ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6181–6200 of 6,211 studies

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections.

McCartney, R A, Banatvala, J E, Bell, E J·Journal of medical virology·1986

This study tested a new blood test (mu-antibody-capture ELISA) to detect recent Coxsackie B virus infections by looking for IgM antibodies, which indicate fresh infection. Researchers tested 760 patients with various conditions including chest pain, heart inflammation, and myalgic encephalomyelitis (ME), plus 304 healthy controls, and found that this IgM test could reliably identify recent Coxsackie B infections without the confusion caused by old antibodies from past infections.

E3 PreliminaryCommentaryPEM unclearEditorial

Raphe nucleus encephalopathy (myalgic encephalomyelitis, epidemic neuromyasthenia).

Maurizi, C P·Medical hypotheses·1985

This 1985 paper proposes that ME/CFS may be caused by damage to a specific brain region called the dorsal raphe nucleus, potentially triggered by Coxsackie B viruses. The symptoms of ME/CFS match what doctors would expect to see if serotonin levels were too low in this area of the brain. The authors suggest that stress and nutritional deficiencies in tryptophan (a building block for serotonin) may make the condition more likely to develop.

Neuroinflammation

E3 PreliminaryCohortPEM unclearCase-Control

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

Byrne, E, Trounce, I, Dennett, X·Australian and New Zealand journal of medicine·1985

This study examined two patients with ongoing muscle pain that started after a viral-like illness and came and went unpredictably. Doctors found the patients had weak muscle fibers and signs that their muscles weren't producing energy as efficiently as they should. The findings suggest these patients may have a mild form of ME/CFS, and importantly, their muscle problems were real biological issues rather than caused by psychological factors.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCross-Sectional

Cutaneous reflex responses recorded in children with various neurological disorders.

Rowlandson, P H, Stephens, J A·Developmental medicine and child neurology·1985

Researchers tested a simple reflex response in the skin and muscles of children with various nervous system conditions, including ME/CFS. By measuring how muscles respond to light touch stimulation on the skin, they found that different neurological conditions produced different patterns of responses. The study suggests this type of testing might be a useful tool to help doctors diagnose difficult neurological problems in children.

E3 PreliminaryCohortPEM unclearObservational

Coxsackie B infection in a Scottish general practice.

Calder, B D, Warnock, P J·The Journal of the Royal College of General Practitioners·1984

This 1984 study from Scotland examined 38 patients with a prolonged illness involving multiple body system symptoms. Blood tests showed that nearly half of the patients tested had high levels of antibodies to Coxsackie B viruses, suggesting recent infection. The illness's pattern resembled ME/CFS, though the cases appeared gradually over four years rather than in sudden clusters.

E3 PreliminaryCohortPEM unclearObservational

Sporadic myalgic encephalomyelitis in a rural practice.

Keighley, B D, Bell, E J·The Journal of the Royal College of General Practitioners·1983

This study from 1983 examined 20 patients in a rural area who had long-lasting, hard-to-define illnesses. Researchers tested their blood for viral infections and found that 16 of these patients had high levels of Coxsackie B virus antibodies. Thirteen of these patients appeared to have myalgic encephalomyelitis (ME), while three had mainly heart-related symptoms. The findings suggest that a viral infection might be connected to ME, though the exact cause remains unclear.

E3 PreliminaryCohortPEM unclear

Myalgic encephalomyelitis "an obscene cosmic joke"?

Church, A J·The Medical journal of Australia·1980

This 1980 case-control study examined patients with myalgic encephalomyelitis (ME/CFS) to better understand the condition. While the full details are limited, the study represents an early medical investigation into a disease that was not well understood at the time and was often dismissed by the medical community.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

Epidemic myalgic encephalomyelitis.

Bishop, J·The Medical journal of Australia·1980

This 1980 observational study by Bishop documented cases of epidemic myalgic encephalomyelitis (ME), a condition causing muscle pain, brain inflammation, and extreme fatigue. The study describes patterns observed during outbreaks of ME, helping early researchers understand how the illness affects groups of people.

E3 PreliminaryReviewPEM unclearReview-Narrative

Post-infectious encephalomyelitis: some aetiological mechanisms.

Behan, P O·Postgraduate medical journal·1978

This 1978 study explores whether two different neurological conditions—acute disseminated encephalomyelitis (ADEM) and epidemic myalgic encephalomyelitis (a historical name for ME/CFS outbreaks)—might develop through similar biological mechanisms. The researcher identified multiple features these two diseases share and suggests that studying ADEM could help us better understand ME/CFS.

E3 PreliminaryCohortPEM unclearObservational

Electro-encephalographic investigations in myalgic encephalomyelitis.

Pampiglione, G, Harris, R, Kennedy, J·Postgraduate medical journal·1978

Researchers used EEG brain scans to study 36 young adults and 12 children with ME/CFS from the 1950s-1970s. They found that the brain activity patterns were slightly abnormal and varied between patients, suggesting that ME/CFS affects how the brain functions. The study suggests that future research should include regular EEG monitoring over 2-3 years to better understand these brain changes.

E3 PreliminaryBehavioralPEM unclear

Benign myalgic encephalomyelitis.

Ramsay, A M·The British journal of psychiatry : the journal of mental science·1973

This 1973 paper by A.M. Ramsay describes myalgic encephalomyelitis (ME) as a benign condition affecting the nervous system and muscles. The author documented clinical observations of patients experiencing fatigue, muscle pain, and neurological symptoms. This early work helped establish ME as a distinct medical condition rather than a psychiatric illness.

E3 PreliminaryBehavioralPEM unclear

Benign myalgic encephalomyelitis.

Parish, J G·The British journal of psychiatry : the journal of mental science·1973

This 1973 study by Parish examined benign myalgic encephalomyelitis (ME), an early medical observation of the condition. The researcher documented cases of ME as a distinct medical illness. This historical paper represents one of the early clinical descriptions of the disease in the medical literature.

E3 PreliminaryCohortPEM unclear

Benign myalgic encephalomyelitis.

The Medical journal of Australia·1970

This 1970 study examined cases of myalgic encephalomyelitis (ME), a condition causing muscle pain and fatigue. The researchers documented patient experiences and clinical features of the illness. This early medical documentation helped establish ME as a recognized clinical condition worthy of scientific investigation.

E3 PreliminaryCommentaryPEM not requiredEditorial

Concept of benign myalgic encephalomyelitis.

McEvedy, C P, Beard, A W·British medical journal·1970

This 1970 study reviewed 15 reported outbreaks of myalgic encephalomyelitis (ME) and concluded that many of these cases may have been caused by mass hysteria or misdiagnosis rather than a physical disease. The authors suggested that future similar cases should be called 'myalgia nervosa' to reflect a psychological rather than biological cause. This interpretation is now considered outdated, as modern research has identified real biological abnormalities in ME/CFS.

E3 PreliminaryCohortPEM unclear

Encephalomyelitis resembling benign myalgic encephalomyelitis.

Innes, S G·Lancet (London, England)·1970

This 1970 case report described patients with symptoms resembling myalgic encephalomyelitis (ME), including muscle pain, fatigue, and neurological symptoms. The study documented clinical presentations that looked similar to what we now call ME/CFS, helping establish early recognition of this condition in medical literature.

E3 PreliminaryCohortPEM unclear

Encephalomyelitis resembling benign myalgic encephalomyelitis.

Lyle, W H·Lancet (London, England)·1970

This 1970 case study from The Lancet described patients with symptoms resembling myalgic encephalomyelitis (ME), a condition causing extreme tiredness, muscle pain, and brain fog. The researchers documented clinical cases to help doctors recognize and understand this illness pattern, which was not well-known at the time.

E3 PreliminaryCohortPEM unclearObservational

Benign myalgic encephalomyelitis in Lebanon.

Mourad, S, Chidiac, J·Le Journal medical libanais. The Lebanese medical journal·1969

This is an early observational study from 1969 describing cases of benign myalgic encephalomyelitis in Lebanon. The researchers documented patients with this condition, contributing to recognition of ME/CFS as a distinct illness in the Middle East during a period when the disease was still being identified and named around the world.

E3 PreliminaryBehavioralPEM unclear

The psychiatric sequelae of benign myalgic encephalomyelitis.

Kendell, R E·The British journal of psychiatry : the journal of mental science·1967

This 1967 study examined whether people with benign myalgic encephalomyelitis (an early name for ME/CFS) experienced psychiatric symptoms or mental health challenges as a result of their illness. The researchers looked at patients with this condition to understand what psychological effects, if any, accompanied the physical symptoms of the disease.

E3 PreliminaryCohortPEM unclearObservational

[Benign myalgic encephalomyelitis, epidemic pseudoneurasthenia].

GSELL, O·Schweizerische medizinische Wochenschrift·1963

This 1963 observational study examined benign myalgic encephalomyelitis (an early name for ME/CFS) and its relationship to a condition called epidemic pseudoneurasthenia. The author documented clinical observations of patients experiencing this illness during what appeared to be epidemic outbreaks, noting the pattern of symptoms and disease presentation.

E3 PreliminaryCohortPEM unclear

Benign myalgic encephalomyelitis. (Report of five cases).

BORNSTEIN, B, BECHAR, M, LASS, H·Psychiatria et neurologia·1960

This is an early medical case report from 1960 describing five patients with myalgic encephalomyelitis (ME), a condition causing muscle pain and neurological symptoms. The authors documented the clinical features these patients experienced, helping establish that ME was a recognizable medical condition rather than a psychiatric illness. This foundational work contributed to understanding ME as a legitimate organic disease.

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Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections.

Raphe nucleus encephalopathy (myalgic encephalomyelitis, epidemic neuromyasthenia).

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

Cutaneous reflex responses recorded in children with various neurological disorders.

Coxsackie B infection in a Scottish general practice.

Sporadic myalgic encephalomyelitis in a rural practice.

Myalgic encephalomyelitis "an obscene cosmic joke"?

Epidemic myalgic encephalomyelitis.

Post-infectious encephalomyelitis: some aetiological mechanisms.

Electro-encephalographic investigations in myalgic encephalomyelitis.

Benign myalgic encephalomyelitis.

Benign myalgic encephalomyelitis.

Benign myalgic encephalomyelitis.

Concept of benign myalgic encephalomyelitis.

Encephalomyelitis resembling benign myalgic encephalomyelitis.

Encephalomyelitis resembling benign myalgic encephalomyelitis.

Benign myalgic encephalomyelitis in Lebanon.

The psychiatric sequelae of benign myalgic encephalomyelitis.

[Benign myalgic encephalomyelitis, epidemic pseudoneurasthenia].

Benign myalgic encephalomyelitis. (Report of five cases).

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