ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6141–6160 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome (myalgic encephalomyelitis)--myth or mystery?

Spracklen, F H·South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1988

This 1988 review article discusses chronic fatigue syndrome (also called myalgic encephalomyelitis) and explains why there has been so much confusion about this condition. The author reviews what doctors know about the illness, including its possible causes and symptoms, and discusses why having a clear definition of the disease is important for research and treatment. The article emphasizes that better understanding and more rigorous studies are needed to help patients.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Chronic fatigue syndrome: a working case definition.

Holmes, G P, Kaplan, J E, Gantz, N M et al.·Annals of internal medicine·1988

This landmark 1988 paper proposed a new name and formal definition for what was previously called 'chronic Epstein-Barr virus syndrome.' The authors recognized that the condition was poorly understood and inconsistently diagnosed, so they renamed it 'chronic fatigue syndrome' (ME/CFS) and created a working definition to help doctors identify and study it more consistently. This definition focused on severe, ongoing fatigue along with other symptoms like sore throat, headaches, and muscle pain.

Diagnostics

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome: possible effective treatment with nifedipine.

Adolphe, A B·The American journal of medicine·1988

This 1988 study explored whether nifedipine, a blood pressure medication, might help people with chronic fatigue syndrome (ME/CFS). The researchers compared a small group of patients who received the treatment with a control group to see if it made a difference in their symptoms. While the study suggested nifedipine could be worth investigating further, it was very preliminary and limited in scope.

E3 PreliminaryPEM unclear

[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].

Berends, G M, Peeters, M F, Lepoutre, J M et al.·Nederlands tijdschrift voor geneeskunde·1988

This 1988 case study examined whether Epstein-Barr virus (EBV)—a common virus that causes infections like mononucleosis—might be connected to ME/CFS. The researchers looked at individual patient cases to explore possible links between EBV infection and the development of chronic fatigue syndrome symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The myalgic encephalomyelitis syndrome.

Murdoch, J C·Family practice·1988

This review examines myalgic encephalomyelitis (ME), a relapsing illness that primarily affects young women and causes severe muscle pain and exhaustion. The authors looked at research from the United Kingdom, United States, and New Zealand over 40 years to understand what might cause this condition. They discuss how difficult it is to treat patients when doctors don't know what's causing the illness, and suggest renaming it 'myalgic exhaustion syndrome.'

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome--a diagnosis for consideration.

Portwood, M F·The Nurse practitioner·1988

This article helps doctors recognize ME/CFS by describing its many symptoms, which can range from mild tiredness to severe disability. Patients often report feeling exhausted, achy, and unable to concentrate, yet standard medical tests often appear normal. The article emphasizes that doctors should take these symptoms seriously and help patients manage their condition, even though there is currently no cure.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human B-lymphotropic virus (human herpesvirus-6).

Ablashi, D V, Josephs, S F, Buchbinder, A et al.·Journal of virological methods·1988

This study describes a virus called human herpesvirus-6 (HHV-6) that was newly discovered in 1986. Researchers found that this virus can infect many different types of cells in the body and detected antibodies to it in about 26% of healthy people. Interestingly, they found higher levels of HHV-6 antibodies in people with certain cancers, autoimmune diseases, HIV/AIDS, and chronic fatigue syndrome, suggesting the virus may play a role in these conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6).

Ablashi, D V, Lusso, P, Hung, C L et al.·International journal of cancer·1988

Researchers grew human herpesvirus 6 (HHV-6) in laboratory cell lines to study how this virus behaves and develops tools to detect it. They found that HHV-6 can infect and replicate in many different types of immune cells and other cell types, not just the B cells initially thought to be vulnerable. Some of these infected cell lines produced large amounts of virus, making them useful for developing tests and studying the virus further.

E3 PreliminaryCohortPEM not requiredCase-Control

Acyclovir-induced renal failure. Clinical course and histology.

Sawyer, M H, Webb, D E, Balow, J E et al.·The American journal of medicine·1988

This study describes four patients with ME/CFS who developed sudden kidney problems after receiving high-dose acyclovir (an antiviral medication) intravenously. Doctors found needle-shaped crystals in the urine and determined that the medication itself was damaging the kidneys. The good news is that lower doses of acyclovir given by mouth did not cause the same problems.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Jones, J F, Williams, M, Schooley, R T et al.·Archives of internal medicine·1988

This 1988 study tested whether people with ME/CFS had unusual antibody patterns against Epstein-Barr virus (EBV), a common virus that causes mononucleosis. Researchers measured antibodies against viral enzymes that are only produced when EBV is actively replicating. A small group of ME/CFS patients with very high EBV antibody levels did show these unusual enzyme antibodies, similar to patterns seen in people with nasopharyngeal cancer.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndromes: relationship to chronic viral infections.

Komaroff, A L·Journal of virological methods·1988

This review examines whether ME/CFS (a condition causing severe, long-lasting tiredness) is connected to chronic viral infections, particularly herpes-type viruses. The authors found that ME/CFS often starts suddenly like the flu and is associated with symptoms like fever, sore throat, and muscle pain. While blood tests sometimes show signs of viral infection, particularly Epstein-Barr virus and human herpesvirus-6, the study could not prove that these viruses actually cause ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis.

Gordon, N·Developmental medicine and child neurology·1988

This is a review article about myalgic encephalomyelitis (ME), a serious condition that causes extreme tiredness, muscle pain, and cognitive difficulties. The author examines what was known about ME in 1988, including how it affects the brain and nervous system, and discusses different theories about what might cause it.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Postviral fatigue syndrome: persistence of enterovirus RNA in muscle and elevated creatine kinase.

Archard, L C, Bowles, N E, Behan, P O et al.·Journal of the Royal Society of Medicine·1988

Researchers looked for traces of enterovirus (a common virus) in muscle tissue from 96 ME/CFS patients who had been ill for up to 20 years. They found viral genetic material in muscle samples from about 20% of patients, but not in healthy controls. This suggests that in some people, the virus may persist in muscles long after the initial infection and could play a role in causing the disease.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: a manifestation of Epstein-Barr virus infection?

Schooley, R T·Current clinical topics in infectious diseases·1988

This 1988 editorial discusses whether Epstein-Barr virus (EBV), a common virus that causes mononucleosis, might be responsible for causing chronic fatigue syndrome (ME/CFS). The author examines the connection between EBV infection and the development of long-lasting fatigue and other symptoms that characterize this illness.

E3 PreliminaryReviewPEM unclearReview-Narrative

Postviral fatigue syndrome.

Behan, P O, Behan, W M·Critical reviews in neurobiology·1988

This review examines ME/CFS, a condition that causes severe exhaustion, muscle pain, and cognitive difficulties, sometimes appearing in outbreaks and sometimes in individual cases. Researchers note that patients often experience emotional changes, memory problems, and depression alongside the physical symptoms. The authors suggest that a lingering viral infection may trigger a metabolic problem in the body, which could explain why people feel so severely fatigued.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome.

Caligiuri, M, Murray, C, Buchwald, D et al.·Journal of immunology (Baltimore, Md. : 1950)·1987

This study examined immune cells called natural killer cells in people with ME/CFS and compared them to healthy controls. Researchers found that ME/CFS patients had fewer of a specific type of natural killer cell and that these cells were less effective at fighting virus-infected cells, even after being stimulated to work harder. This suggests a potential immune system dysfunction in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The post-viral syndrome: a review.

Archer, M I·The Journal of the Royal College of General Practitioners·1987

This 1987 review examines post-viral syndrome (now often called ME/CFS), a condition that develops after viral infections. The author discusses whether the illness is caused by ongoing viral infection, psychological factors, or a combination of both. The review notes that different doctors diagnosed the condition at very different rates, and that many patients struggled to accept psychiatric support as part of their treatment.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections.

McCartney, R A, Banatvala, J E, Bell, E J·Journal of medical virology·1986

This study tested a new blood test (mu-antibody-capture ELISA) to detect recent Coxsackie B virus infections by looking for IgM antibodies, which indicate fresh infection. Researchers tested 760 patients with various conditions including chest pain, heart inflammation, and myalgic encephalomyelitis (ME), plus 304 healthy controls, and found that this IgM test could reliably identify recent Coxsackie B infections without the confusion caused by old antibodies from past infections.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Cutaneous reflex responses recorded in children with various neurological disorders.

Rowlandson, P H, Stephens, J A·Developmental medicine and child neurology·1985

Researchers tested a simple reflex response in the skin and muscles of children with various nervous system conditions, including ME/CFS. By measuring how muscles respond to light touch stimulation on the skin, they found that different neurological conditions produced different patterns of responses. The study suggests this type of testing might be a useful tool to help doctors diagnose difficult neurological problems in children.

E3 PreliminaryCohortPEM unclearCase-Control

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

Byrne, E, Trounce, I, Dennett, X·Australian and New Zealand journal of medicine·1985

This study examined two patients with ongoing muscle pain that started after a viral-like illness and came and went unpredictably. Doctors found the patients had weak muscle fibers and signs that their muscles weren't producing energy as efficiently as they should. The findings suggest these patients may have a mild form of ME/CFS, and importantly, their muscle problems were real biological issues rather than caused by psychological factors.

Energy Metabolism

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Evidence browser

The chronic fatigue syndrome (myalgic encephalomyelitis)--myth or mystery?

Chronic fatigue syndrome: a working case definition.

Chronic fatigue syndrome: possible effective treatment with nifedipine.

[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].

The myalgic encephalomyelitis syndrome.

Chronic fatigue syndrome--a diagnosis for consideration.

Human B-lymphotropic virus (human herpesvirus-6).

Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6).

Acyclovir-induced renal failure. Clinical course and histology.

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Chronic fatigue syndromes: relationship to chronic viral infections.

Myalgic encephalomyelitis.

Postviral fatigue syndrome: persistence of enterovirus RNA in muscle and elevated creatine kinase.

Chronic fatigue syndrome: a manifestation of Epstein-Barr virus infection?

Postviral fatigue syndrome.

Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome.

The post-viral syndrome: a review.

Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections.

Cutaneous reflex responses recorded in children with various neurological disorders.

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

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