ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1581–1600 of 2,768 studies

E2 ModerateBehavioralPEM not requiredObservational

The role of acceptance in chronic fatigue syndrome.

Brooks, Samantha K, Rimes, Katharine A, Chalder, Trudie·Journal of psychosomatic research·2011

This study looked at whether learning to accept ME/CFS (rather than fighting against it) helps patients feel less fatigued and function better in daily life. Researchers gave 259 patients questionnaires and then provided 90 of them with cognitive behavioral therapy (CBT). After treatment, patients who had learned greater acceptance reported less fatigue and better ability to work and socialize.

E2 ModerateCohortPEM not requiredCase-Control

Gynecological history in chronic fatigue syndrome: a population-based case-control study.

Boneva, Roumiana S, Maloney, Elizabeth M, Lin, Jin-Mann et al.·Journal of women's health (2002)·2011

This study looked at whether gynecological history—including conditions like endometriosis, pelvic pain, and surgeries—might be connected to ME/CFS. Researchers compared 36 women with ME/CFS to 48 healthy women and found that women with ME/CFS reported more pelvic pain, endometriosis, and gynecological surgeries. The study suggests that gynecological health may play a role in ME/CFS and deserves closer medical attention.

E2 ModerateCohortPEM not requiredCross-Sectional

Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

Williams, Allison M, Kitchen, Peter, Eby, Jeanette·BMC complementary and alternative medicine·2011

This study looked at how many people in Ontario, Canada visited alternative health care providers like massage therapists, acupuncturists, and naturopaths in 2005. Researchers found that about 13% of adults (over 1.2 million people) used these services. People with chronic conditions, including chronic fatigue syndrome, were more likely to visit alternative providers, especially if they felt their regular doctors weren't meeting their health needs.

E2 ModerateCohortPEM unclearCross-Sectional

No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan.

Furuta, Rika A, Miyazawa, Takayuki, Sugiyama, Takeki et al.·Retrovirology·2011

Researchers tested blood samples from 500 healthy people, 67 prostate cancer patients, and 100 ME/CFS patients in Japan to see if a virus called XMRV was linked to these conditions. They found some antibodies to XMRV in a small number of people (1.6-3.0%), but no clear evidence of active infection in any group, suggesting XMRV is not a cause of ME/CFS in Japan.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive deficits in patients with chronic fatigue syndrome compared to those with major depressive disorder and healthy controls.

Constant, E L, Adam, S, Gillain, B et al.·Clinical neurology and neurosurgery·2011

This study tested memory and attention in people with ME/CFS, comparing them to people with depression and healthy volunteers. People with ME/CFS showed real, measurable problems with attention and memory, but these problems were NOT simply caused by depression or by getting tired during testing. Importantly, the cognitive difficulties in ME/CFS appeared to be their own distinct issue, separate from their mood symptoms.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic conditions and major depression in community-dwelling older adults.

Fiest, Kirsten M, Currie, Shawn R, Williams, Jeanne V A et al.·Journal of affective disorders·2011

This study looked at how common chronic illnesses and depression are together in older adults in Canada. Researchers found that people over 50 with long-term health conditions are much more likely to also have depression. Interestingly, conditions like Chronic Fatigue Syndrome, fibromyalgia, and migraines showed the strongest link with depression in seniors.

E2 ModerateCohortPEM unclearCross-Sectional

An Italian study on health-related quality of life and fatigue in patients with chronic fatigue syndrome and patients with chronic HCV virus infection: similarities and differences.

Racciatti, Delia, Gorgoretti, V, Sepede, G et al.·International journal of immunopathology and pharmacology·2011

This Italian study compared fatigue and quality of life in 39 ME/CFS patients versus 49 people with chronic hepatitis C. Using standard questionnaires, researchers found that ME/CFS patients experienced significantly more severe fatigue and lower quality of life than hepatitis C patients. The study concludes that managing fatigue should be a priority for ME/CFS patients to help improve their overall well-being.

E2 ModerateCohortPEM unclearCross-Sectional

Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome.

Schutzer, Steven E, Angel, Thomas E, Liu, Tao et al.·PloS one·2011

This study examined spinal fluid from people with post-treatment Lyme disease and ME/CFS to see if these two conditions are different. Using advanced laboratory techniques, researchers found that each condition has a unique pattern of proteins in the spinal fluid, meaning they appear to be distinct diseases rather than the same illness. This discovery could eventually help doctors tell these conditions apart and develop better treatments for each.

Neuroinflammation

E2 ModerateCohortPEM not requiredCase-Control

Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.

Smith, Alicia K, Fang, Hong, Whistler, Toni et al.·Neuropsychobiology·2011

Researchers used a novel genetic screening approach to search for genes that might be involved in ME/CFS by comparing DNA variants and gene activity between people with ME/CFS and healthy controls. They identified two genes—GRIK2 and NPAS2—that showed both genetic differences and altered activity levels in people with ME/CFS. GRIK2 is involved in communication between nerve cells, while NPAS2 controls the body's internal clock, suggesting these biological systems may play a role in the condition.

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal health study of US 1991 Gulf War veterans: changes in health status at 10-year follow-up.

Li, Bo, Mahan, Clare M, Kang, Han K et al.·American journal of epidemiology·2011

This study followed US veterans from the 1991 Gulf War for 10 years (1995–2005) to see how their health changed over time. Deployed veterans reported more ongoing health problems, including chronic fatigue syndrome-like illness, than veterans who were not deployed. By 2005, deployed veterans were also more likely to develop new health problems compared to nondeployed veterans.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Clinical characteristics of patients with medically unexplained chronic widespread pain: a primary care center study.

Lee, Kye Hwa, Kim, Cheol Hwan, Shin, Ho Cheol et al.·Korean journal of family medicine·2011

This study examined 109 patients with chronic widespread pain to understand what makes medically unexplained pain different from pain caused by known medical or psychological conditions. Researchers found that patients with unexplained pain had more tender points on their body, greater fatigue, and more functional impairment than those with pain linked to known medical causes, but were very similar to those with pain linked to psychological factors.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected blood donors or individuals in Africa.

Tang, Shixing, Zhao, Jiangqin, Viswanath, Ragupathy et al.·Transfusion·2011

Researchers tested blood samples from HIV-positive individuals and blood donors in Africa to see if they carried a virus called XMRV, which had been suggested as a possible cause of ME/CFS. Using sensitive laboratory tests, they found no evidence of XMRV in any of the 268 samples they examined. This suggests that XMRV may not be common in these populations.

E2 ModerateCohortPEM not requiredCross-Sectional

Up-regulation of TGF-β1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

Zhang, Hai-Ying, Liu, Zhan-Dong, Hu, Chao-Jun et al.·Journal of the Formosan Medical Association = Taiwan yi zhi·2011

Researchers measured levels of a immune signaling molecule called TGF-β1 in blood cells from ME/CFS patients and compared them to healthy people and patients with other illnesses. They found that ME/CFS patients had significantly higher levels of TGF-β1 than both groups, suggesting this molecule may play a role in ME/CFS disease development.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Numbers and types of nonbladder syndromes as risk factors for interstitial cystitis/painful bladder syndrome.

Warren, John W, Wesselmann, Ursula, Morozov, Vadim et al.·Urology·2011

This study looked at whether having multiple conditions alongside bladder pain (like fibromyalgia, chronic fatigue syndrome, and allergies) increases the risk of developing interstitial cystitis/painful bladder syndrome (IC/PBS). Researchers found that people who had more of these accompanying conditions before developing IC/PBS were at higher risk, and that these conditions often appeared before the bladder symptoms started. The specific types of conditions varied, but their number seemed to matter most.

E2 ModerateCohortPEM unclearCross-Sectional

Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia.

Kishi, Akifumi, Natelson, Benjamin H, Togo, Fumiharu et al.·Sleep·2011

This study looked at sleep patterns in women with ME/CFS, comparing those with ME/CFS alone to those who also have fibromyalgia (FM). Researchers found that people with ME/CFS alone had trouble staying asleep and waking up too often from REM sleep, while those with both conditions showed different sleep problems including difficulty maintaining deeper sleep stages. These findings suggest that ME/CFS and fibromyalgia may involve different types of sleep disturbances.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection.

Spindler, J, Hackett, J, Qiu, X et al.·Advances in virology·2011

This study tested blood samples from men in an HIV research study to see if they were infected with XMRV, a virus that had been proposed as a possible cause of ME/CFS. Researchers used two different methods to look for the virus: checking for antibodies (immune system responses) and checking for the virus itself. They found no evidence that XMRV was actually present in any of the samples tested.

E2 ModerateBehavioralPEM unclearCross-Sectional

Alcohol use and selected health conditions of 1991 Gulf War veterans: survey results, 2003-2005.

Coughlin, Steven S, Kang, Han K, Mahan, Clare M·Preventing chronic disease·2011

This study looked at how alcohol use relates to health problems in veterans of the 1991 Gulf War. Researchers surveyed nearly 10,000 veterans and found that those who drank heavily had higher rates of several conditions, including chronic fatigue syndrome-like illness. The findings suggest that veterans with drinking problems and war-related health conditions need better access to treatment.

E2 ModerateCohortPEM not requiredCross-Sectional

Small heart with low cardiac output for orthostatic intolerance in patients with chronic fatigue syndrome.

Miwa, Kunihisa, Fujita, Masatoshi·Clinical cardiology·2011

This study found that ME/CFS patients who experience dizziness or fainting when standing up (orthostatic intolerance) have smaller hearts and pump less blood with each beat compared to ME/CFS patients without these symptoms and healthy people. The researchers used ultrasound imaging to measure heart size and function in different groups and discovered that about half of ME/CFS patients with orthostatic intolerance had unusually small left heart chambers.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

An unbiased metagenomic search for infectious agents using monozygotic twins discordant for chronic fatigue.

Sullivan, Patrick F, Allander, Tobias, Lysholm, Fredrik et al.·BMC microbiology·2011

Researchers used advanced genetic sequencing to search for viruses in the blood of 45 people with chronic fatigue syndrome, comparing each patient to their identical twin who did not have the illness. They found that a virus called GB virus C appeared in a few patients but not in their healthy twins, suggesting it might be linked to ME/CFS. However, the overall results did not strongly support the idea that a single detectable virus causes chronic fatigue.

Immune System

E2 ModerateCohortPEM not requiredObservational

Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.

Frost, Jeana, Okun, Sally, Vaughan, Timothy et al.·Journal of medical Internet research·2011

This study looked at how patients can help doctors understand whether existing medicines work for conditions they weren't originally designed to treat. Researchers analyzed information from an online patient community where people with conditions like ME/CFS shared their experiences with two medicines: amitriptyline and modafinil. The study found that most patients were using these drugs for purposes other than what they were officially approved for, and many reported the drugs helped them.

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The role of acceptance in chronic fatigue syndrome.

Gynecological history in chronic fatigue syndrome: a population-based case-control study.

Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan.

Cognitive deficits in patients with chronic fatigue syndrome compared to those with major depressive disorder and healthy controls.

Chronic conditions and major depression in community-dwelling older adults.

An Italian study on health-related quality of life and fatigue in patients with chronic fatigue syndrome and patients with chronic HCV virus infection: similarities and differences.

Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome.

Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.

Longitudinal health study of US 1991 Gulf War veterans: changes in health status at 10-year follow-up.

Clinical characteristics of patients with medically unexplained chronic widespread pain: a primary care center study.

Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected blood donors or individuals in Africa.

Up-regulation of TGF-β1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

Numbers and types of nonbladder syndromes as risk factors for interstitial cystitis/painful bladder syndrome.

Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia.

Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection.

Alcohol use and selected health conditions of 1991 Gulf War veterans: survey results, 2003-2005.

Small heart with low cardiac output for orthostatic intolerance in patients with chronic fatigue syndrome.

An unbiased metagenomic search for infectious agents using monozygotic twins discordant for chronic fatigue.

Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.

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