ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6141–6160 of 6,211 studies

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome--a new disease picture?].

Nix, W A·Der Nervenarzt·1990

This editorial from 1990 discusses that ME/CFS was becoming more commonly diagnosed at that time, but doctors weren't sure if it was one distinct disease or simply a label given to many different conditions. The author notes that we still need to understand whether ME/CFS has a physical cause, a psychological cause, or both, and that each patient may need individual evaluation.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

[Chronic fatigue syndrome].

Ewig, S, Dengler, H J·Klinische Wochenschrift·1990

This paper discusses chronic fatigue syndrome (CFS) as a condition that can develop after viral infections like Epstein-Barr virus or Coxsackie-B virus. Researchers noted that CFS may actually be several different diseases with different causes rather than one single condition. The authors emphasize that diagnosis requires ruling out other medical conditions first, and that at this time, we don't have enough knowledge to recommend specific treatments.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Sensory and cognitive event-related potentials in myalgic encephalomyelitis.

Prasher, D, Smith, A, Findley, L·Journal of neurology, neurosurgery, and psychiatry·1990

This study tested whether ME/CFS patients have objective brain activity differences related to thinking and attention. Researchers used special sensors to measure how the brain responds to sounds and tasks requiring concentration. While basic sensory responses were normal, they found that brain signals related to attention and processing speed were slower in about one-third to one-half of patients tested, suggesting ME/CFS affects how the brain handles information rather than basic sensation.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Management of Lyme disease.

Goodwin, S D, Sproat, T T, Russell, W L·Clinical pharmacy·1990

This review examines Lyme disease, a tick-borne infection caused by a bacterium called Borrelia burgdorferi. The disease has three stages: early flu-like illness with a rash, middle-stage problems affecting the nervous system and heart, and late-stage arthritis or chronic fatigue. Treatment with antibiotics like doxycycline is most effective when started early.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic fatigue syndrome. A multifactorial approach and the treatment possibilities].

Pinardi, G, Scarlato, G·Recenti progressi in medicina·1990

This review describes ME/CFS as a complex condition marked by severe, long-lasting fatigue accompanied by symptoms like sore throat, headaches, muscle pain, and mood changes. While researchers have suspected viruses like Epstein-Barr virus might cause it, the evidence hasn't been convincing due to study design problems. The authors suggest the condition may result from an abnormal immune response rather than a single virus.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

[Does fibromyalgia exist?].

Serratrice, G·Revue du rhumatisme et des maladies osteo-articulaires·1990

This 1990 editorial questions whether fibromyalgia is a distinct disease, noting that no actual tissue damage (fibrosis) has been found under microscopes. The author argues that fibromyalgia shares symptoms with other conditions like ME/CFS and suggests using the simpler term 'persistent, widespread muscle pain with no recognized organic cause' instead. The author found that only 25% of cases had a clear psychological cause, suggesting most cases have other unexplained factors.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Isolation of human herpesvirus-6 from clinical specimens using human fibroblast cultures.

Luka, J, Okano, M, Thiele, G·Journal of clinical laboratory analysis·1990

Researchers developed a better way to detect and study human herpesvirus-6 (HHV-6) in blood samples by using a specific type of human cell culture. They successfully isolated HHV-6 from blood samples of three ME/CFS patients, along with samples from other patients with different conditions. The virus samples they found had some genetic differences from previously known HHV-6 strains.

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: a return to common sense.

Denman, A M·Postgraduate medical journal·1990

This 1990 opinion piece argues that ME/CFS should be understood through practical, straightforward clinical observation rather than overly complex theories. The author advocates for a 'common sense' approach to recognizing and managing the condition based on what doctors actually observe in patients.

Diagnostics

E3 PreliminaryBehavioralPEM unclearCross-Sectional

The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report.

Altay, H T, Toner, B B, Brooker, H et al.·International journal of psychiatry in medicine·1990

This study looked at whether ME/CFS patients who reported memory and concentration problems actually showed these difficulties when tested. Surprisingly, the patients performed better than average on standard cognitive tests, even though they felt they had cognitive problems. The researchers suggested that psychological factors might explain why patients' subjective experience didn't match their test results.

Cognitive Impairment

E3 PreliminaryCommentaryPEM not requiredEditorial

Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders.

Greenberg, D B·Psychosomatics·1990

In the 1980s, doctors thought chronic fatigue syndrome might be caused by a virus called Epstein-Barr virus (the virus that causes mononucleosis). This editorial explains that while this seemed like a logical explanation, the virus is not actually the cause of chronic fatigue syndrome. The author points out that many people with chronic fatigue also have depression or anxiety, and notes that these mental health conditions should be carefully evaluated and treated rather than overlooked.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA.

Cunningham, L, Bowles, N E, Lane, R J et al.·The Journal of general virology·1990

Researchers found that some ME/CFS patients have enterovirus (a type of virus) present in their muscle tissue. Importantly, when they examined the viral genetic material, they discovered something unusual: the virus was producing equal amounts of two types of RNA strands, whereas in normal viral infections, one strand vastly outnumbers the other. This abnormal pattern suggests the body may not be properly controlling how the virus reproduces.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and the psychiatrist.

Abbey, S E, Garfinkel, P E·Canadian journal of psychiatry. Revue canadienne de psychiatrie·1990

This review article examines ME/CFS and the role psychiatrists can play in caring for patients. The authors note that ME/CFS involves thinking difficulties, mood changes, and behavioral symptoms alongside fatigue. They explain what psychiatrists should know about the condition and how they can help in assessment and treatment.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Koo, D·The Western journal of medicine·1989

Early research suggested that a virus called Epstein-Barr virus (EBV) might cause ME/CFS, leading to the disease sometimes being called "chronic EBV syndrome." However, this review shows that the antibody levels used to detect EBV exposure are similar in people with ME/CFS, healthy people, and people with other illnesses, making it impossible to prove EBV actually causes the condition. Since most people have been exposed to EBV at some point, we cannot easily tell whether the virus causes ME/CFS or if people with ME/CFS simply show different antibody patterns because they are already sick.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Naloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome.

Prieto, J, Subirá, M L, Castilla, A et al.·Scandinavian journal of immunology·1989

Researchers examined immune cells called monocytes in 35 ME/CFS patients and 25 healthy people. They found that most ME/CFS patients had monocytes that weren't working properly, but these cells improved dramatically when treated with naloxone, a drug that blocks opioid effects. This suggests that the body's natural opioid-like chemicals may be overactive in ME/CFS and could be damaging immune function.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.

Bosse, D, Ades, E W·Journal of clinical & laboratory immunology·1989

This study looked at whether adding a immune-boosting substance called IL-2 to a blood treatment (gammaglobulin) could help the body's immune cells better fight cells infected with Epstein-Barr virus. The researchers found in laboratory tests that IL-2 did enhance this immune response, and they suggested it might help ME/CFS patients who receive gammaglobulin treatment.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Treatment of patients with chronic fatigue syndrome.

Gantz, N M, Holmes, G P·Drugs·1989

This 1989 review article examines different ways doctors were treating ME/CFS patients at that time. The authors looked at what treatments were being used and discussed their potential benefits and drawbacks. This early work helped shape how doctors approached ME/CFS care in the following decades.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: review of the literature.

Turgeon, S A·Canadian family physician Medecin de famille canadien·1989

This review article examines what was known about ME/CFS in 1989, a time when the condition was still poorly understood. The authors note that while some initially thought the Epstein-Barr virus (which causes mononucleosis) might cause ME/CFS, that theory no longer seems correct. They found evidence that both psychiatric factors and subtle immune system problems may play a role in the illness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Management of chronic (post-viral) fatigue syndrome.

Wessely, S, David, A, Butler, S et al.·The Journal of the Royal College of General Practitioners·1989

This paper suggests that ME/CFS develops when an initial illness leads to reduced activity, which then worsens fitness and symptoms in a self-reinforcing cycle. The authors propose that cognitive behavioral therapy—a talking therapy that helps patients understand how both physical inactivity and mood problems contribute to their symptoms—combined with gradual return to activity may help break this cycle.

E3 PreliminaryReviewPEM not requiredReview-Narrative

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

Krueger, G R, Sander, C·Pathology, research and practice·1989

This review examines human herpesvirus-6 (HHV-6), a common virus that most people carry in a dormant state. When the immune system is weakened, this virus can reactivate and potentially cause long-lasting fatigue and other health problems. The authors discuss how HHV-6 might contribute to chronic fatigue syndrome and other conditions, particularly in people with weak immune systems.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome associated with Epstein-Barr virus infection].

Parras, F, Salvá, F, Reina, J et al.·Medicina clinica·1989

This study describes a patient who developed chronic fatigue syndrome (CFS) after a confirmed Epstein-Barr virus (EBV) infection. EBV is a common virus that usually causes infectious mononucleosis ("mono"), but this patient went on to experience lasting fatigue, loss of appetite, low-grade fever, and mood changes long after the acute infection. The authors emphasize that diagnosing CFS based on symptoms alone can be risky and may lead to misdiagnosis of other serious conditions.

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[Chronic fatigue syndrome--a new disease picture?].

[Chronic fatigue syndrome].

Sensory and cognitive event-related potentials in myalgic encephalomyelitis.

Management of Lyme disease.

[The chronic fatigue syndrome. A multifactorial approach and the treatment possibilities].

[Does fibromyalgia exist?].

Isolation of human herpesvirus-6 from clinical specimens using human fibroblast cultures.

The chronic fatigue syndrome: a return to common sense.

The neuropsychological dimensions of postinfectious neuromyasthenia (chronic fatigue syndrome): a preliminary report.

Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders.

Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA.

Chronic fatigue syndrome and the psychiatrist.

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Naloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome.

Immunotherapy and enhanced antibody-dependent cell-mediated cytotoxicity using virally-infected target cells.

Treatment of patients with chronic fatigue syndrome.

Chronic fatigue syndrome: review of the literature.

Management of chronic (post-viral) fatigue syndrome.

What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection.

[Chronic fatigue syndrome associated with Epstein-Barr virus infection].

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