Mitterer, M, Pescosta, N, Fend, F et al. · British journal of haematology · 1995 · DOI
This report describes one patient who had an unusual blood disorder involving too many B cells (immune cells) along with symptoms resembling chronic fatigue syndrome, including persistent tiredness and recurring skin rashes. Testing showed the patient had a chronic active Epstein-Barr virus (EBV) infection with the virus actively replicating in their blood cells. The researchers suggest that persistent EBV replication may play a role in developing this lymphoproliferative disorder.
This case highlights a potential link between persistent EBV replication and the development of lymphoproliferative disorders in patients with ME/CFS-like symptoms. For ME/CFS researchers, it provides molecular evidence that EBV can maintain active, productive infection in some patients, which may inform investigations into viral persistence as a potential disease mechanism.
This single case report does not establish that EBV replication causes ME/CFS or PPBL in the general population, nor does it prove that all ME/CFS patients have chronic active EBV. The presence of EBV replication in this patient does not demonstrate causation versus coincidental infection, and findings cannot be generalized beyond this individual case without larger cohort studies.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Mitterer, M, Pescosta, N, Fend, F, Larcher, C, Prang, N, Schwarzmann, F, et al. (1995). Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis.. British journal of haematology. https://doi.org/10.1111/j.1365-2141.1995.tb05579.x
BibTeX
@article{mecfsatlas-mitterer-1995-chronic-active,
author = {Mitterer, M and Pescosta, N and Fend, F and Larcher, C and Prang, N and Schwarzmann, F and Coser, P and Huemer, H P},
title = {Chronic active Epstein-Barr virus disease in a case of persistent polyclonal B-cell lymphocytosis.},
journal = {British journal of haematology},
year = {1995},
doi = {10.1111/j.1365-2141.1995.tb05579.x},
note = {PubMed: 7646989},
url = {https://www.mecfsatlas.com/evidence/mitterer-1995-chronic-active},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/mitterer-1995-chronic-active
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