ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

621–640 of 6,157 studies

E0 ConsensusReviewPEM not requiredReview-Narrative

Fibromyalgia and chronic fatigue syndrome: similarities and differences.

Buchwald, D·Rheumatic diseases clinics of North America·1996

This review compared ME/CFS and fibromyalgia (FM), two conditions that cause fatigue, muscle pain, and sleep problems. The researchers found that these two illnesses are very similar in their symptoms and how they affect people's lives, even though doctors use different criteria to diagnose them. Some patients have both conditions at the same time, which makes their suffering worse.

SleepDiagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

War syndromes and their evaluation: from the U.S. Civil War to the Persian Gulf War.

Hyams, K C, Wignall, F S, Roswell, R·Annals of internal medicine·1996

Researchers reviewed historical records of illnesses that appeared in soldiers after wars, dating back to the U.S. Civil War through the Persian Gulf War. They found that across different wars and time periods, veterans reported similar symptoms like exhaustion, breathing problems, headaches, and difficulty concentrating. However, the researchers concluded that these symptoms don't appear to be one single disease, and that lack of proper comparison groups and research methods made it hard to determine what actually caused these illnesses.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredReview-Narrative

The management of treatment-resistant depression in disorders on the interface of psychiatry and medicine. Fibromyalgia, chronic fatigue syndrome, migraine, irritable bowel syndrome, atypical facial pain, and premenstrual dysphoric disorder.

Gruber, A J, Hudson, J I, Pope, H G·The Psychiatric clinics of North America·1996

This review examined whether antidepressant medications help treat several chronic conditions—including ME/CFS, fibromyalgia, migraines, and irritable bowel syndrome—that often occur alongside depression. The researchers found that many different types of antidepressants appeared to benefit these disorders, suggesting they might share a common underlying biological problem. However, the studies reviewed varied widely in quality and design, so stronger research is needed to confirm these findings.

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. 1: Etiology and pathogenesis.

Farrar, D J, Locke, S E, Kantrowitz, F G·Behavioral medicine (Washington, D.C.)·1995

ME/CFS is a serious illness that causes extreme tiredness and many other symptoms, but doctors don't yet fully understand what causes it or how to treat it best. This review looks at research about what might be happening in the body—including problems with the immune system and stress hormone regulation—but notes that no single explanation has been proven. Right now, treatment approaches are based on guesses rather than solid evidence, and we need better ways to identify which patients have which type of ME/CFS.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

The epidemiology of chronic fatigue syndrome.

Wessely, S·Epidemiologic reviews·1995

This review examined what we know about how common ME/CFS is, who develops it, and how it varies across different populations and regions. The researchers looked at existing research to understand the overall patterns of this illness in society. This helps doctors and patients understand whether ME/CFS is rare or relatively common, and whether certain groups are more likely to be affected.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Clinical correlates of infection with human herpesvirus-6.

Krueger, G R, Klueppelberg, U, Hoffmann, A et al.·In vivo (Athens, Greece)·1994

This review examines connections between human herpesvirus-6 (HHV-6), a common virus most people catch as infants, and various illnesses including ME/CFS. The virus usually stays dormant in the body after infection, but in some people it may reactivate and be linked to several health conditions. The authors reviewed existing knowledge about which diseases show signs of active HHV-6 infection.

Immune System

E0 ConsensusReviewPEM not requiredEditorial

The treatment of chronic fatigue syndrome: science and speculation.

Wilson, A, Hickie, I, Lloyd, A et al.·The American journal of medicine·1994

This review examined different treatments for ME/CFS and found that the condition is complex, affecting people in various ways. No single treatment has been proven to work well for most patients over the long term. The authors suggest that the best approach combines medical care, psychological support, and symptom management tailored to each person's needs.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

Pathogenic tracks in fatigue syndromes.

Moutschen, M, Triffaux, J M, Demonty, J et al.·Acta clinica Belgica·1994

This review examined research on ME/CFS and related fatigue conditions that develop after viral infections, looking at five main areas: infectious triggers, immune system problems, muscle function, hormonal imbalances, and psychiatric factors. The authors suggest that abnormalities in the body's stress-hormone system (HPA axis) may be a primary cause, leading to chronic immune activation and reactivation of dormant viruses like those in the herpes family, which then cause muscle weakness and fatigue symptoms.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Psychotropic treatment of chronic fatigue syndrome and related disorders.

Goodnick, P J, Sandoval, R·The Journal of clinical psychiatry·1993

This review examined whether antidepressant medications can help people with ME/CFS and fibromyalgia, since depression often occurs alongside these conditions. Researchers looked at 23 studies and found that certain antidepressants—particularly at lower doses than used for depression alone—may help reduce both fatigue and pain symptoms. Different types of antidepressants appeared to work better for different symptoms: some were better for pain relief, while others were better for mood.

E0 ConsensusReviewPEM not requiredReview-Narrative

The neuropsychiatry of chronic fatigue syndrome.

Wessely, S·Ciba Foundation symposium·1993

This review examines how ME/CFS relates to psychiatric conditions and brain function. Rather than viewing ME/CFS as purely physical or purely psychological, the authors found evidence that brain system problems—particularly in the hypothalamus, a key control center—play an important role in the condition. The paper argues that understanding ME/CFS requires looking at both brain biology and mental health factors together.

E0 ConsensusReviewPEM not requiredReview-Narrative

Studies of herpesvirus infection in chronic fatigue syndrome.

Straus, S E·Ciba Foundation symposium·1993

This review examined whether common viruses in the herpesvirus family (like Epstein-Barr virus and human herpesvirus 6) cause ME/CFS. Researchers found that while some ME/CFS patients have higher levels of antibodies to these viruses and some cases may start after herpesvirus infection, these viruses are likely not the main cause of the illness for most people.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

The pathophysiology of chronic fatigue syndrome: confirmations, contradictions, and conjectures.

Manu, P, Lane, T J, Matthews, D A·International journal of psychiatry in medicine·1992

This 1992 review examined 32 published studies on ME/CFS to identify what researchers had consistently found, disagreed about, or only reported once. The review confirmed that ME/CFS primarily affects middle-aged white women and is often accompanied by depression, but found conflicting evidence about whether infections cause the illness and whether immune treatments help.

Immune System

E0 ConsensusReviewPEM not requiredEditorial

Fibromyalgia, chronic fatigue, and myofascial pain syndromes.

Goldenberg, D L·Current opinion in rheumatology·1992

This review examined research published on fibromyalgia and chronic fatigue syndrome, looking at what treatments work best and how these conditions are diagnosed. Researchers found that while many studies have been done, no single treatment has proven highly effective for either condition, and the way doctors diagnose chronic fatigue syndrome needs to be improved and made more consistent.

Diagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

Post-infectious neuromyasthenia (chronic fatigue syndrome): a summary of ongoing studies.

Salit, I E, Abbey, S E, Moldofsky, H et al.·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This 1991 review examined multiple ongoing studies about ME/CFS (then called post-infectious neuromyasthenia), a condition that causes extreme fatigue and other symptoms following infections. The researchers summarized what different studies were finding about how this illness affects the body and brain. This work helped organize early research efforts to better understand this serious condition.

Post-Exertional Malaise

E0 ConsensusGuidelinePEM unclearGuideline

A report--chronic fatigue syndrome: guidelines for research.

Sharpe, M C, Archard, L C, Banatvala, J E et al.·Journal of the Royal Society of Medicine·1991

This 1991 document provides guidelines for how researchers should study ME/CFS to ensure consistent and reliable findings. Rather than reporting new experimental results, it offers recommendations on how to standardize research methods, study design, and patient definitions. It represents the thinking of leading medical experts who were trying to establish a common framework for ME/CFS research.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

An overview of chronic fatigue syndrome.

Krupp, L B, Mendelson, W B, Friedman, R·The Journal of clinical psychiatry·1991

This review examined research on ME/CFS to understand whether the illness is caused by psychological factors, immune system problems, or both. Researchers found that ME/CFS patients experience more disabling fatigue than people with other chronic illnesses, and some have immune system abnormalities. However, many ME/CFS patients have no psychiatric illness, suggesting ME/CFS is a real medical condition separate from depression.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and depression: cause, effect, or covariate.

Abbey, S E, Garfinkel, P E·Reviews of infectious diseases·1991

Many people with ME/CFS experience depression, but it's unclear why. This review examines four possible explanations: depression might be the main illness with fatigue as a symptom, depression might develop because of having ME/CFS, both conditions might occur together separately, or depression might be incorrectly diagnosed. The authors discuss how depression can affect medical tests used to study ME/CFS, which is important to understand when interpreting research results.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredReview-Narrative

Cognitive and mood-state changes in patients with chronic fatigue syndrome.

Grafman, J, Johnson, R, Scheffers, M·Reviews of infectious diseases·1991

This review examined whether ME/CFS causes problems with memory, thinking, and mood. The researchers found that while some people with acute mono or EBV infection may have thinking difficulties, they couldn't confirm this happens in ME/CFS patients using objective tests. However, they did notice that people with ME/CFS often have depression or anxiety either before or alongside their illness.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredReview-Narrative

Review of laboratory findings for patients with chronic fatigue syndrome.

Buchwald, D, Komaroff, A L·Reviews of infectious diseases·1991

This review examined blood test results from many ME/CFS patients and found several patterns in how their immune systems function differently. The most common findings included weaker natural killer cells (which normally help fight infections), unusual antibody levels, and signs of past Epstein-Barr virus infection. These patterns appeared across multiple studies, suggesting they may be important features of the condition.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Serologic and immunologic responses in chronic fatigue syndrome with emphasis on the Epstein-Barr virus.

Jones, J F·Reviews of infectious diseases·1991

This review examined whether ME/CFS is connected to Epstein-Barr virus (EBV), the virus that causes mono. Researchers found that people with ME/CFS had higher levels of antibodies to EBV compared to healthy people, but this doesn't prove the virus causes the disease. They also found that immune cells called natural killer cells—which help fight infections—work differently in ME/CFS patients, though the findings varied between studies.

Immune System

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Fibromyalgia and chronic fatigue syndrome: similarities and differences.

War syndromes and their evaluation: from the U.S. Civil War to the Persian Gulf War.

The management of treatment-resistant depression in disorders on the interface of psychiatry and medicine. Fibromyalgia, chronic fatigue syndrome, migraine, irritable bowel syndrome, atypical facial pain, and premenstrual dysphoric disorder.

Chronic fatigue syndrome. 1: Etiology and pathogenesis.

The epidemiology of chronic fatigue syndrome.

Clinical correlates of infection with human herpesvirus-6.

The treatment of chronic fatigue syndrome: science and speculation.

Pathogenic tracks in fatigue syndromes.

Psychotropic treatment of chronic fatigue syndrome and related disorders.

The neuropsychiatry of chronic fatigue syndrome.

Studies of herpesvirus infection in chronic fatigue syndrome.

The pathophysiology of chronic fatigue syndrome: confirmations, contradictions, and conjectures.

Fibromyalgia, chronic fatigue, and myofascial pain syndromes.

Post-infectious neuromyasthenia (chronic fatigue syndrome): a summary of ongoing studies.

A report--chronic fatigue syndrome: guidelines for research.

An overview of chronic fatigue syndrome.

Chronic fatigue syndrome and depression: cause, effect, or covariate.

Cognitive and mood-state changes in patients with chronic fatigue syndrome.

Review of laboratory findings for patients with chronic fatigue syndrome.

Serologic and immunologic responses in chronic fatigue syndrome with emphasis on the Epstein-Barr virus.

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