Search and filter 6,188 studies by evidence level, diagnostic criteria, PEM status, and research domain. Each entry links to the original source.
Studies sorted by evidence level, then year. Browse by topic instead →
Evidence level (E0–E3) reflects study type and replication, not methodological quality. A weak systematic review still sits at E0. How evidence levels work →
6181–6188 of 6,188 studies
GALPINE, J F·The British journal of clinical practice·1958
This 1958 case-control study examined patients with benign myalgic encephalomyelitis (an early name for ME/CFS). The researchers documented clinical presentations and characteristics of the condition to help establish it as a distinct medical illness rather than a purely psychological problem.
GALPINE, J F, BRADY, C·Lancet (London, England)·1957
This 1957 case-control study by Galpine and Brady documented cases of myalgic encephalomyelitis and compared them with control groups to understand the condition's features. The researchers aimed to establish that ME was a distinct medical condition with identifiable characteristics, rather than a purely psychological disorder. This early study helped establish the medical legitimacy of what patients and some doctors were observing as a real illness.
Recenti progressi in medicina·1957
This is a historical medical report from 1957 describing an outbreak of a disease called myalgic encephalomyelitis (now known as ME/CFS). The report documents cases where patients experienced muscle pain and neurological symptoms during what appeared to be an epidemic. This early observation helped establish that ME/CFS could occur in clusters and affect multiple people.
British medical journal·1957
This 1957 study from the British Medical Journal documents cases of myalgic encephalomyelitis occurring in epidemic form—meaning multiple people in a community became ill at the same time. The researchers observed patients with this condition to better understand how it presented and spread.
ACHESON, E D·Lancet (London, England)·1957
This is an early medical observation from 1957 describing ME/CFS as a benign condition. The study documents cases of people experiencing prolonged fatigue and muscle pain after viral infections. This foundational work helped establish that ME/CFS is a real medical condition deserving clinical attention.
DEISHER, J B·Northwest medicine·1957
This 1957 study documented cases of ME/CFS (then called Iceland disease) occurring in Alaska. The report describes observations of patients experiencing the illness in a geographic region where the disease had not been previously well-documented. This early observational account helped establish that ME/CFS was not limited to Iceland but could occur in other parts of the world.
BLATTNER, R J·The Journal of pediatrics·1956
This 1956 study describes an outbreak of a disease called Akureyri disease (also known as Iceland disease) that affected multiple people in Iceland. The disease caused muscle pain and fatigue similar to what we now call ME/CFS. This early medical observation helped document that ME/CFS-like illnesses have occurred in clusters and have affected communities for decades.
Lindan, R·Canadian Medical Association journal·1956
This 1956 paper by Lindan describes a condition called benign myalgic encephalomyelitis, an early medical account of what we now know as ME/CFS. The paper helped establish that this illness was a real medical condition worthy of clinical attention, rather than a psychological problem. It represents one of the early attempts to formally document and name the disease in medical literature.
Or browse by topic
Thematic groupings by clinical question or research area.
PET imaging and other studies providing evidence for brain inflammation in ME/CFS.
NeurologyMetabolomics and mitochondrial function studies revealing energy metabolism disruption.
MetabolismStudies identifying potential biological markers for ME/CFS diagnosis and stratification.
Biomarker