ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

637 studies

101–120 of 637 studies

E0 ConsensusReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in children].

Chutko, L S, Surushkina, S Yu, Yakovenko, E A et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2024

This article reviews existing research on ME/CFS (chronic fatigue syndrome) in children. The authors summarize what scientists have learned about how common the condition is, what causes it, how doctors diagnose it, and what treatments might help. A major focus is on cognitive problems—like difficulty concentrating and brain fog—that children with ME/CFS often experience.

Cognitive Impairment

E0 ConsensusReviewPEM requiredReview-Narrative

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives.

Stallmach, Andreas, Quickert, Stefanie, Puta, Christian et al.·Frontiers in immunology·2024

This review examines whether changes in gut bacteria might play a role in ME/CFS, particularly in cases that develop after infections like COVID-19. The authors found that many ME/CFS patients do show differences in their gut bacteria compared to healthy people, and these changes might trigger immune and inflammatory problems. However, the review concludes that current research hasn't proven that gut bacteria changes actually cause ME/CFS—only that they often occur together.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

Exercise therapy for chronic fatigue syndrome.

Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan et al.·The Cochrane database of systematic reviews·2024

This review looked at eight studies involving 1,518 people with ME/CFS to see if exercise therapy helps. When compared to usual care or passive treatments, exercise probably reduced fatigue somewhat in the short term, but we cannot be sure it helps long-term. When compared to other treatments like cognitive behavioural therapy, exercise did not clearly perform better or worse. The quality of evidence was often too low to draw firm conclusions about safety or effects on pain, quality of life, and other symptoms.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

Functional Somatic Syndromes Are Associated With Varied Postoperative Outcomes and Increased Opioid Use After Spine Surgery: A Systematic Review.

Masood, Raisa, LeRoy, Taryn E, Moverman, Michael A et al.·Global spine journal·2024

This review looked at seven studies involving over 40,000 patients to understand how people with fibromyalgia and other chronic pain conditions fare after spine surgery. The main finding was that patients with fibromyalgia were more likely to use opioid painkillers for longer periods after surgery and reported less improvement in their symptoms compared to those without fibromyalgia. Very little research exists on how other conditions like ME/CFS affect spine surgery outcomes.

E0 ConsensusReviewPEM unclear

Myalgic encephalomyelitis/chronic fatigue syndrome from current evidence to new diagnostic perspectives through skeletal muscle and metabolic disturbances.

Pietrangelo, Tiziana, Cagnin, Stefano, Bondi, Danilo et al.·Acta physiologica (Oxford, England)·2024

This review examines what we know about ME/CFS by focusing on problems in muscles and how the body uses energy. Researchers looked at existing research to understand why ME/CFS causes severe tiredness and muscle problems. The authors suggest that studying muscle tissue more closely might help doctors diagnose ME/CFS better and develop new treatments.

Diagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease.

Arron, Hayley E, Marsh, Benjamin D, Kell, Douglas B et al.·Frontiers in immunology·2024

This review examines what we know about ME/CFS by looking at how the disease develops from a combination of genetic factors, infections, and immune problems. The researchers found that ME/CFS appears to result from multiple body systems going wrong at the same time—including the immune system, inflammation, digestive health, and energy production. The study argues that doctors and scientists need to stop looking at ME/CFS as a single problem and instead understand it as a complex condition involving many interconnected issues.

Energy MetabolismImmune System

E0 ConsensusReviewPEM unclear

Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities.

Obraitis, Dominic, Li, Dawei·Current opinion in virology·2024

This review examines whether viruses trigger myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Scientists have found that some ME/CFS cases may start after viral infections, and blood tests can detect viral genetic material in patients. The review highlights that while viruses are a suspected cause, no single virus has been found in all ME/CFS patients, and researchers need better tools to understand these complex viral patterns.

Long COVID Overlap

E0 ConsensusReviewPEM not requiredMeta-Analysis

Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis.

Maas Genannt Bermpohl, Frederic, Kucharczyk-Bodenburg, Ann-Cathrin, Martin, Alexandra·International journal of behavioral medicine·2024

This review analyzed 15 studies involving over 2,000 people with ME/CFS who received cognitive behavioral therapy (CBT)—a talk therapy that helps change thinking patterns and behavior. The results show that CBT helped reduce fatigue, depression, and anxiety compared to control groups, with benefits lasting at least several months after treatment ended. Most people who started CBT stayed in the program and completed their sessions, suggesting the treatment is acceptable to patients.

E0 ConsensusReviewPEM requiredReview-Narrative

Chronic Fatigue Syndrome: Diagnosis, Treatment, and Future Direction.

Graves, B Sue, Patel, Mitsu, Newgent, Hailey et al.·Cureus·2024

ME/CFS is a serious illness that causes extreme tiredness that doesn't improve with rest and often gets worse with activity. People with ME/CFS also struggle with brain fog, pain, sleep problems, and immune system issues. Right now, doctors don't have a simple blood test or scan to diagnose ME/CFS, which makes it hard to identify and treat the condition properly.

BiomarkersImmune SystemCognitive ImpairmentPost-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Post-Acute Sequelae of SARS-CoV-2 Infection and Its Impact on Adolescents and Young Adults.

Broussard, Camille A, Azola, Alba, Rowe, Peter C·Pediatric clinics of North America·2024

This review examines long-term COVID symptoms that persist in teenagers and young adults after initial infection, sometimes called 'long COVID' or PASC. The researchers looked at how these symptoms present differently in younger people, discussed ways doctors can assess and treat these patients, and highlighted the importance of fair and equitable care for all affected young people.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview.

Mantle, David, Hargreaves, Iain Parry, Domingo, Joan Carles et al.·International journal of molecular sciences·2024

This review examines whether problems with mitochondria—the energy-producing structures inside our cells—contribute to post-viral fatigue conditions like ME/CFS, long COVID, and fibromyalgia. The researchers looked at existing research to see if a supplement called Coenzyme Q10 might help reduce fatigue and pain by supporting mitochondrial function. While mitochondrial dysfunction appears linked to these conditions, more research is needed to confirm whether CoQ10 supplementation is an effective treatment.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

Long COVID: lights and shadows on the clinical characterization of this emerging pathology.

Cogliandro, Viola, Bonfanti, Paolo·The new microbiologica·2024

This review examined Long COVID, a condition affecting 10-20% of people who had COVID-19 infection. Long COVID causes multiple symptoms across different body systems that significantly reduce quality of life. The review highlights that some Long COVID patients develop conditions like POTS (a heart rhythm problem when standing), ME/CFS (severe fatigue and post-exertional symptoms), and brain fog, and summarizes what treatments might help.

Long COVID OverlapPost-Exertional Malaise

E0 ConsensusReviewPEM unclearMeta-Analysis

Is the effect of cognitive behaviour therapy for chronic fatigue syndrome (ME/CFS) moderated by the presence of comorbid depressive symptoms? A meta-analysis of three treatment delivery formats.

Kuut, T A, Buffart, L M, Braamse, A M J et al.·Journal of psychosomatic research·2024

This study looked at whether cognitive behaviour therapy (CBT) works differently for ME/CFS patients depending on whether they also have depression. The researchers combined data from six clinical trials with over 1,000 patients and found that for internet-based CBT, patients with depression improved less than those without depression. However, for face-to-face CBT (whether one-on-one or in groups), depression didn't seem to affect how much patients improved.

E0 ConsensusReviewPEM unclearSystematic-Review

[Long COVID - neurological or somatoform disease?].

Tényi, Dalma, Tényi, Tamás, Janszky, József·Ideggyogyaszati szemle·2024

This study reviews research on long COVID to understand what causes its main symptoms like extreme fatigue, pain, and brain fog. Doctors are still debating whether long COVID is primarily a brain/nerve disease, a whole-body illness affecting multiple systems, or a condition where the brain becomes overly sensitive to signals. The researchers found that long COVID shares many similarities with ME/CFS and other hard-to-diagnose conditions, but no single test currently exists to confirm long COVID diagnosis.

NeuroinflammationPost-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

The impact of gut microbiome and diet on post-acute sequelae of SARS-CoV-2 infection.

Reyes, Zabrina, Stovall, Mary Catherine, Punyamurthula, Sanjana et al.·Journal of the neurological sciences·2024

This study looked at how gut bacteria and diet might affect people who develop Long COVID (symptoms that continue months after a COVID-19 infection). Researchers reviewed existing studies to see if changes in gut bacteria linked to worse COVID illness could be improved by eating foods rich in fiber and antioxidants, like those in the Mediterranean Diet. The idea is that a healthier gut might help prevent or reduce Long COVID symptoms.

Gut MicrobiomeImmune System

E0 ConsensusReviewPEM unclearReview-Narrative

Postacute Sequelae of SARS-CoV-2 in Children.

Rao, Suchitra, Gross, Rachel S, Mohandas, Sindhu et al.·Pediatrics·2024

Some children who have COVID-19 experience symptoms that last for weeks or months after the initial infection—a condition called long COVID. This review summarizes what we currently know about long COVID in children, including how common it is, what symptoms children experience, and what might cause it. The authors also describe major research efforts being funded to better understand long COVID in young people and find effective treatments.

Post-Exertional Malaise

E0 ConsensusReviewPEM requiredSystematic-Review

The persistence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after SARS-CoV-2 infection: A systematic review and meta-analysis.

Dehlia, Ankush, Guthridge, Mark A·The Journal of infection·2024

Researchers looked at studies of people with Long COVID to see how many also meet the diagnostic criteria for ME/CFS. They found that about half of Long COVID patients have symptoms that match ME/CFS, including severe fatigue, sleep problems, muscle and joint pain, and post-exertional malaise (feeling much worse after physical activity). This suggests that Long COVID and ME/CFS may be very similar conditions, at least in some patients.

Severe MESleepPost-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Identifying microRNAs Possibly Implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Review.

Tsamou, Maria, Kremers, Fabiënne A C, Samaritakis, Keano A et al.·International journal of molecular sciences·2024

This review examined tiny molecules called microRNAs that may play a role in ME/CFS and fibromyalgia. Researchers looked at existing studies to identify which microRNAs appear to be abnormal in these conditions and what role they might play in causing symptoms. They found that certain microRNAs may be involved in immune system problems, energy production difficulties, and increased pain sensitivity—processes that could help explain why people with these diseases experience fatigue, pain, and other symptoms.

BiomarkersImmune System

E0 ConsensusReviewPEM unclearEvidence-Map

Healthcare system barriers impacting the care of Canadians with myalgic encephalomyelitis: A scoping review.

Hussein, Said, Eiriksson, Lauren, MacQuarrie, Maureen et al.·Journal of evaluation in clinical practice·2024

This study looked at all available Canadian research to understand why people with ME/CFS struggle to get good healthcare. The researchers found that the main problems are: doctors often don't believe ME is real, healthcare providers aren't trained to recognize it, there's a lack of good information about the disease, and sexism plays a role. The study suggests that improving doctor education and creating better care systems could help ME patients get the support they need.

Diagnostics

E0 ConsensusReviewPEM unclearSystematic-Review

Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis.

Lee, Jin-Seok, Sato, Wakiro, Son, Chang-Gue·Autoimmunity reviews·2024

Researchers combined results from 65 brain imaging studies involving over 1,500 ME/CFS patients to look for signs of inflammation in the brain. They used four different types of brain scans and found that specific brain regions—particularly the insular and thalamic regions that help process emotions and manage body functions—showed reduced activity in ME/CFS patients compared to healthy controls. These findings suggest that problems in how these brain regions communicate may help explain why ME/CFS causes fatigue and other characteristic symptoms.

Neuroinflammation

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[Chronic fatigue syndrome in children].

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives.

Exercise therapy for chronic fatigue syndrome.

Functional Somatic Syndromes Are Associated With Varied Postoperative Outcomes and Increased Opioid Use After Spine Surgery: A Systematic Review.

Myalgic encephalomyelitis/chronic fatigue syndrome from current evidence to new diagnostic perspectives through skeletal muscle and metabolic disturbances.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease.

Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities.

Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis.

Chronic Fatigue Syndrome: Diagnosis, Treatment, and Future Direction.

Post-Acute Sequelae of SARS-CoV-2 Infection and Its Impact on Adolescents and Young Adults.

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview.

Long COVID: lights and shadows on the clinical characterization of this emerging pathology.

Is the effect of cognitive behaviour therapy for chronic fatigue syndrome (ME/CFS) moderated by the presence of comorbid depressive symptoms? A meta-analysis of three treatment delivery formats.

[Long COVID - neurological or somatoform disease?].

The impact of gut microbiome and diet on post-acute sequelae of SARS-CoV-2 infection.

Postacute Sequelae of SARS-CoV-2 in Children.

The persistence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after SARS-CoV-2 infection: A systematic review and meta-analysis.

Identifying microRNAs Possibly Implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Review.

Healthcare system barriers impacting the care of Canadians with myalgic encephalomyelitis: A scoping review.

Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis.

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