ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5841–5860 of 6,211 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

van der Meer, J W·Nederlands tijdschrift voor geneeskunde·1997

This review examines different theories about what causes ME/CFS, ranging from persistent infections and metabolic problems to psychiatric factors. While many potential causes have been proposed—including lingering infections, toxins, immune system problems, nervous system dysfunction, and hormone imbalances—none have been definitively proven. The authors note that psychological factors play an important role in how the illness develops and can be helpful in treating patients.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Evengård, B, Lipkin, W I·Lakartidningen·1997

This review examines Borna disease virus (BDV), a virus found in animals worldwide that can affect the nervous system. Researchers have wondered whether BDV might also infect humans and contribute to conditions like ME/CFS, depression, and schizophrenia. This article summarizes what scientists know about BDV and discusses how it might cause illness in people.

E3 PreliminaryCohortPEM unclearCross-Sectional

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Strom, S S, Baldwin, B J, Sigurdson, A J et al.·Plastic and reconstructive surgery·1997

This study surveyed 292 women who had received saline breast implants to learn about their satisfaction and health outcomes. Most women were happy with their implants and reported getting regular mammograms. A small number of women reported health conditions including chronic fatigue syndrome, but the study was not designed to investigate whether implants caused these conditions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach, J, Bac, P, Durlach, V et al.·Magnesium research·1997

This review discusses how low magnesium levels in the body can affect the nervous system and cause symptoms like fatigue, muscle twitching, heart palpitations, and breathing problems. The authors describe how magnesium deficiency can mimic or contribute to chronic fatigue syndrome and similar conditions, and they explain tests (like EMG and blood tests) that can help diagnose this problem. They also suggest that taking magnesium supplements by mouth at appropriate doses may help relieve these symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredObservational

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Abad, L W et al.·Journal of clinical immunology·1997

This study examined whether people with ME/CFS have abnormal levels of immune signaling molecules (called interleukins) in their blood compared to healthy people. Researchers collected blood samples from women with ME/CFS and matched healthy controls at different points in their menstrual cycles, and tested how their immune cells responded to physical activity. The findings suggest that ME/CFS may involve differences in how the immune system communicates, possibly related to hormonal changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for enteroviral persistence in humans.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1997

Researchers tested blood samples from 8 people with ME/CFS and found traces of enterovirus (a type of virus) in samples taken at least 5 months apart. In 4 of these individuals, the virus appeared to be the same virus persisting in their body over time, rather than a new infection. This suggests that some people with ME/CFS may have viruses that linger in their system rather than being cleared completely.

E3 PreliminaryCohortPEM not requiredCase-Control

Detection of RNA sequences in cultures of a stealth virus isolated from the cerebrospinal fluid of a health care worker with chronic fatigue syndrome. Case report.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1997

Researchers found a virus in the spinal fluid of a nurse with chronic fatigue syndrome. Using a genetic detection method called RT-PCR, they identified RNA sequences matching a virus previously found in monkey cells. This suggests that certain viruses associated with ME/CFS may exist in a replicating form that could be targeted by treatments.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.

Plioplys, A V·Neurology·1997

Researchers investigated whether people with ME/CFS have antibodies (immune proteins) in their blood that attack muscles or the brain, which could explain fatigue and brain fog symptoms. They compared 10 ME/CFS patients with 10 healthy controls but did not find evidence of these harmful antibodies in either group.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Clements, A, Sharpe, M, Simkin, S et al.·Journal of psychosomatic research·1997

This study interviewed 66 people with ME/CFS to understand what they believe causes their illness and how they think they can manage it. Most patients believed their illness was primarily physical, though over half also thought stress played a role. Patients felt they could control symptoms by reducing activity, but believed they could not influence the underlying disease itself.

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome/myalgic encephalomyelitis as a twentieth-century disease: analytic challenges.

Simpson, M, Bennett, A, Holland, P·The Journal of analytical psychology·1997

This study explores why ME/CFS is so difficult for doctors to understand and treat. The authors look at how psychological factors—such as denial and unconscious defense mechanisms—might play a role in the condition alongside physical symptoms. They examined five patient cases and found that talking therapy helped some patients improve their symptoms.

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. A practical guide to assessment and management.

Sharpe, M, Chalder, T, Palmer, I et al.·General hospital psychiatry·1997

This guide explains how doctors should assess and manage ME/CFS by building trust with patients, taking a detailed history, and ruling out other conditions. Treatment focuses on helping patients understand their illness, establish consistent activity and sleep patterns, and gradually return to normal activities, with cognitive behavioral therapy being the only proven effective approach. The authors emphasize that ME/CFS is a real, treatable condition and provide practical strategies to help patients avoid misinterpreting their symptoms or fearing activity.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mood disorders in the female patient.

Redmond, G·International journal of fertility and women's medicine·1997

This paper discusses why women often experience mood changes and fatigue, and how doctors can help. The authors suggest that these symptoms are often related to depression rather than hormonal problems alone, and that SSRIs (a common type of antidepressant) can be helpful for many women. They also emphasize the importance of listening to patients about stress and life challenges.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Profile of patients with chemical injury and sensitivity.

Ziem, G, McTamney, J·Environmental health perspectives·1997

This study looked at people who react strongly to everyday chemicals—like cleaning products, pesticides, and new materials—at levels that don't bother most people. Researchers gave these patients questionnaires and ran medical tests to understand their symptoms. They found that chemical sensitivity often overlaps with ME/CFS and fibromyalgia, and that several body systems (liver, nervous system, immune system) appear to be affected in these patients.

Immune System

E3 PreliminaryPEM unclear

Meeting the frustrations of chronic fatigue syndrome.

Plioplys, A V, Plioplys, S, Davis, J S·Hospital practice (1995)·1997

This article discusses the challenges that ME/CFS patients face, including long-lasting disability and doctors who may not understand or believe in the condition. The authors explain that while there are no blood tests that definitively prove ME/CFS, doctors can confidently diagnose it using established criteria and ruling out other diseases. They suggest that medications can help manage symptoms while patients work toward recovery.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Confronting AIDS in older adults.

Berlin, B·New Jersey medicine : the journal of the Medical Society of New Jersey·1997

This case report describes a 57-year-old man who experienced severe flu-like symptoms and weight loss, and was initially tested for chronic fatigue syndrome and mononucleosis before eventually being diagnosed with HIV. The story illustrates how HIV infection can present with symptoms similar to other conditions and how important it is for doctors to consider HIV testing when patients have unexplained fatigue and illness. This highlights that conditions causing severe fatigue can have different underlying causes that require proper diagnosis.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome--aetiological aspects.

Dickinson, C J·European journal of clinical investigation·1997

This review examines why ME/CFS develops, looking at evidence from 40 years of research. The author discusses how ME/CFS may involve damage to the brain stem (the oldest part of the brain that controls basic functions like sleep and alertness), possibly from a previous viral infection. Brain imaging studies have found small patches of damage in the brain stems of some ME/CFS patients, similar to what is seen in other conditions like post-polio fatigue.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.

Regland, B, Andersson, M, Abrahamsson, L et al.·Scandinavian journal of rheumatology·1997

Researchers tested the spinal fluid of 12 women who had both fibromyalgia and ME/CFS and found unusually high levels of a molecule called homocysteine in their brains and spinal cords. They also noticed that patients with lower vitamin B12 levels in their spinal fluid reported more severe fatigue. This suggests that a vitamin B12 deficiency might prevent the body from properly breaking down homocysteine, which could contribute to symptoms like exhaustion.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

The 'worn-out athlete': a clinical approach to chronic fatigue in athletes.

Derman, W, Schwellnus, M P, Lambert, M I et al.·Journal of sports sciences·1997

Doctors who treat athletes need to be able to tell the difference between normal tiredness from hard training and severe, long-lasting fatigue that signals a real medical problem. This article presents a framework to help doctors figure out what's causing persistent fatigue in athletes, including checking for treatable diseases, overtraining, and possible muscle disorders that might not show up on standard tests.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Definition of "chronic fatigue syndrome" (CFS)].

Heyll, U, Wachauf, P, Senger, V et al.·Medizinische Klinik (Munich, Germany : 1983)·1997

In 1988, doctors created an official definition for chronic fatigue syndrome (CFS) to help researchers study it consistently. However, this study found that the original definition didn't work as well as hoped—it didn't capture the condition accurately, and patients with CFS turned out to be quite different from each other. The authors suggest that CFS should be understood as a descriptive condition rather than a single disease with one cause.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome.

Allain, T J, Bearn, J A, Coskeran, P et al.·Biological psychiatry·1997

This study looked at hormone levels in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients had lower levels of two growth-related hormones (IGF-I and IGF-II), a weaker response to a hormone stimulation test, higher insulin levels, and lower levels of a protein that regulates these hormones. These differences suggest the hormone system that controls growth and metabolism may work differently in ME/CFS.

Energy Metabolism

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[Chronic fatigue syndrome].

[A known virus in animals is suspected in humans. Borna disease virus has been detected in human neuropathy].

Cosmetic saline breast implants: a survey of satisfaction, breast-feeding experience, cancer screening, and health.

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome.

Evidence for enteroviral persistence in humans.

Detection of RNA sequences in cultures of a stealth virus isolated from the cerebrospinal fluid of a health care worker with chronic fatigue syndrome. Case report.

Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.

Chronic fatigue syndrome: a qualitative investigation of patients' beliefs about the illness.

Chronic fatigue syndrome/myalgic encephalomyelitis as a twentieth-century disease: analytic challenges.

Chronic fatigue syndrome. A practical guide to assessment and management.

Mood disorders in the female patient.

Profile of patients with chemical injury and sensitivity.

Meeting the frustrations of chronic fatigue syndrome.

Confronting AIDS in older adults.

Chronic fatigue syndrome--aetiological aspects.

Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.

The 'worn-out athlete': a clinical approach to chronic fatigue in athletes.

[Definition of "chronic fatigue syndrome" (CFS)].

Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome.

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