Morris, Gerwyn, Walder, Ken, Puri, Basant K et al. · Molecular neurobiology · 2016 · DOI
This review explains how harmful molecules called oxidative and nitrosative stress damage specific fatty structures in cells that are important for cell communication and brain function. These damaged structures may contribute to ME/CFS, along with other conditions affecting the brain and immune system. The authors suggest that omega-3 fatty acid supplements might help restore these damaged cellular structures.
This study identifies a potentially unifying cellular mechanism—disrupted lipid-based signaling—that could explain multiple neurological and immunological symptoms in ME/CFS. Understanding this pathway could lead to targeted therapeutic approaches like omega-3 supplementation that address root causes rather than just symptoms.
This is a narrative review, not a clinical trial or empirical study; it does not directly measure O&NS, palmitoylation, or lipid raft function in ME/CFS patients. The review does not prove that n-3 PUFA supplementation is effective in treating ME/CFS or that lipid-signaling disruption is the primary driver of disease rather than a secondary consequence.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Morris, Gerwyn, Walder, Ken, Puri, Basant K, Berk, Michael, & Maes, Michael (2016). The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.. Molecular neurobiology. https://doi.org/10.1007/s12035-015-9392-y
BibTeX
@article{mecfsatlas-morris-2016-deleterious-effects,
author = {Morris, Gerwyn and Walder, Ken and Puri, Basant K and Berk, Michael and Maes, Michael},
title = {The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.},
journal = {Molecular neurobiology},
year = {2016},
doi = {10.1007/s12035-015-9392-y},
note = {PubMed: 26310971},
url = {https://www.mecfsatlas.com/evidence/morris-2016-deleterious-effects},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/morris-2016-deleterious-effects
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