Scully, Paul, McKernan, Declan P, Keohane, John et al. · The American journal of gastroenterology · 2010 · DOI
This study looked at inflammation markers in the blood of women with irritable bowel syndrome (IBS), particularly those who also had fibromyalgia, premenstrual symptoms, or chronic fatigue syndrome. Researchers found that women with IBS plus these extra conditions had higher levels of four inflammation-related substances (IL-1β, IL-6, IL-8, and TNFα) compared to healthy women, while those with IBS alone had elevated levels of two of these markers.
This study is significant for ME/CFS patients because it provides evidence that the cluster of conditions often occurring together—including chronic fatigue syndrome, fibromyalgia, and IBS—share a common pro-inflammatory signature involving multiple cytokines. Understanding this shared immune dysregulation may help explain why these conditions co-occur and could inform future treatment strategies targeting inflammation in ME/CFS.
This study does not establish causation—elevated cytokines may be a consequence of illness rather than a cause. It cannot determine whether the inflammatory profile is specific to ME/CFS or simply reflects the broader syndrome of IBS with comorbidities. Additionally, cross-sectional design means we cannot determine whether cytokine elevations precede symptom onset or develop as a result of chronic illness.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Scully, Paul, McKernan, Declan P, Keohane, John, Groeger, David, Shanahan, Fergus, Dinan, Timothy G, et al. (2010). Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.. The American journal of gastroenterology. https://doi.org/10.1038/ajg.2010.159
BibTeX
@article{mecfsatlas-scully-2010-plasma-cytokine,
author = {Scully, Paul and McKernan, Declan P and Keohane, John and Groeger, David and Shanahan, Fergus and Dinan, Timothy G and Quigley, Eamonn M M},
title = {Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.},
journal = {The American journal of gastroenterology},
year = {2010},
doi = {10.1038/ajg.2010.159},
note = {PubMed: 20407431},
url = {https://www.mecfsatlas.com/evidence/scully-2010-plasma-cytokine},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/scully-2010-plasma-cytokine
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