Reiffenberger, D H, Amundson, L H · American family physician · 1996
Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.
This review is relevant to ME/CFS patients and researchers because it acknowledges the differential diagnosis relationship between fibromyalgia and chronic fatigue syndrome, two frequently overlapping or confused conditions. Understanding fibromyalgia's symptom profile and treatment approaches may help clarify distinctions and overlaps with ME/CFS, supporting more accurate diagnosis and patient care.
This review does not establish the underlying biological mechanisms of fibromyalgia, does not prove causation for any symptom associations, and does not demonstrate the efficacy of specific treatments through controlled trials. The distinction between fibromyalgia and chronic fatigue syndrome remains descriptive rather than mechanistic, and no causal relationships between symptoms are established.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Reiffenberger, D H & Amundson, L H (1996). Fibromyalgia syndrome: a review.. American family physician. https://pubmed.ncbi.nlm.nih.gov/8623696/
BibTeX
@article{mecfsatlas-reiffenberger-1996-fibromyalgia-syndrome,
author = {Reiffenberger, D H and Amundson, L H},
title = {Fibromyalgia syndrome: a review.},
journal = {American family physician},
year = {1996},
note = {PubMed: 8623696},
url = {https://www.mecfsatlas.com/evidence/reiffenberger-1996-fibromyalgia-syndrome},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/reiffenberger-1996-fibromyalgia-syndrome
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