Berends, G M, Peeters, M F, Lepoutre, J M et al. · Nederlands tijdschrift voor geneeskunde · 1988
This 1988 case study examined whether Epstein-Barr virus (EBV)—a common virus that causes infections like mononucleosis—might be connected to ME/CFS. The researchers looked at individual patient cases to explore possible links between EBV infection and the development of chronic fatigue syndrome symptoms.
This study is historically significant as part of early investigations into infectious triggers for ME/CFS, particularly the EBV hypothesis that has remained relevant in ME/CFS research for decades. Understanding potential viral contributions to ME/CFS remains important for patients seeking to understand their condition's origins and for researchers developing potential preventive or therapeutic strategies.
As a case report without a control group, this study cannot establish causation or prove that EBV causes ME/CFS. The findings do not demonstrate how common EBV infection is in ME/CFS patients compared to the general population, nor can they rule out other contributing factors or explain why only some EBV-infected people develop ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Berends, G M, Peeters, M F, Lepoutre, J M, van Liebergen, F J, Kurstjens, R M, & Koolen, M I (1988). [Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].. Nederlands tijdschrift voor geneeskunde. https://pubmed.ncbi.nlm.nih.gov/3374676/
BibTeX
@article{mecfsatlas-berends-1988-chronic-fatigue,
author = {Berends, G M and Peeters, M F and Lepoutre, J M and van Liebergen, F J and Kurstjens, R M and Koolen, M I},
title = {[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].},
journal = {Nederlands tijdschrift voor geneeskunde},
year = {1988},
note = {PubMed: 3374676},
url = {https://www.mecfsatlas.com/evidence/berends-1988-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/berends-1988-chronic-fatigue
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