Repka-Ramirez, M S, Naranch, K, Park, Y J et al. · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2001 · DOI
Researchers tested whether people with ME/CFS have higher levels of IgE, a protein the immune system makes during allergic reactions. They compared IgE levels in 95 ME/CFS patients and 109 healthy people, including those with and without allergies. They found IgE levels were the same in both groups, suggesting that allergies are probably not a major cause of ME/CFS.
Some ME/CFS patients report allergic symptoms, leading to theories that allergies or mast cell dysfunction could cause the illness. This study provides evidence against this hypothesis, helping researchers focus on other immune mechanisms and saving patients from pursuing allergy-based treatments that may not address the underlying cause.
This study does not prove that allergies play no role in any ME/CFS subset; it only shows that overall IgE elevation is not more common in CFS populations. It also does not rule out other allergy-related mechanisms (such as local mucosal IgE, IgG, or mast cell activation) that might not be reflected in serum IgE levels. Cross-sectional design means causality cannot be established.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Repka-Ramirez, M S, Naranch, K, Park, Y J, Velarde, A, Clauw, D, & Baraniuk, J N (2001). IgE levels are the same in chronic fatigue syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. https://doi.org/10.1016/S1081-1206(10)62229-6
BibTeX
@article{mecfsatlas-repka-ramirez-2001-ige-levels,
author = {Repka-Ramirez, M S and Naranch, K and Park, Y J and Velarde, A and Clauw, D and Baraniuk, J N},
title = {IgE levels are the same in chronic fatigue syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types.},
journal = {Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
year = {2001},
doi = {10.1016/S1081-1206(10)62229-6},
note = {PubMed: 11570618},
url = {https://www.mecfsatlas.com/evidence/repka-ramirez-2001-ige-levels},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/repka-ramirez-2001-ige-levels
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