Cohen, Jessica, Mathew, Annette, Dourvetakis, Kirk D et al. · Cells · 2024 · DOI
This review examines how inflammation in the brain and nervous system contributes to several chronic diseases, including ME/CFS and Gulf War Illness. The authors discuss how immune cells and inflammatory molecules can damage the brain and cause persistent symptoms. They highlight promising new laboratory techniques using human stem cells to create brain cells for testing potential treatments.
This review establishes ME/CFS as a legitimate neuroimmune disorder alongside recognized neurological diseases, validating the inflammatory basis of the condition. The emphasis on iPSC-derived cell models offers hope for future targeted therapies and personalized medicine approaches specifically for ME/CFS patients who currently lack FDA-approved treatments.
This is a literature review, not an original research study, so it does not present new experimental data or prove specific therapeutic efficacy. It does not establish causal mechanisms in ME/CFS specifically—only that neuroimmune dysfunction is associated with the disease. Individual studies cited may have limitations regarding sample size, biomarker specificity, or disease heterogeneity.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Cohen, Jessica, Mathew, Annette, Dourvetakis, Kirk D, Sanchez-Guerrero, Estella, Pangeni, Rajendra P, Gurusamy, Narasimman, et al. (2024). Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.. Cells. https://doi.org/10.3390/cells13060511
BibTeX
@article{mecfsatlas-cohen-2024-recent-research,
author = {Cohen, Jessica and Mathew, Annette and Dourvetakis, Kirk D and Sanchez-Guerrero, Estella and Pangeni, Rajendra P and Gurusamy, Narasimman and Aenlle, Kristina K and Ravindran, Geeta and Twahir, Assma and Isler, Dylan and Sosa-Garcia, Sara Rukmini and Llizo, Axel and Bested, Alison C and Theoharides, Theoharis C and Klimas, Nancy G and Kempuraj, Duraisamy},
title = {Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.},
journal = {Cells},
year = {2024},
doi = {10.3390/cells13060511},
note = {PubMed: 38534355},
url = {https://www.mecfsatlas.com/evidence/cohen-2024-recent-research},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/cohen-2024-recent-research
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