Nijs, Jo, Van de Putte, Karen, Louckx, Fred et al. · Pain medicine (Malden, Mass.) · 2008 · DOI
This study looked at 36 women with ME/CFS who experience widespread pain to understand how their thoughts about pain (called 'pain catastrophizing'—expecting the worst and feeling helpless) relate to their actual pain levels, ability to exercise, and daily functioning. Researchers found that negative thinking patterns about pain were strongly connected to how much bodily pain patients reported and how much their condition limited their activities. The study suggests that addressing these thought patterns might be an important part of managing ME/CFS with pain.
Understanding the psychological factors that modulate pain perception in ME/CFS is crucial for developing comprehensive treatment approaches beyond purely biomedical interventions. This study provides empirical support for cognitive and psychological interventions targeting catastrophic thinking as potential therapeutic targets to reduce pain burden and improve functional capacity in this population.
This study does not establish causation—it cannot determine whether pain catastrophizing causes increased pain or whether chronic pain leads to catastrophic thinking patterns. The cross-sectional design captures only a single moment in time and cannot track how these relationships evolve. Results apply only to female CFS patients with widespread pain and may not generalize to male patients or those without concurrent pain.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Nijs, Jo, Van de Putte, Karen, Louckx, Fred, Truijen, Steven, & De Meirleir, Kenny (2008). Exercise performance and chronic pain in chronic fatigue syndrome: the role of pain catastrophizing.. Pain medicine (Malden, Mass.). https://doi.org/10.1111/j.1526-4637.2007.00368.x
BibTeX
@article{mecfsatlas-nijs-2008-exercise-performance,
author = {Nijs, Jo and Van de Putte, Karen and Louckx, Fred and Truijen, Steven and De Meirleir, Kenny},
title = {Exercise performance and chronic pain in chronic fatigue syndrome: the role of pain catastrophizing.},
journal = {Pain medicine (Malden, Mass.)},
year = {2008},
doi = {10.1111/j.1526-4637.2007.00368.x},
note = {PubMed: 19086101},
url = {https://www.mecfsatlas.com/evidence/nijs-2008-exercise-performance},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/nijs-2008-exercise-performance
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