at least 5 months apart. In 4 of these individuals, the virus appeared to be the same virus persisting in their body over time, rather than a new infection. This suggests that some people with ME/CFS may have viruses that linger in their system rather than being cleared completely.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

van der Meer, J W·Nederlands tijdschrift voor geneeskunde·1997

This review examines different theories about what causes ME/CFS, ranging from persistent infections and metabolic problems to psychiatric factors. While many potential causes have been proposed—including lingering infections, toxins, immune system problems, nervous system dysfunction, and hormone imbalances—none have been definitively proven. The authors note that psychological factors play an important role in how the illness develops and can be helpful in treating patients.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1997

This review examines three related conditions—fibromyalgia, ME/CFS, and myofascial pain syndrome—and discusses ongoing challenges in diagnosing and treating them. The study found that psychiatric conditions are not a core feature of these diseases, but rather reflect that people with these conditions are more likely to seek medical help. The researchers identified that a blood pressure problem called neurally mediated hypotension may play a role in ME/CFS, and that treating patients in multidisciplinary groups (rather than in isolation) showed more promise than traditional individual treatments.

Autonomic Nervous SystemDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Enterovirus infections in new disguise].

Fohlman, J, Friman, G, Tuvemo, T·Lakartidningen·1997

Enteroviruses are common viruses that usually cause mild illnesses like colds, but researchers have discovered that in some cases, these viruses may persist in the body long after the initial infection. This review suggests that chronic or recurring enteroviral infections might contribute to several unexplained diseases, including chronic fatigue syndrome, by either persisting in the body or triggering abnormal immune responses.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic parvovirus B19 infection resulting in chronic fatigue syndrome: case history and review.

Jacobson, S K, Daly, J S, Thorne, G M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1997

This case study describes a young woman whose severe fatigue, fever, and other symptoms resembled ME/CFS, but were traced to a persistent parvovirus B19 infection. Doctors detected the virus in her blood using sensitive testing methods, even though her body had produced antibodies against it. When she received intravenous immunoglobulin treatment, her fever improved.

Immune System

E3 PreliminaryGuidelinePEM not requiredGuideline

[Indications for management in long-term, physically unexplained fatigue symptoms].

van der Meer, J W, Rijken, P M, Bleijenberg, G et al.·Nederlands tijdschrift voor geneeskunde·1997

This guideline, developed by Dutch doctors and health officials, suggests that chronic fatigue lasting more than 6 months without a clear medical cause should be managed differently depending on how long someone has had it. Rather than continuously searching for hidden causes, patients are encouraged to gradually rebuild activity using a structured schedule and focus on overall health promotion.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mood disorders in the female patient.

Redmond, G·International journal of fertility and women's medicine·1997

This paper discusses why women often experience mood changes and fatigue, and how doctors can help. The authors suggest that these symptoms are often related to depression rather than hormonal problems alone, and that SSRIs (a common type of antidepressant) can be helpful for many women. They also emphasize the importance of listening to patients about stress and life challenges.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Holland, P·The Journal of analytical psychology·1997

This study describes how one woman with ME/CFS improved over three years of talk therapy that focused on her emotions and relationships. The therapy helped her recognize patterns from her past—particularly how she swung between wanting closeness and withdrawing into isolation—which seemed connected to her physical exhaustion. As she worked through these patterns and built better relationships, including becoming pregnant, her fatigue improved.

E3 PreliminaryReviewPEM unclearReview-Narrative

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Dröge, W, Holm, E·FASEB journal : official publication of the Federation of American Societies for Experimental Biology·1997

This study proposes that several diseases—including ME/CFS, HIV, cancer, and inflammatory bowel disease—share a common pattern: low levels of certain amino acids (cysteine and glutamine), weakened immune cells called natural killer cells, and muscle weakness. The researchers suggest these low amino acid levels may be both a cause and a consequence of muscle wasting, and that boosting cysteine might help treatment when combined with disease-specific therapies.

Immune System

E3 PreliminaryMechanismPEM not requiredCase-Control

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Dinan, T G, Majeed, T, Lavelle, E et al.·Psychoneuroendocrinology·1997

This study tested whether a specific brain chemical system called serotonin works properly in ME/CFS patients. Researchers gave patients and healthy people a medication that activates serotonin receptors, then measured how the body's stress-response system (the HPA axis) reacted. They found that ME/CFS patients had a weaker response than healthy people, suggesting this brain system doesn't function normally in ME/CFS.

Endocrine Disruption

E3 PreliminaryPEM unclear

Meeting the frustrations of chronic fatigue syndrome.

Plioplys, A V, Plioplys, S, Davis, J S·Hospital practice (1995)·1997

This article discusses the challenges that ME/CFS patients face, including long-lasting disability and doctors who may not understand or believe in the condition. The authors explain that while there are no blood tests that definitively prove ME/CFS, doctors can confidently diagnose it using established criteria and ruling out other diseases. They suggest that medications can help manage symptoms while patients work toward recovery.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Gupta, S, Aggarwal, S, See, D et al.·Journal of psychiatric research·1997

Researchers tested immune cells from people with ME/CFS to measure inflammation-related proteins called cytokines. They found that certain immune cells from ME/CFS patients produced higher levels of inflammatory proteins (TNF-alpha and IL-6) without any stimulation, but produced lower levels of a protective protein (IL-10) compared to healthy people. These imbalances might explain some of the symptoms people with ME/CFS experience.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Profile of patients with chemical injury and sensitivity.

Ziem, G, McTamney, J·Environmental health perspectives·1997

This study looked at people who react strongly to everyday chemicals—like cleaning products, pesticides, and new materials—at levels that don't bother most people. Researchers gave these patients questionnaires and ran medical tests to understand their symptoms. They found that chemical sensitivity often overlaps with ME/CFS and fibromyalgia, and that several body systems (liver, nervous system, immune system) appear to be affected in these patients.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

The psychotherapeutic effects of estrogens.

[Chronic fatigue syndrome in young persons].

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Evidence for enteroviral persistence in humans.

[Chronic fatigue syndrome].

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

[Enterovirus infections in new disguise].

Chronic parvovirus B19 infection resulting in chronic fatigue syndrome: case history and review.

[Indications for management in long-term, physically unexplained fatigue symptoms].

Mood disorders in the female patient.

Coniunctio--in bodily and psychic modes: dissociation, devitalization and integration in a case of chronic fatigue syndrome.

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.

Blunted serotonin-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Meeting the frustrations of chronic fatigue syndrome.

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Profile of patients with chemical injury and sensitivity.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research