Yang, Tse-Yen, Lin, Cheng-Li, Yao, Wei-Cheng et al. · Journal of translational medicine · 2022 · DOI
This study found that people who have had a tuberculosis infection are about 23% more likely to develop ME/CFS than people who have never had tuberculosis. Researchers in Taiwan tracked over 38,000 people for about 10 years and noticed that tuberculosis and ME/CFS share similar symptoms and immune system patterns. The link was especially strong in men and in people aged 65 and older.
This study provides epidemiological evidence linking a common infectious trigger (tuberculosis) to ME/CFS development, suggesting shared immunological pathways between these conditions. Understanding post-infectious ME/CFS may inform prevention strategies and identify subgroups at elevated risk, particularly older adults and men. The finding of similar immunosignatures between post-TB and ME/CFS could accelerate biomarker research and targeted therapeutic development.
This study demonstrates association but does not establish causation—tuberculosis infection may increase ME/CFS risk through direct immune mechanisms, or confounding variables (socioeconomic factors, healthcare access, comorbidities) may explain the relationship. The study cannot determine whether TB treatment, TB severity, or latent versus active TB drives the elevated risk. Registry-based diagnoses may not capture subclinical disease or capture coding artifacts rather than true disease occurrence.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Yang, Tse-Yen, Lin, Cheng-Li, Yao, Wei-Cheng, Lio, Chon-Fu, Chiang, Wen-Po, Lin, Kuan, et al. (2022). How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population-based retrospective cohort study.. Journal of translational medicine. https://doi.org/10.1186/s12967-022-03301-1
BibTeX
@article{mecfsatlas-yang-2022-how-mycobacterium,
author = {Yang, Tse-Yen and Lin, Cheng-Li and Yao, Wei-Cheng and Lio, Chon-Fu and Chiang, Wen-Po and Lin, Kuan and Kuo, Chien-Feng and Tsai, Shin-Yi},
title = {How mycobacterium tuberculosis infection could lead to the increasing risks of chronic fatigue syndrome and the potential immunological effects: a population-based retrospective cohort study.},
journal = {Journal of translational medicine},
year = {2022},
doi = {10.1186/s12967-022-03301-1},
note = {PubMed: 35189895},
url = {https://www.mecfsatlas.com/evidence/yang-2022-how-mycobacterium},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/yang-2022-how-mycobacterium
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