Ravindran, Murugan, Adewuyi, Oluwatoyin, Zheng, Yin et al. · Global journal of health science · 2012 · DOI
Many people with ME/CFS experience shortness of breath, but this study found that their lungs work normally—the problem isn't with how well air moves in and out. Instead, people with ME/CFS seem to be overly sensitive to physical sensations like rapid heartbeat, chest pain, and dizziness during exertion, which makes them feel breathless. This suggests the shortness of breath in ME/CFS comes from how the nervous system processes these sensations rather than from damaged lungs.
Dyspnea is a common and debilitating symptom in ME/CFS, but understanding its cause is essential for developing effective treatments. This study provides evidence that the breathing difficulties are not due to lung disease, redirecting clinical and research focus toward nervous system dysfunction and abnormal symptom perception—potentially opening new avenues for management strategies that target sensory processing rather than respiratory mechanics.
This study does not establish the *cause* of sensory hypersensitivity in ME/CFS—it only demonstrates an association. It also does not prove that dyspnea in all ME/CFS patients stems from the same mechanism, as individual variation may exist. Cross-sectional design means temporal relationships cannot be determined, and we cannot know whether the sensory hypersensitivity precedes or results from ME/CFS development.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Ravindran, Murugan, Adewuyi, Oluwatoyin, Zheng, Yin, Rayhan, Rakib U, Le, Uyenphuong, Timbol, Christian, et al. (2012). Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies.. Global journal of health science. https://doi.org/10.5539/gjhs.v5n2p94
BibTeX
@article{mecfsatlas-ravindran-2012-dyspnea-chronic,
author = {Ravindran, Murugan and Adewuyi, Oluwatoyin and Zheng, Yin and Rayhan, Rakib U and Le, Uyenphuong and Timbol, Christian and Merck, Samantha and Esteitie, Rania and Read, Charles and Cooney, Michelle and Baraniuk, James},
title = {Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies.},
journal = {Global journal of health science},
year = {2012},
doi = {10.5539/gjhs.v5n2p94},
note = {PubMed: 23445698},
url = {https://www.mecfsatlas.com/evidence/ravindran-2012-dyspnea-chronic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/ravindran-2012-dyspnea-chronic
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