Liu, Jun, Liao, Junfeng, Lin, Fan et al. · Alternative therapies in health and medicine · 2024
Researchers tested whether a traditional Chinese herbal supplement (Qiye Shen'an Pian) combined with glutathione and vitamin B1 could help ME/CFS patients feel less tired and improve their immune system. Over 8 weeks, patients receiving the herbal supplement along with the standard treatment showed greater improvements in fatigue levels, immune markers, and overall quality of life compared to those receiving only the standard treatment.
ME/CFS patients have limited evidence-based treatment options and often experience impaired immune function and oxidative stress. This study suggests a potential therapeutic approach combining traditional medicine with micronutrient support to address multiple pathophysiological features of the disease, offering hope for symptom management strategies.
This study does not prove that Qiye Shen'an Pian is a cure or that improvements will persist long-term, as follow-up beyond 8 weeks is not reported. The study cannot establish causation definitively because it lacks information on blinding, placebo controls, and does not demonstrate that immune changes directly cause symptom improvement rather than both resulting from a third factor. Results in a Chinese population may not generalize to other ethnic or geographic groups.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Liu, Jun, Liao, Junfeng, Lin, Fan, & Nie, Chenyang (2024). Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.. Alternative therapies in health and medicine. https://pubmed.ncbi.nlm.nih.gov/38702173/
BibTeX
@article{mecfsatlas-liu-2024-effects-qiye,
author = {Liu, Jun and Liao, Junfeng and Lin, Fan and Nie, Chenyang},
title = {Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.},
journal = {Alternative therapies in health and medicine},
year = {2024},
note = {PubMed: 38702173},
url = {https://www.mecfsatlas.com/evidence/liu-2024-effects-qiye},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/liu-2024-effects-qiye
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