ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6121–6140 of 6,211 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Lewis, S F, Haller, R G·Reviews of infectious diseases·1991

This review article explains how scientists measure exercise capacity and fatigue in the body. It describes three key concepts: aerobic fitness (how efficiently your heart and muscles use oxygen), muscle strength (your muscles' ability to produce force), and fatigue (the loss of strength that happens during activity). The authors discuss how these measurements might help us better understand what happens in ME/CFS when patients experience excessive fatigue.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A supplemental interview for forms of "affective spectrum disorder".

Pope, H G, Hudson, J I·International journal of psychiatry in medicine·1991

Researchers created a standardized interview tool to help diagnose seven different conditions—including chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines, narcolepsy, Tourette's disorder, and kleptomania—based on the idea that these disorders may be related to each other. They developed questions following a recognized medical interview format and tested the tool with over 100 patients. The authors suggest these conditions may share common underlying features related to mood and emotion regulation.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Clinical spectrum of postviral fatigue syndrome.

Behan, P O, Bakheit, A M·British medical bulletin·1991

This review article examines postviral fatigue syndrome (also called ME/CFS), a condition that develops after viral infections and causes severe tiredness and other symptoms. The authors describe how this syndrome appears both in individual cases and in epidemic clusters worldwide, and explain why doctors historically had difficulty recognizing it until outbreaks occurred.

E3 PreliminaryCohortPEM unclearCase-Control

Fibromyalgia and parvovirus infection.

Leventhal, L J, Naides, S J, Freundlich, B·Arthritis and rheumatism·1991

This study describes three patients who developed fibromyalgia (a condition causing widespread pain and fatigue) shortly after having parvovirus B19 infections. Blood tests confirmed the virus was present, and sleep studies showed abnormal sleep patterns in two patients. The researchers suggest that doctors should look more carefully for viral infections in fibromyalgia patients whose symptoms started with flu-like illness.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Anti-neuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities.

Buchwald, D, Wener, M H, Komaroff, A L·Arthritis and rheumatism·1991

This study looked at whether people with ME/CFS who have neurological symptoms (like problems with thinking or nerve function) have unusual antibodies in their blood that attack nerve cells. Researchers tested blood samples from ME/CFS patients and compared antibody levels between those with and without neurological problems. The goal was to understand whether immune system misdirection might be causing some of the neurological symptoms patients experience.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Molecular approaches to epidemiologic evaluation of viruses as risk factors for patients who have chronic fatigue syndrome.

Miller, G·Reviews of infectious diseases·1991

This paper proposes that studying how viral infections like flu, hepatitis, and mono can trigger long-term fatigue might help us understand ME/CFS. The researchers suggest examining not just whether someone had a virus, but how much virus was present, which type of virus it was, where it spread in the body, and whether the virus was active or dormant. They also recommend looking carefully at how individual patients' immune systems respond to specific parts of viruses.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome: a reappraisal and unifying hypothesis.

Byrne, E·Clinical and experimental neurology·1991

This 1991 review examined ME/CFS from multiple scientific angles—including viral infection, immune system problems, metabolism, and mental health—to understand why this condition develops. The authors proposed that ME/CFS typically results from a combination of factors: personal characteristics before illness (like psychological traits or immune vulnerabilities), a trigger (such as a virus), and how someone's emotions respond to being sick. Rather than having one single cause, ME/CFS appears to exist on a spectrum of different presentations.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Analysis of clinical, epidemiologic, and laboratory data on chronic fatigue syndrome.

Redmond, C K·Reviews of infectious diseases·1991

This paper reviews how ME/CFS research has been studied and analyzed over time. The authors found that many ME/CFS studies don't use the best statistical methods available. They recommend that future ME/CFS research should include expert statisticians who can use more advanced analytical techniques to better understand patterns in patient data and find clues about what causes this illness.

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis (chronic fatigue syndrome): an historic perspective.

Hyde, B M·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This article provides a historical overview of myalgic encephalomyelitis (ME/CFS), tracing how the condition has been understood and documented over time. It examines the disease's recognition in medical literature and explores how ME/CFS has been characterized throughout history. This historical perspective helps patients and the public understand how medical understanding of this illness has evolved.

E3 PreliminaryCommentaryPEM not requiredEditorial

Neuro-ocular Lyme borreliosis.

Smith, J L·Neurologic clinics·1991

This study suggests that some patients diagnosed with chronic fatigue syndrome (CFS) might actually have Lyme disease, a tick-borne infection that can affect the brain and eyes. The authors recommend doctors ask CFS patients detailed questions about tick exposure and check for specific eye and neurological problems, then use blood and urine tests to look for evidence of Lyme infection.

Diagnostics

E3 PreliminaryBehavioralPEM unclearCase-Control

Nortriptyline in chronic fatigue syndrome: a double blind, placebo-controlled single case study.

Gracious, B, Wisner, K L·Biological psychiatry·1991

This study tested whether a medication called nortriptyline (an older type of antidepressant) could help one person with ME/CFS. The researchers gave the patient either the medication or a placebo (inactive pill) without telling them which was which, and tracked how they felt. This type of single-patient study can provide useful information, but it only shows what happened with one individual and cannot prove the treatment works for everyone with ME/CFS.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).

Ablashi, D V, Zompetta, C, Lease, C et al.·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This review article examines whether human herpesvirus 6 (HHV6), a common virus that infects most people in childhood, might be connected to ME/CFS. The authors gathered available evidence about HHV6 and its potential role in causing or contributing to chronic fatigue syndrome symptoms.

Immune System

E3 PreliminaryMechanismPEM unclear

Immunodysregulation and chronic fatigue syndrome.

Kundu, S K, Ahronheim, G A, Menezes, J·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This study examined whether ME/CFS involves problems with the immune system that aren't working properly. The researchers looked at immune system dysfunction in patients with chronic fatigue syndrome to understand if an imbalance in immune responses might explain the illness. This early research helped establish that immune abnormalities could be involved in ME/CFS.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Assessment of depression in patients with chronic fatigue syndrome.

Thase, M E·Reviews of infectious diseases·1991

This paper examines how depression and ME/CFS are connected and how to tell them apart. The authors warn that depression is sometimes mistakenly diagnosed as ME/CFS, while in other cases ME/CFS itself may cause depression-like symptoms. They recommend that doctors use multiple assessment tools and be careful to distinguish between these conditions rather than assuming one is the cause of the other.

E3 PreliminaryReviewPEM unclearReview-Narrative

Depression, chronic fatigue syndrome, and the adolescent.

Strickland, M C·Primary care·1991

This paper discusses how depression and ME/CFS affect teenagers and their families, noting that the many symptoms can make it hard for doctors to figure out what's really going on. The authors recommend that doctors look carefully at what stress and life challenges teenagers are facing, and suggest that talking to a mental health specialist may help if these issues seem to be making symptoms worse or preventing normal development.

E3 PreliminaryBehavioralPEM unclearCase-Control

Mania and recovery from chronic fatigue syndrome.

Sharpe, M C, Johnson, B A, McCann, J·Journal of the Royal Society of Medicine·1991

This 1991 study examined cases where people with chronic fatigue syndrome (ME/CFS) experienced periods of unusually elevated mood and energy (mania) and whether this was connected to recovery from their illness. The researchers looked at individual case examples to explore this unusual pattern and what it might tell us about how ME/CFS develops and resolves.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and the psychiatrist.

Abbey, S E, Garfinkel, P E·Canadian journal of psychiatry. Revue canadienne de psychiatrie·1990

This review article examines ME/CFS and the role psychiatrists can play in caring for patients. The authors note that ME/CFS involves thinking difficulties, mood changes, and behavioral symptoms alongside fatigue. They explain what psychiatrists should know about the condition and how they can help in assessment and treatment.

Cognitive Impairment

E3 PreliminaryCommentaryPEM not requiredEditorial

Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders.

Greenberg, D B·Psychosomatics·1990

In the 1980s, doctors thought chronic fatigue syndrome might be caused by a virus called Epstein-Barr virus (the virus that causes mononucleosis). This editorial explains that while this seemed like a logical explanation, the virus is not actually the cause of chronic fatigue syndrome. The author points out that many people with chronic fatigue also have depression or anxiety, and notes that these mental health conditions should be carefully evaluated and treated rather than overlooked.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: a return to common sense.

Denman, A M·Postgraduate medical journal·1990

This 1990 opinion piece argues that ME/CFS should be understood through practical, straightforward clinical observation rather than overly complex theories. The author advocates for a 'common sense' approach to recognizing and managing the condition based on what doctors actually observe in patients.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome, fibromyalgia and depression].

Martin-Du-Pan, R·Revue medicale de la Suisse romande·1990

This 1990 review article examines the relationships between chronic fatigue syndrome (ME/CFS), fibromyalgia, and depression. The author discusses how these three conditions sometimes occur together and explores whether they share common features or causes. The paper helps clarify how ME/CFS and fibromyalgia are distinct from depression, even though all three can cause fatigue and other overlapping symptoms.

Diagnostics

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Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

A supplemental interview for forms of "affective spectrum disorder".

Clinical spectrum of postviral fatigue syndrome.

Fibromyalgia and parvovirus infection.

Anti-neuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities.

Molecular approaches to epidemiologic evaluation of viruses as risk factors for patients who have chronic fatigue syndrome.

The chronic fatigue syndrome: a reappraisal and unifying hypothesis.

Analysis of clinical, epidemiologic, and laboratory data on chronic fatigue syndrome.

Myalgic encephalomyelitis (chronic fatigue syndrome): an historic perspective.

Neuro-ocular Lyme borreliosis.

Nortriptyline in chronic fatigue syndrome: a double blind, placebo-controlled single case study.

Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).

Immunodysregulation and chronic fatigue syndrome.

Assessment of depression in patients with chronic fatigue syndrome.

Depression, chronic fatigue syndrome, and the adolescent.

Mania and recovery from chronic fatigue syndrome.

Chronic fatigue syndrome and the psychiatrist.

Neurasthenia in the 1980s: chronic mononucleosis, chronic fatigue syndrome, and anxiety and depressive disorders.

The chronic fatigue syndrome: a return to common sense.

[Chronic fatigue syndrome, fibromyalgia and depression].

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