ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5821–5840 of 6,211 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Bennett, R·Current opinion in rheumatology·1998

This review examines how fibromyalgia, chronic fatigue syndrome, and widespread pain are related conditions that share similar features. Researchers found that these conditions run in families, involve abnormal pain processing in the nervous system, and may share some underlying biological problems like growth hormone imbalances and low blood pressure. Several medications and treatments showed promise in reducing symptoms.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and chronic fatigue: the holistic perspective.

Kenner, C·Holistic nursing practice·1998

This article discusses fibromyalgia syndrome and chronic fatigue syndrome (CFS), two conditions that affect mostly women and can significantly impact physical and emotional health. The authors argue that treating these conditions effectively requires a comprehensive, team-based approach that includes both conventional medical care and complementary therapies. They emphasize that patients and families need support strategies tailored to their individual situations to manage these long-term illnesses.

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Cramer, C R·Journal of athletic training·1998

This article reviews what we know about ME/CFS and fibromyalgia, two conditions that cause severe fatigue, muscle pain, and sleep problems. The authors looked at medical research and government health information to summarize how these conditions affect people, especially athletes. They discuss various treatments being tested, including exercise, relaxation therapy, and medications, and emphasize the importance of careful medical evaluation and psychological support during diagnosis and treatment.

Pain and SensitizationSleep

E3 PreliminaryBehavioralPEM unclearCase-Control

Childhood abuse, personality disorder and chronic fatigue syndrome.

Cuykx, V, Van Houdenhove, B, Neerinckx, E·General hospital psychiatry·1998

This study looked at whether people with ME/CFS were more likely to have experienced childhood abuse or have certain personality patterns compared to healthy controls. The researchers compared groups of ME/CFS patients with people without the condition to explore possible connections between early life experiences and the development of ME/CFS.

E3 PreliminaryMechanismPEM unclearObservational

Increased brain serotonin function in men with chronic fatigue syndrome.

Sharpe, M, Hawton, K, Clements, A et al.·BMJ (Clinical research ed.)·1997

This 1997 study examined whether people with ME/CFS have differences in serotonin activity in their brains. Serotonin is a chemical messenger that affects mood, sleep, and energy. The researchers found that men with ME/CFS showed increased brain serotonin function compared to healthy controls, which was unexpected since low serotonin is often associated with fatigue and depression.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Enterovirus infections in new disguise].

Fohlman, J, Friman, G, Tuvemo, T·Lakartidningen·1997

Enteroviruses are common viruses that usually cause mild illnesses like colds, but researchers have discovered that in some cases, these viruses may persist in the body long after the initial infection. This review suggests that chronic or recurring enteroviral infections might contribute to several unexplained diseases, including chronic fatigue syndrome, by either persisting in the body or triggering abnormal immune responses.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The 'worn-out athlete': a clinical approach to chronic fatigue in athletes.

Derman, W, Schwellnus, M P, Lambert, M I et al.·Journal of sports sciences·1997

Doctors who treat athletes need to be able to tell the difference between normal tiredness from hard training and severe, long-lasting fatigue that signals a real medical problem. This article presents a framework to help doctors figure out what's causing persistent fatigue in athletes, including checking for treatable diseases, overtraining, and possible muscle disorders that might not show up on standard tests.

E3 PreliminaryCohortPEM unclear

Chronic fatigue syndrome: chronic ciguatera poisoning as a differential diagnosis.

Pearn, J H·The Medical journal of Australia·1997

This study examines whether some people diagnosed with ME/CFS might actually have chronic ciguatera poisoning, a illness caused by eating contaminated seafood. The researchers suggest that certain ME/CFS cases could be misdiagnosed cases of ciguatera, which can cause similar long-lasting fatigue and other symptoms. The study calls for doctors to consider this possibility when evaluating patients with ME/CFS symptoms.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Clements, A, Sharpe, M, Simkin, S et al.·Journal of psychosomatic research·1997

This study interviewed 66 people with ME/CFS to understand what they believe causes their illness and how they think they can manage it. Most patients believed their illness was primarily physical, though over half also thought stress played a role. Patients felt they could control symptoms by reducing activity, but believed they could not influence the underlying disease itself.

E3 PreliminaryMechanismPEM not requiredMechanistic

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

See, D M, Broumand, N, Sahl, L et al.·Immunopharmacology·1997

This study tested whether two herbal supplements—echinacea and ginseng—could boost immune cells taken from healthy people and patients with ME/CFS or HIV/AIDS. Researchers found that both herbs increased the activity of natural killer cells and antibody-dependent immune responses in blood samples from all three groups. While the results suggest these herbs may help activate certain immune functions, this was a laboratory experiment using cells in a dish, not a study of people taking the supplements.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Demitrack, M A, Engleberg, N C·Current therapy in endocrinology and metabolism·1997

This is a review article that summarizes what was known about ME/CFS in 1997, focusing on endocrine and metabolic aspects of the illness. The authors examined how ME/CFS affects hormones and the body's energy systems. This paper provides an overview of medical understanding from that time period rather than presenting new research findings.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Definition of "chronic fatigue syndrome" (CFS)].

Heyll, U, Wachauf, P, Senger, V et al.·Medizinische Klinik (Munich, Germany : 1983)·1997

In 1988, doctors created an official definition for chronic fatigue syndrome (CFS) to help researchers study it consistently. However, this study found that the original definition didn't work as well as hoped—it didn't capture the condition accurately, and patients with CFS turned out to be quite different from each other. The authors suggest that CFS should be understood as a descriptive condition rather than a single disease with one cause.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

A body with chronic fatigue syndrome as a battleground for the fight to separate from the mother.

Simpson, M·The Journal of analytical psychology·1997

This study describes the therapy of one 20-year-old woman who experienced concentration and memory difficulties she attributed to ME/CFS. Through dream analysis and psychological exploration, a therapist found that her symptoms may have been connected to unresolved emotional conflicts with her mother. After working through these psychological issues in therapy, her symptoms improved.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Gupta, S, Aggarwal, S, See, D et al.·Journal of psychiatric research·1997

Researchers tested immune cells from people with ME/CFS to measure inflammation-related proteins called cytokines. They found that certain immune cells from ME/CFS patients produced higher levels of inflammatory proteins (TNF-alpha and IL-6) without any stimulation, but produced lower levels of a protective protein (IL-10) compared to healthy people. These imbalances might explain some of the symptoms people with ME/CFS experience.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome--aetiological aspects.

Dickinson, C J·European journal of clinical investigation·1997

This review examines why ME/CFS develops, looking at evidence from 40 years of research. The author discusses how ME/CFS may involve damage to the brain stem (the oldest part of the brain that controls basic functions like sleep and alertness), possibly from a previous viral infection. Brain imaging studies have found small patches of damage in the brain stems of some ME/CFS patients, similar to what is seen in other conditions like post-polio fatigue.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Profile of patients with chemical injury and sensitivity.

Ziem, G, McTamney, J·Environmental health perspectives·1997

This study looked at people who react strongly to everyday chemicals—like cleaning products, pesticides, and new materials—at levels that don't bother most people. Researchers gave these patients questionnaires and ran medical tests to understand their symptoms. They found that chemical sensitivity often overlaps with ME/CFS and fibromyalgia, and that several body systems (liver, nervous system, immune system) appear to be affected in these patients.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mood disorders in the female patient.

Redmond, G·International journal of fertility and women's medicine·1997

This paper discusses why women often experience mood changes and fatigue, and how doctors can help. The authors suggest that these symptoms are often related to depression rather than hormonal problems alone, and that SSRIs (a common type of antidepressant) can be helpful for many women. They also emphasize the importance of listening to patients about stress and life challenges.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Myasthenia gravis.

Pourmand, R·Disease-a-month : DM·1997

This article discusses myasthenia gravis, a different disease from ME/CFS in which the immune system attacks the connection between nerves and muscles, causing weakness and fatigue that worsen with activity. The authors explain how doctors diagnose this condition and review improved treatments that have made it less serious than it used to be. While myasthenia gravis can sometimes look like ME/CFS or depression, it is a distinct autoimmune disorder with specific antibodies in the blood.

E3 PreliminaryPEM unclear

Meeting the frustrations of chronic fatigue syndrome.

Plioplys, A V, Plioplys, S, Davis, J S·Hospital practice (1995)·1997

This article discusses the challenges that ME/CFS patients face, including long-lasting disability and doctors who may not understand or believe in the condition. The authors explain that while there are no blood tests that definitively prove ME/CFS, doctors can confidently diagnose it using established criteria and ruling out other diseases. They suggest that medications can help manage symptoms while patients work toward recovery.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome.

Allain, T J, Bearn, J A, Coskeran, P et al.·Biological psychiatry·1997

This study looked at hormone levels in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients had lower levels of two growth-related hormones (IGF-I and IGF-II), a weaker response to a hormone stimulation test, higher insulin levels, and lower levels of a protein that regulates these hormones. These differences suggest the hormone system that controls growth and metabolism may work differently in ME/CFS.

Energy Metabolism

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Evidence browser

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Fibromyalgia and chronic fatigue: the holistic perspective.

Fibromyalgia and chronic fatigue syndrome: an update for athletic trainers.

Childhood abuse, personality disorder and chronic fatigue syndrome.

Increased brain serotonin function in men with chronic fatigue syndrome.

[Enterovirus infections in new disguise].

The 'worn-out athlete': a clinical approach to chronic fatigue in athletes.

Chronic fatigue syndrome: chronic ciguatera poisoning as a differential diagnosis.

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.

Chronic fatigue syndrome.

[Definition of "chronic fatigue syndrome" (CFS)].

A body with chronic fatigue syndrome as a battleground for the fight to separate from the mother.

Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome.

Chronic fatigue syndrome--aetiological aspects.

Profile of patients with chemical injury and sensitivity.

Mood disorders in the female patient.

Myasthenia gravis.

Meeting the frustrations of chronic fatigue syndrome.

Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome.

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