Miike, Teruhisa · Nihon rinsho. Japanese journal of clinical medicine · 2007
This review discusses chronic fatigue syndrome (CFS) in children and teenagers, a serious condition affecting 3-5% of young people. Children with CFS experience extreme tiredness, sleep problems, trouble learning and remembering, and immune system issues. While routine blood tests often look normal, special testing can reveal abnormalities in how their bodies handle energy, regulate temperature, and control hormones.
Understanding CFS in children is critical because early-onset disease may have different pathophysiology and long-term outcomes than adult-onset CFS. Establishing pediatric-specific diagnostic criteria and identifying measurable biomarkers can improve recognition, validate the biological basis of the condition, and guide targeted interventions before disease becomes entrenched.
This review does not establish causation for any observed abnormalities, nor does it prove that circadian rhythm correction and energy supplementation are effective treatments—it only suggests they are reasonable therapeutic targets. The study provides no original experimental data and does not determine whether the 3-5% prevalence figure applies across all populations or countries. No treatment outcomes are quantified.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Miike, Teruhisa (2007). [Childhood chronic fatigue syndrome].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/17561704/
BibTeX
@article{mecfsatlas-miike-2007-childhood-chronic,
author = {Miike, Teruhisa},
title = {[Childhood chronic fatigue syndrome].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {2007},
note = {PubMed: 17561704},
url = {https://www.mecfsatlas.com/evidence/miike-2007-childhood-chronic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/miike-2007-childhood-chronic
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