ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1581–1600 of 2,807 studies

E2 ModerateCohortPEM not requiredObservational

Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus.

Balada, Eva, Castro-Marrero, Jesús, Felip, Lledó et al.·Journal of clinical immunology·2011

Researchers tested whether a virus called XMRV—which had been found in some ME/CFS patients—might also be present in people with lupus (SLE), a different autoimmune disease that also causes severe fatigue. They checked blood samples from 95 lupus patients and 50 healthy people but found no sign of XMRV in any of them. This suggests that XMRV is probably not responsible for the fatigue seen in lupus patients.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychophysical distress and alexithymic traits in chronic fatigue syndrome with and without comorbid depression.

Sepede, G, Racciatti, D, Gorgoretti, V et al.·International journal of immunopathology and pharmacology·2011

This study compared people with ME/CFS to healthy people and looked at two things: emotional distress and difficulty recognizing their own feelings. They found that ME/CFS patients had more physical symptoms and emotional complaints than healthy people, especially those who also had depression. Interestingly, even ME/CFS patients without depression had some difficulty identifying their emotions, though less than those with depression.

E2 ModerateBehavioralPEM not requiredLongitudinal

Fatigue, depressive symptoms, and anxiety from adolescence up to young adulthood: a longitudinal study.

ter Wolbeek, Maike, van Doornen, Lorenz J P, Kavelaars, Annemieke et al.·Brain, behavior, and immunity·2011

This study followed 633 teenage girls for 4.5 years to understand what causes fatigue and ME/CFS-like symptoms in young adulthood. Researchers found that fatigue, depression, and anxiety tend to rise and fall together over time, and that certain immune markers and emotional problems during teenage years could predict who would develop fatigue later. The study suggests that warning signs of future fatigue can sometimes be spotted years before symptoms become serious.

Immune System

E2 ModeratePEM not requiredRegistry-Resource

A Disease Register for ME/CFS: Report of a Pilot Study.

Pheby, Derek, Lacerda, Eliana, Nacul, Luis et al.·BMC research notes·2011

Researchers created a disease register (a database) to identify and track people with ME/CFS in a fair and systematic way. They searched GP records in three regions of England and found 510 patients with unexplained chronic fatigue, of which 160 agreed to join the register. By following these patients over time, researchers can better understand how ME/CFS progresses and use this group for future studies.

Diagnostics

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Cella, Matteo, Stahl, Daniel, Reme, Silje Endresen et al.·Psychotherapy research : journal of the Society for Psychotherapy Research·2011

This study looked at whether it matters which therapist treats patients with ME/CFS when they receive cognitive behavioral therapy (CBT). Researchers tracked 374 ME/CFS patients treated by 12 different therapists in a specialized clinic and measured changes in fatigue and disability. They found that while patients improved overall, the individual therapist made almost no difference in outcomes—the patients' improvements were similar regardless of which qualified therapist treated them.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Characterization of chronic fatigue in patients with sarcoidosis in clinical remission.

Korenromp, Ingrid H E, Heijnen, Cobi J, Vogels, Oscar J M et al.·Chest·2011

This study looked at 75 people with sarcoidosis (an inflammatory disease) whose disease was no longer active, but who still felt extremely tired. Nearly half of these fatigued patients met the diagnostic criteria for chronic fatigue syndrome (CFS). The researchers found that fatigue was linked to depression, anxiety, reduced quality of life, lower physical activity, and muscle weakness—even though their sarcoidosis was considered under control.

E2 ModerateCohortPEM not requiredObservational

Peripheral blood gene expression in postinfective fatigue syndrome following from three different triggering infections.

Galbraith, Sally, Cameron, Barbara, Li, Hui et al.·The Journal of infectious diseases·2011

Researchers studied blood samples from 18 people who developed long-lasting fatigue after three different infections (Epstein-Barr virus, Ross River virus, and Q fever) and compared them to 18 healthy people who recovered normally. They looked for patterns in which genes were turned on or off that might explain the fatigue syndrome. While they found some differences in gene activity, these patterns were not consistent across the different infection groups, suggesting there may not be a single blood-based marker that identifies post-infectious fatigue.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

Does the heterogeneity of chronic fatigue syndrome moderate the response to cognitive behaviour therapy? An exploratory study.

Cella, Matteo, Chalder, Trudie, White, Peter D·Psychotherapy and psychosomatics·2011

This study looked at whether ME/CFS patients are different from each other in ways that predict how well they respond to cognitive behaviour therapy (CBT), a type of talking therapy. Researchers analyzed data from 236 patients and found that most patients improved with CBT regardless of their characteristics, but they identified a smaller group with certain traits—including weight changes, tremors, anxiety, and pain—who were less likely to benefit. The findings suggest CBT can help most people with ME/CFS, though a minority may need different approaches.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

Long-term sickness absence among patients with chronic fatigue syndrome.

Knudsen, Ann Kristin, Henderson, Max, Harvey, Samuel B et al.·The British journal of psychiatry : the journal of mental science·2011

This study looked at ME/CFS patients who were on long-term sick leave from work and compared them to those still working. Patients taking sick leave had more severe physical fatigue and sleep problems than other patients. Interestingly, those on sick leave also tended to avoid situations they found embarrassing and rested more often as a coping strategy. The researchers suggest that helping patients manage embarrassment-related thoughts and avoidance behaviors might help them return to work.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Xenotropic murine leukemia virus-related virus is not associated with chronic fatigue syndrome in patients from different areas of the us in the 1990s.

Ali, Mir A, Dale, Janet K, Kozak, Christine A et al.·Virology journal·2011

A 2009 study claimed to find a virus called XMRV in most ME/CFS patients, raising hopes for a viral cause. This 2011 study looked for the same virus in ME/CFS patients from similar U.S. regions but found no clear evidence it was present or unique to ME/CFS patients. The small DNA signals they detected appeared to be contamination from mouse DNA rather than actual virus infection.

E2 ModerateCohortPEM not requiredCross-Sectional

No detectable XMRV in subjects with chronic fatigue syndrome from Quebec.

Cool, Marc, Bouchard, Nathalie, Massé, Ginette et al.·Virology·2011

This study tested whether a virus called XMRV could be found in blood samples from 72 Canadian patients with ME/CFS. Researchers used several different methods to look for the virus, including testing for viral DNA, antibodies, and infectious virus particles. They found no evidence of XMRV in any of the patients tested.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study.

Simmons, Graham, Glynn, Simone A, Komaroff, Anthony L et al.·Science (New York, N.Y.)·2011

Some researchers had claimed that a virus called XMRV might be linked to ME/CFS. This study tested blood samples from 15 people previously reported to have this virus and 15 healthy people without it, sending them to 9 different labs for testing. The labs could not consistently find the virus, and when they did find it, the results were similar in both ME/CFS patients and healthy people. This suggests the virus is not reliably present in ME/CFS patients' blood.

E2 ModerateCohortPEM not requiredCross-Sectional

No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome.

Steffen, Imke, Tyrrell, D Lorne, Stein, Eleanor et al.·PloS one·2011

Researchers tested blood samples from 58 Canadian ME/CFS patients and 57 healthy people to look for two viruses (XMRV and MLV) that had been suggested as possible causes of ME/CFS. Using multiple sensitive tests, they found no trace of these viruses or antibodies against them in any of the samples. This study challenges earlier reports that had linked these viruses to ME/CFS.

E2 ModerateCohortPEM unclearObservational

Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis.

de Carvalho Leite, Jose C, de L Drachler, Maria, Killett, Anne et al.·International journal for equity in health·2011

This study asked 35 people with ME/CFS in England about what support they needed from health and social care services. Participants described needing personalized help with managing symptoms, practical support for daily life, and financial assistance—but found it difficult to access these services because doctors and providers often didn't understand their condition. The researchers found that some groups, including certain ethnic minorities, faced even greater barriers to getting the help they needed.

E2 ModerateBehavioralPEM not requiredLongitudinal

Psychopathology and physical activity as predictors of chronic fatigue syndrome in the 1958 british birth cohort: a replication study of the 1946 and 1970 birth cohorts.

Goodwin, Laura, White, Peter D, Hotopf, Matthew et al.·Annals of epidemiology·2011

This study followed over 11,000 people born in 1958 in Britain to see whether emotional or mental health problems, and physical activity levels before they got sick, were connected to developing ME/CFS later in life. Researchers found that people who had psychological difficulties in their twenties and thirties were more likely to later develop ME/CFS, but childhood emotional problems or exercise habits didn't show this connection.

E2 ModerateBehavioralPEM not requiredLongitudinal

Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome--a 6-month follow-up study.

Kawatani, Junko, Mizuno, Kei, Shiraishi, Seishi et al.·Brain & development·2011

This study looked at thinking and attention problems in children with ME/CFS using a specialized test that measures how quickly and accurately the brain can process information. Children with ME/CFS performed worse on attention tasks compared to healthy children, especially when they had to switch between different tasks. After 6 months of combined treatment with therapy and medication, children showed improvements in both their thinking ability and fatigue levels.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

The pathway from glandular fever to chronic fatigue syndrome: can the cognitive behavioural model provide the map?

Moss-Morris, R, Spence, M J, Hou, R·Psychological medicine·2011

This study followed 246 people with glandular fever (infectious mononucleosis) to see who developed chronic fatigue syndrome (CFS) in the months after infection. The researchers found that certain psychological factors—like anxiety, depression, perfectionism, and negative beliefs about the illness—were associated with developing CFS. Interestingly, an 'all-or-nothing' approach to activity (pushing hard then stopping completely) was the strongest predictor of CFS at 6 months.

E2 ModerateCohortPEM unclearObservational

What stops children with a chronic illness accessing health care: a mixed methods study in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Webb, Carly M, Collin, Simon M, Deave, Toity et al.·BMC health services research·2011

Children with ME/CFS are waiting much longer than recommended to see a specialist—the typical wait is 18 months, while guidelines suggest assessment should happen within 3-6 months. This study found that many GPs and other doctors don't know enough about ME/CFS or how to refer children properly, and some had negative attitudes toward the condition. Parents also found it hard to explain an 'invisible' illness to healthcare providers, which delayed their children from getting the specialist care they needed.

E2 ModerateCohortPEM unclearObservational

The role of changes in activity as a function of perceived available and expended energy in nonpharmacological treatment outcomes for ME/CFS.

Brown, Molly, Khorana, Neha, Jason, Leonard A·Journal of clinical psychology·2011

This study looked at how people with ME/CFS respond to gradual activity increases. The key finding was that patients who stayed within their energy limits—not pushing beyond what energy they had available—improved more in both physical function and fatigue compared to those who pushed beyond their limits. This suggests that personalized treatment based on each person's actual energy availability might be more helpful than one-size-fits-all activity programs.

E2 ModerateCohortPEM unclearCross-Sectional

Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.

Elfaitouri, Amal, Shao, Xingwu, Mattsson Ulfstedt, Johan et al.·PloS one·2011

Researchers tested whether a virus called XMRV (xenotropic murine retrovirus) was present in Swedish patients with ME/CFS and fibromyalgia. Using sensitive tests on blood samples from 78 ME/CFS patients and 168 healthy blood donors, they found no evidence that this virus was present in any of the samples. This study helps answer questions about whether XMRV plays a role in ME/CFS.

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Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus.

Psychophysical distress and alexithymic traits in chronic fatigue syndrome with and without comorbid depression.

Fatigue, depressive symptoms, and anxiety from adolescence up to young adulthood: a longitudinal study.

A Disease Register for ME/CFS: Report of a Pilot Study.

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Characterization of chronic fatigue in patients with sarcoidosis in clinical remission.

Peripheral blood gene expression in postinfective fatigue syndrome following from three different triggering infections.

Does the heterogeneity of chronic fatigue syndrome moderate the response to cognitive behaviour therapy? An exploratory study.

Long-term sickness absence among patients with chronic fatigue syndrome.

Xenotropic murine leukemia virus-related virus is not associated with chronic fatigue syndrome in patients from different areas of the us in the 1990s.

No detectable XMRV in subjects with chronic fatigue syndrome from Quebec.

Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study.

No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome.

Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis.

Psychopathology and physical activity as predictors of chronic fatigue syndrome in the 1958 british birth cohort: a replication study of the 1946 and 1970 birth cohorts.

Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome--a 6-month follow-up study.

The pathway from glandular fever to chronic fatigue syndrome: can the cognitive behavioural model provide the map?

What stops children with a chronic illness accessing health care: a mixed methods study in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

The role of changes in activity as a function of perceived available and expended energy in nonpharmacological treatment outcomes for ME/CFS.

Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.

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