ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

1141–1160 of 2,784 studies

E2 ModerateCohortPEM unclearCross-Sectional

Factors facilitating patient satisfaction among women with medically unexplained long-term fatigue: A relational perspective.

Lian, Olaug S, Hansen, Anne Helen·Health (London, England : 1997)·2016

This study surveyed 431 women with ME/CFS about their experiences with doctors in Norway. The researchers found that patients were most satisfied when their doctor understood their illness, saw them regularly, and referred them to specialists. The most important factor was feeling like an equal partner with their doctor rather than just being told what to do.

Diagnostics

E2 ModerateCohortPEM unclearObservational

Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register.

Roberts, Emmert, Wessely, Simon, Chalder, Trudie et al.·Lancet (London, England)·2016

This study looked at whether people with ME/CFS die at higher rates than the general population. Researchers examined medical records of 2,147 people diagnosed with ME/CFS in England and Wales over 7 years and found they did not have higher overall death rates. However, the study did find a concerning increase in deaths by suicide among people with ME/CFS, suggesting that mental health support is particularly important for this group.

E2 ModerateCohortPEM not requiredObservational

Long-term methylphenidate intake in chronic fatigue syndrome.

Blockmans, Daniel, Persoons, Philippe·Acta clinica Belgica·2016

This study looked at whether a medication called methylphenidate (also known as Ritalin) could help ME/CFS patients with concentration problems and fatigue over the long term. Researchers sent surveys to patients who had been prescribed this medication and found that about one-third of those still taking it reported significant improvement in both fatigue and concentration difficulties, and were able to work more hours.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of patients contacting a center for undiagnosed and rare diseases.

Mueller, Tobias, Jerrentrup, Andreas, Bauer, Max Jakob et al.·Orphanet journal of rare diseases·2016

This study looked at 522 adults who visited a hospital center for help with diseases that hadn't been diagnosed yet. Most patients were women, and their main complaints were general weakness, joint pain, and stomach discomfort. The researchers found that many patients had been given diagnoses like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome—conditions where symptoms are real but hard to explain with standard medical tests.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Binocular Vision in Chronic Fatigue Syndrome.

Godts, Daisy, Moorkens, Greta, Mathysen, Danny G P·The American orthoptic journal·2016

This study found that people with ME/CFS have differences in how their eyes work together compared to healthy people. Specifically, ME/CFS patients had weaker ability to focus both eyes on nearby objects, reduced eye convergence (bringing eyes together to focus), and a smaller range of accommodation (adjusting focus from far to near). The researchers suggest that ME/CFS patients may benefit from reading glasses or vision exercises earlier than other people.

Pain and Sensitization

E2 ModerateCohortPEM not requiredLongitudinal

Chronic Fatigue Syndrome at Age 16 Years.

Collin, Simon M, Norris, Tom, Nuevo, Roberto et al.·Pediatrics·2016

This study found that about 1.9% of 16-year-olds in the UK experience chronic fatigue syndrome (CFS)—a condition causing severe, long-lasting tiredness that lasts at least 6 months and cannot be explained by other illnesses. Girls were nearly twice as likely as boys to have CFS at this age, and young people experiencing more family stress or difficulties were at higher risk. Children with CFS missed significantly more school than their peers.

E2 ModerateCohortPEM not requiredObservational

Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study.

Newton, Julia L, Finkelmeyer, Andreas, Petrides, George et al.·Open heart·2016

This study found that people with ME/CFS have smaller hearts and lower blood volumes than healthy people. Interestingly, these differences were not related to how long someone had been sick, suggesting the heart changes are not simply from being inactive. Patients with more severe fatigue tended to have lower plasma volume (the liquid part of blood), which might be a target for future treatment.

Autonomic Nervous System

E2 ModeratePEM unclearRegistry-Resource

Comorbidities treated in primary care in children with chronic fatigue syndrome / myalgic encephalomyelitis: A nationwide registry linkage study from Norway.

Bakken, Inger J, Tveito, Kari, Aaberg, Kari M et al.·BMC family practice·2016

This large Norwegian study looked at health problems that children with ME/CFS commonly experience in primary care compared to other children. Children with ME/CFS were much more likely to have records of extreme tiredness, depression, anxiety, migraines, and muscle pain. Interestingly, many children with ME/CFS had a recent infection (especially infectious mononucleosis) before their diagnosis, suggesting infections might play a role in developing the condition.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

[The influence of physical load on the propriate immune and physiological parameters.].

Milicková, M, Zákovská, A, Chlíbková, D·Ceskoslovenska fysiologie·2016

This study looked at how intense physical exercise affects the immune system by measuring antibodies (immune proteins) in ultramarathon runners before and after a race. The researchers found that two types of antibodies—IgA and IgG—increased after the race, suggesting that extreme physical stress temporarily changes how the immune system works. Understanding these changes may help explain why some people develop chronic fatigue after intense exercise.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

Cognitive behaviour therapy for chronic fatigue syndrome: Differences in treatment outcome between a tertiary treatment centre in the United Kingdom and the Netherlands.

Worm-Smeitink, M, Nikolaus, S, Goldsmith, K et al.·Journal of psychosomatic research·2016

This study compared how well cognitive behaviour therapy (CBT) worked for ME/CFS patients at two different treatment centers—one in the Netherlands and one in the UK. Both centers used CBT but with slightly different approaches. The Dutch center saw larger improvements in fatigue, physical functioning, and ability to work or socialize compared to the UK center. The researchers found that differences in how patients were treated, rather than differences in the patients themselves, likely explained why one center had better results.

Interventions

E2 ModerateCohortPEM unclearCross-Sectional

Experiences of general practitioner continuity among women with chronic fatigue syndrome/myalgic encephalomyelitis: a cross-sectional study.

Hansen, Anne Helen, Lian, Olaug S·BMC health services research·2016

This study asked Norwegian women with ME/CFS about their experiences with their general practitioners across three areas: whether doctors shared information with them, whether their care was well-coordinated, and whether they felt their doctor understood them personally. Most women (about two-thirds) reported positive experiences in all three areas, though information-sharing and care coordination could be improved. The study found that longer relationships with the same GP and better communication were linked to more positive experiences.

E2 ModerateCohortPEM unclearCase-Control

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.

Hornig, M, Gottschalk, G, Peterson, D L et al.·Molecular psychiatry·2016

Researchers examined fluid from around the spine (cerebrospinal fluid) in ME/CFS patients and compared it to healthy people and those with multiple sclerosis. They found that ME/CFS patients had unusual patterns of immune proteins called cytokines in this fluid, suggesting their immune system in the brain and spinal cord is activated differently. The most notable finding was higher levels of a protein called eotaxin, which typically helps recruit immune cells involved in allergic responses.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

Landi, Abdolamir, Broadhurst, David, Vernon, Suzanne D et al.·Cytokine·2016

Researchers measured 34 different immune system proteins in blood samples from 100 ME/CFS patients and 79 healthy controls. They found that three specific immune proteins—IL-16, IL-7, and VEGF-A—were significantly lower in ME/CFS patients. This pattern was different from what is seen in other chronic diseases with similar fatigue symptoms, suggesting it may be unique to ME/CFS.

BiomarkersImmune System

E2 ModerateMechanismPEM unclearMechanistic

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome.

Loebel, Madlen, Grabowski, Patricia, Heidecke, Harald et al.·Brain, behavior, and immunity·2016

Researchers tested whether ME/CFS patients have unusually high levels of antibodies (immune proteins) that attack nerve signaling receptors in the body. They found that about 30% of ME/CFS patients had elevated antibodies against certain receptors involved in adrenaline and acetylcholine signaling—chemicals that control heart rate, breathing, and other automatic body functions. Importantly, patients who received rituximab (a treatment that depletes B cells) and improved showed decreases in these antibody levels, suggesting a possible link between these antibodies and disease activity.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Electroencephalogram characteristics in patients with chronic fatigue syndrome.

Wu, Tong, Qi, Xianghua, Su, Yuan et al.·Neuropsychiatric disease and treatment·2016

Researchers used brain wave recordings (EEG) to study electrical activity in the brains of ME/CFS patients compared to healthy controls. They found that ME/CFS patients had reduced brain activity with certain wave patterns being more prominent, particularly in specific regions of the brain. This suggests that ME/CFS affects how the brain's electrical system functions.

E2 ModerateCohortPEM not requiredCross-Sectional

What is in a name? Comparing diagnostic criteria for chronic fatigue syndrome with or without fibromyalgia.

Meeus, Mira, Ickmans, Kelly, Struyf, Filip et al.·Clinical rheumatology·2016

This study compared people with ME/CFS to people with multiple sclerosis and healthy volunteers to see how sick they were and how well they could function. Researchers found that people with ME/CFS had worse physical abilities (like muscle strength and recovery), more severe symptoms, lower quality of life, and more difficulty with daily activities. They also discovered that when ME/CFS patients also had fibromyalgia (widespread pain), their overall symptom burden was much greater.

DiagnosticsCognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

Association of biomarkers with health-related quality of life and history of stressors in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Fenouillet, Emmanuel, Vigouroux, Aude, Steinberg, Jean Guillaume et al.·Journal of translational medicine·2016

This study examined blood markers and muscle function in 36 ME/CFS patients compared to 11 healthy controls to understand whether biological changes relate to symptoms and quality of life. Researchers found three key differences: problems with muscle response to exercise, increased oxidative stress (cellular damage), and changes in immune cells. These biomarkers correlated with how much ME/CFS affected patients' daily lives, especially in those whose illness started after a severe infection.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of hyperacusis in the general population.

Paulin, Johan, Andersson, Linus, Nordin, Steven·Noise & health·2016

This study looked at how common sound sensitivity (hyperacusis) is in the general population and what characteristics people with this condition share. Researchers surveyed thousands of people and found that sound sensitivity often occurs alongside other conditions like ME/CFS, anxiety, depression, and fibromyalgia. People with sound sensitivity tend to avoid loud environments and may seek medical help for their symptoms.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.

Maltese, P E, Venturini, L, Poplavskaya, E et al.·Genetics and molecular research : GMR·2016

This study looked at three genes that help muscles produce energy during physical activity. The researchers compared these genes in 17 patients with ME/CFS and 50 healthy people to see if differences in these genes might explain why ME/CFS patients experience severe fatigue after exertion. The study found no significant genetic differences between the two groups, suggesting these particular genes are not responsible for causing ME/CFS.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of serological and molecular test for diagnosis of infectious mononucleosis.

Salehi, Hassan, Salehi, Marziyeh, Roghanian, Rasoul et al.·Advanced biomedical research·2016

This study compared two different tests for diagnosing infectious mononucleosis (IM), a viral infection caused by Epstein-Barr virus (EBV). Researchers tested 100 patients suspected of having IM and 100 healthy people using two methods: a blood test (ELISA) and a genetic test (PCR). The blood test was easier, faster, and cheaper than the genetic test, making it a better choice for initial diagnosis.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Factors facilitating patient satisfaction among women with medically unexplained long-term fatigue: A relational perspective.

Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register.

Long-term methylphenidate intake in chronic fatigue syndrome.

Characteristics of patients contacting a center for undiagnosed and rare diseases.

Binocular Vision in Chronic Fatigue Syndrome.

Chronic Fatigue Syndrome at Age 16 Years.

Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study.

Comorbidities treated in primary care in children with chronic fatigue syndrome / myalgic encephalomyelitis: A nationwide registry linkage study from Norway.

[The influence of physical load on the propriate immune and physiological parameters.].

Cognitive behaviour therapy for chronic fatigue syndrome: Differences in treatment outcome between a tertiary treatment centre in the United Kingdom and the Netherlands.

Experiences of general practitioner continuity among women with chronic fatigue syndrome/myalgic encephalomyelitis: a cross-sectional study.

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.

Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome.

Electroencephalogram characteristics in patients with chronic fatigue syndrome.

What is in a name? Comparing diagnostic criteria for chronic fatigue syndrome with or without fibromyalgia.

Association of biomarkers with health-related quality of life and history of stressors in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Characteristics of hyperacusis in the general population.

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.

Comparison of serological and molecular test for diagnosis of infectious mononucleosis.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research