Kundu, S K, Ahronheim, G A, Menezes, J · Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada · 1991
This study examined whether ME/CFS involves problems with the immune system that aren't working properly. The researchers looked at immune system dysfunction in patients with chronic fatigue syndrome to understand if an imbalance in immune responses might explain the illness. This early research helped establish that immune abnormalities could be involved in ME/CFS.
This study was important because it helped shift understanding of ME/CFS from a purely psychological condition toward a biomedical framework involving measurable immune abnormalities. Early mechanistic studies like this laid the groundwork for decades of subsequent immunological research that continues to inform current theories about ME/CFS pathophysiology.
This early study does not definitively establish which immune abnormalities are primary causes versus secondary consequences of ME/CFS. It does not provide evidence about whether immune dysregulation causes the fatigue or whether it simply accompanies the illness. The findings cannot be generalized to all ME/CFS patients without larger, more comprehensive studies.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kundu, S K, Ahronheim, G A, & Menezes, J (1991). Immunodysregulation and chronic fatigue syndrome.. Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada. https://pubmed.ncbi.nlm.nih.gov/1669353/
BibTeX
@article{mecfsatlas-kundu-1991-immunodysregulation-chronic,
author = {Kundu, S K and Ahronheim, G A and Menezes, J},
title = {Immunodysregulation and chronic fatigue syndrome.},
journal = {Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada},
year = {1991},
note = {PubMed: 1669353},
url = {https://www.mecfsatlas.com/evidence/kundu-1991-immunodysregulation-chronic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/kundu-1991-immunodysregulation-chronic
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